Works about UBIQUITIN ligases

Results: 3472

The Mdm2-p53 axis links cementocyte survival to cellular cementum volume.

Published in:

Journal of Bone & Mineral Research, 2025, v. 40, n. 4, p. 548, doi. 10.1093/jbmr/zjaf025

By:

Tian, Xue;
Yang, Guobin;
Zheng, Huiwen;
Pi, Yixing;
Cao, Zhengguo;
Duan, Peipei;
Chen, Zhi;
Yuan, Guohua

Publication type:

Article

Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.106844

By:

Han Zhou;
Tonglian Zhou;
Wenli Yu;
Liping Liu;
Yeonjin Ko;
Johnson, Kristen A.;
Wilson, Ian A.;
Schultz, Peter G.;
Bollong, Michael J.

Publication type:

Article

马铃薯SUMO E3连接酶基因家族分析及StSIZ1基因的克隆与表达模式分析.

Published in:

Biotechnology Bulletin, 2025, v. 41, n. 6, p. 119, doi. 10.13560/j.cnki.biotech.bull.1985.2024-1252

By:

许慧珍;
Ghimire, SHANTWANA;
Kharel, RAJU;
岳云;
司怀军;
唐勋

Publication type:

Article

Remdesivir inhibits endothelial activation and atherosclerosis by coupling TAL1 to TRAF6.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06673-2

By:

Zhang, Hanning;
Li, Ruru;
Huo, Qianqian;
Li, Li;
Li, Min;
Hu, Shunxin;
Ren, Changjie;
Wu, Zongyin;
Zhang, Chenghu

Publication type:

Article

SE(3)-equivariant ternary complex prediction towards target protein degradation.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61272-5

By:

Xue, Fanglei;
Zhang, Meihan;
Li, Shuqi;
Gao, Xinyu;
Wohlschlegel, James A.;
Huang, Wenbing;
Yang, Yi;
Deng, Weixian

Publication type:

Article

The N-degron pathway governs autophagy to promote thermotolerance in Arabidopsis.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61191-5

By:

Kim, Seu Ha;
Park, Jun Seok;
Lee, Myoung-Hoon;
Seo, Joongyu;
Kim, Jaekwan;
Yang, Woo Seok;
Park, Jihye;
Yoo, Kwangmin;
Choi, Jungmin;
Seo, Jong-Bok;
Song, Hyun Kyu;
Park, Ohkmae K.

Publication type:

Article

In situ construction of intracellular supramolecular assemblies as an alternative strategy for protein degradation.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61175-5

By:

Hu, Xiaoqian;
Yao, Qingxin;
Wu, Xiaobo;
Chen, Jiali;
Zhang, Ruijia;
Zhao, Yan;
Gao, Yuan

Publication type:

Article

ER-related E2-E3 ubiquitin enzyme pair regulates ethylene response by modulating the turnover of ethylene receptors.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61066-9

By:

Zhao, Qingcui;
Zhou, Xiaofeng;
Chen, Qian;
Yang, Ruoyun;
Li, Yonghong;
Zhao, Jiaxin;
Fu, Xijia;
Lin, Yan;
Liu, Yuming;
Zhao, Liangjun;
Jiang, Cai-Zhong;
Gan, Su-Sheng;
Xie, Qi;
Gao, Junping;
Ma, Nan

Publication type:

Article

HIV-1 vif mediates ubiquitination of the proximal protomer in the APOBEC3H dimer to induce degradation.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60984-y

By:

Skorupka, Katarzyna A.;
Matsuoka, Kazuhiro;
Hassan, Bakar;
Ghirlando, Rodolfo;
Balachandran, Vanivilasini;
Chen, Ting-Hua;
Walters, Kylie J.;
Schiffer, Celia A.;
Wolf, Matthias;
Iwatani, Yasumasa;
Matsuo, Hiroshi

Publication type:

Article

E3 ubiquitin ligase Smurf1 promotes cardiomyocyte pyroptosis by mediating ubiquitin-dependent degradation of TRIB2 in a rat model of heart failure.

Published in:

International Reviews of Immunology, 2025, v. 44, n. 4, p. 165, doi. 10.1080/08830185.2024.2434058

By:

Liu, Wei;
Cai, Xin;
Duan, Shiying;
Shen, Jihua;
Wu, Jiayuan;
Zhou, Zhengwei;
Yu, Kaili;
He, Caihong;
Wang, Yuqin

Publication type:

Article

E3 ubiquitin-protein ligase CBL inhibits non-small cell lung cancer progression via ubiquitination and degradation of KDR.

Published in:

Cell Division, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13008-025-00159-9

By:

Tu, Zhiyue;
Shen, Yongshuai;
Li, Hua

Publication type:

Article

Genome-Wide Identification, Characterization, and Expression Analysis of the U-Box Gene Family in Cucumber (Cucumis sativus).

Published in:

Plants (2223-7747), 2025, v. 14, n. 12, p. 1801, doi. 10.3390/plants14121801

By:

Chen, Quanqing;
Zhao, Tian;
Song, Hao;
Sha, Siyuan;
Ma, Jun;
Zhang, Ruihan;
Kong, Weiwen;
Yang, Shuying;
Liu, Jinglan;
Wang, Yiping

Publication type:

Article

Beyond Respiration: Rethinking CO 2 as a Regulator of Cellular Signaling in Microenvironmental Stress and Disease.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5796, doi. 10.3390/ijms26125796

By:

Shigemura, Masahiko

Publication type:

Article

TRIM21 functions as an oncogene in glioblastoma by transactivating FOSL1 and promoting the ubiquitination of p27.

Published in:

Cell Communication & Signaling, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12964-025-02325-6

By:

Ramar, Vanajothi;
Sidhu, Rajveer Singh;
Pako, Osei;
Cisse, Cheyenne R.;
Guo, Alyssa A.;
Li, Jason;
Stapleton, Kelcey;
Guo, Shanchun;
Wang, Guangdi;
Liu, Mingli

Publication type:

Article

RNF20/RNF40 supports the aggressive behavior in cervical cancer by regulating a peroxisome-based anti-ferroptotic mechanism.

Published in:

Cell Communication & Signaling, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12964-025-02279-9

By:

Jansari, Shaishavi;
Blandau, Anna;
Prokakis, Evangelos;
Grimm, Daniela;
Naßl, Anja Maria;
Küffer, Stefan;
Möbius, Wiebke;
Dullin, Christian;
Ramos-Gomes, Fernanda;
Schüürhuis, Leona;
Fritsche, Lena;
Schridde, Laura;
Plessner, Matthias;
Bast, Carolin. A.;
Gayer, Fabian A.;
Thoms, Sven;
Gallwas, Julia;
Wegwitz, Florian

Publication type:

Article

HIV: Tagged for destruction.

Published in:

Nature Reviews Microbiology, 2012, v. 10, n. 2, p. 81, doi. 10.1038/nrmicro2739

By:

Molloy, Sheilagh

Publication type:

Article

Protection of Armadillo/β-Catenin by Armless, a Novel Positive Regulator of Wingless Signaling.

Published in:

PLoS Biology, 2014, v. 12, n. 11, p. 1, doi. 10.1371/journal.pbio.1001988

By:

Reim, Gerlinde;
Hruzova, Martina;
Goetze, Sandra;
Basler, Konrad

Publication type:

Article

Changes in Oscillatory Dynamics in the Cell Cycle of Early <i>Xenopus laevis</i> Embryos.

Published in:

PLoS Biology, 2014, v. 12, n. 2, p. 1, doi. 10.1371/journal.pbio.1001788

By:

Tsai, Tony Y.-C.;
Theriot, Julie A.;
Ferrell Jr, James E.

Publication type:

Article

A Cullin1-Based SCF E3 Ubiquitin Ligase Targets the InR/PI3K/TOR Pathway to Regulate Neuronal Pruning.

Published in:

PLoS Biology, 2013, v. 11, n. 9, p. 1, doi. 10.1371/journal.pbio.1001657

By:

Wong, Jack Jing Lin;
Li, Song;
Lim, Edwin Kok Hao;
Wang, Yan;
Wang, Cheng;
Zhang, Heng;
Kirilly, Daniel;
Wu, Chunlai;
Liou, Yih-Cherng;
Wang, Hongyan;
Yu, Fengwei

Publication type:

Article

A Meiosis-Specific Form of the APC/C Promotes the Oocyte-to-Embryo Transition by Decreasing Levels of the Polo Kinase Inhibitor Matrimony.

Published in:

PLoS Biology, 2013, v. 11, n. 9, p. 1, doi. 10.1371/journal.pbio.1001648

By:

Whitfield, Zachary J.;
Chisholm, Jennifer;
Hawley, R. Scott;
Orr-Weaver, Terry L.

Publication type:

Article

Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome.

Published in:

PLoS Biology, 2013, v. 11, n. 2, p. 1, doi. 10.1371/journal.pbio.1001478

By:

Cao, Cong;
Rioult-Pedotti, Mengia S.;
Migani, Paolo;
Yu, Crystal J.;
Tiwar, Rakesh;
Parang, Keykavous;
Spaller, Mark R.;
Goebel, Dennis J.;
Marshall, John

Publication type:

Article

The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

Published in:

PLoS Biology, 2012, v. 10, n. 12, p. 1, doi. 10.1371/journal.pbio.1001440

By:

Xiong, Xin;
Hao, Yan;
Sun, Kan;
Li, Jiaxing;
Li, Xia;
Mishra, Bibhudatta;
Soppina, Pushpanjali;
Wu, Chunlai;
Hume, Richard I.;
Collins, Catherine A.

Publication type:

Article

CULLIN-3 Controls TIMELESS Oscillations in the Drosophila Circadian Clock.

Published in:

PLoS Biology, 2012, v. 10, n. 8, p. 1, doi. 10.1371/journal.pbio.1001367

By:

Grima, Brigitte;
Dognon, Alexandre;
Lamouroux, Annie;
Chélot, Elisabeth;
Rouyer, François

Publication type:

Article

Two Distinct E3 Ubiquitin Ligases Have Complementary Functions in the Regulation of Delta and Serrate Signaling in Drosophila.

Published in:

PLoS Biology, 2005, v. 3, n. 3, p. 1, doi. 10.1371/journal.pbio.0030096

By:

Le Borgne, Roland;
Remaud, Sylvie;
Hamel, Sophie;
Schweisguth, François

Publication type:

Article

Regulation of β-catenin by IGFBP2 and its cytoplasmic actions in glioma.

Published in:

Journal of Neuro-Oncology, 2020, v. 149, n. 2, p. 209, doi. 10.1007/s11060-020-03596-4

By:

Verma, Brijesh Kumar;
Kondaiah, Paturu

Publication type:

Article

Jab1 promotes glioma cell proliferation by regulating Siah1/β-catenin pathway.

Published in:

Journal of Neuro-Oncology, 2017, v. 131, n. 1, p. 31, doi. 10.1007/s11060-016-2279-6

By:

Zhu, Yufu;
Qiu, Zhichao;
Zhang, Xiang;
Qian, Fengyuan;
Wang, Bin;
Wang, Lei;
Shi, Hengliang;
Yu, Rutong

Publication type:

Article

In vitro ubiquitination of Mycobacterium tuberculosis by E3 ubiquitin ligase, MKRN1.

Published in:

Biotechnology Letters, 2020, v. 42, n. 8, p. 1527, doi. 10.1007/s10529-020-02873-6

By:

Subrahmanian, Meenu;
Marimuthu, Jeya;
Sairam, Thiagarajan;
Sankaran, Ramalingam

Publication type:

Article

UHRF2 promotes DNA damage response by decreasing p21 via RING finger domain.

Published in:

Biotechnology Letters, 2018, v. 40, n. 8, p. 1181, doi. 10.1007/s10529-018-2577-5

By:

Wang, Yangyang;
Yan, Xinke;
Zeng, Shengyuan;
Zhang, Ting;
Cheng, Fengjuan;
Chen, Rongjuan;
Duan, Changzhu

Publication type:

Article

The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectives.

Published in:

Molecular Medicine, 2023, v. 29, n. 1, p. 1, doi. 10.1186/s10020-023-00628-3

By:

Zhang, Rui;
Shi, Shaoqing

Publication type:

Article

USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity.

Published in:

Molecular Medicine, 2022, v. 28, n. 1, p. 1, doi. 10.1186/s10020-022-00596-0

By:

Shin, Jaemin;
Kim, Young Hun;
Lee, Bin;
Chang, Jae Ho;
Choi, Hee Youn;
Lee, Hoojung;
Song, Ki Chan;
Kwak, Man Sup;
Choi, Ji Eun;
Shin, Jeon-Soo

Publication type:

Article

Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis.

Published in:

Molecular Medicine, 2022, v. 28, n. 1, p. 1, doi. 10.1186/s10020-022-00538-w

By:

Xiao, Juan;
Zeng, Wenying;
Zhang, Pengcheng;
Zhou, Yuan;
Fang, Qiangqiang

Publication type:

Article

LncRNA-Fendrr protects against the ubiquitination and degradation of NLRC4 protein through HERC2 to regulate the pyroptosis of microglia.

Published in:

Molecular Medicine, 2021, v. 27, n. 1, p. 1, doi. 10.1186/s10020-021-00299-y

By:

Wang, Li-Qing;
Zheng, Yue-Ying;
Zhou, Heng-Jun;
Zhang, Xiong-Xin;
Wu, Pin;
Zhu, Sheng-Mei

Publication type:

Article

Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression.

Published in:

Molecular Medicine, 2020, v. 26, n. 1, p. N.PAG, doi. 10.1186/s10020-020-00226-7

By:

Du, Lei;
Li, Cong-Rong;
He, Qi-Feng;
Li, Xiao-Hua;
Yang, Lin-Fei;
Zou, Yuan;
Yang, Zhi-Xia;
Zhang, Dong;
Xing, Xiao-Wei

Publication type:

Article

Cdc48/Shp1 participates in dissociation of protein complexes to regulate their activity.

Published in:

Current Genetics, 2021, v. 67, n. 2, p. 263, doi. 10.1007/s00294-020-01136-1

By:

Lauinger, Linda;
Flick, Karin;
Kaiser, Peter

Publication type:

Article

N-degron-mediated degradation and regulation of mitochondrial PINK1 kinase.

Published in:

Current Genetics, 2020, v. 66, n. 4, p. 693, doi. 10.1007/s00294-020-01062-2

By:

Eldeeb, Mohamed A.;
Ragheb, Mohamed A.

Publication type:

Article

Genome-wide identification of genes encoding putative secreted E3 ubiquitin ligases and functional characterization of PbRING1 in the biotrophic protist Plasmodiophora brassicae.

Published in:

Current Genetics, 2019, v. 65, n. 6, p. 1355, doi. 10.1007/s00294-019-00989-5

By:

Yu, Fangwei;
Wang, Shenyun;
Zhang, Wei;
Tang, Jun;
Wang, Hong;
Yu, Li;
Zhang, Xin;
Fei, Zhangjun;
Li, Jianbin

Publication type:

Article

Spatiotemporal regulation of the Dma1-mediated mitotic checkpoint coordinates mitosis with cytokinesis.

Published in:

Current Genetics, 2019, v. 65, n. 3, p. 663, doi. 10.1007/s00294-018-0921-x

By:

Cullati, Sierra N.;
Gould, Kathleen L.

Publication type:

Article

The paradox of proteasome granules.

Published in:

Current Genetics, 2018, v. 64, n. 1, p. 137, doi. 10.1007/s00294-017-0739-y

By:

Enenkel, Cordula

Publication type:

Article

MoGrr1, a novel F-box protein, is involved in conidiogenesis and cell wall integrity and is critical for the full virulence of Magnaporthe oryzae.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 19, p. 8075, doi. 10.1007/s00253-015-6820-x

By:

Guo, Min;
Gao, Fei;
Zhu, Xiaolei;
Nie, Xiang;
Pan, YueMin;
Gao, Zhimou

Publication type:

Article

PUB40 attenuates Phytophthora capsici resistance by destabilizing the MEK2-SIPK/WIPK cascade in Nicotiana benthamiana.

Published in:

Phytopathology Research, 2024, v. 6, n. 1, p. 1, doi. 10.1186/s42483-024-00249-6

By:

Zhang, Yifan;
Wang, Jinghao;
Pi, Lei;
Wang, Nan;
Peng, Hao;
Xu, Guangyuan;
Yin, Zhiyuan;
Dou, Daolong

Publication type:

Article

The E2 ubiquitin-conjugating enzyme CfRad6 regulates the autophagy and pathogenicity of Colletotrichum fructicola on Camellia oleifera.

Published in:

Phytopathology Research, 2023, v. 5, n. 1, p. 1, doi. 10.1186/s42483-023-00191-z

By:

Luo, Jing;
Chen, Yan;
Guo, Yuan;
Li, He;
Zhang, Shengpei

Publication type:

Article

Crystal structure of rice APIP6 reveals a new dimerization mode of RING-type E3 ligases that facilities the construction of its working model.

Published in:

Phytopathology Research, 2023, v. 5, n. 1, p. 1, doi. 10.1186/s42483-023-00186-w

By:

Zheng, Yangyang;
Zhang, Xin;
Liu, Yang;
Zhu, Tongtong;
Wu, Xuefeng;
Ning, Yuese;
Liu, Junfeng;
Wang, Dongli

Publication type:

Article

Comprehensive analysis of the role of NEDD4 in pan-cancer and experimental verification of its role in KIRC progression.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02945-x

By:

Chen, Yanjiong;
Lin, Lifan;
Tao, Qiqi;
Zhang, Weizhi;
Zheng, Jianjian;
Wang, Siqi

Publication type:

Article

Identification of DCAF5 as a novel cancer prognostic and immunotherapy biomarker through pan-cancer analysis and renal clear cell carcinoma clinical data validation.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02974-6

By:

Yan, Huaqing;
Zhang, Liqi;
Xu, Fan;
Chen, Tieding;
Li, Rubing

Publication type:

Article

ZNF432 suppresses endometrial cancer progression by promoting UPF1 ubiquitination and inducing apoptosis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02915-3

By:

Li, Xinjun;
Qi, Jie;
Xu, Ren;
Xu, Shuo;
Wang, Shengpu;
Wang, Chunxiao;
Zhao, Sufen

Publication type:

Article

TRIM19 enhances the chemosensitivity of endometrial cancer by regulating the TBX2/NRF2 axis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02717-7

By:

Ding, Ning;
Li, Yujiao;
Yu, Xiaohui

Publication type:

Article

USP37 as a novel regulator of NRF2 protein stability and chemoresistance in HCC.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-01913-9

By:

Zhang, Shujiao;
Ding, Feihu;
Jia, Fuxin;
Lu, Xiubo

Publication type:

Article

DYNLL1 ubiquitinated and degraded by E3 ligase PRKN regulates cell cycle arrest and apoptosis in lung adenocarcinoma cells.

Published in:

Discover Oncology, 2024, v. 15, n. 1, p. 1, doi. 10.1007/s12672-024-01686-7

By:

Tang, Hongjie;
Wei, Changjiang

Publication type:

Article

Molecular features defining the efficiency of bioPROTACs.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08352-w

By:

Winkelvoß, Dorothea;
Vukovic, David;
Hänny, Anna-Carina;
Riermeier, Luca;
Udovcic, Anto;
Kolibius, Jonas;
Honegger, Annemarie;
Mittl, Peer R. E.;
Michel, Erich;
Hansen, Simon;
Plückthun, Andreas

Publication type:

Article

Pioneering protein degradation for agricultural applications.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08013-y

By:

Morgan, Gina L.;
Dickson, Hamilton;
Ford, Breanna;
Noras, Aleksandra;
Bremmer, Steven C.;
Watts, Brian E.;
Pilotte, Joseph;
Anderson, Ed;
Sullivan, Eric D.;
Stoner, Mikayla;
Ouedraogo, Daniel;
Saltzberg, Daniel J.;
Pothula, Karunakar R.;
Ingram, Paul;
Catalano, John;
Lillich, Melina;
Kolbe, Carl-Christian;
Pfeiffer, Anne;
Ladner, Christopher C.;
Gattis, Sam

Publication type:

Article