Works about SIRTUINS

Results: 2711

SIRT2 -dependent CPT1A deacetylation in macrophages inhibits periodontitis.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1574141

By:

Jiang, Yixuan;
Yao, Xiu;
Jiang, Zhizhong;
Liu, Xiaomeng;
Sun, Boyuan;
Guan, Zhengyu;
Zhou, Lin;
Li, Hongjiao

Publication type:

Article

Molecular Crosstalk Between SIRT1, Wnt/β-Catenin Signaling, and Inflammatory Pathways in Renal Transplant Rejection: Role of miRNAs, lncRNAs, IL-1, IL-6, and Tubulointerstitial Inflammation.

Published in:

Medicina (1010660X), 2025, v. 61, n. 6, p. 1073, doi. 10.3390/medicina61061073

By:

Aksungur, Nurhak;
Kizilkaya, Murat;
Altundaş, Necip;
Balkan, Eda;
Kara, Salih;
Demirci, Elif;
Uyanik, Abdullah

Publication type:

Article

SIRT1-Mediated Epigenetic Protective Mechanisms of Phytosome-Encapsulated Zea mays L. var. ceratina Tassel Extract in a Rat Model of PM2.5-Induced Cardiovascular Inflammation.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5759, doi. 10.3390/ijms26125759

By:

Thukham-Mee, Wipawee;
Wattanathorn, Jintanaporn;
Palachai, Nut

Publication type:

Article

Relaxin‐2 Alleviates Hyperoxia‐Induced Acute Lung Injury in Neonatal Rats by Inhibiting TLR4/NF‐κB.

Published in:

Chemical Biology & Drug Design, 2025, v. 105, n. 6, p. 1, doi. 10.1111/cbdd.70140

By:

Yang, Mei;
Liu, Qian;
Xuan, Aili

Publication type:

Article

葛根素调控 SIRT1-FOXO1 通路抑制成骨细胞凋亡.

Published in:

Chinese Journal of Osteoporosis, 2025, v. 31, n. 5, p. 671, doi. 10.3969/j.issn.10067108.2025.05.008

By:

周凡;
高扬;
胡艳平;
向超;
万骐;
周茹

Publication type:

Article

Caloric Restriction Mimetics: A comparative analysis of natural and synthetic agents in autophagy modulation.

Published in:

Ars Pharmaceutica, 2025, v. 66, n. 3, p. 385, doi. 10.30827/ars.v66i3.32081

By:

Fernando Murillo-Cancho, Antonio;
José Nievas-Soriano, Bruno;
Lozano-Paniagua, David

Publication type:

Article

The Sirt1 Gene Promotes Insulin Secretion in Accord with Diet.

Published in:

PLoS Biology, 2005, v. 3, n. 12, p. 1, doi. 10.1371/journal.pbio.0040044

By:

Chanut, Françoise

Publication type:

Article

Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells.

Published in:

PLoS Biology, 2005, v. 3, n. 12, p. 1, doi. 10.1371/journal.pbio.0040031

By:

Bordone, Laura;
Motta, Maria Carla;
Picard, Frederic;
Robinson, Ashley;
Jhala, Ulupi S;
Apfeld, Javier;
McDonagh, Thomas;
Lemieux, Madeleine;
McBurney, Michael;
Szilvasi, Akos;
Easlon, Erin J;
Lin, Su-Ju;
Guarente, Leonard

Publication type:

Article

SIRT1 Regulates HIV Transcription via Tat Deacetylation.

Published in:

PLoS Biology, 2005, v. 3, n. 2, p. 1, doi. 10.1371/journal.pbio.0030041

By:

Pagans, Sara;
Pedal, Angelika;
North, Brian J;
Kaehlcke, Katrin;
Marshall, Brett L;
Dorr, Alexander;
Hetzer-Egger, Claudia;
Henklein, Peter;
Frye, Roy;
McBurney, Michael W;
Hruby, Henning;
Jung, Manfred;
Verdin, Eric;
Ott, Melanie

Publication type:

Article

Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway.

Published in:

Biotechnology Letters, 2018, v. 40, n. 3, p. 509, doi. 10.1007/s10529-017-2493-0

By:

Lee, Hyunjin;
Kim, Minji;
Park, Yun-Hee;
Park, Jun-Beom

Publication type:

Article

Overexpression of Sirtuin2 prevents high glucose-induced vascular endothelial cell injury by regulating the p53 and NF-κB signaling pathways.

Published in:

Biotechnology Letters, 2018, v. 40, n. 2, p. 271, doi. 10.1007/s10529-017-2487-y

By:

Zhang, Wenguang;
Liu, Dongmei;
Ren, Jianzhuang;
Zhou, Pengli;
Han, Xinwei

Publication type:

Article

Bone marrow mesenchymal stem cell-derived exosomal lncRNA KLF3-AS1 stabilizes Sirt1 protein to improve cerebral ischemia/reperfusion injury via miR-206/USP22 axis.

Published in:

Molecular Medicine, 2023, v. 29, n. 1, p. 1, doi. 10.1186/s10020-022-00595-1

By:

Xie, Xiaowei;
Cao, Yu;
Dai, Liangping;
Zhou, Dingzhou

Publication type:

Article

TGF-β-induced α-SMA expression is mediated by C/EBPβ acetylation in human alveolar epithelial cells.

Published in:

Molecular Medicine, 2021, v. 27, n. 1, p. 1, doi. 10.1186/s10020-021-00283-6

By:

Ding, Hui;
Chen, Jinjun;
Qin, Jingping;
Chen, Ruhua;
Yi, Zili

Publication type:

Article

Involvement of IL‐6/JAK/STAT3/SOCS3, SIRT1, and Cytoglobin Signaling in Diacerein Protective Effect against Intestinal Injury Induced by Methotrexate.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 6, p. 1, doi. 10.1002/jbt.70339

By:

Ali, Gaber F.;
Hassanein, Emad H. M.;
Abdel‐Reheim, Mustafa Ahmed;
Arafa, El‐shaimaa A.;
Mohamed, Wafaa R.

Publication type:

Article

Kisspeptin‐10 Protects Against TNF‐α‐Induced Chondrocyte Senescence via the SIRT1/p53/p21 Signaling.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 6, p. 1, doi. 10.1002/jbt.70298

By:

Qiu, Jinchao;
Chen, Guosheng;
Peng, Guoxuan;
Qu, Guoxin;
Ren, Tingguo;
Deng, Jin

Publication type:

Article

Salvianolic Acid A Attenuates Lipopolysaccharide‐Induced Acute Lung Injury by Activating AMPK/SIRT1/Nrf2 Signaling Pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 5, p. 1, doi. 10.1002/jbt.70282

By:

Wang, Pengwei;
Sun, Yu;
Zhang, Ru;
Guo, Yongli;
Zhang, Yongheng;
Guo, Shengjie;
Wang, Yemin;
Gao, Jianlian;
Yang, Pengfei;
Deng, Zhijian

Publication type:

Article

Sirtuin 1 Suppresses Hydrogen Peroxide‐Induced Senescence and Promotes Viability and Migration in Lens Epithelial Cells by Inhibiting Forkhead Box Protein O1/Toll‐Like Receptor 4 Pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 2, p. 1, doi. 10.1002/jbt.70150

By:

Jiang, Hongda;
Liu, Yuting;
Yu, Yinggui;
Yan, Yu

Publication type:

Article

Paeonol Alleviates Subarachnoid Hemorrhage Injury in Rats Through Upregulation of SIRT1 and Inhibition of HMGB1/TLR4/MyD88/NF‐κB Pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 12, p. 1, doi. 10.1002/jbt.70035

By:

Liu, Zhao;
Zhu, Jun;
Pan, Enyu;
Pang, Lujun;
Zhou, Xiwei;
Che, Yanjun

Publication type:

Article

SIRT2 deacetylates and decreases the expression of FOXM1 in colon cancer.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 11, p. 1, doi. 10.1002/jbt.70018

By:

Yildiz, Baris;
Demirel, Ramazan;
Staudacher, Jonas J.;
Beseren, Hatice;
Yildiz, Gulden;
Akpinar, Ali Emre;
Park, Seong‐Hoon;
Ozden, Ozkan

Publication type:

Article

AGK2, a SIRT2 inhibitor, ameliorates D‐galactose‐induced liver fibrosis by inhibiting fibrogenic factors.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 11, p. 1, doi. 10.1002/jbt.70000

By:

Bahar, Aslı Nur;
Keskin‐Aktan, Arzu;
Akarca‐Dizakar, Saadet Özen;
Sonugür, Gizem;
Akbulut, Kazime Gonca

Publication type:

Article

Attenuation of chromium (VI) and arsenic (III)‐induced oxidative stress and hepatic apoptosis by phloretin, biochanin‐A, and coenzyme Q10 via activation of SIRT1/Nrf2/HO‐1/NQO1 signaling.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 9, p. 1, doi. 10.1002/jbt.23817

By:

Tripathi, Swapnil;
Parmar, Dharati;
Raval, Samir;
Mishra, Rajeev;
Singh, Gyanendra

Publication type:

Article

The influential responsibility of sirtuins in senescence and associated diseases: A review.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 9, p. 1, doi. 10.1002/jbt.23812

By:

Mishra, Deepak;
Mohapatra, Lucy;
Tripathi, Alok S.;
Paswan, Shravan Kumar

Publication type:

Article

Nephro-protective effects of alpha-lipoic acid in type I diabetes.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 4, p. 1, doi. 10.1002/jbt.23712

By:

Kushwaha, Kriti;
Mandal, Debojyoti;
Khurana, Navneet;
Gupta, Jeena

Publication type:

Article

Tropisetron restores normal expression of BAD, SIRT1, SIRT3, and SIRT7 in the rat pressure overload‐induced cardiac hypertrophy model.

Published in:

Journal of Biochemical & Molecular Toxicology, 2023, v. 37, n. 7, p. 1, doi. 10.1002/jbt.23355

By:

Karimollah, Alireza;
Hemmatpur, Anahid;
Safari, Fatemeh;
Fakhrgholami, Mahsa;
Travat, Tina

Publication type:

Article

Beneficial effects of quercetin on vincristine‐induced liver injury in rats: Modulating the levels of Nrf2/HO‐1, NF‐kB/STAT3, and SIRT1/PGC‐1α.

Published in:

Journal of Biochemical & Molecular Toxicology, 2023, v. 37, n. 5, p. 1, doi. 10.1002/jbt.23326

By:

Çomaklı, Selim;
Özdemir, Selçuk;
Küçükler, Sefa;
Kandemir, Fatih M.

Publication type:

Article

Corynoline protects against zearalenone‐induced liver injury by activating the SIRT1/Nrf2 signaling pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2023, v. 37, n. 1, p. 1, doi. 10.1002/jbt.23224

By:

Sun, Liqun;
He, Dan;
Liu, Yuhuan;
Wei, Yunyun;
Wang, Li

Publication type:

Article

Mechanical stress‐caused chondrocyte dysfunction and cartilage injury can be attenuated by dioscin via activating sirtuin1/forkhead box O1.

Published in:

Journal of Biochemical & Molecular Toxicology, 2022, v. 36, n. 12, p. 1, doi. 10.1002/jbt.23212

By:

Jiang, Shilin;
Zhang, Chengyuan;
Lu, Ye;
Yuan, Feng

Publication type:

Article

Epigallocatechin‐3‐gallate (EGCG) attenuates inflammatory responses and oxidative stress in lipopolysaccharide (LPS)‐induced endometritis via silent information regulator transcript‐1 (SIRT1)/nucleotide oligomerization domain (NOD)‐like receptor pyrin domain‐containing 3 (NLRP3) pathway

Published in:

Journal of Biochemical & Molecular Toxicology, 2022, v. 36, n. 12, p. 1, doi. 10.1002/jbt.23203

By:

Di, Man;
Zhang, Qianfeng;
Wang, Jingjing;
Xiao, Xifeng;
Huang, Jianlei;
Ma, Yuan;
Yang, Hongya;
Li, Mao

Publication type:

Article

Downregulation of miR‐34c‐5p alleviates chronic intermittent hypoxia‐induced myocardial damage by targeting sirtuin 1.

Published in:

Journal of Biochemical & Molecular Toxicology, 2022, v. 36, n. 10, p. 1, doi. 10.1002/jbt.23164

By:

Zhang, Jun;
Xie, Bo;
Tang, Yanrong;
Zhou, Bo;
Wang, Qiong;
Ge, Qing;
Zhou, Yufei;
Gu, Tongqing

Publication type:

Article

Versatile role of sirtuins in metabolic disorders: From modulation of mitochondrial function to therapeutic interventions.

Published in:

Journal of Biochemical & Molecular Toxicology, 2022, v. 36, n. 7, p. 1, doi. 10.1002/jbt.23047

By:

Afzaal, Ammara;
Rehman, Kanwal;
Kamal, Shagufta;
Akash, Muhammad Sajid Hamid

Publication type:

Article

Studies on male gonadal toxicity of bisphenol A in diabetic rats: An example of exacerbation effect.

Published in:

Journal of Biochemical & Molecular Toxicology, 2022, v. 36, n. 4, p. 1, doi. 10.1002/jbt.22996

By:

Sahu, Chittaranjan;
Singla, Shivani;
Jena, Gopabandhu

Publication type:

Article

The modulation of SIRT1 and SIRT3 by natural compounds as a therapeutic target in doxorubicin‐induced cardiotoxicity: A review.

Published in:

Journal of Biochemical & Molecular Toxicology, 2022, v. 36, n. 1, p. 1, doi. 10.1002/jbt.22946

By:

Tabrizi, Fatemeh B.;
Yarmohammadi, Fatemeh;
Hayes, A. Wallace;
Karimi, Gholamreza

Publication type:

Article

Omarigliptin protects against nonalcoholic fatty liver disease by ameliorating oxidative stress and inflammation.

Published in:

Journal of Biochemical & Molecular Toxicology, 2021, v. 35, n. 12, p. 1, doi. 10.1002/jbt.22914

By:

Li, Zeyu;
Wang, Hong;
Wu, Kanglin;
Zhang, Lianfeng

Publication type:

Article

Faster lipid β‐oxidation rate by acetyl‐CoA carboxylase 2 inhibition alleviates high‐glucose‐induced insulin resistance via SIRT1/PGC‐1α in human podocytes.

Published in:

Journal of Biochemical & Molecular Toxicology, 2021, v. 35, n. 7, p. 1, doi. 10.1002/jbt.22797

By:

Wang, Qinglian;
Zhao, Bing;
Zhang, Jie;
Sun, Jingshu;
Wang, Simeng;
Zhang, Xinyu;
Xu, Ying;
Wang, Rong

Publication type:

Article

Ameliorative effect of betanin on experimental cisplatin‐induced liver injury; the novel impact of miRNA‐34a on the SIRT1/PGC‐1α signaling pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2021, v. 35, n. 6, p. 1, doi. 10.1002/jbt.22753

By:

El Shaffei, Ismail;
Abdel‐Latif, Ghada A.;
Farag, Doaa B.;
Schaalan, Mona;
Salama, Rania M.

Publication type:

Article

Nephroprotective effect of umbelliferone against cisplatin‐induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO‐3, and NF‐ kB‐p65 signaling pathways.

Published in:

Journal of Biochemical & Molecular Toxicology, 2021, v. 35, n. 5, p. 1, doi. 10.1002/jbt.22738

By:

Ali, Fares E. M.;
Hassanein, Emad H. M.;
El‐Bahrawy, Ali H.;
Omar, Zainab M. M.;
Rashwan, Eman K.;
Abdel‐Wahab, Basil A.;
Abd‐Elhamid, Tarek H.

Publication type:

Article

Modulation of antioxidant enzymes, SIRT1 and NF‐κB by resveratrol and nicotinamide in alcohol‐aflatoxin B1‐induced hepatocellular carcinoma.

Published in:

Journal of Biochemical & Molecular Toxicology, 2021, v. 35, n. 1, p. 1, doi. 10.1002/jbt.22625

By:

Rawat, Divya;
Chhonker, Saurabh Kumar;
Naik, Rayees Ahmad;
Koiri, Raj Kumar

Publication type:

Article

Tissue-specific gene expression and fasting regulation of sirtuin family in gilthead sea bream ( Sparus aurata).

Published in:

Journal of Comparative Physiology B: Biochemical, Systemic & Environmental Physiology, 2017, v. 187, n. 1, p. 153, doi. 10.1007/s00360-016-1014-0

By:

Simó-Mirabet, Paula;
Bermejo-Nogales, Azucena;
Calduch-Giner, Josep;
Pérez-Sánchez, Jaume

Publication type:

Article

Pancreatic Ductal Cells Acquire Mesenchymal Characteristics through Cell Fusion with Bone Marrow-Derived Mesenchymal Stem Cells and SIRT1 Attenuates the Apoptosis of Hybrid Cells.

Published in:

Cells Tissues Organs, 2012, v. 196, n. 2, p. 129, doi. 10.1159/000332988

By:

Gou, Shanmiao;
Liu, Tao;
Li, Xiangsheng;
Cui, Jing;
Wan, Chidan;
Wang, Chunyou

Publication type:

Article

miR-135a Mediates Mitochondrial Oxidative Respiratory Function through SIRT1 to Regulate Atrial Fibrosis.

Published in:

Cardiology, 2024, v. 149, n. 3, p. 286, doi. 10.1159/000536059

By:

Ding, Tianhang;
Zeng, Liyan;
Xia, Ying;
Zhang, Baojun;
Cui, Dongji

Publication type:

Article

Targeting Epigenetic Regulators Using Machine Learning: Potential Sirtuin 2 Inhibitors.

Published in:

Journal of Computational Biophysics & Chemistry, 2021, v. 20, n. 8, p. 841, doi. 10.1142/S2737416521500526

By:

Kessler, Andrew;
Kouznetsova, Valentina L.;
Tsigelny, Igor F.

Publication type:

Article

The relationship between coronary artery disease and SIRT1 protein.

Published in:

Northern Clinics of Istanbul, 2020, v. 7, n. 6, p. 631, doi. 10.14744/nci.2020.31391

By:

Askin, Lutfu;
Tibilli, Hakan;
Tanriverdi, Okan;
Turkmen, Serdar

Publication type:

Article

Pharmacophore-based Virtual Screening: Identification of Selective Sirtuin 2 Inhibitors.

Published in:

Journal of Research in Pharmacy, 2023, v. 27, n. 4, p. 1366, doi. 10.29228/jrp.424

By:

KARAMAN MAYACK, Berin;
ALAYOUBI, Muhammed Moyasar

Publication type:

Article

Class I histone deacetylase inhibition by aryl butenoic acid derivatives: In silico and in vitro studies.

Published in:

Journal of Research in Pharmacy, 2019, v. 23, n. 5, p. 952, doi. 10.35333/jrp.2019.42

By:

BORA, Gamze;
SARI, Suat;
TAŞKOR, Gülce;
DALKARA, Sevim;
ERDEM-YURTER, Hayat

Publication type:

Article

Deacetylation of nuclear AIF provides a braking mechanism for caspase-independent chromatinolysis and necrotic brain injury.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08255-w

By:

Hu, Chen;
Geng, Jichuan;
Shan, Peipei;
Zhang, Tongqing;
Zhang, Zhuqing;
Zhang, Xiaoyu;
Lin, Menghan;
Zhang, Xiaoxia;
Chang, Dong;
He, Baokun;
Jia, Deshui;
Zhang, Mary;
Wang, Chuangui;
Zhang, Shengping

Publication type:

Article

Activation of the bacterial defense-associated sirtuin system.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07743-3

By:

Zhu, Kaixiang;
Shang, Kun;
Wang, Linyue;
Yu, Xia;
Hua, Lei;
Zhang, Weihe;
Qin, Bo;
Wang, Jia;
Gao, Xiaopan;
Zhu, Hongtao;
Cui, Sheng

Publication type:

Article

Saikogenin A improves ethanol-induced liver injury by targeting SIRT1 to modulate lipid metabolism.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07234-x

By:

Jiang, Mingzhu;
Feng, Ying;
Wang, Jingxian;
Xu, Xiang;
Liu, Zegan;
Li, Tongfei;
Ma, Shinan;
Wang, Yufeng;
Guo, Xingrong;
Du, Shiming

Publication type:

Article

原花青素 B2 对猪颗粒细胞氧化损伤的保护作用及机制研究.

Published in:

Journal of Henan Agricultural Sciences, 2022, v. 51, n. 1, p. 146, doi. 10.15933/j.cnki.1004‑3268.2022.01.018

By:

邢宝松;
张家庆;
任巧玲;
吕玲燕;
王献伟;
陈俊峰;
高彬文;
马强

Publication type:

Article

IN VITRO BISPHENOL A EFFECT ON TFAM AND SIRT1 GENE EXPRESSION IN PORCINE OOCYTE MITOCHONDRIA.

Published in:

Lucrari Stiintifice: Seria Medicina Veterinara, 2023, v. 66, n. 2, p. 69, doi. 10.61900/SPJVS.2023.02.14

By:

Spataru, Ioana-Irina;
Boldura, Oana-Maria;
Lungu, Bianca Cornelia;
Marc, Simona;
Torda, Iuliu;
Daniel, Bratu;
Otava, Gabriel;
Hutu, Ioan;
Mircu, Calin

Publication type:

Article

Amodiaquine ameliorates stress-induced premature cellular senescence via promoting SIRT1-mediated HR repair.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02201-1

By:

Du, Jie;
Chen, Fuqiang;
Du, Chenghong;
Zhao, Wenna;
Chen, Zihan;
Ding, Zhenhua;
Zhou, Meijuan

Publication type:

Article