Works matching DE "PROTEIN engineering"

Results: 2677

Scalable modulation of CRISPR‒Cas enzyme activity using photocleavable phosphorothioate DNA.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61094-5

By:

Hu, Menglu;
Zhang, Bingni;
Shan, Yuanyue;
Cao, Feng;
Wang, Yihui;
Qi, Weiwei;
Wang, Xue;
Shen, Yuting;
Guo, Xinyi;
Zhang, Mengmeng;
Tian, Tian;
Xie, Wei;
Zhang, Mingfeng;
Liang, Fang;
Pei, Duanqing;
Zhou, Xiaoming

Publication type:

Article

Data-driven protease engineering by DNA-recording and epistasis-aware machine learning.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60622-7

By:

Huber, Lukas;
Kucera, Tim;
Höllerer, Simon;
Borgwardt, Karsten;
Panke, Sven;
Jeschek, Markus

Publication type:

Article

Construction of dual cofactor‐driven biocatalytic system for effective production of chiral amino acids.

Published in:

AIChE Journal, 2025, v. 71, n. 8, p. 1, doi. 10.1002/aic.18894

By:

Cheng, Feng;
Li, Ju‐Mou;
Sun, Feng‐Qin;
Gao, Ya‐Ting;
Zou, Shu‐Ping;
Xu, Jian‐Miao;
Xue, Ya‐Ping;
Zheng, Yu‐Guo

Publication type:

Article

Protein-ligand co-design: a case for improving binding affinity between type II NADH:quinone oxidoreductase and quinones.

Published in:

Journal of Computer-Aided Molecular Design, 2025, v. 39, n. 1, p. 1, doi. 10.1007/s10822-025-00613-4

By:

Porokhin, Vladimir;
Brown, Anne M.;
Hassoun, Soha

Publication type:

Article

A novel long-acting relaxin-2 fusion, AZD3427, improves cardiac performance in non-human primates with cardiac dysfunction Open Access.

Published in:

Cardiovascular Research, 2025, v. 121, n. 6, p. 871, doi. 10.1093/cvr/cvaf031

By:

Papworth, Monika;
Kulkarni, Spoorthy;
Antonsson, Madeleine;
Sermadiras, Isabelle;
Hovdal, Daniel;
Connolly, Kathleen;
Olsson, Jan;
Shukla, Animesh;
Cotton, Peter;
Althage, Magnus;
Paterson, Judy;
Martin, Esther;
Wolny, Marcin;
Ferraro, Franco;
Sadowska, Agnieszka;
Hao, Weidong;
Larsson, Niklas;
Backmark, Anna;
Marlow, Tom;
Perez, Rosario

Publication type:

Article

Predicting Affinity Through Homology (PATH): Interpretable binding affinity prediction with persistent homology.

Published in:

PLoS Computational Biology, 2025, v. 21, n. 6, p. 1, doi. 10.1371/journal.pcbi.1013216

By:

Long, Yuxi;
Donald, Bruce R.

Publication type:

Article

Front Cover: AI.zymes – A Modular Platform for Evolutionary Enzyme Design (Angew. Chem. 27/2025).

Published in:

Angewandte Chemie, 2025, v. 137, n. 27, p. 1, doi. 10.1002/ange.202512748

By:

Merlicek, Lucas P.;
Neumann, Jannik;
Lear, Abbie;
Degiorgi, Vivian;
de Waal, Moor M.;
Cotet, Tudor‐Stefan;
Mulholland, Adrian J.;
Bunzel, H. Adrian

Publication type:

Article

Intrinsically Disordered Peptide Nanofibers from a Structured Motif Within Proteins.

Published in:

Angewandte Chemie, 2025, v. 137, n. 27, p. 1, doi. 10.1002/ange.202425456

By:

Qiao, Yuchen;
Zia, Ayisha;
Shy, Adrianna;
Wu, Grace;
Chu, Matthew;
Liu, Zhiyu;
Wang, Fengbin;
Xu, Bing

Publication type:

Article

Improving the Properties of Laccase Through Heterologous Expression and Protein Engineering.

Published in:

Microorganisms, 2025, v. 13, n. 6, p. 1422, doi. 10.3390/microorganisms13061422

By:

Guan, Guoqiang;
Li, Beidian;
Xu, Ling;
Qian, Jingya;
Zou, Bin;
Huo, Shuhao;
Ding, Zhongyang;
Cui, Kai;
Wang, Feng

Publication type:

Article

SsDiHal: discovery and engineering of a novel tryptophan dihalogenase.

Published in:

Journal of Biological Engineering, 2025, v. 19, n. 1, p. 1, doi. 10.1186/s13036-025-00518-8

By:

Sher, Hassan;
Hardtke, Haley;
Tang, Wenzhu;
Ren, Jie;
Ullah, Hayat;
Zhou, Xudong;
Zhang, Y. Jessie;
Zhan, Jixun

Publication type:

Article

Tools for investigating host-microbe crosstalk using glycan analysis probes inspired by human lectins.

Published in:

Glycobiology, 2025, v. 35, n. 7, p. 1, doi. 10.1093/glycob/cwaf031

By:

Ghosh, Soumi;
Chorghade, Rajeev;
Diehl, Roger C;
Dodge, Greg J;
Bae, Sunhee;
Dugan, Amanda E;
Halim, Melanie;
Wuo, Michael G;
Bartlett, Helen;
Herndon, Liam;
Kiessling, Laura L;
Imperiali, Barbara

Publication type:

Article

INM004: Polyclonal Neutralizing Antibodies Against Shiga Toxin as a Treatment for Hemolytic Uremic Syndrome.

Published in:

Toxins, 2025, v. 17, n. 6, p. 282, doi. 10.3390/toxins17060282

By:

Rivas, Marta;
Pichel, Mariana;
Zylberman, Vanesa;
Colonna, Mariana;
Valerio, Marina;
Massa, Carolina;
Pardo, Romina;
Ciocchini, Andrés E.;
Sanguineti, Santiago;
Roubicek, Ian;
Spatz, Linus;
Goldbaum, Fernando Alberto

Publication type:

Article

Deacetylation Ensures Timely Regulation of Flowering.

Published in:

PLoS Biology, 2013, v. 11, n. 9, p. 1, doi. 10.1371/journal.pbio.1001646

By:

Coombs, Amy

Publication type:

Article

A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms.

Published in:

PLoS Biology, 2011, v. 9, n. 4, p. 1, doi. 10.1371/journal.pbio.1001041

By:

Xiaokun Shu;
Lev-Ram, Varda;
Deerinck, Thomas J.;
Yingchuan Qi;
Ramko, Ericka B.;
Davidson, Michael W.;
Yishi Jin;
Ellisman, Mark H.;
Tsien, Roger Y.

Publication type:

Article

Global Conformational Dynamics of a Y-Family DNA Polymerase during Catalysis.

Published in:

PLoS Biology, 2009, v. 7, n. 10, p. 1, doi. 10.1371/journal.pbio.1000225

By:

Cuiling Xu;
Maxwell, Brian A.;
Brown, Jessica A.;
Likui Zhang;
Zucai Suo

Publication type:

Article

Evolutionary Influences on Proteins.

Published in:

PLoS Biology, 2007, v. 5, n. 2, p. 130, doi. 10.1371/journal.pbio.0050026

By:

Jones, Rachel

Publication type:

Article

Different Catalytic Mechanisms in Mammalian Selenocysteine- and Cysteine-Containing Methionine-R-Sulfoxide Reductases.

Published in:

PLoS Biology, 2005, v. 3, n. 11, p. 1, doi. 10.1371/journal.pbio.0030375

By:

Kim, Hwa-Young;
Gladyshev, Vadim N

Publication type:

Article

Bonding Quality of Chemically-Modified Soybean Protein Concentrate-Based Adhesives in Particleboards from Rice Husks.

Published in:

Journal of the American Oil Chemists' Society (JAOCS), 2012, v. 89, n. 9, p. 1733, doi. 10.1007/s11746-012-2058-2

By:

Ciannamea, E.;
Martucci, J.;
Stefani, P.;
Ruseckaite, R.

Publication type:

Article

Engineering Protein Venoms as Self‐Assembling CXCR4‐Targeted Cytotoxic Nanoparticles.

Published in:

Particle & Particle Systems Characterization, 2020, v. 37, n. 6, p. 1, doi. 10.1002/ppsc.202000040

By:

Serna, Naroa;
Cano‐Garrido, Olivia;
Sánchez‐García, Laura;
Pesarrodona, Mireia;
Unzueta, Ugutz;
Sánchez‐Chardi, Alejandro;
Mangues, Ramon;
Vázquez, Esther;
Villaverde, Antonio

Publication type:

Article

Affinity and chemical enrichment strategies for mapping low‐abundance protein modifications and protein‐interaction networks.

Published in:

Journal of Separation Science, 2021, v. 44, n. 1, p. 310, doi. 10.1002/jssc.202000930

By:

Zacharias, Adway O.;
Fang, Zixiang;
Rahman, Aurchie;
Talukder, Akash;
Cornelius, Sharel;
Chowdhury, Saiful M.

Publication type:

Article

Transparent and Capacitive Bioanode Based on Specifically Engineered Glucose Oxidase.

Published in:

Electroanalysis, 2016, v. 28, n. 6, p. 1290, doi. 10.1002/elan.201600096

By:

González‐Arribas, Elena;
Pankratov, Dmitry;
Gounel, Sébastien;
Mano, Nicolas;
Blum, Zoltan;
Shleev, Sergey

Publication type:

Article

Mn-porphyrins in a four-helix bundle participate in photo-induced electron transfer with a bacterial reaction center.

Published in:

Photosynthesis Research, 2024, v. 162, n. 2, p. 1, doi. 10.1007/s11120-023-01051-9

By:

Williams, J. C.;
Faillace, M. S.;
Gonzalez, E. J.;
Dominguez, R. E.;
Knappenberger, K.;
Heredia, D. A.;
Moore, T. A.;
Moore, A. L.;
Allen, J. P.

Publication type:

Article

Designing photosystem II: molecular engineering of photo-catalytic proteins.

Published in:

Photosynthesis Research, 2008, v. 98, n. 1-3, p. 687, doi. 10.1007/s11120-008-9355-5

By:

Brendon Conlan

Publication type:

Article

Staged self-assembly: nanomanufacture of arbitrary shapes with O (1) glues.

Published in:

Natural Computing, 2008, v. 7, n. 3, p. 347, doi. 10.1007/s11047-008-9073-0

By:

Erik Demaine;
Martin Demaine;
Sándor Fekete;
Mashhood Ishaque;
Eynat Rafalin;
Robert Schweller;
Diane Souvaine

Publication type:

Article

AmyJ33, a truncated amylase with improved catalytic properties.

Published in:

Biotechnology Letters, 2022, v. 44, n. 12, p. 1447, doi. 10.1007/s10529-022-03311-5

By:

Hernández-Heredia, Sarahi;
Peña-Castro, Julián Mario;
Aguilar-Uscanga, María Guadalupe;
Olvera, Clarita;
Nolasco-Hipólito, Cirilo;
del Moral, Sandra

Publication type:

Article

Production of phenylpyruvic acid by engineered l-amino acid deaminase from Proteus mirabilis.

Published in:

Biotechnology Letters, 2022, v. 44, n. 5/6, p. 635, doi. 10.1007/s10529-022-03245-y

By:

Liu, Jia;
Liu, Jianmin;
Yang, Bin;
Gao, Cong;
Song, Wei;
Hu, Guipeng;
Liu, Liming;
Wu, Jing

Publication type:

Article

Design of fusion protein for efficient preparation of cyanovirin-n and rapid enrichment of pseudorabies virus.

Published in:

Biotechnology Letters, 2021, v. 43, n. 8, p. 1575, doi. 10.1007/s10529-021-03141-x

By:

Wang, Bin;
Yang, Zhi;
Gao, Dan;
Wang, Fei;
Liu, Min;
Chen, Guanjun;
Ma, Lixin;
Yu, Xiaolan

Publication type:

Article

Switching the secondary and natural activity of Nitrilase from Acidovorax facilis 72 W for the efficient production of 2-picolinamide.

Published in:

Biotechnology Letters, 2021, v. 43, n. 8, p. 1617, doi. 10.1007/s10529-021-03137-7

By:

Wang, Liuzhu;
Jiang, Shuiqin;
Sun, Yangyang;
Yang, Zeyu;
Chen, Zhi;
Wang, Hualei;
Wei, Dongzhi

Publication type:

Article

Characterization and engineering of two new GH9 and GH48 cellulases from a Bacillus pumilus isolated from Lake Bogoria.

Published in:

Biotechnology Letters, 2021, v. 43, n. 3, p. 691, doi. 10.1007/s10529-020-03056-z

By:

Ogonda, Lydia A.;
Saumonneau, Amélie;
Dion, Michel;
Muge, Edward K.;
Wamalwa, Benson M.;
Mulaa, Francis J.;
Tellier, Charles

Publication type:

Article

Small design from big alignment: engineering proteins with multiple sequence alignment as the starting point.

Published in:

Biotechnology Letters, 2020, v. 42, n. 8, p. 1305, doi. 10.1007/s10529-020-02914-0

By:

Wang, Tianwen;
Liang, Chen;
Hou, Yajing;
Zheng, Mengyuan;
Xu, Hongju;
An, Yafei;
Xiao, Sa;
Liu, Lu;
Lian, Shuaibin

Publication type:

Article

New trends in aggregating tags for therapeutic protein purification.

Published in:

Biotechnology Letters, 2018, v. 40, n. 5, p. 745, doi. 10.1007/s10529-018-2543-2

By:

Yang, Xiaofeng;
Pistolozzi, Marco;
Lin, Zhanglin

Publication type:

Article

Characterization and mutation analysis of a halotolerant serine protease from a new isolate of <italic>Bacillus subtilis</italic>.

Published in:

Biotechnology Letters, 2018, v. 40, n. 1, p. 189, doi. 10.1007/s10529-017-2459-2

By:

Takenaka, Shinji;
Yoshinami, Jyun;
Kuntiya, Ampin;
Techapun, Charin;
Leksawasdi, Noppol;
Seesuriyachan, Phisit;
Chaiyaso, Thanongsak;
Watanabe, Masanori;
Tanaka, Kosei;
Yoshida, Ken-ichi

Publication type:

Article

Design and characterization of new β-glucuronidase active site variants with altered substrate specificity.

Published in:

Biotechnology Letters, 2018, v. 40, n. 1, p. 111, doi. 10.1007/s10529-017-2447-6

By:

Li, Ye;
Wang, Zhiqing;
Cirino, Patrick C.

Publication type:

Article

Change of the N-terminal codon bias combined with tRNA supplementation outperforms the selected fusion tags for production of human d-amino acid oxidase as active inclusion bodies.

Published in:

Biotechnology Letters, 2017, v. 39, n. 11, p. 1733, doi. 10.1007/s10529-017-2413-3

By:

Wang, Weiyu;
Sun, Jiaqi;
Xiao, Wenjun;
Jiang, Li;
Wang, Ruyue;
Fan, Jun

Publication type:

Article

Modification of fatty acid selectivity of Candida antarctica lipase A by error-prone PCR.

Published in:

Biotechnology Letters, 2017, v. 39, n. 5, p. 767, doi. 10.1007/s10529-017-2299-0

By:

Głód, Dagmara

Publication type:

Article

A new thermostable virus-like platform for molecular transport.

Published in:: Biotechnology & Bioengineering, 2008, v. 101, n. 4, p. fmv, doi. 10.1002/bit.22130
Publication type:: Article

Protein engineering of Acidovorax facilis 72W nitrilase for bioprocess development.

Published in:

Biotechnology & Bioengineering, 2007, v. 97, n. 4, p. 689, doi. 10.1002/bit.21289

By:

Shijun Wu;
Fogiel, Arthur J.;
Petrillo, Kelly L.;
Hann, Eugenia C.;
Mersinger, Lawrence J.;
DiCosimo, Robert;
O'Keefe, Daniel P.;
Ben-Bassat, Arie;
Payne, Mark S.

Publication type:

Article

Theoretical distribution of truncation lengths in incremental truncation libraries.

Published in:

Biotechnology & Bioengineering, 2003, v. 82, n. 5, p. 564, doi. 10.1002/bit.10604

By:

Marc Ostermeier

Publication type:

Article

A Collaborative Journey towards the Late‐Stage Functionalization of Added‐Value Chemicals Using Engineered Halogenases.

Published in:

Helvetica Chimica Acta, 2023, v. 106, n. 1, p. 1, doi. 10.1002/hlca.202200128

By:

Büchler, Johannes;
Hegarty, Eimear;
Schroer, Kirsten;
Snajdrova, Radka;
Turner, Nicholas J.;
Loiseleur, Olivier;
Buller, Rebecca;
Le Chapelain, Camille

Publication type:

Article

Characteristics, protein engineering and applications of microbial thermostable pullulanases and pullulan hydrolases.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 13, p. 5661, doi. 10.1007/s00253-016-7572-y

By:

Nisha, M.;
Satyanarayana, T.

Publication type:

Article

Enzymes useful for chiral compound synthesis: structural biology, directed evolution, and protein engineering for industrial use.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 13, p. 5747, doi. 10.1007/s00253-016-7603-8

By:

Kataoka, Michihiko;
Miyakawa, Takuya;
Shimizu, Sakayu;
Tanokura, Masaru

Publication type:

Article

Arginine deiminase: recent advances in discovery, crystal structure, and protein engineering for improved properties as an anti-tumor drug.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 11, p. 4747, doi. 10.1007/s00253-016-7490-z

By:

Han, Rui-Zhi;
Xu, Guo-Chao;
Dong, Jin-Jun;
Ni, Ye

Publication type:

Article

Protein engineering of microbial cholesterol oxidases: a molecular approach toward development of new enzymes with new properties.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 10, p. 4323, doi. 10.1007/s00253-016-7497-5

By:

Moradpour, Zahra;
Ghasemian, Abdollah

Publication type:

Article

Modulating the function of a β-1,3-glucanosyltransferase to that of an endo-β-1,3-glucanase by structure-based protein engineering.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 4, p. 1765, doi. 10.1007/s00253-015-7057-4

By:

Qin, Zhen;
Yan, Qiaojuan;
Yang, Shaoqing;
Jiang, Zhengqiang

Publication type:

Article

Construction of a linker library with widely controllable flexibility for fusion protein design.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 1, p. 215, doi. 10.1007/s00253-015-6985-3

By:

Li, Gang;
Huang, Ziliang;
Zhang, Chong;
Dong, Bo-Jun;
Guo, Ruo-Hai;
Yue, Hong-Wei;
Yan, Li-Tang;
Xing, Xin-Hui

Publication type:

Article

Improving the catalytic performance of a GH11 xylanase by rational protein engineering.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 22, p. 9503, doi. 10.1007/s00253-015-6712-0

By:

Cheng, Ya-Shan;
Chen, Chun-Chi;
Huang, Jian-Wen;
Ko, Tzu-Ping;
Huang, Zhiyong;
Guo, Rey-Ting

Publication type:

Article

An amino acid at position 512 in β-glucosidase from Clavibacter michiganensis determines the regioselectivity for hydrolyzing gypenoside XVII.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 19, p. 7987, doi. 10.1007/s00253-015-6549-6

By:

Shin, Kyung-Chul;
Hong, Seung-Hye;
Seo, Min-Ju;
Oh, Deok-Kun

Publication type:

Article

Insights into the surface topology of polyhydroxyalkanoate synthase: self-assembly of functionalized inclusions.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 19, p. 8045, doi. 10.1007/s00253-015-6719-6

By:

Hooks, David;
Rehm, Bernd

Publication type:

Article

Identification and regulation of the catalytic promiscuity of (−)-γ-lactamase from Microbacterium hydrocarbonoxydans.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 18, p. 7559, doi. 10.1007/s00253-015-6503-7

By:

Sun, Yu;
Zhao, Hongtao;
Wang, Jianjun;
Zhu, Junge;
Wu, Sheng

Publication type:

Article

Double substituted variant of Bacillus amyloliquefaciens esterase with enhanced enantioselectivity and high activity towards 1-(3′,4′-methylenedioxyphenyl)ethyl acetate.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 4, p. 1701, doi. 10.1007/s00253-014-5992-0

By:

Liu, Jia-Yan;
Bian, Han-Ping;
Tang, Yun;
Bai, Yun-Peng;
Xu, Jian-He

Publication type:

Article