Works in Nucleic Acids Research, 2020, Vol 48, Issue 1

Results: 42

In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3′ and 5′ thiophosphate linkages.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 63, doi. 10.1093/nar/gkz1099

By:

Duschmalé, Jörg;
Hansen, Henrik Frydenlund;
Duschmalé, Martina;
Koller, Erich;
Albaek, Nanna;
Møller, Marianne Ravn;
Jensen, Klaus;
Koch, Troels;
Wengel, Jesper;
Bleicher, Konrad

Publication type:

Article

A novel 5′-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 349, doi. 10.1093/nar/gkz1107

By:

Doamekpor, Selom K;
Gozdek, Agnieszka;
Kwasnik, Aleksandra;
Kufel, Joanna;
Tong, Liang

Publication type:

Article

Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 16, doi. 10.1093/nar/gkz1101

By:

Zheng, Li;
Meng, Yuan;
Campbell, Judith L;
Shen, Binghui

Publication type:

Article

Phylogenetic debugging of a complete human biosynthetic pathway transplanted into yeast.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 486, doi. 10.1093/nar/gkz1098

By:

Agmon, Neta;
Temple, Jasmine;
Tang, Zuojian;
Schraink, Tobias;
Baron, Maayan;
Chen, Jun;
Mita, Paolo;
Martin, James A;
Tu, Benjamin P;
Yanai, Itai;
Fenyö, David;
Boeke, Jef D

Publication type:

Article

Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 231, doi. 10.1093/nar/gkz977

By:

Liebelt, Frauke;
Schimmel, Joost;
Verlaan – de Vries, Matty;
Klemann, Esra;
van Royen, Martin E;
van der Weegen, Yana;
Luijsterburg, Martijn S;
Mullenders, Leon H;
Pines, Alex;
Vermeulen, Wim;
Vertegaal, Alfred C O

Publication type:

Article

Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 36, doi. 10.1093/nar/gkz976

By:

Caron, Nicholas S;
Southwell, Amber L;
Brouwers, Cynthia C;
Cengio, Louisa Dal;
Xie, Yuanyun;
Black, Hailey Findlay;
Anderson, Lisa M;
Ko, Seunghyun;
Zhu, Xiang;
van Deventer, Sander J;
Evers, Melvin M;
Konstantinova, Pavlina;
Hayden, Michael R

Publication type:

Article

Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 212, doi. 10.1093/nar/gkz960

By:

Romero, Zachary J;
Armstrong, Thomas J;
Henrikus, Sarah S;
Chen, Stefanie H;
Glass, David J;
Ferrazzoli, Alexander E;
Wood, Elizabeth A;
Chitteni-Pattu, Sindhu;
van Oijen, Antoine M;
Lovett, Susan T;
Robinson, Andrew;
Cox, Michael M

Publication type:

Article

FIN-Seq: transcriptional profiling of specific cell types from frozen archived tissue of the human central nervous system.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. e4, doi. 10.1093/nar/gkz968

By:

Amamoto, Ryoji;
Zuccaro, Emanuela;
Curry, Nathan C;
Khurana, Sonia;
Chen, Hsu-Hsin;
Cepko, Constance L;
Arlotta, Paola

Publication type:

Article

SAME-clustering: Single-cell Aggregated Clustering via Mixture Model Ensemble.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 86, doi. 10.1093/nar/gkz959

By:

Huh, Ruth;
Yang, Yuchen;
Jiang, Yuchao;
Shen, Yin;
Li, Yun

Publication type:

Article

Evolution-guided engineering of small-molecule biosensors.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. e3, doi. 10.1093/nar/gkz954

By:

Snoek, Tim;
Chaberski, Evan K;
Ambri, Francesca;
Kol, Stefan;
Bjørn, Sara P;
Pang, Bo;
Barajas, Jesus F;
Welner, Ditte H;
Jensen, Michael K;
Keasling, Jay D

Publication type:

Article

Gene knockdown in malaria parasites via non-canonical RNAi.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. e2, doi. 10.1093/nar/gkz927

By:

Hentzschel, Franziska;
Mitesser, Vera;
Fraschka, Sabine Anne-Kristin;
Krzikalla, Daria;
Carrillo, Elena Herrera;
Berkhout, Ben;
Bártfai, Richárd;
Mueller, Ann-Kristin;
Grimm, Dirk

Publication type:

Article

A nucleotide-dependent oligomerization of the Escherichia coli replication initiator DnaA requires residue His136 for remodeling of the chromosomal origin.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 200, doi. 10.1093/nar/gkz939

By:

Saxena, Rahul;
Stanley, Christopher B;
Kumar, Pankaj;
Cuneo, Matthew J;
Patil, Digvijay;
Jha, Jyoti;
Weiss, Kevin L;
Chattoraj, Dhruba K;
Crooke, Elliott

Publication type:

Article

A single amino acid switch converts the Sleeping Beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 316, doi. 10.1093/nar/gkz1119

By:

Kesselring, Lisa;
Miskey, Csaba;
Zuliani, Cecilia;
Querques, Irma;
Kapitonov, Vladimir;
Laukó, Andrea;
Fehér, Anita;
Palazzo, Antonio;
Diem, Tanja;
Lustig, Janna;
Sebe, Attila;
Wang, Yongming;
Dinnyés, András;
Izsvák, Zsuzsanna;
Barabas, Orsolya;
Ivics, Zoltán

Publication type:

Article

An improved platform for functional assessment of large protein libraries in mammalian cells.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. e1, doi. 10.1093/nar/gkz910

By:

Matreyek, Kenneth A;
Stephany, Jason J;
Chiasson, Melissa A;
Hasle, Nicholas;
Fowler, Douglas M

Publication type:

Article

Targeted delivery and enhanced gene-silencing activity of centrally modified folic acid–siRNA conjugates.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 75, doi. 10.1093/nar/gkz1115

By:

Salim, Lidya;
Islam, Golam;
Desaulniers, Jean-Paul

Publication type:

Article

Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 500, doi. 10.1093/nar/gkz1116

By:

Holzer, Sandro;
Degliesposti, Gianluca;
Kilkenny, Mairi L;
Maslen, Sarah L;
Matak-Vinkovíc, Dijana;
Skehel, Mark;
Pellegrini, Luca

Publication type:

Article

A guide to computational methods for G-quadruplex prediction.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 1, doi. 10.1093/nar/gkz1097

By:

Puig Lombardi, Emilia;
Londoño-Vallejo, Arturo

Publication type:

Article

Sinorhizobium meliloti YbeY is a zinc-dependent single-strand specific endoribonuclease that plays an important role in 16S ribosomal RNA processing.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 332, doi. 10.1093/nar/gkz1095

By:

Babu, Vignesh M P;
Sankari, Siva;
Budnick, James A;
Caswell, Clayton C;
Walker, Graham C

Publication type:

Article

A double-stranded RNA platform is required for the interaction between a host restriction factor and the NS1 protein of influenza A virus.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 304, doi. 10.1093/nar/gkz1094

By:

Chen, Guifang;
Ma, Li-Chung;
Wang, Shanshan;
Woltz, Ryan L;
Grasso, Emily M;
Montelione, Gaetano T;
Krug, Robert M

Publication type:

Article

Discovery of a new predominant cytosine DNA modification that is linked to gene expression in malaria parasites.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 184, doi. 10.1093/nar/gkz1093

By:

Hammam, Elie;
Ananda, Guruprasad;
Sinha, Ameya;
Scheidig-Benatar, Christine;
Bohec, Mylene;
Preiser, Peter R;
Dedon, Peter C;
Scherf, Artur;
Vembar, Shruthi S

Publication type:

Article

Global H-NS counter-silencing by LuxR activates quorum sensing gene expression.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 171, doi. 10.1093/nar/gkz1089

By:

Chaparian, Ryan R;
Tran, Minh L N;
Miller Conrad, Laura C;
Rusch, Douglas B;
van Kessel, Julia C

Publication type:

Article

Epigenetic modification of cytosines fine tunes the stability of i-motif DNA.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 55, doi. 10.1093/nar/gkz1082

By:

Wright, Elisé P;
Abdelhamid, Mahmoud A S;
Ehiabor, Michelle O;
Grigg, Melanie C;
Irving, Kelly;
Smith, Nicole M;
Waller, Zoë A E

Publication type:

Article

Structural insights into target DNA recognition by R2R3-MYB transcription factors.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 460, doi. 10.1093/nar/gkz1081

By:

Wang, Baihui;
Luo, Qiang;
Li, Yingping;
Yin, Liufan;
Zhou, Nana;
Li, Xiangnan;
Gan, Jianhua;
Dong, Aiwu

Publication type:

Article

Nanopore sequencing and Hi-C scaffolding provide insight into the evolutionary dynamics of transposable elements and piRNA production in wild strains of Drosophila melanogaster.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 290, doi. 10.1093/nar/gkz1080

By:

Ellison, Christopher E;
Cao, Weihuan

Publication type:

Article

A unique internal ribosome entry site representing a dynamic equilibrium state of RNA tertiary structure in the 5′-UTR of Wheat yellow mosaic virus RNA1.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 390, doi. 10.1093/nar/gkz1073

By:

Geng, Guowei;
Yu, Chengming;
Li, Xiangdong;
Yuan, Xuefeng

Publication type:

Article

Nuclear Ccr4-Not mediates the degradation of telomeric and transposon transcripts at chromatin in the Drosophila germline.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 141, doi. 10.1093/nar/gkz1072

By:

Kordyukova, Maria;
Sokolova, Olesya;
Morgunova, Valeriya;
Ryazansky, Sergei;
Akulenko, Natalia;
Glukhov, Sergey;
Kalmykova, Alla

Publication type:

Article

RbfA and IF3 couple ribosome biogenesis and translation initiation to increase stress tolerance.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 359, doi. 10.1093/nar/gkz1065

By:

Sharma, Indra Mani;
Woodson, Sarah A

Publication type:

Article

ILF3 contributes to the establishment of the antiviral type I interferon program.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 116, doi. 10.1093/nar/gkz1060

By:

Watson, Samir F;
Bellora, Nicolas;
Macias, Sara

Publication type:

Article

Pol5 is required for recycling of small subunit biogenesis factors and for formation of the peptide exit tunnel of the large ribosomal subunit.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 405, doi. 10.1093/nar/gkz1079

By:

Braun, Christina M;
Hackert, Philipp;
Schmid, Catharina E;
Bohnsack, Markus T;
Bohnsack, Katherine E;
Perez-Fernandez, Jorge

Publication type:

Article

A heterodimer of evolved designer-recombinases precisely excises a human genomic DNA locus.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 472, doi. 10.1093/nar/gkz1078

By:

Lansing, Felix;
Paszkowski-Rogacz, Maciej;
Schmitt, Lukas Theo;
Schneider, Paul Martin;
Romanos, Teresa Rojo;
Sonntag, Jan;
Buchholz, Frank

Publication type:

Article

PRMT1-mediated methylation of the microprocessor-associated proteins regulates microRNA biogenesis.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 96, doi. 10.1093/nar/gkz1051

By:

Spadotto, Valeria;
Giambruno, Roberto;
Massignani, Enrico;
Mihailovich, Marija;
Maniaci, Marianna;
Patuzzo, Francesca;
Ghini, Francesco;
Nicassio, Francesco;
Bonaldi, Tiziana

Publication type:

Article

The histone variant H2A.Z in yeast is almost exclusively incorporated into the +1 nucleosome in the direction of transcription.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 157, doi. 10.1093/nar/gkz1075

By:

Bagchi, Dia N;
Battenhouse, Anna M;
Park, Daechan;
Iyer, Vishwanath R

Publication type:

Article

Targeted PMP22 TATA-box editing by CRISPR/Cas9 reduces demyelinating neuropathy of Charcot-Marie-Tooth disease type 1A in mice.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 130, doi. 10.1093/nar/gkz1070

By:

Lee, Ji-Su;
Lee, Jae Y;
Song, Dong W;
Bae, Hee S;
Doo, Hyun M;
Yu, Ho S;
Lee, Kyu J;
Kim, Hee K;
Hwang, Hyun;
Kwak, Geon;
Kim, Daesik;
Kim, Seokjoong;
Hong, Young B;
Lee, Jung M;
Choi, Byung-Ok

Publication type:

Article

Structural transitions in the RNA 7SK 5′ hairpin and their effect on HEXIM binding.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 373, doi. 10.1093/nar/gkz1071

By:

Röder, Konstantin;
Stirnemann, Guillaume;
Dock-Bregeon, Anne-Catherine;
Wales, David J;
Pasquali, Samuela

Publication type:

Article

An in vitro single-molecule assay for eukaryotic cap-dependent translation initiation kinetics.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. e6, doi. 10.1093/nar/gkz1066

By:

Wang, Hongyun;
Sun, Lexi;
Gaba, Anthony;
Qu, Xiaohui

Publication type:

Article

'Drc', a structurally novel ssDNA-binding transcription regulator of N4-related bacterial viruses.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 445, doi. 10.1093/nar/gkz1048

By:

Boon, Maarten;
De Zitter, Elke;
De Smet, Jeroen;
Wagemans, Jeroen;
Voet, Marleen;
Pennemann, Friederike L;
Schalck, Thomas;
Kuznedelov, Konstantin;
Severinov, Konstantin;
Van Meervelt, Luc;
De Maeyer, Marc;
Lavigne, Rob

Publication type:

Article

A general strategy exploiting m<sup>5</sup>C duplex-remodelling effect for selective detection of RNA and DNA m<sup>5</sup>C methyltransferase activity in cells.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. e5, doi. 10.1093/nar/gkz1047

By:

Yang, Tianming;
Low, Joanne J A;
Woon, Esther C Y

Publication type:

Article

Structural insight into the length-dependent binding of ssDNA by SP_0782 from Streptococcus pneumoniae, reveals a divergence in the DNA-binding interface of PC4-like proteins.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 432, doi. 10.1093/nar/gkz1045

By:

Li, Shuangli;
Lu, Guoliang;
Fang, Xiang;
Ramelot, Theresa A;
Kennedy, Michael A;
Zhou, Xin;
Gong, Peng;
Zhang, Xu;
Liu, Maili;
Zhu, Jiang;
Yang, Yunhuang

Publication type:

Article

A non-canonical monovalent zinc finger stabilizes the integration of Cfp1 into the H3K4 methyltransferase complex COMPASS.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 421, doi. 10.1093/nar/gkz1037

By:

Yang, Yidai;
Joshi, Monika;
Takahashi, Yoh-hei;
Ning, Zhibin;
Qu, Qianhui;
Brunzelle, Joseph S;
Skiniotis, Georgios;
Figeys, Daniel;
Shilatifard, Ali;
Couture, Jean-François

Publication type:

Article

Exploring trophoblast-specific Tead4 enhancers through chromatin conformation capture assays followed by functional screening.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 278, doi. 10.1093/nar/gkz1034

By:

Tomikawa, Junko;
Takada, Shuji;
Okamura, Kohji;
Terao, Miho;
Ogata-Kawata, Hiroko;
Akutsu, Hidenori;
Tanaka, Satoshi;
Hata, Kenichiro;
Nakabayashi, Kazuhiko

Publication type:

Article

Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 264, doi. 10.1093/nar/gkz1006

By:

Schmidt, Tobias T;
Sharma, Sushma;
Reyes, Gloria X;
Kolodziejczak, Anna;
Wagner, Tina;
Luke, Brian;
Hofer, Anders;
Chabes, Andrei;
Hombauer, Hans

Publication type:

Article

Genome replication dynamics of a bacteriophage and its satellite reveal strategies for parasitism and viral restriction.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 1, p. 249, doi. 10.1093/nar/gkz1005

By:

Barth, Zachary K;
Silvas, Tania V;
Angermeyer, Angus;
Seed, Kimberley D

Publication type:

Article