Works in eLife, 2025

Results: 536

Emergence of Dip2-mediated specific DAG-based PKC signalling axis in eukaryotes.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.104011

By:

Shambhavi, Sakshi;
Mondal, Sudipta;
Chakraborty, Arnab;
Shukla, Nikita;
Panda, Bapin Kumar;
Kumar, Santhosh;
Kinatukara, Priyadarshan;
Pal, Biswajit;
Kamat, Siddhesh S.;
Sankaranarayanan, Rajan

Publication type:

Article

Anti-drift pose tracker (ADPT), a transformer-based network for robust animal pose estimation cross-species.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.95709

By:

Guoling Tang;
Yaning Han;
Xing Sun;
Ruonan Zhang;
Ming-Hu Han;
Quanying Liu;
Pengfei Wei

Publication type:

Article

Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.103615

By:

Qian Wang;
Hongge Li;
Yingyu Mao;
Garg, Ankur;
Eun Sil Park;
Yihua Wu;
Chow, Alyssa;
Peregrin, John;
Xin Zhang

Publication type:

Article

The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.101299

By:

Jie Fang;
Singh, Shivendra;
Wells, Brennan;
Qiong Wu;
Hongjian Jin;
Janke, Laura J.;
Shibiao Wan;
Steele, Jacob A.;
Connelly, Jon P.;
Murphy, Andrew J.;
Ruoning Wang;
Davidoff, Andrew;
Ashcroft, Margaret;
Pruett-Miller, Shondra M.;
Jun Yang

Publication type:

Article

Reprograming gene expression in 'hibernating' C. elegans involves the IRE-1/XBP-1 pathway.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.101186

By:

Engelfriet, Melanie Lianne;
Yanwu Guo;
Arnold, Andreas;
Valen, Eivind;
Ciosk, Rafal

Publication type:

Article

Differences in size and number of embryonic type II neuroblast lineages correlate with divergent timing of central complex development between beetle and fly.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.99717

By:

Rethemeier, Simon;
Fritzsche, Sonja;
Mühlen, Dominik;
Bucher, Gregor;
Hunnekuhl, Vera S.

Publication type:

Article

RAG suppresses group 2 innate lymphoid cells.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.98287

By:

Ver Heul, Aaron M.;
Mack, Madison;
Zamidar, Lydia;
Tamari, Masato;
Ting-Lin Yang;
Trier, Anna M.;
Do-Hyun Kim;
Janzen-Meza, Hannah;
Van Dyken, Steven J.;
Chyi-Song Hsieh;
Karo, Jenny M.;
Sun, Joseph C.;
Kim, Brian S.

Publication type:

Article

Quantifying feral pig interactions to inform disease transmission networks.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.102643

By:

Tatiana Proboste, Tatiana;
Turnlund, Abigail;
Bengsen, Andrew;
Gentle, Matthew;
Wilson, Cameron;
Harriott, Lana;
Fuller, Richard A.;
Marshall, Darren

Publication type:

Article

Not all dimers are equal: Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.105018

By:

PATEL, JEET H.;
MULLINS, MARY C.

Publication type:

Article

Disruption of the novel nested gene Aff3ir mediates disturbed flow-induced atherosclerosis in mice.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.103413

By:

Shuo He;
Lei Huang;
Zhuozheng Chen;
Ze Yuan;
Yue Zhao;
Lingfang Zeng;
Yi Zhu;
Jinlong He

Publication type:

Article

Aberration correction in long GRIN lens-based microendoscopes for extended field-of-view two-photon imaging in deep brain regions.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.101420

By:

Sattin, Andrea;
Nardin, Chiara;
Daste, Simon;
Moroni, Monica;
Reddy, Innem;
Liberale, Carlo;
Panzeri, Stefano;
Fleischmann, Alexander;
Fellin, Tommaso

Publication type:

Article

Temporal dynamics analysis reveals that concurrent working memory load eliminates the Stroop effect through disrupting stimulus-response mapping.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.100918

By:

Yafen Li;
Yixuan Lin;
Qing Li;
Yongqiang Chen;
Zhifang Li;
Antao Chen

Publication type:

Article

The neuropeptide sulfakinin is a peripheral regulator of insect behavioral switch between mating and foraging.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.100870

By:

Hong-Fei Li;
Bao Dong;
Yuan-Yuan Peng;
Hao-Yue Luo;
Xiao-Lan Ou;
Zheng-Lin Ren;
Yoonseong Park;
Jin-Jun Wang;
Hong-Bo Jiang

Publication type:

Article

Semantical and geometrical protein encoding toward enhanced bioactivity and thermostability.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.98033

By:

Yang Tan;
Bingxin Zhou;
Lirong Zheng;
Guisheng Fan;
Liang Hong

Publication type:

Article

Interdependence of plasma membrane nanoscale dynamics of a kinase and its cognate substrate underlies Arabidopsis response to viral infection.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.90309

By:

Jolivet, Marie-Dominique;
Deroubaix, Anne Flore;
Boudsocq, Marie;
Abel, Nikolaj B.;
Rocher, Marion;
Robbe, Terezinha;
Wattelet-Boyer, Valérie;
Huard, Jennifer;
Lefebvre, Dorian;
Yi-Ju Lu;
Day, Brad;
Saias, Grégoire;
Ahmed, Jahed;
Cotelle, Valérie;
Giovinazzo, Nathalie;
Gallois, Jean-Luc;
Yasuyuki Yamaji;
German-Retana, Sylvie;
Gronnier, Julien;
Ott, Thomas

Publication type:

Article

ATP-release pannexin channels are gated by lysophospholipids.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.107067

By:

Henze, Erik;
Burkhardt, Russell N.;
Fox, Bennett William;
Schwertfeger, Tyler J.;
Gelsleichter, Eric;
Michalski, Kevin;
Kramer, Lydia;
Lenfest, Margret;
Boesch, Jordyn M.;
Hening Lin;
Schroeder, Frank C.;
Toshimitsu Kawate

Publication type:

Article

Complex system modeling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.104121

By:

Mukherjee, Sromona D.;
Batagello, Carlos;
Adler, Ava;
Agudelo, Jose;
Zampini, Anna;
Suryavanshi, Mangesh;
Nguyen, Andrew;
Orr, Terry;
Dearing, Denise;
Monga, Manoj;
Miller, Aaron W.

Publication type:

Article

The first complete 3D reconstruction and morphofunctional mapping of an insect eye.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.103247

By:

Makarova, Anastasia A.;
Chua, Nicholas J.;
Diakova, Anna V.;
Desyatirkina, Inna A.;
Pat Gunn;
Song Pang;
Shan Xu, C.;
Hess, Harald F.;
Chklovskii, Dmitri B.;
Polilov, Alexey A.

Publication type:

Article

GPRC6A as a novel kokumi receptor responsible for enhanced taste preferences by ornithine.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.101629

By:

Takashi Yamamoto;
Kayoko Ueji;
Haruno Mizuta;
Chizuko Inui-Yamamoto;
Natsuko Kumamoto;
Yasuhiro Shibata;
Shinya Ugawa

Publication type:

Article

Seasonal and comparative evidence of adaptive gene expression in mammalian brain size plasticity.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.100788

By:

Thomas, William R.;
Richter, Troy;
O'Neil, Erin T.;
Baldoni, Cecilia;
Corthals, Angelique;
von Elverfeldt, Dominik;
Nieland, John D.;
Dechmann, Dina;
Hunter, Richard;
Davalos, Liliana M.

Publication type:

Article

Neural geometry from mixed sensorimotor selectivity for predictive sensorimotor control.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.100064

By:

Yiheng Zhang;
Yun Chen;
Tianwei Wang;
He Cui

Publication type:

Article

Physiological magnetic field strengths help magnetotactic bacteria navigate in simulated sediments.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.98001

By:

Codutti, Agnese;
Charsooghi, Mohammad A.;
Marx, Konrad;
Cerdá-Doñate, Elisa;
Muñoz, Omar;
Zaslansky, Paul;
Robinson, Tom;
Faivre, Damien;
Klumpp, Stefan

Publication type:

Article

Perceptual and attentional impairments of conscious access involve distinct neural mechanisms despite equal task performance.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.97900

By:

Noorman, Samuel;
Stein, Timo;
Fahrenfort, Johannes Jacobus;
van Gaal, Simon

Publication type:

Article

With a little help from T cells.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.106854

By:

BURTCHETT, TROY;
HAMMER, NEAL

Publication type:

Article

Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.104237

By:

Abramsson, Mia L.;
Corey, Robin A.;
Skerle, Jan L.;
Persson, Louise J.;
Anden, Olivia;
Oluwole, Abraham O.;
Howard, Rebecca J.;
Lindahl, Erik;
Robinson, Carol V.;
Strisovsky, Kvido;
Marklund, Erik G.;
Drew, David;
Stansfeld, Phillip J.;
Landreh, Michael

Publication type:

Article

Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.103497

By:

Rudgalvyte, Martina;
Zehan Hu;
Kressler, Dieter;
Dengjel, Jörn;
Glauser, Dominique A.

Publication type:

Article

DNA replication in primary hepatocytes without the six-subunit ORC.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.102915

By:

Przanowska, Róża K.;
Yuechuan Chen;
Takayuki-Okano Uchida;
Etsuko Shibata;
Xiaoxiao Hao;
Rueda, Isaac Segura;
Jensen, Kate;
Przanowski, Piotr;
Trimboli, Anthony;
Yoshiyuki Shibata;
Leone, Gustavo;
Dutta, Anindya

Publication type:

Article

Untangling stability and gain modulation in cortical circuits with multiple interneuron classes.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.99808

By:

Bos, Hannah;
Miehl, Christoph;
Michelle Oswald, Anne-Marie;
Doiron, Brent

Publication type:

Article

Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD).

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.96513

By:

Deganutti, Giuseppe;
Pipito, Ludovico;
Rujan, Roxana Maria;
Weizmann, Tal;
Griffin, Peter;
Ciancetta, Antonella;
Moro, Stefano;
Reynolds, Christopher Arthur

Publication type:

Article

Interpreting roles of mutations associated with the emergence of S. aureus USA300 strains using transcriptional regulatory network reconstruction.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.90668

By:

Poudel, Saugat;
Hyun, Jason;
Ying Hefner;
Monk, Jon;
Nizet, Victor;
Palsson, Bernhard O.

Publication type:

Article

Transcriptome profiling of tendon fibroblasts at the onset of embryonic muscle contraction reveals novel force-responsive genes.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.105802

By:

Nayak, Pavan K.;
Subramanian, Arul;
Schilling, Thomas F.

Publication type:

Article

A toolbox for ablating excitatory and inhibitory synapses.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.103757

By:

Bareghamyan, Aida;
Changfeng Deng;
Daoudi, Sarah;
Yadav, Shubhash C.;
Xiaocen Lu;
Wei Zhang;
Campbell, Robert E.;
Kramer, Richard H.;
Chenoweth, David M.;
Arnold, Don B.

Publication type:

Article

A circadian clock drives behavioral activity in Antarctic krill (Euphausia superba) and provides a potential mechanism for seasonal timing.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.103096

By:

Hüppe, Lukas;
Bahlburg, Dominik;
Driscoll, Ryan;
Helfrich-Förster, Charlotte;
Meyer, Bettina

Publication type:

Article

IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.100406

By:

Mengjia Li;
Hengchao Zhang;
Xiuyun Wu;
Mengqi Yu;
Qianqian Yang;
Lei Sun;
Wei Li;
Zhongxing Jiang;
Fumin Xue;
Ting Wang;
Xuili An;
Lixiang Chen

Publication type:

Article

Microglia aging in the hippocampus advances through intermediate states that drive activation and cognitive decline.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.97671

By:

Shea, Jeremy M.;
Villeda, Saul A.

Publication type:

Article

Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.95629

By:

Phelps, Patricia E.;
Sung Min Ha;
Khankan, Rana R.;
Mekonnen, Mahlet A.;
Juarez, Giovanni;
Ingraham Dixie, Kaitlin L.;
Yen-Wei Chen;
Xia Yang

Publication type:

Article

An atypical basement membrane forms a midline barrier during left-right asymmetric gut development in the chicken embryo.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.89494

By:

Demler, Cora;
Lawlor, John C.;
Yelin, Ronit;
Llivichuzcha-Loja, Dhana;
Shaulov, Lihi;
Kim, David;
Stewart, Megan;
Lee, Frank K.;
Shylo, Natalia;
Trainor, Paul A.;
Schultheiss, Thomas M.;
Kurpios, Natasza A.

Publication type:

Article

Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.85599

By:

Hockeimer, William;
Ruo-Yah Lai;
Natrajan, Maanasa;
Snider, William;
Knierim, James J.

Publication type:

Article

Rhythmic circuit function is more robust to changes in synaptic than intrinsic conductances.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.102938

By:

Fournier, Zachary;
Alonso, Leandro M.;
Marder, Eve

Publication type:

Article

Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.99389

By:

Khosravi-Maharlooei, Mohsen;
Vecchione, Andrea;
Danzl, Nichole;
Hao Wei Li;
Nauman, Grace;
Madley, Rachel;
Waffarn, Elizabeth;
Winchester, Robert;
Ruiz, Amanda;
Xiaolan Ding;
Fousteri, Georgia;
Sykes, Megan

Publication type:

Article

The epididymis contributes to sperm DNA integrity and early embryo development through Cysteine-Rich Secretory Proteins.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.97105

By:

Sulzyk, Valeria;
Curci, Ludmila;
González, Lucas N.;
Cid, Abril Rebagliati;
Muñoz, Mariana Weigel;
Cuasnicu, Patricia S.

Publication type:

Article

Major nuclear locales define nuclear genome organization and function beyond A and B compartments.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.99116

By:

Gholamalamdari, Omid;
van Schaik, Tom;
Yuchuan Wang;
Kumar, Pradeep;
Liguo Zhang;
Yang Zhang;
Hernandez Gonzalez, Gabriela A.;
Vouzas, Athanasios E.;
Zhao, Peiyao A.;
Gilbert, David M.;
Jian Ma;
van Steensel, Bas;
Belmont, Andrew S.

Publication type:

Article

Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.95545

By:

Boisen, Ida Marie;
Knudsen, Nadia Krarup;
Nielsen, John E.;
Kooij, Ireen;
Bagger, Mathilde Louise;
Kaludjerovic, Jovanna;
O'Shaughnessy, Peter;
Andrews, Peter W.;
Ide, Noriko;
Toft, Birgitte G.;
Juul, Anders;
Mehmedbasic, Arnela;
Jørgensen, Anne;
Smith, Lee B.;
Norman, Richard;
Rajpert-De Meyts, Ewa;
Lanske, Beate;
Jensen, Martin Blomberg

Publication type:

Article

Barcode-free multiplex plasmid sequencing using Bayesian analysis and nanopore sequencing.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.88794

By:

Uematsu, Masaaki;
Baskin, Jeremy M.

Publication type:

Article

When working memory works for our goals.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.106869

By:

MILLER, JACOB A.

Publication type:

Article

Re-focusing visual working memory during expected and unexpected memory tests.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.100532

By:

Sisi Wang;
van Ede, Freek

Publication type:

Article

Pronounced expression of extracellular matrix proteoglycans regulated by Wnt pathway underlies the parallel evolution of lip hypertrophy in East African cichlids.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.99160

By:

Nagatoshi Machii;
Ryo Hatashima;
Tatsuya Niwa;
Hideki Taguchi;
Kimirei, Ismael A.;
Mrosso, Hillary D. J.;
Mitsuto Aibara;
Tatsuki Nagasawa;
Masato Nikaido

Publication type:

Article

Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.105576

By:

Li, Keva;
Tolman, Nicholas;
Segrè, Ayellet V.;
Stuart, Kelsey V.;
Zeleznik, Oana A.;
Vallabh, Neeru A.;
Kuang Hu;
Zebardast, Nazlee;
Akiko Hanyuda;
Yoshihiko Raita;
Montgomery, Christa;
Chi Zhang;
Hysi, Pirro G.;
Ron Do;
Khawaja, Anthony P.;
Wiggs, Janey L.;
Kang, Jae H.;
John, Simon W. M.;
Pasquale, Louis R.

Publication type:

Article

Stabilization of GTSE1 by cyclin D1-CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.101075

By:

García-Vázquez, Nelson;
González-Robles, Tania J.;
Lane, Ethan;
Spasskaya, Daria;
Qingyue Zhang;
Kerzhnerman, Marc A.;
YeonTae Jeong;
Collu, Marta;
Simoneschi, Daniele;
Ruggles, Kelly V.;
Róna, Gergely;
Kaisari, Sharon;
Pagano, Michele

Publication type:

Article

MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.97165

By:

Peters, Linsey;
Rakateli, Leonida;
Huchzermeier, Rosanna;
Bonnin-Marquez, Andrea;
Maas, Sanne L.;
Cheng Lin;
Jans, Alexander;
Yana Geng;
Gorter, Alan;
Gijbels, Marion;
Rensen, Sander;
Olinga, Peter;
Hendrikx, Tim;
Krawczyk, Marcin;
Brisbois, Malvina;
Jankowski, Joachim;
Bidzhekov, Kiril;
Weber, Christian;
Biessen, Erik A. L.;
Shiri-Sverdlov, Ronit

Publication type:

Article