Works about SPHINGOSINE

Results: 815

Delta 4-desaturase sphingolipid 2 enhances prostate cancer stem-like traits through phytoceramide-mediated PI3K-AKT signaling pathway.

Published in:

Carcinogenesis, 2025, v. 46, n. 2, p. 1, doi. 10.1093/carcin/bgaf024

By:

Luo, Yuanyuan;
Yu, Jiachuan;
Li, Qi;
Wang, Xiaolin;
Liu, Xinyu;
Xu, Guowang;
Qin, Wangshu

Publication type:

Article

Tetrandrine regulates NAADP-mediated calcium signaling through a LIMP-2-dependent and sphingosine-mediated mechanism.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61565-9

By:

Chan, Wing-Cheung;
Zhao, Qian;
Wong, Koon Ho;
Tang, Hok-Him;
Mok, Daniel Kam-Wah;
Pardeshi, Lakhansing;
Ruan, Ye Chun;
Yang, Yang;
Wong, Chi-Ming;
Wong, Clarence T. T.;
Zhao, Yong-Juan;
Chan, Ka Ying;
Yin, Zengsheng;
Leung, Howard Ho-Wai;
Ma, Xiyang;
Chau, Mary P.;
Leung, Franco King-Chi;
Lui, Ying-Ying;
Au, Shannon Wing-Ngor;
Sun, Kailei

Publication type:

Article

The Liganding of Glycolipid Transfer Protein Is Controlled by Glycolipid Acyl Structure.

Published in:

PLoS Biology, 2006, v. 4, n. 11, p. 1996, doi. 10.1371/journal.pbio.0040362

By:

Malinina, Lucy;
Malakhova, Margarita L.;
Kanack, Alex T.;
Min Lu;
Abagyan, Ruben;
Brown, Rhoderick E.;
Patel, Dinshaw J.

Publication type:

Article

Too Long, Too Short, or Just Right: Glycosphingolipid-Protein Binding Varies with Acyl Chain Length.

Published in:

PLoS Biology, 2006, v. 4, n. 11, p. 1886, doi. 10.1371/journal.pbio.0040397

By:

Robinson, Richard

Publication type:

Article

Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/ EDG1 axis in hepatocellular carcinoma.

Published in:

Liver International, 2012, v. 32, n. 2, p. 331, doi. 10.1111/j.1478-3231.2011.02666.x

By:

Bao, Meiyan;
Chen, Zhiao;
Xu, Yongfen;
Zhao, Yingjun;
Zha, Ruopeng;
Huang, Shenglin;
Liu, Li;
Chen, Taoyang;
Li, Jinjun;
Tu, Hong;
He, Xianghuo

Publication type:

Article

The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells.

Published in:

Journal of Neuro-Oncology, 2011, v. 102, n. 3, p. 353, doi. 10.1007/s11060-010-0345-z

By:

Estrada-Bernal, Adriana;
Lawler, Sean;
Nowicki, Michal;
Ray Chaudhury, Abhik;
Van Brocklyn, James

Publication type:

Article

The expression level of sphingosine-1-phosphate receptor type 1 is related to MIB-1 labeling index and predicts survival of glioblastoma patients.

Published in:

Journal of Neuro-Oncology, 2010, v. 98, n. 1, p. 41, doi. 10.1007/s11060-009-0064-5

By:

Yoshida, Yuya;
Nakada, Mitsutoshi;
Harada, Tomoya;
Tanaka, Shingo;
Furuta, Takuya;
Hayashi, Yasuhiko;
Kita, Daisuke;
Uchiyama, Naoyuki;
Hayashi, Yutaka;
Hamada, Jun-ichiro

Publication type:

Article

Production of tetraacetyl phytosphingosine (TAPS) in Wickerhamomyces ciferrii is catalyzed by acetyltransferases Sli1p and Atf2p.

Published in:

Applied Microbiology & Biotechnology, 2013, v. 97, n. 19, p. 8537, doi. 10.1007/s00253-012-4670-3

By:

Veld, Frank;
Wolff, Daniel;
Schorsch, Christoph;
Köhler, Tim;
Boles, Eckhard;
Poetsch, Ansgar

Publication type:

Article

The Expression of Sphingosine Kinase-1 in Head and Neck Carcinoma.

Published in:

Cells Tissues Organs, 2010, v. 192, n. 5, p. 314, doi. 10.1159/000318173

By:

Facchinetti, María M.;
Gandini, Norberto A.;
Fermento, María E.;
Sterin-Speziale, Norma B.;
Ji, Youngmi;
Patel, Vyomesh;
Gutkind, J. Silvio;
Rivadulla, Maria G.;
Curino, Alejandro C.

Publication type:

Article

Stratification of Sphingosine Kinase-1 Expression and Activity in Rat Kidney.

Published in:

Cells Tissues Organs, 2008, v. 188, n. 4, p. 384, doi. 10.1159/000139770

By:

Facchinetti, Maria M.;
Nieto, Francisco Leocata;
Márquez, Maria G.;
Sterin-Speziale, Norma

Publication type:

Article

PmST2: A novel Pasteurella multocida glycolipid α2-3-sialyltransferase.

Published in:

Glycobiology, 2011, v. 21, n. 9, p. 1206, doi. 10.1093/glycob/cwr054

By:

Thon, Vireak;
Lau, Kam;
Yu, Hai;
Tran, Bao K;
Chen, Xi

Publication type:

Article

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells.

Published in:

Nature Immunology, 2010, v. 11, n. 11, p. 1047, doi. 10.1038/ni.1939

By:

Liu, Guangwei;
Yang, Kai;
Burns, Samir;
Shrestha, Sharad;
Chi, Hongbo

Publication type:

Article

Research Highlights.

Published in:: 2010
Publication type:: Abstract

Research Highlights.

Published in:

2010

By:

Dempsey, Laurie A.;
Visan, Ioana;
Wilson, Jamie D. K.

Publication type:

Abstract

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR.

Published in:

Nature Immunology, 2009, v. 10, n. 7, p. 769, doi. 10.1038/ni.1743

By:

Guangwei Liu;
Burns, Samir;
Gonghua Huang;
Boyd, Kelli;
Proia, Richard L.;
Flavell, Richard A.;
Hongbo Chi

Publication type:

Article

A novel modifier of regulatory T cells.

Published in:

Nature Immunology, 2009, v. 10, n. 7, p. 685, doi. 10.1038/ni0709-685

By:

Ohkura, Naganari;
Sakaguchi, Shimon

Publication type:

Article

Research Highlights.

Published in:

Nature Immunology, 2006, v. 7, n. 8, p. 801, doi. 10.1038/ni0806-801

By:

Borowski, Christine;
Braaten, Douglas C.;
Dempsey, Laurie A.

Publication type:

Article

Signals for lymphocyte egress.

Published in:

Nature Immunology, 2005, v. 6, n. 12, p. 1215, doi. 10.1038/ni1205-1215

By:

Ley, Klaus;
Morris, Maggie

Publication type:

Article

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses.

Published in:

Nature Immunology, 2005, v. 6, n. 12, p. 1228, doi. 10.1038/ni1269

By:

Wei, Sindy H.;
Rosen, Hugh;
Matheu, Melanie P.;
Sanna, M. Germana;
Sheng-Kai Wang;
Euijung Jo;
Chi-Huey Wong;
Parker, Ian;
Cahalan, Michael D.

Publication type:

Article

The crystal structure of human CD1d with and without α-galactosylceramide.

Published in:

Nature Immunology, 2005, v. 6, n. 8, p. 819, doi. 10.1038/ni1225

By:

Koch, Michael;
Stronge, Victoria S.;
Shepherd, Dawn;
Gadola, Stephan D.;
Mathew, Bini;
Ritter, Gerd;
Fersht, Alan R.;
Besra, Gurdyal S.;
Schmidt, Richard R.;
Jones, E. Yvonne;
Cerundolo, Vincenzo

Publication type:

Article

Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.

Published in:

Nature Immunology, 2004, v. 5, n. 7, p. 713, doi. 10.1038/ni1083

By:

Cinamon, Guy;
Matloubian, Mehrdad;
Lesneski, Matthew I.;
Ying Xu;
Low, Caroline;
Theresa Lu;
Proia, Richard L.;
Cyster, Jason G.

Publication type:

Article

Research notes.

Published in:

Nature Immunology, 2004, v. 5, n. 5, p. 479, doi. 10.1038/ni0504-479

By:

P. T. L.;
L. A. D.;
J. D. K. W.

Publication type:

Article

Disease Reactivation in Secondary Progressive Multiple Sclerosis Patients Switching from Fingolimod to Siponimod: A Case Series.

Published in:

2022

By:

Abbadessa, Gianmarco;
Maida, Elisabetta;
Miele, Giuseppina;
Bile, Floriana;
Lavorgna, Luigi;
Bonavita, Simona

Publication type:

Case Study

Sphingosine 1-phosphate receptor modulators: a new class of immunosuppressants.

Published in:

Clinical Transplantation, 2006, v. 20, n. 6, p. 788, doi. 10.1111/j.1399-0012.2006.00570.x

By:

Yopp, Adam C.;
Ledgerwood, Levi G.;
Ochando, Jordi C.;
Bromberg, Jonathan S.

Publication type:

Article

Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate.

Published in:

Scientific Reports, 2014, p. 7595, doi. 10.1038/srep07595

By:

Purdue, P. Edward;
Crotti, Tania N.;
Shen, Zhenxin;
Swantek, Jennifer;
Li, Jun;
Hill, Jonathan;
Hanidu, Adedayo;
Dimock, Janice;
Nabozny, Gerald;
Goldring, Steven R.;
McHugh, Kevin P.

Publication type:

Article

Cardiovascular Evaluation of Etrasimod, a Selective Sphingosine 1‐phosphate Receptor Modulator, in Healthy Adults: Results of a Randomized, Thorough QT/QTc Study.

Published in:

Clinical Pharmacology in Drug Development, 2024, v. 13, n. 4, p. 326, doi. 10.1002/cpdd.1388

By:

Darpo, Borje;
Connor, Kalvin;
Cabell, Christopher H.;
Grundy, John S.

Publication type:

Article

Arabidopsis mutants in sphingolipid synthesis as tools to understand the structure and function of membrane microdomains in plasmodesmata.

Published in:

Frontiers in Plant Science, 2014, v. 4, p. 1, doi. 10.3389/fpls.2014.00003

By:

González-Solís, Ariadna;
Cano-Ramírez, Dora L.;
Morales-Cedillo, Francisco;
de Aquino, Cinthya Tapia;
Gavilanes-Ruiz, Marina

Publication type:

Article

Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)).

Published in:

2009

By:

Jongsma, M.;
van Unen, J.;
van Loenen, P. B.;
Michel, M. C.;
Peters, S. L. M.;
Alewijnse, A. E.

Publication type:

journal article

Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.

Published in:

2008

By:

Salomone, S.;
Potts, E. M.;
Tyndall, S.;
Ip, P. C.;
Chun, J.;
Brinkmann, V.;
Waeber, C.

Publication type:

journal article

FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism.

Published in:

2007

By:

Xin, C.;
Ren, S.;
Eberhardt, W.;
Pfeilschifter, J.;
Huwiler, A.

Publication type:

journal article

Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity.

Published in:

British Journal of Pharmacology, 2007, v. 150, n. 3, p. 271, doi. 10.1038/sj.bjp.0706983

By:

Klawitter, S.;
Hofmann, L. P.;
Pfeilschifter, J.;
Huwiler, A.

Publication type:

Article

Renal mesangial cells: moving on sphingosine kinase-1.

Published in:

British Journal of Pharmacology, 2007, v. 150, n. 3, p. 255, doi. 10.1038/sj.bjp.0706986

By:

Meyer zu Heringdorf, D.;
Jakobs, K. H.

Publication type:

Article

BML-241 fails to display selective antagonism at the sphingosine-1-phosphate receptor, S1P3.

Published in:

British Journal of Pharmacology, 2006, v. 149, n. 3, p. 277, doi. 10.1038/sj.bjp.0706872

By:

Jongsma, M.;
Hendriks-Balk, M. C.;
Michel, M. C.;
Peters, S. L. M.;
Alewijnse, A. E.

Publication type:

Article

Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation.

Published in:

2006

By:

Mathieson, Fiona A.;
Nixon, Graeme F.

Publication type:

journal article

Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind?

Published in:

British Journal of Pharmacology, 2006, v. 147, n. 4, p. 347, doi. 10.1038/sj.bjp.0706602

By:

Alewijnse, Astrid E.;
Michel, Martin C.

Publication type:

Article

Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells.

Published in:

British Journal of Pharmacology, 2004, v. 143, n. 5, p. 581, doi. 10.1038/sj.bjp.0705980

By:

Cuiyan Xin;
Shuyu Ren;
Pfeilschifter, Josef;
Huwiler, Andrea

Publication type:

Article

Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats.

Published in:

British Journal of Pharmacology, 2004, v. 143, n. 2, p. 276, doi. 10.1038/sj.bjp.0705752

By:

Hemmings, D.G.;
Xu, Y.;
Davidge, S.T.

Publication type:

Article

Pharmacological characterization of human S1P4 using a novel radioligand, [4,5-3H]-dihydrosphingosine-1-phosphate.

Published in:

British Journal of Pharmacology, 2004, v. 142, n. 5, p. 851, doi. 10.1038/sj.bjp.0705856

By:

Fossetta, James;
Deno, Gregory;
Gonsiorek, Waldemar;
Fan, Xuedong;
Lavey, Brian;
Das, Pradip;
Lunn, Charles;
Zavodny, Paul J.;
Lundell, Daniel;
Hipkin, R. William

Publication type:

Article

Regulated and constitutive activation of specific signalling pathways by the human S1P5 receptor.

Published in:

British Journal of Pharmacology, 2003, v. 138, n. 3, p. 481, doi. 10.1038/sj.bjp.0705055

By:

Niedernberg, Anke;
Blaukat, Andree;
Schoneberg, Torsten;
Kostenis, Evi

Publication type:

Article

Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function.

Published in:

British Journal of Pharmacology, 2003, v. 138, n. 3, p. 435, doi. 10.1038/sj.bjp.0705063

By:

Altmann, Christoph;
zu Heringdorf, Dagmar Meyer;
Boyukbas, Dilek;
Haude, Michael;
Jakobs, Karl H.;
Michel, Martin C.

Publication type:

Article

Sphingosine 1-phosphate enhances spontaneous transmitter release at the frog neuromuscular junction.

Published in:

2002

By:

Brailoiu, E.;
Cooper, R.L.;
Dun, N.J.;
Brailoiu, Eugen;
Cooper, Robin L;
Dun, Nae J

Publication type:

journal article

Topical sphingolipids in antisepsis and antifungal therapy.

Published in:

Clinical & Experimental Dermatology, 1995, v. 20, n. 5, p. 395, doi. 10.1111/j.1365-2230.1995.tb01356.x

By:

Bibel, D. J.;
Aly, R.;
Shinefield, H. R.

Publication type:

Article

Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48954-2

By:

Xia, Jialin;
Chen, Hong;
Wang, Xiaoxiao;
Chen, Weixuan;
Lin, Jun;
Xu, Feng;
Nie, Qixing;
Ye, Chuan;
Zhong, Bitao;
Zhao, Min;
Yun, Chuyu;
Zeng, Guangyi;
Mao, Yuejian;
Wen, Yongping;
Zhang, Xuguang;
Yan, Sen;
Wang, Xuemei;
Sun, Lulu;
Liu, Feng;
Zhong, Chao

Publication type:

Article

Sphingolipid-mediated restoration of Mitf expression and repigmentation in vivo in a mouse model of hair graying.

Published in:

Pigment Cell & Melanoma Research, 2009, v. 22, n. 2, p. 205, doi. 10.1111/j.1755-148X.2009.00548.x

By:

Saha, Bidisha;
Singh, Suman Kumar;
Mallick, Shampa;
Bera, Rabindranath;
Datta, Pijush K.;
Mandal, Mriganka;
Roy, Syamal;
Bhadra, Ranjan

Publication type:

Article

Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs.

Published in:

PLoS ONE, 2022, v. 17, n. 7, p. 1, doi. 10.1371/journal.pone.0271620

By:

Carstens, Henning;
Kalka, Katharina;
Verhaegh, Rabea;
Schumacher, Fabian;
Soddemann, Matthias;
Wilker, Barbara;
Keitsch, Simone;
Sehl, Carolin;
Kleuser, Burkhard;
Hübler, Michael;
Rauen, Ursula;
Becker, Anne Katrin;
Koch, Achim;
Gulbins, Erich;
Kamler, Markus

Publication type:

Article

A2 B Adenosine Receptors and Sphingosine 1-Phosphate Signaling Cross-Talk in Oligodendrogliogenesis.

Published in:

Frontiers in Neuroscience, 2021, v. 15, p. 1, doi. 10.3389/fnins.2021.677988

By:

Coppi, Elisabetta;
Cencetti, Francesca;
Cherchi, Federica;
Venturini, Martina;
Donati, Chiara;
Bruni, Paola;
Pedata, Felicita;
Pugliese, Anna Maria

Publication type:

Article

Efficacy and safety of etrasimod, a sphingosine 1‐phosphate receptor modulator, in adults with moderate‐to‐severe atopic dermatitis (ADVISE).

Published in:

Journal of the European Academy of Dermatology & Venereology, 2023, v. 37, n. 7, p. 1366, doi. 10.1111/jdv.18914

By:

Silverberg, Jonathan I.;
Bissonnette, Robert;
Kircik, Leon;
Murrell, Dedee F.;
Selfridge, Andrew;
Liu, Kris;
Ahluwalia, Gurpreet;
Guttman‐Yassky, Emma

Publication type:

Article

Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro

Published in:

Molecular Oncology, 2012, v. 6, n. 4, p. 392, doi. 10.1016/j.molonc.2012.04.002

By:

Yao, Chen;
Wu, Sujia;
Li, Dong;
Ding, Huimin;
Wang, Zuyu;
Yang, Yongjiang;
Yan, Shichang;
Gu, Zhangping

Publication type:

Article

Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential.

Published in:

Mediators of Inflammation, 2016, p. 1, doi. 10.1155/2016/8606878

By:

Aoki, Masayo;
Aoki, Hiroaki;
Ramanathan, Rajesh;
Hait, Nitai C.;
Takabe, Kazuaki

Publication type:

Article

Preparation of enantiopure long chain threo-2-amino-3-hydroxyesters via chiral morpholinone-derived azomethine ylids.

Published in:

Canadian Journal of Chemistry, 2006, v. 84, n. 10, p. 1448, doi. 10.1139/V06-121

By:

Brome, Victoria A.;
Harwood, Laurence M.;
Osborn, Helen M. I.

Publication type:

Article