Works in Molecular Medicine, 2025, Vol 31, Issue 1

Results: 190

QRICH1 regulates ATF6 transcription to affect pathological cardiac hypertrophy progression.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01241-2

By:

Zhang, Lihui;
Chen, Hongping;
Zou, Guangmei;
Jia, Wenjuan;
Dong, Haibin;
Wang, Chunxiao;
Wang, Hua;
Liu, Yugang;
Teng, Da;
Xu, Bowen;
Zhong, Lin;
Gong, Lei;
Yang, Jun

Publication type:

Article

Correction: NEK8 promotes the progression of gastric cancer by reprogramming asparagine metabolism.

Published in:

2025

By:

Wang, Mingliang;
Yu, Kexun;
Meng, Futao;
Wang, Huizhen;
Li, Yongxiang

Publication type:

Correction Notice

Melatonin alleviates sepsis-induced acute lung injury by inhibiting necroptosis via reducing circulating mtDNA release.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01228-z

By:

Peng, Yuce;
Xu, Jia;
Wei, Lingyu;
Luo, Minghao;
Chen, Shenglong;
Wei, Xuebiao;
Luo, Suxin;
Su, Zedazhong;
Wang, Zhonghua

Publication type:

Article

Unraveling the complex genetic landscape of OTOF-related hearing loss: a deep dive into cryptic variants and haplotype phasing.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01225-2

By:

Lin, Pei-Hsuan;
Tsai, Cheng-Yu;
Chiang, Yu-Ting;
Ho, Chang-Han;
Lu, Yue-Sheng;
Hsu, Jacob Shu-Jui;
Cheng, Yen-Fu;
Tsai, Shih-Feng;
Hsu, Chuan-Jen;
Chen, Pei-Lung;
Wu, Chen-Chi

Publication type:

Article

The MYC/TXNIP axis mediates NCL-Suppressed CD8<sup>+</sup>T cell immune response in lung adenocarcinoma.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01224-3

By:

Xiao, Dan;
Chen, Tanxiu;
Yu, Xinlin;
Song, Ying;
Liu, Yigang;
Yan, Wei

Publication type:

Article

Transcriptome-wide analysis reveals potential roles of CFD and ANGPTL4 in fibroblasts regulating B cell lineage for extracellular matrix-driven clustering and novel avenues for immunotherapy in breast cancer.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01237-y

By:

Wang, Hongwei;
Zhu, Yu-nan;
Zhang, Sifan;
Liu, Kexin;
Huang, Rong;
Li, Zhigao;
Mei, Lan;
Li, Yingpu

Publication type:

Article

Melatonin alleviates sepsis-induced acute lung injury by inhibiting necroptosis via reducing circulating mtDNA release.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01228-z

By:

Peng, Yuce;
Xu, Jia;
Wei, Lingyu;
Luo, Minghao;
Chen, Shenglong;
Wei, Xuebiao;
Luo, Suxin;
Su, Zedazhong;
Wang, Zhonghua

Publication type:

Article

Enhanced potency of immune checkpoint inhibitors against poorly immunological solid tumors by immune stimulatory oncolytic adenoviruses-mediated remodeling of the tumor microenvironment.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01223-4

By:

Ahn, Hyo Min;
Jung, Bo-Kyeong;
Hong, JinWoo;
Hong, Dayoung;
Yoon, A-Rum;
Yun, Chae-Ok

Publication type:

Article

Surgery/anesthesia may cause monocytes to promote tumor development.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01213-6

By:

Wang, Yang-Yang;
Zhu, Rui-Lou;
Chang, En-Qiang;
Liu, Xiao-Zhuan;
Wang, Guang-Zhi;
Li, Ning-Tao;
Zhang, Wei;
Zhou, Jun;
Sun, Ming-Yang;
Zou, Xin;
Hao, Jie;
Zhang, Jia-Qiang

Publication type:

Article

COX-2 inhibition as a therapeutic strategy for bone loss in Staphylococcus aureus osteomyelitis.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01202-9

By:

Chen, Yuhui;
Li, Chao;
Jia, Jishan;
Jiang, Yuhui;
Zhang, Ping;
Cheng, Caiyu;
Zhang, Guangyan;
Gao, Lang;
Yang, Xiang;
Zhao, Jiawei;
Li, Kaiqun;
Yu, Bin

Publication type:

Article

Paclitaxel alleviates spinal cord injury via activation of the Wnt/β-catenin signaling pathway.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01240-3

By:

Chen, Zhifeng;
Wo, Da;
Wu, Celiang;
Ma, En;
Peng, Jinhui;
Zhu, Weidong;
Ren, Dan-ni

Publication type:

Article

A pilot study on the effect of SARS-CoV-2 spike protein on IL-1β-mediated inflammation in peripheral blood immune cells from AIED patients.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01227-0

By:

Pathak, Shresh;
Tan, Natalie;
Vambutas, Andrea

Publication type:

Article

Exosomes derived from human amniotic mesenchymal stem cells promotes angiogenesis in hUVECs by delivering novel miRNA N-194.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01192-8

By:

Song, Yang;
Zhang, Tao;
Shi, Ping;
Gao, Yingzhuo;
Pang, Xining

Publication type:

Article

NEK8 promotes the progression of gastric cancer by reprogramming asparagine metabolism.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-024-01062-9

By:

Wang, Mingliang;
Yu, Kexun;
Meng, Futao;
Wang, Huizhen;
Li, Yongxiang

Publication type:

Article

Drug screening targeting TREM2-TYROBP transmembrane binding.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01229-y

By:

Cobas-Carreño, M.;
Esteban-Martos, A.;
Tomas-Gallardo, L.;
Iribarren, I.;
Gonzalez-Palma, L.;
Rivera-Ramos, A.;
Elena-Guerra, J.;
Alarcon-Martin, E.;
Ruiz, R.;
Bravo, M. J.;
Venero, J. L.;
Morató, X.;
Ruiz, A.;
Royo, J. L.

Publication type:

Article

Bacteriophage-derived endolysins restore antibiotic susceptibility in β-lactam- and macrolide-resistant Streptococcus pneumoniae infections.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01226-1

By:

Vander Elst, Niels;
Farmen, Kristine;
Knörr, Lisa;
Merlijn, Lotte;
Iovino, Federico

Publication type:

Article

Inhibition of TLR4 mitigates sensorineural hearing loss resulting from cochlear inflammation.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01219-0

By:

Lou, Jintao;
Wu, Fan;
Liu, Wei;
Hu, Rui;
He, Wuhui;
Feng, Yisi;
Huang, Yan;
Guo, Jia;
Deng, Jingman;
Zhao, Zhen;
Zhang, Zhigang;
Si, Yu

Publication type:

Article

Recent advances in the roles of extracellular vesicles in cardiovascular diseases: pathophysiological mechanisms, biomarkers, and cell-free therapeutic strategy.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01200-x

By:

Wang, Mengyang;
Chen, Yuwu;
Xu, Biyi;
Zhu, Xinxin;
Mou, Junke;
Xie, Jiani;
Che, Ziao;
Zuo, Liyang;
Li, Ji;
Jia, Haibo;
Yu, Bo

Publication type:

Article

Calpain1 inhibition enhances autophagy-lysosomal pathway and ameliorates tubulointerstitial fibrosis in Nephronophthisis.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01231-4

By:

Li, Dantong;
Zhang, Jinglan;
Su, Xinyu;
Yang, Yichen;
Lai, Jiayong;
Wei, Xiaoya;
Chen, Huamu;
Liu, Yaqing;
Wang, Haiyan;
Sun, Liangzhong

Publication type:

Article

STMN1–IGFBP5 axis induces senescence and extracellular matrix degradation in nucleus pulposus cells: In vivo and in vitro insights.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01220-7

By:

Li, Lei;
Zhang, Guangzhi;
Yang, Zhili;
Cao, Zhenyu;
Wang, Dongxin;
Kang, Xuewen

Publication type:

Article

Peripheral tissue BDNF expression is affected by promoter IV defect and enriched environments in mice: negative hippocampus-intestine and positive thymus-serum-muscle correlations.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01196-4

By:

Wang, Janet;
Schupp, William;
Sakata, Kazuko

Publication type:

Article

USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01182-w

By:

Wang, Zhiyong;
Yu, Cheng;
Xie, Gengchen;
Tao, Kaixiong;
Yin, Zhijie;
Lv, Qing

Publication type:

Article

Electron-beam FLASH whole brain irradiation induced a unique changes of intestinal flora.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-024-01053-w

By:

Gao, Feifei;
Cheng, Wei;
Ma, Yanxi;
Yu, Boyi;
Lang, Xinle;
Jin, Xiaodong;
Wang, Jianxin;
Liu, Xianhong;
Di, Cuixia;
Wang, Hui;
Ye, Fei;
Zhao, Ting;
Chen, Weiqiang;
Li, Qiang

Publication type:

Article

CNPY3's regulation of tumor microenvironment and its impact on colon cancer aggressiveness.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01145-1

By:

Gao, Xucan;
Zhou, Biaohuan;
Feng, Xiudong;
Ji, Zhouxin;
Li, Qiang;
Liu, Huining

Publication type:

Article

Empagliflozin ameliorates renal and metabolic derangements in obese type 2 diabetic mice by blocking advanced glycation end product–receptor axis.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01138-0

By:

Matsui, Takanori;
Sotokawauchi, Ami;
Nishino, Yuri;
Koga, Yoshinori;
Yamagishi, Sho-ichi

Publication type:

Article

Empagliflozin ameliorates renal and metabolic derangements in obese type 2 diabetic mice by blocking advanced glycation end product–receptor axis.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01138-0

By:

Matsui, Takanori;
Sotokawauchi, Ami;
Nishino, Yuri;
Koga, Yoshinori;
Yamagishi, Sho-ichi

Publication type:

Article

A genome-wide association study identifies a novel East Asian–specific locus for dementia with Lewy bodies in Japanese subjects.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01115-7

By:

Mitsumori, Risa;
Asanomi, Yuya;
Morizono, Takashi;
Shigemizu, Daichi;
Niida, Shumpei;
Ozaki, Kouichi

Publication type:

Article

Cholesterol promotes hair growth through activating sympathetic nerves and enhancing the proliferation of hair follicle stem cells.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01139-z

By:

Guo, Mengchen;
Jiang, Junkun;
Zhang, Anke;
Yu, Wenjing;
Huang, Xin

Publication type:

Article

miR-6516-3p-mediated downregulation of the endogenous MMP-9 inhibitor RECK in mesangial cells might exacerbate lupus nephritis.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01124-6

By:

Tomita, Hiroyuki;
Hayakawa, Kunihiro;
Ikeda, Keigo;
Tsushima, Hiroshi;
Shinoura, Marina;
Fujishiro, Maki;
Kataoka, Yuko;
Yamaji, Ken;
Takamori, Kenji;
Tamura, Naoto;
Sekigawa, Iwao;
Morimoto, Shinji

Publication type:

Article

Natural flavonoid Orientin restricts 5-Fluorouracil induced cancer stem cells mediated angiogenesis by regulating HIF1α and VEGFA in colorectal cancer.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-024-01032-1

By:

Ghosh, Rituparna;
Bhowmik, Arijit;
Biswas, Souradeep;
Samanta, Priya;
Sarkar, Rupali;
Pakhira, Shampa;
Mondal, Mrinmoyee;
Hajra, Subhadip;
Saha, Prosenjit

Publication type:

Article

Effects of hydrogel stiffness and viscoelasticity on organoid culture: a comprehensive review.

Published in:

2025

By:

Lai, Wei;
Geliang, Hu;
Bin, Xu;
Wang, Wei

Publication type:

Literature Review

Characterization and chemoproteomic profiling of protein O-GlcNAcylation in SOD1-G93A mouse model.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01134-4

By:

Hao, Yi;
Li, Zhongzhong;
Du, Xinyan;
Xie, Qingsong;
Li, Dongxiao;
Lei, Shaoyuan;
Guo, Yansu

Publication type:

Article

Constitutive systemic inflammation in Shwachman-Diamond Syndrome.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01133-5

By:

Sabbioni, Giuseppe;
D'Aversa, Elisabetta;
Breveglieri, Giulia;
Altieri, Maria Teresa;
Boni, Christian;
Pegoraro, Anna;
Finotti, Alessia;
Gambari, Roberto;
D'Amico, Giovanna;
Vella, Antonio;
Lippi, Giuseppe;
Cipolli, Marco;
Bezzerri, Valentino;
Borgatti, Monica

Publication type:

Article

Instantaneous dose rate as a crucial factor in reducing mortality and normal tissue toxicities in murine total-body irradiation: a comparative study of dose rate combinations.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01135-3

By:

Zhu, Hongyu;
Liu, Shihua;
Qiu, Jiaqi;
Hu, Ankang;
Zhou, Wanyi;
Wang, Jian;
Gu, Weihang;
Zhu, Yinuo;
Zha, Hao;
Xiang, Rong;
Li, Junli;
Qiu, Rui;
Zhao, Chong;
Huang, Peng;
Deng, Xiaowu

Publication type:

Article

Caveolin-3: therapeutic target for diabetic myocardial ischemia/reperfusion injury.

Published in:

2025

By:

Wen, Xinyu;
Ji, Yanwei;
Tang, Hepeng;
Jin, Zhenshuai;
Su, Wating;
Zhou, Lu;
Xia, Zhong-Yuan;
Li, Lin;
Lei, Shaoqing

Publication type:

Literature Review

A novel mechanism of FTO modulating the progression of endometriosis through mediating the m6A methylation of GEF-H1 in a YTHDF1-dependent manner.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01130-8

By:

Ding, Xin-Yu;
Zhang, Hua-Ying;
Chen, Jia-Hao;
Yang, Meng-Jie;
Huang, Zhi-Xiong;
Lei, Yi-Hong;
Sun, Qin-Kun;
Bai, Jian-Bin;
Lin, Dian-Chao;
Lan, Jian-Fa;
Ren, Lu-Lu;
Chen, Zheng-Yi;
Zhou, Wei-Dong;
Chen, Qiong-Hua

Publication type:

Article

CPEB3 can regulate seizure susceptibility by inhibiting the transcriptional activity of STAT3 on NMDARs expression.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01136-2

By:

You, Zhipeng;
Huang, Cong;
Wei, Fan;
Li, Jiran;
Liu, Yang;
Liu, Xingan;
Fan, Zhijie;
Gao, Xiaoying;
Sun, Jiahang

Publication type:

Article

Integrated metabolomics and transcriptomics reveal the potential of hydroxy-alpha-sanshool in alleviating insulin resistance.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01129-1

By:

Zhu, Yuping;
Yang, Pan;
Ren, Tingyuan;
Chen, Zhuqi;
Tian, Huanhuan;
Wang, Mingfen;
Zhang, Chunlin

Publication type:

Article

CYFIP1 coordinate with RNMT to induce osteosarcoma cuproptosis via AURKAIP1 m7G modification.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01127-3

By:

Lin, Zili;
Wu, Ziyi;
He, Yizhe;
Li, Xiangyao;
Luo, Wei

Publication type:

Article

FTO inhibition mitigates high-fat diet-induced metabolic disturbances and cognitive decline in SAMP8 mice.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01126-4

By:

Irisarri, Alba;
Corral, Ana;
Perez-Salvador, Núria;
Bellver-Sanchis, Aina;
Ribalta-Vilella, Marta;
Bentanachs, Roger;
Alegret, Marta;
Laguna, Juan Carlos;
Barroso, Emma;
Palomer, Xavier;
Ortuño-Sahagún, Daniel;
Vázquez-Carrera, Manuel;
Pallàs, Mercè;
Herrero, Laura;
Griñán-Ferré, Christian

Publication type:

Article

Mesenchymal stem cells and mesenchymal stem cell-derived exosomes: a promising strategy for treating retinal degenerative diseases.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01120-w

By:

An, Wenjing;
Zhang, Wenliang;
Qi, Jia;
Xu, Weihui;
Long, Yushan;
Qin, Huan;
Yao, Kai

Publication type:

Article

The vasoconstrictor adenosine 5′-tetraphosphate is a danger signal that induces IL-1β.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01116-6

By:

Bockstiegel, Judith;
Engelhardt, Jonas;
Schuchardt, Mirjam;
Tölle, Markus;
Weindl, Günther

Publication type:

Article

Matrix metalloproteinases and their tissue inhibitors as upcoming biomarker signatures of connective tissue diseases-related interstitial lung disease: towards an earlier and accurate diagnosis.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01128-2

By:

Pulito-Cueto, Verónica;
Atienza-Mateo, Belén;
Batista-Liz, Joao C.;
Sebastián Mora-Gil, María;
Mora-Cuesta, Víctor M.;
Iturbe-Fernández, David;
Izquierdo Cuervo, Sheila;
Aguirre Portilla, Carolina;
Blanco, Ricardo;
López-Mejías, Raquel

Publication type:

Article

DLAT activates EMT to promote HCC metastasis by regulating GLUT1-mediated aerobic glycolysis.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01125-5

By:

Yin, Qian;
Yao, Yinye;
Ni, Jiaojiao;
Zhang, Yiwen;
Wu, Jia;
Zeng, Hui;
Wu, Wei;
Zhuo, Wei;
Ying, Jieer;
Li, Jingjing

Publication type:

Article

Cancer-secreted exosomal miR-1246 promotes colorectal cancer liver metastasis by activating hepatic stellate cells.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01112-w

By:

Liu, Xiaolong;
Liu, Jialong;
Wang, Xuanyin;
Zou, Yang;
Tao, Xinyi;
Li, Jingyu;
Ye, Mengnan;
Xu, Wanbei;
Deng, Yunyao;
Liu, Lixin;
Sun, Jingbo;
Zhang, Qingling

Publication type:

Article

Radiation symptoms resemble laminopathies and the physical underlying cause may sit at the lamin A C-terminus.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01081-0

By:

Waldherr, Alexandra;
Fogtman, Anna

Publication type:

Article

High-salt diet decreases FOLFOX efficacy via gut bacterial tryptophan metabolism in colorectal cancer.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01122-8

By:

Deng, Yufei;
Hou, Xiaoying;
Fang, Qian;
Wang, Haiping;
Li, Xiaoxuan;
Hu, Zhiyong;
Liu, Zhaolu;
Fan, Limei;
Liu, Yunyi;
Fu, Zhengqi;
Shu, Xiji;
Sun, Binlian;
Huang, Lijun;
Liu, Yuchen

Publication type:

Article

Molecular mechanisms of m6A modifications regulating tumor radioresistance.

Published in:

2025

By:

Shen, Ruolin;
Jiang, Zhenyang;
Wang, Huanhuan;
Zheng, Zhuangzhuang;
Jiang, Xin

Publication type:

Literature Review

RTN3 regulates collagen biosynthesis and profibrotic macrophage differentiation to promote pulmonary fibrosis via interacting with CRTH2.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01119-3

By:

Wang, Chen-Yu;
Chen, Ya-Qin;
Huang, Hao;
Yuan, Zhuang-Zhuang;
Dong, Yi;
Jin, Jie-Yuan;
Long, Jie-Yi;
Liu, Lv;
Fan, Liang-Liang;
Xiang, Rong

Publication type:

Article

Gαq/11 aggravates acute lung injury in mice by promoting endoplasmic reticulum stress-mediated NETosis.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01118-4

By:

Xiang, Qian;
Tian, Yang;
Yang, Kai;
Du, Yaqin;
Xie, Jian

Publication type:

Article