Works about TRIPTOLIDE

Results: 319

Studies on the chemical constituents and quality evaluation of Rosa cymosa Tratt. root.

Published in:

Journal of Separation Science, 2020, v. 43, n. 24, p. 4379, doi. 10.1002/jssc.202000005

By:

Fan, Xiaorui;
Bai, Lu;
Lin, Limei;
Liao, Duanfang;
Gong, Yun;
Liu, Xiaoqian;
Wang, Zhimin;
Li, Chun

Publication type:

Article

Triptolide reverses helper T cell inhibition and down-regulates IFN-γ induced PD-L1 expression in glioma cell lines.

Published in:

Journal of Neuro-Oncology, 2019, v. 143, n. 3, p. 429, doi. 10.1007/s11060-019-03193-0

By:

Zhang, Lei;
Yu, John S.

Publication type:

Article

Triptolide inhibits proliferation and invasion of malignant glioma cells.

Published in:

Journal of Neuro-Oncology, 2012, v. 109, n. 1, p. 53, doi. 10.1007/s11060-012-0885-5

By:

Zhang, Haipeng;
Zhu, Wenbo;
Su, Xingwen;
Wu, Sihan;
Lin, Yuan;
Li, Jingjie;
Wang, Youqiong;
Chen, Jingkao;
Zhou, Yuxi;
Qiu, Pengxin;
Yan, Guangmei;
Zhao, Shujin;
Hu, Jun;
Zhang, Jingxia

Publication type:

Article

Transcriptional expression of CXCL10 and STAT1 in lupus nephritis and the intervention effect of triptolide.

Published in:

Clinical Rheumatology, 2023, v. 42, n. 2, p. 539, doi. 10.1007/s10067-022-06400-y

By:

Shi, Dongliang;
Li, Yan;
Shi, Xiaomei;
Yao, Meihong;
Wu, Dan;
Zheng, Yuhui;
Lin, Qing;
Yang, Yinghong

Publication type:

Article

Triptolide Inhibits Th17 Response by Upregulating microRNA-204-5p and Suppressing STAT3 Phosphorylation in Psoriasis.

Published in:

Genetics Research, 2022, p. 1, doi. 10.1155/2022/7468396

By:

He, Qi;
Wu, Xingyue;
Shi, Quan;
Hesham, Abd El-Latif

Publication type:

Article

A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.85862

By:

Qiaomu Tian;
Peng Zhang;
Yihan Wang;
Youhui Si;
Dengping Yin;
Weber, Christopher R.;
Fishel, Melissa L.;
Pollok, Karen E.;
Bo Qiu;
Fei Xiao;
Chong, Anita S.

Publication type:

Article

A metabolomic study on the anti-depressive effects of two active components from Chrysanthemum morifolium.

Published in:

Artificial Cells, Nanomedicine & Biotechnology, 2020, v. 48, n. 1, p. 718, doi. 10.1080/21691401.2020.1774597

By:

Liu, Tong;
Zhou, Ning;
Xu, Ruihao;
Cao, Yangang;
Zhang, Yanli;
Liu, Zhen;
Zheng, Xiaoke;
Feng, Weisheng

Publication type:

Article

Integrated network pharmacology and targeted metabolomics to reveal the mechanism of nephrotoxicity of triptolide.

Published in:

Toxicology Research, 2019, v. 8, n. 6, p. 850, doi. 10.1039/c9tx00067d

By:

Huang, Wei;
Liu, Chuanxin;
Xie, Lijuan;
Wang, Yuming;
Xu, Yanyan;
Li, Yubo

Publication type:

Article

Dephosphorylation of Tak1 at Ser412 greatly contributes to the spermatocyte-specific testis toxicity induced by (5R)-5-hydroxytriptolide in C57BL/6 mice.

Published in:

Toxicology Research, 2016, v. 5, n. 2, p. 594, doi. 10.1039/c5tx00409h

By:

Qi, Xinming;
Li, Chunzhu;
Wu, Chunyong;
Yu, Cunzhi;
Liu, Mingxia;
Gao, Man;
Li, Chenggang;
Yan, Hong;
Ren, Jin

Publication type:

Article

A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F.

Published in:

Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00104

By:

Chen, Shao-Ru;
Dai, Yan;
Zhao, Jing;
Lin, Ligen;
Wang, Yitao;
Wang, Ying

Publication type:

Article

Effect of the Natural Product Triptolide on Pancreatic Cancer: A Systematic Review of Preclinical Studies.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00490

By:

Chi Zhang;
Xiao-Juan He;
Li Li;
Cheng Lu;
Ai-Ping Lu

Publication type:

Article

Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00260

By:

Jing Yang;
Lixin Sun;
Lu Wang;
Hassan, Hozeifa M.;
Xuan Wang;
Hylemon, Phillip B.;
Tao Wang;
Huiping Zhou;
Luyong Zhang;
Zhenzhou Jiang

Publication type:

Article

Triptolide Induces Glioma Cell Autophagy and Apoptosis via Upregulating the ROS/JNK and Downregulating the Akt/mTOR Signaling Pathways.

Published in:

Frontiers in Oncology, 2019, p. N.PAG, doi. 10.3389/fonc.2019.00387

By:

Liu, Xihong;
Zhao, Peiyuan;
Wang, Xiujuan;
Wang, Lei;
Zhu, Yingjun;
Gao, Wei

Publication type:

Article

Improved Retinal Ganglion Cell Survival through Retinal Microglia Suppression by a Chinese Herb Extract, Triptolide, in the DBA/2J Mouse Model of Glaucoma.

Published in:

Ocular Immunology & Inflammation, 2013, v. 21, n. 5, p. 378, doi. 10.3109/09273948.2013.806989

By:

Yang, Fan;
Wu, Lingling;
Guo, Xiujuan;
Wang, Dongmei;
Li, Ying

Publication type:

Article

[Retracted] Triptolide inhibits migration and proliferation of fibroblasts from ileocolonic anastomosis of patients with Crohn's disease via regulating the miR‑16‑1/HSP70 pathway.

Published in:

2025

By:

Chen, Min;
Wang, Jin-Min;
Wang, Dong;
Wu, Rong;
Hou, Hong-Wei

Publication type:

Correction Notice

Triptolide promotes ferroptosis by suppressing Nrf2 to overcome leukemia cell resistance to doxorubicin.

Published in:

Molecular Medicine Reports, 2023, v. 27, n. 1, p. N.PAG

By:

Wu, Xia;
Chen, Shangqing;
Huang, Kechu;
Lin, Gongping

Publication type:

Article

Mangiferin inhibits cell migration and angiogenesis via PI3K/AKT/mTOR signaling in high glucose- and hypoxia-induced RRCECs.

Published in:

Molecular Medicine Reports, 2021, v. 23, n. 6, p. N.PAG, doi. 10.3892/mmr.2021.12112

By:

Shi, Jia;
Lv, Hongbin;
Tang, Chen;
Li, Yujie;
Huang, Jing;
Zhang, Hong

Publication type:

Article

Triptolide inhibits migration and proliferation of fibroblasts from ileocolonic anastomosis of patients with Crohn's disease via regulating the miR-16-1/HSP70 pathway.

Published in:

Molecular Medicine Reports, 2019, v. 19, n. 6, p. 4841, doi. 10.3892/mmr.2019.10117

By:

Chen, Min;
Wang, Jin-Min;
Wang, Dong;
Wu, Rong;
Hou, Hong-Wei

Publication type:

Article

Triptolide exhibits antitumor effects by reversing hypermethylation of WIF-1 in lung cancer cells.

Published in:

Molecular Medicine Reports, 2018, v. 18, n. 3, p. 3041, doi. 10.3892/mmr.2018.9263

By:

Mao, Xiaoliang;
Tong, Jichun;
Wang, Yong;
Zhu, Zheng;
Yin, Yajun;
Wang, Yeming

Publication type:

Article

Effects of triptolide on the expression of MHC II in microglia in kainic acid‑induced epilepsy.

Published in:

Molecular Medicine Reports, 2018, v. 17, n. 6, p. 8357, doi. 10.3892/mmr.2018.8891

By:

Sun, ZhENg;
Du, MENg;
Lu, Yao;
ZENg, Chang-Qian

Publication type:

Article

Mechanism of triptolide in treating ankylosing spondylitis through the anti-ossification effect of the BMP/Smad signaling pathway.

Published in:

Molecular Medicine Reports, 2018, v. 17, n. 2, p. 2731, doi. 10.3892/mmr.2017.8117

By:

Wang, Guilong;
Cai, Jing;
Zhang, Jinshan;
Li, Cuiyun

Publication type:

Article

Triptolide inhibits proliferation, differentiation and induces apoptosis of osteoblastic MC3T3‑E1 cells.

Published in:

Molecular Medicine Reports, 2017, v. 16, n. 5, p. 7391, doi. 10.3892/mmr.2017.7568

By:

WEI JI;
XIA ZHAO;
YUNKE GUO;
SHIJIA LIU;
SHA XIA;
MENYUN YIN;
YUEYANG LU;
XIAO XU

Publication type:

Article

Arsenic trioxide and triptolide synergistically induce apoptosis in the SKM-1 human myelodysplastic syndrome cell line.

Published in:

Molecular Medicine Reports, 2016, v. 14, n. 5, p. 4180, doi. 10.3892/mmr.2016.5779

By:

HAI-YING HUA;
HUA-QIANG GAO;
AI-NING SUN;
JIAN-NONG CEN;
LI-LI WU

Publication type:

Article

Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN by targeting miR-21.

Published in:

Molecular Medicine Reports, 2016, v. 13, n. 3, p. 2763, doi. 10.3892/mmr.2016.4844

By:

XIAOFANG LI;
AIMIN ZANG;
YOUCHAO JIA;
JINCHAO ZHANG;
WUFANG FAN;
JIA FENG;
MINDAN DUAN;
LEI ZHANG;
RAN HUO;
JIN JIAO;
XIAOWEI ZHU

Publication type:

Article

Triptolide reverses the Taxol resistance of lung adenocarcinoma by inhibiting the NF-κB signaling pathway and the expression of NF-κB-regulated drug-resistant genes.

Published in:

Molecular Medicine Reports, 2016, v. 13, n. 1, p. 153, doi. 10.3892/mmr.2015.4493

By:

NING JIANG;
XIAO-PENG DONG;
SUO-LIN ZHANG;
QING-YONG YOU;
XING-TAO JIANG;
XIAO-GANG ZHAO

Publication type:

Article

Triptolide suppresses proliferation, hypoxia-inducible factor-1α and c-Myc expression in pancreatic cancer cells.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 3, p. 4508, doi. 10.3892/mmr.2015.3960

By:

XIAOLING DING;
XIAORONG ZHOU;
BO JIANG;
QUN ZHAO;
GUOXIONG ZHOU

Publication type:

Article

Triptolide ameliorates colonic fibrosis in an experimental rat model.

Published in:

Molecular Medicine Reports, 2015, v. 12, n. 2, p. 1891, doi. 10.3892/mmr.2015.3582

By:

QINGSONG TAO;
BAOCHAI WANG;
YU ZHENG;
GUANWEI LI;
JIANAN REN

Publication type:

Article

Triptolide inhibits cell proliferation and tumorigenicity of human neuroblastoma cells.

Published in:

Molecular Medicine Reports, 2015, v. 11, n. 2, p. 791, doi. 10.3892/mmr.2014.2814

By:

XIAOMIN YAN;
XIAO-XUE KE;
HAILONG ZHAO;
MENGYING HUANG;
RENJIAN HU;
HONGJUAN CUI

Publication type:

Article

Effect of triptolide on the regulation of ATP-binding cassette transporter A1 expression in lipopolysaccharide-induced acute lung injury of rats.

Published in:

Molecular Medicine Reports, 2014, v. 10, n. 6, p. 3015, doi. 10.3892/mmr.2014.2636

By:

JUN CHEN;
JIANLIN GAO;
JIANPING YANG;
YUKUN ZHANG;
LINA WANG

Publication type:

Article

Anti-inflammatory effects of triptolide by inhibiting the NF-κB signalling pathway in LPS-induced acute lung injury in a murine model.

Published in:

Molecular Medicine Reports, 2014, v. 10, n. 1, p. 447, doi. 10.3892/mmr.2014.2191

By:

XIAN WANG;
LEI ZHANG;
WEI DUAN;
BIN LIU;
PING GONG;
YUSONG DING;
XIONGWEN WU

Publication type:

Article

Triptolide induces apoptosis in endometrial cancer via a p53-independent mitochondrial pathway.

Published in:

Molecular Medicine Reports, 2014, v. 9, n. 1, p. 39, doi. 10.3892/mmr.2013.1783

By:

XIAO-FEI WANG;
YI-BING ZHAO;
QIANG WU;
ZHI-HUA SUN;
HAI-JIN LI

Publication type:

Article

The mechanism of triptolide in the treatment of connective tissue disease-related interstitial lung disease based on network pharmacology and molecular docking.

Published in:

Annals of Medicine, 2022, v. 54, n. 1, p. 541, doi. 10.1080/07853890.2022.2034931

By:

Zhu, Wen;
Li, Yehui;
Zhao, Junjie;
Wang, Yifan;
Li, Yixi;
Wang, Yue

Publication type:

Article

Triptolide Protects Against Ischemic Stroke in Rats.

Published in:

Inflammation, 2015, v. 38, n. 4, p. 1617, doi. 10.1007/s10753-015-0137-x

By:

Hao, Maolin;
Li, Xianghua;
Feng, Jianli;
Pan, Ning

Publication type:

Article

Anti-inflammatory Effects of Triptolide in LPS-Induced Acute Lung Injury in Mice.

Published in:

Inflammation, 2014, v. 37, n. 4, p. 1307, doi. 10.1007/s10753-014-9858-5

By:

Wei, Dong;
Huang, Zhihong

Publication type:

Article

Triptolide Inhibits Osteoclast Differentiation and Bone Resorption In Vitro via Enhancing the Production of IL-10 and TGF-β1 by Regulatory T Cells.

Published in:

Mediators of Inflammation, 2016, p. 1, doi. 10.1155/2016/8048170

By:

Xu, Huihui;
Zhao, Hongyan;
Lu, Cheng;
Qiu, Qi;
Wang, Gui;
Huang, Jing;
Guo, Minghui;
Guo, Baosheng;
Tan, Yong;
Xiao, Cheng

Publication type:

Article

Triptolide inhibits the Apoptosis and Reactive Oxygen Species Production in Hydrogen Peroxide-Treated Nasal Epithelial Cells by Regulating PTEN/PI3K/AKT Signaling Pathway.

Published in:

Indian Journal of Pharmaceutical Sciences, 2022, v. 84, p. 114

By:

WANG, X.;
XIAOYAN ZHU;
QINGHUA GUO;
XIAOYANG ZHANG;
HONGWEI GU

Publication type:

Article

Triptolide improves systolic function and myocardial energy metabolism of diabetic cardiomyopathy in streptozotocin-induced diabetic rats.

Published in:

BMC Cardiovascular Disorders, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12872-015-0030-4

By:

Zhongshu Liang;
Sunnar Leo;
Helin Wen;
Mao Ouyang;
Weihong Jiang;
Kan Yang

Publication type:

Article

Aggregate cell suspension cultures of Tripterygium wilfordii Hook. f. for triptolide, wilforgine, and wilforine production.

Published in:

Plant Cell, Tissue & Organ Culture, 2013, v. 112, n. 1, p. 109, doi. 10.1007/s11240-012-0211-0

By:

Miao, Guo-peng;
Zhu, Chuan-shu;
Feng, Jun-tao;
Han, Juan;
Song, Xiao-Wei;
Zhang, Xing

Publication type:

Article

Diterpenoid Alkaloids from the Roots of Aconitum iochanicum.

Published in:

Chemistry of Natural Compounds, 2020, v. 56, n. 3, p. 492, doi. 10.1007/s10600-020-03069-0

By:

Hu, Jiang;
Lv, Yan;
Li, Qiang;
Mao, Xia;
Peng, Tianfeng;
Gao, Xiu;
Jin, Nianhua;
Yin, Si;
Shi, Xiaodong;
Wang, Wei

Publication type:

Article

Treatment of db/db diabetic mice with triptolide: a novel therapy for diabetic nephropathy.

Published in:

Nephrology Dialysis Transplantation, 2010, v. 25, n. 11, p. 3539, doi. 10.1093/ndt/gfq245

By:

Gao, Qing;
Shen, Wenwen;
Qin, Weisong;
Zheng, Chunxia;
Zhang, Mingchao;
Zeng, Caihong;
Wang, Shengyu;
Wang, Jianping;
Zhu, Xiaodong;
Liu, Zhihong

Publication type:

Article

Triptolide inhibits extracellular matrix protein synthesis by suppressing the Smad2 but not the MAPK pathway in TGF-β1-stimulated NRK-49F cells.

Published in:

Nephrology Dialysis Transplantation, 2010, v. 25, n. 10, p. 3180, doi. 10.1093/ndt/gfq239

By:

Zhu, Bin;
Wang, Yong-jun;
Zhu, Cai-feng;
Lin, Yi;
Zhu, Xiao-ling;
Wei, Sheng;
Lu, Ying;
Cheng, Xiao-xia

Publication type:

Article

Triptolide improves spinal cord injury by promoting autophagy and inhibiting apoptosis.

Published in:

Cell Biology International, 2020, v. 44, n. 3, p. 785, doi. 10.1002/cbin.11273

By:

Zhu, Ning;
Ruan, Jianwei;
Yang, Xinming;
Huang, Yang;
Jiang, Yuting;
Wang, Yucheng;
Cai, Danyang;
Geng, Yu;
Fang, Marong

Publication type:

Article

Triptolide protects against podocyte injury in diabetic nephropathy by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome pathway.

Published in:

Renal Failure, 2023, v. 45, n. 1, p. 1, doi. 10.1080/0886022X.2023.2165103

By:

Lv, Chenlei;
Cheng, Tianyang;
Zhang, Bingbing;
Sun, Ke;
Lu, Keda

Publication type:

Article

Efficacy of triptolide on the apoptosis of tonsillar mononuclear cells from patients with IgA nephropathy.

Published in:

Renal Failure, 2016, v. 38, n. 1, p. 109, doi. 10.3109/0886022X.2015.1096730

By:

Yan, Wenzhe;
Peng, Youming;
Liu, Chan;
Ye, Muyao;
Chen, Xian;
Peng, Xiaofei;
He, Liyu;
Wang, Jiayi;
Liu, Hong;
Liu, Fuyou;
Zhang, Guangsen

Publication type:

Article

Effect of triptolide on expression of thrombospondin-1 and transforming growth factor- β 1 in renal tubular cells.

Published in:

Renal Failure, 2015, v. 37, n. 6, p. 1039, doi. 10.3109/0886022X.2015.1040705

By:

Zeng, Rong;
Duan, Lei;
Sun, Lina;
Kong, Yuke;
Yang, Kehu

Publication type:

Article

Preparation and anti-inflammatory activity of triptolide ethosomes in an erythema model.

Published in:

Journal of Liposome Research, 2010, v. 20, n. 4, p. 297, doi. 10.3109/08982100903544144

By:

Chen, Jin-Guang;
Liu, Yu-Feng;
Gao, Tian-Wen

Publication type:

Article

Metabolic pathways leading to detoxification of triptolide, a major active component of the herbal medicine Tripterygium wilfordii.

Published in:

Journal of Applied Toxicology, 2014, v. 34, n. 8, p. 878, doi. 10.1002/jat.2906

By:

Du, Fuying;
Liu, Zhaohua;
Li, Xinxiu;
Xing, Jie

Publication type:

Article

Retraction Note to: Triptolide (TPL) improves locomotor function recovery in rats and reduces inflammation after spinal cord injury.

Published in:

2017

By:

Wang, Bing;
Chen, Chen;
Zhang, Jing-Tao;
Song, Ruo-Xian;
Yu, Xiu-Chun

Publication type:

journal article

Triptolide (TPL) improves locomotor function recovery in rats and reduces inflammation after spinal cord injury.

Published in:

Neurological Sciences, 2015, v. 36, n. 5, p. 701, doi. 10.1007/s10072-014-2001-4

By:

Wang, Bing;
Chen, Chen;
Zhang, Jing-Tao;
Song, Ruo-Xian;
Yu, Xiu-Chun

Publication type:

Article

Effects of triptolide on degeneration of dendritic spines induced by Aβ injection in rat hippocampus.

Published in:

Neurological Sciences, 2014, v. 35, n. 1, p. 35, doi. 10.1007/s10072-013-1463-0

By:

Wan, Bin;
Hu, Xiaoling;
Nie, Jing;
Zhou, Ming;
Yang, Baolin;
Li, Yaobing;
Wen, Wei;
Lü, Cheng

Publication type:

Article