Works about PHOSPHATIDYLINOSITOL 3-kinases

Results: 2478

The molecular logic of Gtr1/2- and Pib2-dependent TORC1 regulation in budding yeast.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.94628

By:

Cecil, Jacob H.;
Padilla, Cristina M.;
Lipinski, Austin A.;
Langlais, Paul;
Xiangxia Luo;
Capaldi, Andrew P.

Publication type:

Article

The key regulation of LncRNA MALAT during reprogramming of primary mouse hepatocytes into insulin producing cells.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-08106-y

By:

Luo, Yunfei;
Liu, Shuang;
Xu, Shan;
Zeng, Haixia;
Zhang, Yuying;
Li, Jin-E;
Yang, Shiqi;
Liu, Quanwen;
Xin, Hongbo;
Liu, Jianping

Publication type:

Article

Self-assembled transdermal nanogels control scar formation by inhibiting fibroblast proliferation and fibrosis with glycolysis regulation via the PI3K/Akt/mTOR pathway.

Published in:

Journal of Nanobiotechnology, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12951-025-03562-0

By:

Meng, Xinxian;
Yu, Zhixi;
Wu, Shiqi;
Xu, Wanyu;
Tang, Yuzhen;
Chen, Zixuan;
Zhang, Yixin;
Chen, Yunsheng;
Zhang, Zheng

Publication type:

Article

Inactivation of the Reactive Oxygen Species-Dependent PI3K/Akt/Mtor Signaling Pathway by Phloroglucinol Contributes to Cytotoxicity in Hep3B Human Hepatocellular Carcinoma Cells.

Published in:

Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2025, v. 59, n. 3, p. 389, doi. 10.33594/000000781

By:

So Young Kim;
Hyun Hwangbo;
Gi-Young Kim;
Yung Hyun Choi

Publication type:

Article

PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.91779

By:

Antonio Valer, José;
Deber, Alexandre;
Wits, Marius;
Pimenta-Lope, Carolina;
Goumans, Marie-José;
Luis Rosa, Jose;
Sánchez-Duffhues, Gonzalo;
Ventura, Francesc

Publication type:

Article

The association of PTEN/PI3K/Akt pathway gene expression with insulin indices in adipose tissues of non-diabetic female adults: a cross-sectional study.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-05233-4

By:

Zarkesh, Maryam;
Saba, Romina;
Aghazadeh, Hamidreza;
Teymoori, Farshad;
Akbarzadeh, Mahdi;
Asghari, Golaleh;
Montazeri, Marzieh;
Ghasemi, Asghar;
Yuzbashian, Emad;
Zadeh-Vakili, Azita;
Hedayati, Mehdi;
Khalaj, Alireza

Publication type:

Article

BERBERINE INHIBITS COLON CANCER PROGRESSION THROUGH MIR-181A/PTEN/PI3K/AKT AXIS IN RATS.

Published in:

Acta Poloniae Pharmaceutica, 2025, v. 82, n. 1, p. 155, doi. 10.32383/appdr/203457

By:

CHEN LI;
XU LI

Publication type:

Article

BERBERINE INHIBITS COLON CANCER PROGRESSION THROUGH MIR-181A/PTEN/PI3K/AKT AXIS IN RATS.

Published in:

Acta Poloniae Pharmaceutica, 2025, v. 82, n. 1, p. 155, doi. 10.32383/appdr/203457

By:

CHEN LI;
XU LI

Publication type:

Article

Development and validation of a UPLC-MS/MS method for the quantification of parsaclisib and its application to pharmacokinetics and metabolic stability studies.

Published in:

BMC Chemistry, 2025, v. 19, n. 1, p. 1, doi. 10.1186/s13065-025-01569-0

By:

Zhou, Chenjian;
Wang, Peiqi;
Chen, Jie;
Wu, Hualu;
Yu, Yige

Publication type:

Article

Atractylenolide I inhibits the growth, proliferation and migration of B16 melanoma cells via the PI3K/AKT/mTOR pathway.

Published in:

Oncology Letters, 2025, v. 30, n. 2, p. N.PAG, doi. 10.3892/ol.2025.15118

By:

Xu, Xiaochun;
Kang, Ping;
Che, Hong

Publication type:

Article

SRC and ERK Regulate the Turnover of Cytoskeletal Keratin Filaments.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5476, doi. 10.3390/ijms26125476

By:

Moch, Marcin;
Leube, Rudolf E.

Publication type:

Article

LC-MS 联合网络药理学分析探讨壮骨强肌方治疗 POP 作用机制.

Published in:

Chinese Journal of Osteoporosis, 2025, v. 31, n. 5, p. 708, doi. 10.3969/j.issn.1006-7108.2025.05.014

By:

东智卓玛;
唐子佳;
刘树华;
李小韵;
李扬博;
杨东升;
万雷;
黄宏兴

Publication type:

Article

Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells.

Published in:

PLoS Biology, 2005, v. 3, n. 3, p. 1, doi. 10.1371/journal.pbio.0030082

By:

Tze, Lina E;
Schram, Brian R;
Lam, Kong-Peng;
Hogquist, Kristin A;
Hippen, Keli L;
Liu, Jiabin;
Shinton, Susan A;
Otipoby, Kevin L;
Rodine, Peter R;
Vegoe, Amanda L;
Kraus, Manfred;
Hardy, Richard R;
Schlissel, Mark S;
Rajewsky, Klaus;
Behrens, Timothy W

Publication type:

Article

The role of AKT isoforms in glioblastoma: AKT3 delays tumor progression.

Published in:

Journal of Neuro-Oncology, 2016, v. 130, n. 1, p. 43, doi. 10.1007/s11060-016-2220-z

By:

Joy, Anna;
Kapoor, Manisha;
Georges, Joseph;
Butler, Lacy;
Chang, Yongchang;
Li, Chaokun;
Crouch, Acacia;
Smirnov, Ivan;
Nakada, Mitsitoshi;
Hepler, James;
Marty, Max;
Feuerstein, Burt

Publication type:

Article

Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats.

Published in:

Journal of Neuro-Oncology, 2016, v. 129, n. 1, p. 57, doi. 10.1007/s11060-016-2158-1

By:

Netland, I.;
Førde, H.;
Sleire, L.;
Leiss, L.;
Rahman, M.;
Skeie, B.;
Miletic, H.;
Enger, P.;
Goplen, D.

Publication type:

Article

PI3K pathway inhibitors for the treatment of brain metastases with a focus on HER2+ breast cancer.

Published in:

Journal of Neuro-Oncology, 2014, v. 117, n. 1, p. 7, doi. 10.1007/s11060-014-1369-6

By:

Peddi, Parvin;
Hurvitz, Sara

Publication type:

Article

T11TS impedes glioma angiogenesis by inhibiting VEGF signaling and pro-survival PI3K/Akt/eNOS pathway with concomitant upregulation of PTEN in brain endothelial cells.

Published in:

Journal of Neuro-Oncology, 2013, v. 113, n. 1, p. 13, doi. 10.1007/s11060-013-1095-5

By:

Bhattacharya, Debanjan;
Singh, Manoj;
Chaudhuri, Suhnrita;
Acharya, Sagar;
Basu, Anjan;
Chaudhuri, Swapna

Publication type:

Article

In vitro facilitating role of polygonatum sibiricum polysaccharide in osteogenic differentiation of bone marrow mesenchymal stem cells from patients with multiple myeloma.

Published in:

Biotechnology Letters, 2021, v. 43, n. 7, p. 1311, doi. 10.1007/s10529-021-03125-x

By:

Zhao, Jianqiang;
Ma, Lijie;
Ni, Zengfeng;
Liu, Hui

Publication type:

Article

Effect of Ag-1031 on apoptosis in gastric cancer AGS cells and its effects on the PI3K/AKT/mTOR signaling pathway.

Published in:

Biotechnology Letters, 2020, v. 42, n. 11, p. 2447, doi. 10.1007/s10529-020-02954-6

By:

Dai, Jianhua;
Liu, Danfeng;
Chen, Longjiang;
Sun, LiXia

Publication type:

Article

Unveiling myricetin's pharmacological potency: A comprehensive exploration of the molecular pathways with special focus on PI3K/AKT and Nrf2 signaling.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 6, p. 1, doi. 10.1002/jbt.23739

By:

Goyal, Ahsas;
Sikarwar, Om;
Verma, Aanchal;
Solanki, Kunal;
Agrawal, Neetu;
Dubey, Nandini;
Yadav, Harlokesh Narayan

Publication type:

Article

Antidiabetic activity of eupafolin through peroxisome proliferator‐activated receptor‐gamma and PI3K/Akt signaling in Type 2 diabetic rats.

Published in:

Journal of Biochemical & Molecular Toxicology, 2023, v. 37, n. 11, p. 1, doi. 10.1002/jbt.23463

By:

Wu, Su;
Ai, Wenwei;
Nie, Lei;
Lu, Xiao

Publication type:

Article

Dieckol, a natural polyphenolic drug, inhibits the proliferation and migration of colon cancer cells by inhibiting PI3K, AKT, and mTOR phosphorylation.

Published in:

Journal of Biochemical & Molecular Toxicology, 2023, v. 37, n. 5, p. 1, doi. 10.1002/jbt.23313

By:

Dai, Wei;
Dai, Yong gang;
Ren, Dong feng;
Zhu, Da wei

Publication type:

Article

Inhibition of spindle and kinetochore associated complex subunit 3 suppresses the proliferation and invasion and induced the apoptosis of cutaneousmelanomabyaffecting the PI3K/Akt pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2021, v. 35, n. 11, p. 1, doi. 10.1002/jbt.22895

By:

Yan Liang;
Yan Zheng;
Kuanhou Mou;
Dan Han;
Lijuan Wang;
Rui Ge;
Anfeng Meng

Publication type:

Article

Arbutin exerts anticancer activity against rat C6 glioma cells by inducing apoptosis and inhibiting the inflammatory markers and P13/Akt/mTOR cascade.

Published in:

Journal of Biochemical & Molecular Toxicology, 2021, v. 35, n. 9, p. 1, doi. 10.1002/jbt.22857

By:

Yang, Zhangkai;
Shi, Hangyu;
Chinnathambi, Arunachalam;
Salmen, Saleh H.;
Alharbi, Sulaiman A.;
Veeraraghavan, Vishnu Priya;
Surapaneni, Krishna Mohan;
Arulselvan, Palanisamy

Publication type:

Article

Pseudogene ANXA2P2 knockdown shows tumor‐suppressive function by inhibition of the PI3K/PKB pathway in glioblastoma cells.

Published in:

Journal of Biochemical & Molecular Toxicology, 2021, v. 35, n. 8, p. 1, doi. 10.1002/jbt.22824

By:

Ni, Hongzao;
Zhi, Rongrong;
Zuo, Jiandong;
Liu, Wenguang;
Xie, Peng;
Zhi, Zhongwen

Publication type:

Article

In vivo immunotoxicity of Gd2O3:Eu3+ nanoparticles and the associated molecular mechanism.

Published in:

Journal of Biochemical & Molecular Toxicology, 2020, v. 34, n. 11, p. 1, doi. 10.1002/jbt.22562

By:

Zheng, Cunjing;
Tian, Xiumei;
Cai, Jing;
Huang, Long;
Wang, Shunxin;
Yang, Fanwen;
Ma, Yanping;
Xie, Fukang;
Li, Li

Publication type:

Article

Propranolol inhibits the activity of PI3K, AKT, and HIF-1α in infantile hemangiomas.

Published in:

2018

By:

Lin, Zhenying;
Wang, Luanhong;
Huang, Guang;
Wang, Wenyan;
Lin, Han

Publication type:

journal article

Activation of ATR-related protein kinase upon DNA damage recognition.

Published in:

Current Genetics, 2020, v. 66, n. 2, p. 327, doi. 10.1007/s00294-019-01039-w

By:

Ma, Minh;
Rodriguez, Anibian;
Sugimoto, Katsunori

Publication type:

Article

Branching the Tel2 pathway for exact fit on phosphatidylinositol 3-kinase-related kinases.

Published in:

Current Genetics, 2018, v. 64, n. 5, p. 965, doi. 10.1007/s00294-018-0817-9

By:

Sugimoto, Katsunori

Publication type:

Article

Successful Treatment of Hypoglycemia With Alpelisib in Pediatric Patients With PIK3CA-Related Overgrowth Spectrum.

Published in:

JCEM Case Reports, 2023, v. 1, n. 2, p. 1, doi. 10.1210/jcemcr/luad027

By:

Nasomyont, Nat;
Rutter, Meilan M;
Backeljauw, Philippe F

Publication type:

Article

Genomic and immunological profiling reveals novel prognostic biomarkers for limited-stage small cell lung cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02925-1

By:

Li, Ye;
Ma, Xiaolong;
Wan, Zhiyi;
Bao, Pengfei;
Zhang, Enli;
Liu, Lihua;
Jiao, Shunchang;
Sun, Shengjie

Publication type:

Article

Anti-tumor immune modulation and favorable survival outcomes in uterine corpus endometrial carcinoma: insights from PIK3CA/ARID1A co-mutation analysis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02422-5

By:

Han, Dongmei;
Wu, Caihong;
Jin, Hao

Publication type:

Article

Tanshinone IIA affects the proliferation of A549/Tax by affecting the expression of MMP7 through the PI3K-AKT-mTOR signaling pathway.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02152-8

By:

Chen, Fangjun;
Xiang, Wenqiong;
Qiang, Guangliang

Publication type:

Article

POT, an optogenetics-based endogenous protein degradation system.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07919-x

By:

Chen, Yunyue;
Wang, Siyifei;
Zhang, Luhao;
Peng, Dandan;
Huang, Ke;
Ji, Baohua;
Fu, Junfen;
Xu, Yingke

Publication type:

Article

The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis.

Published in:

Modern Rheumatology, 2018, v. 28, n. 3, p. 530, doi. 10.1080/14397595.2017.1367116

By:

Hirotaka Kimura;
Yasushi Matsuyama;
Sachiko Araki;
Atsushi Koizumi;
Yumi Kariya;
Shunsuke Takasuga;
Satoshi Eguchi;
Hiroki Nakanishi;
Junko Sasaki;
Takehiko Sasaki

Publication type:

Article

The negative effect of the PI3K inhibitor 3-methyladenine on planarian regeneration via the autophagy signalling pathway.

Published in:

Ecotoxicology, 2021, v. 30, n. 9, p. 1941, doi. 10.1007/s10646-021-02439-w

By:

Kang, Jing;
Chen, Jinzi;
Dong, Zimei;
Chen, Guangwen;
Liu, Dezeng

Publication type:

Article

Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02314-1

By:

Zhang, Jiayu;
Peng, Jianmin;
Wang, Siyu;
Wang, Li;
Sun, Yutong;
Xia, Juan;
Cheng, Bin;
Hu, Qinchao

Publication type:

Article

Personalised medical management of patients with melanoma (part 1).

Published in:

Nowotwory, 2021, v. 71, n. 3, p. 169, doi. 10.5603/NJO.2021.0032

By:

Gil, Justyna;
Łaczmańska, Izabela;
Sąsiadek, Maria M.;
Ziętek, Marcin

Publication type:

Article

Targeting IRAK4 with Emavusertib in Lymphoma Models with Secondary Resistance to PI3K and BTK Inhibitors.

Published in:

Journal of Clinical Medicine, 2023, v. 12, n. 2, p. 399, doi. 10.3390/jcm12020399

By:

Guidetti, Francesca;
Arribas, Alberto J.;
Sartori, Giulio;
Spriano, Filippo;
Barnabei, Laura;
Tarantelli, Chiara;
Von Roemeling, Reinhard;
Martinez, Elizabeth;
Zucca, Emanuele;
Bertoni, Francesco

Publication type:

Article

Female Oncofertility: Current Understandings, Therapeutic Approaches, Controversies, and Future Perspectives.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 23, p. 5690, doi. 10.3390/jcm10235690

By:

Vo, Kim Cat Tuyen;
Kawamura, Kazuhiro

Publication type:

Article

Intra-Cellular Calcium Signaling Pathways (PKC, RAS/RAF/MAPK, PI3K) in Lamina Cribrosa Cells in Glaucoma.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 1, p. 62, doi. 10.3390/jcm10010062

By:

Irnaten, Mustapha;
Duff, Aisling;
Clark, Abbot;
O'Brien, Colm

Publication type:

Article

CDK 4/6 Inhibition Overcomes Acquired and Inherent Resistance to PI3Kα Inhibition in Pre-Clinical Models of Head and Neck Squamous Cell Carcinoma.

Published in:

Journal of Clinical Medicine, 2020, v. 9, n. 10, p. 3214, doi. 10.3390/jcm9103214

By:

Remer, Eric;
Badarni, Mai;
Hikri, Elad;
Dayan, Avraham;
Levi, Lirit;
Popovtzer, Aron;
Iraqi, Muhammed;
Porgador, Angel;
Joshua, Ben-Zion;
Bachar, Gideon;
Elkabets, Moshe;
Scaltriti, Maurizio;
Mizrachi, Aviram

Publication type:

Article

Targeting PI3K/Akt/mTOR in AML: Rationale and Clinical Evidence.

Published in:

Journal of Clinical Medicine, 2020, v. 9, n. 9, p. 2934, doi. 10.3390/jcm9092934

By:

Darici, Salihanur;
Alkhaldi, Hazem;
Horne, Gillian;
Jørgensen, Heather G.;
Marmiroli, Sandra;
Huang, Xu

Publication type:

Article

Hippo Pathway and YAP Signaling Alterations in Squamous Cancer of the Head and Neck.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 12, p. 2131, doi. 10.3390/jcm8122131

By:

Santos-de-Frutos, Karla;
Segrelles, Carmen;
Lorz, Corina

Publication type:

Article

Intraoperative chlorhexidine-induced anaphylaxis suggesting an immunoglobulin-E-dependent mechanism indicated by basophil activation tests: two case reports.

Published in:

2022

By:

Orihara, Masaki;
Takazawa, Tomonori;
Horiuchi, Tatsuo;
Nagumo, Kazuhiro;
Maruyama, Noboru;
Tomioka, Akihiro;
Saito, Shigeru

Publication type:

Case Study

Promising Response with PI3K Inhibitor for a Patient with Heavily Pretreated PIK3CA Mutation Head-and-Neck Cancer.

Published in:

Journal of Cancer Research & Practice, 2023, v. 10, n. 2, p. 75, doi. 10.4103/ejcrp.eJCRP-D-22-00018

By:

Ming-Jing Lee;
Hsiang-Fong Kao

Publication type:

Article

The effect and mechanism of selenium supplementation on the proliferation capacity of bovine endometrial epithelial cells exposed to lipopolysaccharide in vitro under high cortisol background.

Published in:

Journal of Animal Science, 2024, v. 102, p. 1, doi. 10.1093/jas/skae021

By:

Li, Hanqing;
Dong, Junsheng;
Cui, Luying;
Liu, Kangjun;
Guo, Long;
Li, Jianji;
Wang, Heng

Publication type:

Article

Impact of repeated lipopolysaccharide administration on ovarian signaling during the follicular phase of the estrous cycle in post-pubertal pigs.

Published in:

Journal of Animal Science, 2018, v. 96, n. 9, p. 3622, doi. 10.1093/jas/sky226

By:

Bidne, Katie L;
Kvidera, Sara S;
Ross, Jason W;
Baumgard, Lance H;
Keating, Aileen F

Publication type:

Article

A Novel Gastrodin Derivative with Neuroprotection Promotes NGF-Mimic Activity by Targeting INSR and ACTN4 to Activate PI3K/Akt Signaling Pathway in PC12 Cells.

Published in:

Antioxidants, 2025, v. 14, n. 3, p. 344, doi. 10.3390/antiox14030344

By:

Zeng, Jiayuan;
Mo, Jianxia;
Muroi, Makoto;
Osada, Hiroyuki;
Xiang, Lan;
Qi, Jianhua

Publication type:

Article

Procyanidin A1 from Peanut Skin Exerts Anti-Aging Effects and Attenuates Senescence via Antioxidative Stress and Autophagy Induction.

Published in:

Antioxidants, 2025, v. 14, n. 3, p. 322, doi. 10.3390/antiox14030322

By:

Li, Yajing;
Xiang, Lan;
Qi, Jianhua

Publication type:

Article