Works about KEAP1 (Protein)

Results: 153

Effects of rhaponticin on retinal oxidative stress and inflammation in diabetes through NRF2/HO‐1/NF‐κB signalling.

Published in:

Journal of Biochemical & Molecular Toxicology, 2020, v. 34, n. 11, p. 1, doi. 10.1002/jbt.22568

By:

Shi, Qiang;
Cheng, Yuhong;
Dong, Xiaomin;
Zhang, Ming;
Pei, Cheng;
Zhang, Mingzhen

Publication type:

Article

Protective effect of carnosic acid on acrylamide‐induced liver toxicity in rats: Mechanistic approach over Nrf2‐Keap1 pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2020, v. 34, n. 9, p. 1, doi. 10.1002/jbt.22524

By:

Donmez, Dilek B.;
Kacar, Sedat;
Bagci, Ridvan;
Sahinturk, Varol

Publication type:

Article

CB5712809, a novel Keap1 inhibitor upregulates SQSTM1/p62 mediated Nrf2 activation to induce cell death in colon cancer cells.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02787-7

By:

Dera, Ayed A.;
Al Fayi, Majed

Publication type:

Article

The relationship between Nrf2/Keap1 system and endoplasmic reticulum stress and inflammatory markers in peripheral blood mononuclear cells of type 2 diabetic subjects.

Published in:

Clinical Diabetology, 2021, v. 10, n. 5, p. 394, doi. 10.5603/DK.a2021.0032

By:

Niazpour, Farshad;
Hoseini, Hosein;
Seyyedebrahimi, ShadiSadat;
Esfahani, Ensieh Nasli;
Meshkani, Reza

Publication type:

Article

甜菜碱提高LO2 细胞中抗氧化酶的表达水平.

Published in:

Modern Food Science & Technology, 2022, v. 38, n. 2, p. 28, doi. 10.13982/j.mfst.1673-9078.2022.2.0590

By:

张猛猛;
辛璇;
赖富饶;
吴晖

Publication type:

Article

Illicium verum extracts and probiotics with added glucose oxidase promote antioxidant capacity through upregulating hepatic and jejunal Nrf2/Keap1 of weaned piglets.

Published in:

Journal of Animal Science, 2020, v. 98, n. 3, p. N.PAG, doi. 10.1093/jas/skaa077

By:

Zhang, Jian;
Liu, Yanjun;
Yang, Zaibin;
Yang, Weiren;
Huang, Libo;
Xu, Chang;
Liu, Mei;
Ge, Jinshan;
Wang, Yuxi;
Jiang, Shuzhen

Publication type:

Article

In Silico Identification of Natural Products and World-Approved Drugs Targeting the KEAP1/NRF2 Pathway Endowed with Potential Antioxidant Profile.

Published in:

Computation, 2023, v. 11, n. 12, p. 255, doi. 10.3390/computation11120255

By:

Brogi, Simone;
Guarino, Ilaria;
Flori, Lorenzo;
Sirous, Hajar;
Calderone, Vincenzo

Publication type:

Article

Anti-Inflammasome Effect of Impressic Acid on Diesel Exhaust Particulate Matter-Induced NLRP1 Inflammasome via the Keap1/p62/Nrf2-Signaling Pathway in Keratinocytes.

Published in:

Antioxidants, 2025, v. 14, n. 5, p. 610, doi. 10.3390/antiox14050610

By:

Lee, Seung Yeon;
Lee, Gi Ho;
Maeng, Jeonghwan;
Kim, Su Yeon;
Yun, Hwi-Yeol;
Jeong, Gil-Saeng;
Jeong, Hye Gwang

Publication type:

Article

Isolation and Characterization of Antioxidant Peptides from Dairy Cow (Bos taurus) Placenta and Their Antioxidant Activities.

Published in:

Antioxidants, 2024, v. 13, n. 8, p. 913, doi. 10.3390/antiox13080913

By:

Tian, Xinyu;
Zhang, Zeru;
Zhao, Yuquan;
Tang, Anguo;
Zeng, Zhi;
Zheng, Weijian;
Zhang, Hanwen;
Luo, Yuxin;
Lu, Wei;
Fan, Lei;
Shen, Liuhong

Publication type:

Article

RSM- and ANN-Based Multifrequency Ultrasonic Extraction of Polyphenol-Rich Sargassum horneri Extracts Exerting Antioxidative Activity via the Regulation of MAPK/Nrf2/HO-1 Machinery.

Published in:

Antioxidants, 2024, v. 13, n. 6, p. 690, doi. 10.3390/antiox13060690

By:

Javed, Ahsan;
Alam, Md Badrul;
Naznin, Marufa;
Ahmad, Raees;
Lee, Chang Hyung;
Kim, Sunghwan;
Lee, Sang-Han

Publication type:

Article

Alginate Oligosaccharides Protect Gastric Epithelial Cells against Oxidative Stress Damage through Induction of the Nrf2 Pathway.

Published in:

Antioxidants, 2024, v. 13, n. 5, p. 618, doi. 10.3390/antiox13050618

By:

Acevedo, Samantha;
Covarrubias, Alejandra A.;
Haeger, Paola;
Pancetti, Floria;
Tala, Fadia;
de la Fuente-Ortega, Erwin

Publication type:

Article

Antioxidant Defense Expressed as Glutathione Status and Keap1-Nrf2 System Action in Relation to Anthropometric Parameters and Body Composition in Young Women with Polycystic Ovary Syndrome.

Published in:

Antioxidants, 2023, v. 12, n. 3, p. 730, doi. 10.3390/antiox12030730

By:

Chełchowska, Magdalena;
Jurczewska, Justyna;
Gajewska, Joanna;
Mazur, Joanna;
Szostak-Węgierek, Dorota;
Rudnicka, Ewa;
Ambroszkiewicz, Jadwiga

Publication type:

Article

Vitamin D Mitigates Hyperglycemia-Induced Cognition Decline in Danio rerio (Zebrafish) through the Activation of Antioxidant Mechanisms.

Published in:

Antioxidants, 2022, v. 11, n. 11, p. 2114, doi. 10.3390/antiox11112114

By:

Uthaiah, Chinnappa A.;
Devaru, Nandini C.;
Shivakumar, Nandini H.;
R, Rajalakshmi;
Madhunapantula, SubbaRao V.

Publication type:

Article

Neuroprotective Capability of Narcissoside in 6-OHDA-Exposed Parkinson's Disease Models through Enhancing the MiR200a/Nrf-2/GSH Axis and Mediating MAPK/Akt Associated Signaling Pathway.

Published in:

Antioxidants, 2022, v. 11, n. 11, p. 2089, doi. 10.3390/antiox11112089

By:

Fu, Ru-Huei;
Tsai, Chia-Wen;
Liu, Shih-Ping;
Chiu, Shao-Chih;
Chen, Yen-Chuan;
Chiang, Yu-Ting;
Kuo, Yun-Hua;
Shyu, Woei-Cherng;
Lin, Shinn-Zong

Publication type:

Article

The role of aberrant Nrf2/Keap1 pathway activation across a broad spectrum of human cancers.

Published in:

Western Undergraduate Research Journal: Health & Natural Sciences, 2015, v. 5, n. 1, p. 2, doi. 10.5206/wurjhns.2014-15.11

By:

Baker, Shannon;
Duennwald, Martin;
Howlett, Christopher

Publication type:

Article

Identification and inhibition of PIN1-NRF2 protein–protein interactions through computational and biophysical approaches.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-89342-0

By:

Ozleyen, Adem;
Duran, Gizem Nur;
Donmez, Serhat;
Ozbil, Mehmet;
Doveston, Richard G.;
Tumer, Tugba Boyunegmez

Publication type:

Article

Polygala tenuifolia Willd. Extract delays non-alcoholic fatty liver disease progression in rats via the COX2 and PERK-elF2α-ATF4 pathway.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1595752

By:

Sun, Zhiliang;
Zhou, Zhongshi;
Liao, Kezheng;
Liu, Yanju;
Liu, Yanyun;
Wang, Chaoyang;
Zhang, Zhihua;
Wen, Li

Publication type:

Article

Editorial: Drugs and methods that enhance the anti-cancer efficacy of artesunate.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1566700

By:

Uzun, Tuğçenur

Publication type:

Article

Effects of low-intensity blood flow restriction training on myocardial injury indices, antioxidant and anti-apoptotic capacity in rats.

Published in:

Frontiers in Physiology, 2025, p. 1, doi. 10.3389/fphys.2025.1508305

By:

ShangGuan, Yuwen;
Huang, Kunyi;
Zhu, Zining;
Yuan, Yuan;
Song, Yawei;
Wang, Hao;
Chen, Liang;
Yu, Shiqi;
Zheng, Guangzhi;
Liang, Qi

Publication type:

Article

Effects of Inhibition of IKK Kinase Phosphorylation On the Cellular Defence System and HSP90 Activity.

Published in:

Inflammation, 2024, v. 47, n. 1, p. 74, doi. 10.1007/s10753-023-01894-3

By:

Giacomarra, Miriam;
La Torre, Martina;
Montana, Giovanna

Publication type:

Article

Synthesis of C17-[5-methyl-1,3]-oxazoles by N-propargylation of triterpenic acids and evaluation of their cytotoxic activity.

Published in:

Natural Product Research, 2021, v. 35, n. 21, p. 3850, doi. 10.1080/14786419.2020.1744139

By:

Khusnutdinova, E. F.;
Petrova, A. V.;
Lobov, A.N.;
Kukovinets, O. S.;
Baev, D. S.;
Kazakova, O. B.

Publication type:

Article

Downregulation of SELENBP1 enhances oral squamous cell carcinoma chemoresistance through KEAP1–NRF2 signaling.

Published in:

Cancer Chemotherapy & Pharmacology, 2021, v. 88, n. 2, p. 223, doi. 10.1007/s00280-021-04284-4

By:

Zeng, Hui;
Zhao, Xubing;
Tang, Chengfang

Publication type:

Article

Fumonisin B1 alters global m6A RNA methylation and epigenetically regulates Keap1-Nrf2 signaling in human hepatoma (HepG2) cells.

Published in:

Archives of Toxicology, 2021, v. 95, n. 4, p. 1367, doi. 10.1007/s00204-021-02986-5

By:

Arumugam, Thilona;
Ghazi, Terisha;
Chuturgoon, Anil A.

Publication type:

Article

Keap1-Nrf2 signaling pathway: Mechanisms of regulation and role in protection of cells against toxicity caused by xenobiotics and electrophiles.

Published in:

Biochemistry (00062979), 2013, v. 78, n. 2, p. 111, doi. 10.1134/S0006297913020016

By:

Turpaev, K.

Publication type:

Article

tert‐Butylhydroquinone‐induced formation of high‐molecular‐weight p62: A novel mechanism in the activation of Nrf2‐Keap1.

Published in:

Cell Biology International, 2022, v. 46, n. 9, p. 1345, doi. 10.1002/cbin.11849

By:

Chen, Yunfang;
Cao, Hua;
He, Wan;
Zhang, Xi;
Xu, Ruilian

Publication type:

Article

地黄苷 A 对 CLP 诱导的脓毒症大鼠脑功能障碍和 Nrf2/GPX4介导的铁死亡通路的影响.

Published in:

Progress in Modern Biomedicine, 2024, v. 24, n. 14, p. 2619, doi. 10.13241/j.cnki.pmb.2024.14.004

By:

许静;
霍康;
郭秦乐;
白立曦;
李娜;
杜俊凯

Publication type:

Article

miR-19 通过 Keap-Nrf2/HO-1 信号通路对卵巢癌细胞增殖的影响.

Published in:

Progress in Modern Biomedicine, 2021, v. 21, n. 17, p. 3217, doi. 10.13241/j.cnki.pmb.2021.17.004

By:

姜红云;
邬琳;
葛俊丽;
姚念玲;
康锋

Publication type:

Article

miR-19 通过 Keap-Nrf2/HO-1 信号通路对卵巢癌细胞增殖的影响.

Published in:

Progress in Modern Biomedicine, 2021, n. 13, p. 3217, doi. 10.13241/j.cnki.pmb.2021.17.004

By:

姜红云;
邬琳;
葛俊丽;
姚念玲;
康锋

Publication type:

Article

Expression of Keap1 and Nrf2 in diffuse large B-cell lymphoma and its clinical significance.

Published in:

Experimental & Therapeutic Medicine, 2018, v. 16, n. 2, p. 573, doi. 10.3892/etm.2018.6208

By:

Yi, Xuemei;
Zhao, Yajun;
Xue, Li;
Zhang, Jing;
Qiao, Yujie;
Jin, Qianqian;
Li, Hongling

Publication type:

Article

Fresh Medium or L-Cystine as an Effective Nrf2 Inducer for Cytoprotection in Cell Culture.

Published in:

Cells (2073-4409), 2023, v. 12, n. 2, p. 291, doi. 10.3390/cells12020291

By:

Dai, Wujing;
Chen, Qin M.

Publication type:

Article

The Challenge of Dimethyl Fumarate Repurposing in Eye Pathologies.

Published in:

Cells (2073-4409), 2022, v. 11, n. 24, p. 4061, doi. 10.3390/cells11244061

By:

Manai, Federico;
Govoni, Stefano;
Amadio, Marialaura

Publication type:

Article

Dynamics of Metabolic Pathways and Stress Response Patterns during Human Neural Stem Cell Proliferation and Differentiation.

Published in:

Cells (2073-4409), 2022, v. 11, n. 9, p. N.PAG, doi. 10.3390/cells11091388

By:

Semkova, Vesselina;
Haupt, Simone;
Segschneider, Michaela;
Bell, Catherine;
Ingelman-Sundberg, Magnus;
Hajo, Mohamad;
Weykopf, Beatrice;
Muthukottiappan, Pathma;
Till, Andreas;
Brüstle, Oliver

Publication type:

Article

Galangin Exhibits Neuroprotective Effects in 6-OHDA-Induced Models of Parkinson's Disease via the Nrf2/Keap1 Pathway.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 8, p. 1014, doi. 10.3390/ph15081014

By:

Chen, Qiu-Xu;
Zhou, Ling;
Long, Tao;
Qin, Da-Lian;
Wang, Yi-Ling;
Ye, Yun;
Zhou, Xiao-Gang;
Wu, Jian-Ming;
Wu, An-Guo

Publication type:

Article

Kahweol activates the Nrf2/HO-1 pathway by decreasing Keap1 expression independently of p62 and autophagy pathways.

Published in:

PLoS ONE, 2020, v. 15, n. 10, p. 1, doi. 10.1371/journal.pone.0240478

By:

Seo, Hye-Young;
Lee, So-Hee;
Lee, Ji-Ha;
Hwang, Jae Seok;
Kim, Mi Kyung;
Jang, Byoung Kuk

Publication type:

Article

Tributyltin activates the Keap1-Nrf2 pathway via a macroautophagy-independent reduction in Keap1.

Published in:

Journal of Toxicological Sciences, 2023, v. 48, n. 3, p. 161, doi. 10.2131/jts.48.161

By:

Misaki Hatano;
Shunichi Hatamiya;
Masatsugu Miyara;
Yaichiro Kotake

Publication type:

Article

Heat stress upregulates arachidonic acid to trigger autophagy in sertoli cells via dysfunctional mitochondrial respiratory chain function.

Published in:

Journal of Translational Medicine, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12967-024-05182-y

By:

Hu, Yu;
Luo, Nan Jian;
Gan, Lu;
Xue, Hong Yan;
Luo, Ke Yan;
Zhang, Jiao Jiao;
Wang, Xian Zhong

Publication type:

Article

Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators.

Published in:

Biological Chemistry, 2022, v. 403, n. 4, p. 391, doi. 10.1515/hsz-2021-0396

By:

Rothweiler, Elisabeth M.;
Brennan, Paul E.;
Huber, Kilian V. M.

Publication type:

Article

Antioxidant Potential of Rhodiola Heterodonta Extract: Activation of Nrf2 Pathway Via Integrative In Vivo and In Silico Studies.

Published in:

Trends in Sciences, 2025, v. 22, n. 5, p. 1, doi. 10.48048/tis.2025.9521

By:

Abdullaev, Azizbek;
Abdullaev, Izzatullo;
Bogbekov, Anvarbek;
Gayibov, Ulugbek;
Omonturdiev, Sirojiddin;
Gayibova, Sabina;
Turahodjayev, Muratbek;
Ruziboev, Khaydarali;
Aripov, Takhir

Publication type:

Article

Novel dipeptidyl hydroxamic acids that inhibit human and bacterial dipeptidyl peptidase III.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, p. 40, doi. 10.1080/14756366.2016.1186021

By:

Cvitešić, Ana;
Sabljić, Igor;
Makarević, Janja;
Abramić, Marija

Publication type:

Article

Impact of two-month sodium citrate supplementation along with moderate-intensity continuous training on PGC-1α and Nrf2 expression in diabetic rats.

Published in:

Physiology & Pharmacology, 2024, v. 28, n. 2, p. 157, doi. 10.61186/phypha.28.2.157

By:

Nabilpour, Maghsoud;
Seifi-Skishahr, Farnaz;
PourRahim, Ameneh;
Nobari, Hadi

Publication type:

Article

GPR30 Activation by 17β-Estradiol Promotes p62 Phosphorylation and Increases Estrogen Receptor α Protein Expression by Inducing Its Release from a Complex Formed with KEAP1.

Published in:

Journal of Personalized Medicine, 2021, v. 11, n. 9, p. 906, doi. 10.3390/jpm11090906

By:

Tsai, Chia-Lung;
Lin, Chiao-Yun;
Chao, Angel;
Lee, Yun-Shien;
Wu, Ren-Chin;
Tsai, Chi-Neu;
Yen, Chih-Feng;
Chao, An-Shine

Publication type:

Article

Astaxanthin Protects Human Granulosa Cells against Oxidative Stress through Activation of NRF2/ARE Pathway and Its Downstream Phase II Enzymes.

Published in:

Cell Journal (Yakhteh), 2021, v. 23, n. 3, p. 319, doi. 10.22074/cellj.2021.7222.

By:

Eslami, Mojtaba;
Esfandyari, Sahar;
Aghahosseini, Marzieh;
Rashidi, Zahra;
Hosseinishental, Shirzad;
Brenjian, Samane;
Sobhani, Aligholi;
Amidi, Fardin

Publication type:

Article

A Novel Germline Mutation of KEAP 1 (R483H) Associated with a Non-Toxic Multinodular Goiter.

Published in:

2016

By:

Eijun Nishihara;
Akira Hishinuma;
Takahiko Kogai;
Nami Takada;
Mitsuyoshi Hirokawa;
Shuji Fukata;
Mitsuru Ito;
Tomonori Yabuta;
Mitsushige Nishikawa;
Hirotoshi Nakamura;
Nobuyuki Amino;
Akira Miyauchi

Publication type:

Case Study

Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue.

Published in:

Frontiers in Aging Neuroscience, 2021, v. 13, p. N.PAG, doi. 10.3389/fnagi.2021.673205

By:

Hushpulian, Dmitry M.;
Ammal Kaidery, Navneet;
Ahuja, Manuj;
Poloznikov, Andrey A.;
Sharma, Sudarshana M.;
Gazaryan, Irina G.;
Thomas, Bobby

Publication type:

Article

A Quantitative Proteomics Approach to Gain Insight into NRF2-KEAP1 Skeletal Muscle System and Its Cysteine Redox Regulation.

Published in:

Genes, 2021, v. 12, n. 11, p. 1655, doi. 10.3390/genes12111655

By:

Abu, Rafay;
Yu, Li;
Kumar, Ashok;
Gao, Lie;
Kumar, Vikas

Publication type:

Article

Dexmedetomidine Alleviates Ferroptosis Induced by Sepsis-Induced Renal Injury by Activating Keap1-Nrf2 Signaling Pathway.

Published in:

Clinical Laboratory, 2024, v. 70, n. 11, p. 2143, doi. 10.7754/Clin.Lab.2024.240539

By:

Yan Yan;
Zhigao Zhu;
Haofeng Ding;
Xingchun Zhu;
Jiahao Zhang;
Chengwen Fu;
Dandan Li;
Jiaxin Chu;
Li Ren;
Congli Zhang

Publication type:

Article

P357Nrf2 sequesters Keap1 preventing endothelial dysfunction.

Published in:

2018

By:

Kopacz, A;
Kloska, D;
Cysewski, D;
Dulak, J;
Jozkowicz, A;
Grochot-Przeczek, A

Publication type:

Abstract

The hepatoprotective effect of Sophora viciifolia fruit extract against acetaminophen-induced liver injury in mice.

Published in:

Journal of Applied Biomedicine, 2023, v. 21, n. 2, p. 91, doi. 10.32725/jab.2023.008

By:

Qi, Shanshan;
Lin, Beibei;
Wu, Sanqiao;
Hao, Hao;
Zheng, Hongxin;
Liu, Xiang;
Zhang, Xiaoying;
Yue, Lijuan;
Chen, Chen

Publication type:

Article

Potential of NRF2 Inhibitors—Retinoic Acid, K67, and ML-385—In Overcoming Doxorubicin Resistance in Promyelocytic Leukemia Cells.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 19, p. 10257, doi. 10.3390/ijms251910257

By:

Juszczak, Michał;
Tokarz, Paulina;
Woźniak, Katarzyna

Publication type:

Article

Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 6, p. 3521, doi. 10.3390/ijms25063521

By:

Andrés, Celia María Curieses;
Pérez de la Lastra, José Manuel;
Bustamante Munguira, Elena;
Juan, Celia Andrés;
Plou, Francisco J.;
Pérez Lebeña, Eduardo

Publication type:

Article