Works in eLife, 2025

Results: 750

The double-edged nature of trained immunity.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.102068

By:

LEOPOLD WAGER, CHRISSY M.;
SCHLESINGER, LARRY S.

Publication type:

Article

Intrinsic dynamic shapes responses to external stimulation in the human brain.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.104996

By:

Nentwich, Maximilian;
Leszczynski, Marcin;
Schroeder, Charles E.;
Bickel, Stephan;
Parra, Lucas C.

Publication type:

Article

Elucidating the selection mechanisms in context-dependent computation through low-rank neural network modeling.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.103636

By:

Yiteng Zhang;
Jianfeng Feng;
Bin Min

Publication type:

Article

Assemblies, synapse clustering, and network topology interact with plasticity to explain structure-function relationships of the cortical connectome.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.101850

By:

Ecker, András;
Egas Santander, Daniela;
Abdellah, Marwan;
Blanco Alonso, Jorge;
Bolaños-Puchet, Sirio;
Chindemi, Giuseppe;
Gowri Mariyappan, Dhuruva Priyan;
Isbister, James B.;
King, James;
Kumbhar, Pramod;
Magkanaris, Ioannis;
Muller, Eilif B.;
Reimann, Michael W.

Publication type:

Article

C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.101830

By:

Toru Tanaka;
Naoto Sasaki;
Aga Krisnanda;
Hilman Zulkifli Amin;
Ken Ito;
Sayo Horibe;
Kazuhiko Matsuo;
Ken-ichi Hirata;
Takashi Nakayama;
Yoshiyuki Rikitake

Publication type:

Article

Responses to membrane potential-modulating ionic solutions measured by magnetic resonance imaging of cultured cells and in vivo rat cortex.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.101642

By:

Kyeongseon Min;
Sungkwon Chung;
Seung-Kyun Lee;
Jongho Lee;
Phan Tan Toi;
Daehong Kim;
Jung Seung Lee;
Jang-Yeon Park

Publication type:

Article

Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.99752

By:

Ka Kiu Lee;
Łapińska, Urszula;
Tolle, Giulia;
Micaletto, Maureen;
Bing Zhang;
Phetsang, Wanida;
Verderosa, Anthony D.;
Invergo, Brandon M.;
Westley, Joseph;
Bebes, Attila;
Yuecel, Raif;
O'Neill, Paul A.;
Farbos, Audrey;
Jeffries, Aaron R.;
van Houte, Stineke;
Caboni, Pierluigi;
Blaskovich, Mark A. T.;
Housden, Benjamin E.;
Tsaneva-Atanasova, Krasimira;
Pagliara, Stefano

Publication type:

Article

The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.96414

By:

Maassen, Fabienne;
Vu Thuy Khanh Le-Trilling;
Betke, Luisa;
Bracht, Thilo;
Siegmund, Corinna;
Bayer, Malte;
Katschinski, Benjamin;
Belter, Antonia;
Becker, Tanja;
Mennerich, Denise;
Voigt, Sebastian;
Frappier, Lori;
Sitek, Barbara;
Fleischhauer, Katharina;
Trilling, Mirko

Publication type:

Article

Current insights into insect immune memory.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.1050111

By:

Krejčová, Gabriela;
Bajgar, Adam

Publication type:

Article

Cardiac fibroblasts regulate myocardium and coronary vasculature development in the murine heart via the collagen signaling pathway.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.102305

By:

Yiting Deng;
Yuanhang He;
Juan Xu;
Haoting He;
Manling Zhang;
Guang Li

Publication type:

Article

A neuromorphic model of active vision shows how spatiotemporal encoding in lobula neurons can aid pattern recognition in bees.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.89929

By:

MaBouDi, HaDi;
Roper, Mark;
Guiraud, Marie-Geneviève;
Juusola, Mikko;
Chittka, Lars;
Marshall, James A. R.

Publication type:

Article

Neurons throughout the brain embed robust signatures of their anatomical location into spike trains.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.101506

By:

Tolossa, Gemechu Bekele;
Schneider, Aidan M.;
Dyer, Eva;
Hengen, Keith B.

Publication type:

Article

Structural characterization and dynamics of AdhE ultrastructures from Clostridium thermocellum show a containment strategy for toxic intermediates.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.96966

By:

Ziegler, Samantha J.;
Knott, Brandon C.;
Gruber, Josephine N.;
Hengge, Neal N.;
Qi Xu;
Olson, Daniel G.;
Romero, Eduardo E.;
Joubert, Lydia-Marie;
Bomble, Yannick J.

Publication type:

Article

Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.103559

By:

Yiran Zhang;
Hanyang Guan;
Shijin Liu;
Haoquan Li;
Zili Bian;
Jiashuai He;
Zhan Zhao;
Shenghui Qiu;
Tianmu Mo;
Xiangwei Zhang;
Zuyang Chen;
Hui Ding;
Xiaoxu Zhao;
Liang Wang;
Yunlong Pan;
Jinghua Pan

Publication type:

Article

Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.96157

By:

Kumar, Abhishek;
Tanaka, Keiichiro;
Schwartz, Martin A.

Publication type:

Article

Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.105152

By:

Sinha, Nirvik;
Israely, Sharon;
Harosh, Ora Ben;
Harel, Ran;
Dewald, Julius PA;
Prut, Yifat

Publication type:

Article

Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.104772

By:

Lan Yao;
Wanwan Zhang;
Xiaogang Yang;
Meisheng Yi;
Kuntong Jia

Publication type:

Article

Tissue- resident memory CD4+ T cells are sustained by site- specific levels of selfrenewal and continuous replacement.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.104278

By:

Chandler, Jodie;
Bullock, M. Elise;
Swain, Arpit C.;
Williams, Cayman;
van Dorp, Christiaan H.;
Seddon, Benedict;
Yates, Andrew J.

Publication type:

Article

Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.102253

By:

Sia, Cheryll M.;
Ambrose, Rebecca L.;
Valcanis, Mary;
Andersson, Patiyan;
Ballard, Susan A.;
Howden, Benjamin P.;
Williamson, Deborah A.;
Pearson, Jaclyn S.;
Ingle, Danielle J.

Publication type:

Article

Learning and cognition in highspeed decision making.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.99634

By:

Krause, Martin;
Schulze, Wolfram;
Schuster, Stefan

Publication type:

Article

Investigating working memory updating processes of the human subcortex using 7T MRI.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.97874

By:

Trutti, Anne C.;
Sjoerds, Zsuzsika;
Boag, Russell J.;
Walstra, Solenn LY;
Miletić, Steven;
Isherwood, Scott JS;
Bazin, Pierre- Louis;
Hommel, Bernhard;
Habli, Sarah;
Tse, Desmond HY;
Håberg, Asta K.;
Forstmann, Birte U.

Publication type:

Article

mirror determines the far posterior domain in butterfly wings.

Published in:

eLife, 2025, p. 1

By:

Chatterjee, Martik;
Xin Yi Yu;
Brady, Noah K.;
Amendola, Connor;
Hatto, Gabriel C.;
Reed, Robert D.

Publication type:

Article

Mapping HIV-1 RNA structure, homodimers, long-range interactions and persistent domains by HiCapR.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.102550

By:

Yan Zhang;
Jingwan Han;
Xie Dejian;
Wenlong Shen;
Ping Li;
Jian You Lau;
Jingyun Li;
Lin Li;
Grzegorz Kudla;
Zhihu Zhao

Publication type:

Article

Evidence from pupillometry, fMRI, and RNN modelling shows that gain neuromodulation mediates task-relevant perceptual switches.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.93191

By:

Wainstein, Gabriel;
Whyte, Christopher J.;
Ehgoetz Martens, Kaylena A.;
Müller, Eli J.;
Medel, Vicente;
Anderson, Britt;
Stöttinger, Elisabeth;
Danckert, James;
Munn, Brandon R.;
Shine, James M.

Publication type:

Article

Salmonella exploits host- and bacterial-derived β-alanine for replication inside host macrophages.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.103714

By:

Shuai Ma;
Bin Yang;
Yuyang Sun;
Xinyue Wang;
Houliang Guo;
Ruiying Liu;
Ting Ye;
Chenbo Kang;
Jingnan Chen;
Lingyan Jiang

Publication type:

Article

Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.101128

By:

Hang Li;
Shengwei Ji;
Ariefta, Nanang R.;
Galon, Eloiza May S.;
El-Sayed, Shimaa A. E. S.;
Thom Do;
Lijun Jia;
Miako Sakaguchi;
Masahito Asada;
Yoshifumi Nishikawa;
Xin Qin;
Mingming Liu;
Xuenan Xuan

Publication type:

Article

Reading the DNA of telomeres.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.107648

By:

ROY, SHAMAYITA;
AZZALIN, CLAUS M.

Publication type:

Article

Trained immunity: A new player in cancer immunotherapy.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.104920

By:

Shu Li;
Yi Zou;
McMasters, Austin;
Fuxiang Chen;
Jun Yan

Publication type:

Article

A causal role of the NMDA receptor in recurrent processing during perceptual integration.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.100530

By:

Noorman, Samuel;
Stein, Timo;
Zantvoord, Jasper;
Fahrenfort, Johannes;
van Gaal, Simon

Publication type:

Article

A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.99849

By:

Kailai Li;
Junyi Liang;
Nan Li;
Jianbo Fang;
Xinyi Zhou;
Jian Zhang;
Anqi Lin;
Peng Luo;
Hui Meng

Publication type:

Article

Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.99825

By:

Akiko Hozumi;
Nozomu M. Totsuka;
Arata Onodera;
Yanbin Wang;
Mayuko Hamada;
Akira Shiraishi;
Honoo Satake;
Takeo Horie;
Kohji Hotta;
Yasunori Sasakura

Publication type:

Article

In mice, discrete odors can selectively promote the neurogenesis of sensory neuron subtypes that they stimulate.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.96152

By:

Hossain, Kawsar;
Smith, Madeline;
Rufenacht, Karlin E.;
O'Rourke, Rebecca;
Santoro, Stephen W.

Publication type:

Article

A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.105422

By:

Krishnan, Seetha;
Dong, Can;
Ratigan, Heather;
Morales-Rodriguez, Denisse;
Cherian, Chery;
Sheffield, Mark

Publication type:

Article

Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.100604

By:

Hanna, Joseph;
Touahri, Yacine;
Pak, Alissa;
Belfiore, Lauren;
van Oosten, Edwin;
David, Luke Ajay;
Han, Sisu;
Ilnytskyy, Yaroslav;
Kovalchuk, Igor;
Kurrasch, Deborah;
Satoshi Okawa;
del Sol, Antonio;
Screaton, Robert A.;
Aubert, Isabelle;
Schuurmans, Carol

Publication type:

Article

Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation in Drosophila olfactory receptor neurons.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.99650

By:

Masaya Muramoto;
Nozomi Hanawa;
Misako Okumura;
Takahiro Chihara;
Masayuki Miura;
Natsuki Shinoda

Publication type:

Article

Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.99337

By:

Xin Zhang;
Guangyu Zhang;
Shuli Sang;
Yang Fei;
Xiaopeng Cao;
Wenge Song;
Feide Liu;
Jinze Che;
Haoxia Tao;
Hongwei Wang;
Lihua Zhang;
Yiyan Guan;
Shipeng Rong;
Lijuan Pei;
Sheng Yao;
Yanchun Wang;
Min Zhang;
Chunjie Liu

Publication type:

Article

PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.91779

By:

Antonio Valer, José;
Deber, Alexandre;
Wits, Marius;
Pimenta-Lope, Carolina;
Goumans, Marie-José;
Luis Rosa, Jose;
Sánchez-Duffhues, Gonzalo;
Ventura, Francesc

Publication type:

Article

Multiple roles for a mitochondrial enzyme: The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.94794

By:

XICONG TANG;
HONGYU QIU

Publication type:

Article

Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.106844

By:

Han Zhou;
Tonglian Zhou;
Wenli Yu;
Liping Liu;
Yeonjin Ko;
Johnson, Kristen A.;
Wilson, Ian A.;
Schultz, Peter G.;
Bollong, Michael J.

Publication type:

Article

CARD8 inflammasome activation during HIV-1 cell-to-cell transmission.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.102676

By:

Kulsuptrakul, Jessie;
Emerman, Michael;
Mitchell, Patrick S.

Publication type:

Article

Microglia are required for developmental specification of AgRP innervation in the hypothalamus of offspring exposed to maternal high- fat diet during lactation.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.101391

By:

Mendoza-Romero, Haley N.;
Biddinger, Jessica E.;
Bedenbaugh, Michelle N.;
Simerly, Richard

Publication type:

Article

Rate of brain aging associates with future executive function in Asian children and older adults.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.97036

By:

Cheng, Susan F.;
Wan Lin Yue;
Kwun Kei Ng;
Xing Qian;
Siwei Liu;
Tan, Trevor W. K.;
Kim-Ngan Nguyen;
Leong, Ruth L. F.;
Hilal, Saima;
Ching-Yu Cheng;
Ai Peng Tan;
Law, Evelyn C.;
Gluckman, Peter D.;
Li-Hsian Chen, Christopher;
Yap Seng Chong;
Meaney, Michael J.;
Chee, Michael W. L.;
Yeo, B. T. Thomas;
Zhou, Juan Helen

Publication type:

Article

A common alteration in effort-based decision-making in apathy, anhedonia, and late circadian rhythm.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.96803

By:

Mehrhof, Sara Z.;
Nord, Camilla L.

Publication type:

Article

Spectral decomposition unlocks ascidian morphogenesis.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.94391

By:

Dokmegang, Joel;
Faure, Emmanuel;
Lemaire, Patrick;
Munro, Edwin;
Mani, Madhav

Publication type:

Article

Predictive learning rules generate a cortical- like replay of probabilistic sensory experiences.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.92712

By:

Toshitake Asabuki;
Tomoki Fukai

Publication type:

Article

Stumpy forms are the predominant transmissible forms of Trypanosoma brucei.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.91602

By:

Tsagmo Ngoune, Jean Marc;
Sharma, Parul;
Crouzols, Aline;
Petiot, Nathalie;
Rotureau, Brice

Publication type:

Article

Four individually identified paired dopamine neurons signal taste punishment in larval Drosophila.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.91387

By:

Weber, Denise;
Vogt, Katrin;
Miroschnikow, Anton;
Pankratz, Michael J.;
Thum, Andreas S.

Publication type:

Article

Morphology and ultrastructure of external sense organs of Drosophila larvae.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.91155

By:

Richter, Vincent;
Rist, Anna;
Kislinger, Georg;
Laumann, Michael;
Schoofs, Andreas;
Miroschnikow, Anton;
Pankratz, Michael J.;
Cardona, Albert;
Thum, Andreas S.

Publication type:

Article

A lasting impression.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.107620

By:

ACKERLEY, ROCHELLE;
WATKINS, ROGER H.

Publication type:

Article

BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.100497

By:

Guozhu Ning;
Yu Lin;
Haixia Ma;
Jiaqi Zhang;
Liping Yang;
Zhengyu Liu;
Lei Li;
Xinyu He;
Qiang Wang

Publication type:

Article