Works about GENOME-wide association studies

Results: 5000

Dietary factors and risk for endometriosis: a Mendelian randomization analysis.

Published in:

Nutrition & Metabolism, 2025, v. 22, n. 1, p. 1, doi. 10.1186/s12986-025-00970-9

By:

Zhang, Xia;
Zheng, Qiaomei;
Chen, Lihong

Publication type:

Article

Genetic and transcriptome analyses of the effect of genotype-by-environment interactions on Brassica napus seed oil content.

Published in:

Plant Cell, 2025, v. 37, n. 4, p. 1, doi. 10.1093/plcell/koaf062

By:

Han, Xu;
Wu, Xiaowei;
Zhang, Yawen;
Tang, Qingqing;
Zeng, Lingju;
Liu, Yunhao;
Xiang, Yuyan;
Hou, Keqin;
Fang, Shuai;
Lei, Weixia;
Li, Haojie;
Tang, Shan;
Zhao, Hu;
Peng, Yan;
Yao, Xuan;
Guo, Tingting;
Zhang, Yuan-Ming;
Guo, Liang

Publication type:

Article

Genetic risk and polygenic risk score assessment of prediabetes and progression to type 2 diabetes.

Published in:

Diabetes, Obesity & Metabolism, 2025, v. 27, n. 8, p. 4469, doi. 10.1111/dom.16490

By:

Aliyu, Usama;
Umlai, Umm‐Kulthum Ismail;
Al‐Thani, Nayra M.;
Toor, Salman M.;
Abou‐Samra, Abdul Badi;
Albagha, Omar M. E.

Publication type:

Article

No Causal Association Between Inguinal Hernia and Aortic Aneurysm Using Mendelian Randomization Analysis.

Published in:

Angiology, 2025, v. 76, n. 6, p. 525, doi. 10.1177/00033197241226509

By:

Yao, Sicheng;
Ci, Hongbo

Publication type:

Article

Sedentary behaviors, physical activity, and risk of allergic rhinitis and asthma: evidence from cohort and Mendelian randomization studies.

Published in:

BMC Pulmonary Medicine, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12890-025-03779-7

By:

Wang, Xiaoyu;
Gao, Yaya;
Lou, Lin;
Yang, Wenjie;
Xu, Wei;
Zhao, Yu;
Ren, Jianjun

Publication type:

Article

Smoking can increase the risk of osteoarthritis in European women.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-09546-2

By:

Mao, Beini;
Li, Hetong;
Zhong, Jintao;
Li, Xiuwang;
Sang, Hongxun

Publication type:

Article

Exploring the impact of neutrophils on lung adenocarcinoma using Mendelian randomization and transcriptomic study.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-08490-5

By:

Xiao, Xiang;
Wu, Xuan-Yu;
Zhang, Jing-Qi;
Li, Wen-Yuan;
You, Feng-Ming;
Guo, Jing

Publication type:

Article

Genome and transcriptome wide association study identify candidate genes regulating folate levels in maize.

Published in:

Frontiers in Plant Science, 2025, p. 1, doi. 10.3389/fpls.2025.1606220

By:

Zou, Chenglin;
Yang, Meng;
Huang, Aihua;
Mo, Runxiu;
Zhai, Ruining;
Huang, Kaijian

Publication type:

Article

Investigation of the causal relationship of saturated fat acids on heart stroke: evidence from two-sample Mendelian randomization.

Published in:

BMC Nutrition, 2025, v. 11, n. 1, p. 1, doi. 10.1186/s40795-025-01094-2

By:

Habibi, Danial;
Hamraz, Iman;
Teymoori, Farshad;
Saeidian, Amir Hesam;
Mirtavoos-Mahyari, Hanifeh;
Kasnavi, Qumars;
Taloubaghi, Alireza Soleymani;
Masoudi, Homayoon;
Azizi, Fereidoun;
Daneshpour, Maryam Sadat;
Hedayati, Mehdi;
Akbarzadeh, Mahdi;
Mansourian, Marjan

Publication type:

Article

Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06782-y

By:

Kasela, Silva;
Luitva, Laura Birgit;
Krebs, Kristi;
Möls, Märt;
Milani, Lili;
Alver, Maris

Publication type:

Article

Genetic prediction of lower limb isometric strength changes after 12 weeks of resistance training.

Published in:

Biology of Sport, 2025, v. 42, n. 3, p. 3, doi. 10.5114/biolsport.2025.145918

By:

Mei, Tao;
Li, Yanchun;
Bao, Dapeng;
Yang, Xiangang;
Yang, Xiaolin;
Li, Liang;
He, Zihong

Publication type:

Article

Uncovering causal gene-tissue pairs and variants through a multivariate TWAS controlling for infinitesimal effects.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61423-8

By:

Yang, Yihe;
Lorincz-Comi, Noah;
Zhu, Xiaofeng

Publication type:

Article

Natural variation in GNP3 determines grain number and grain yield in rice.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61326-8

By:

Ma, Zhiqi;
Ming, Yuhang;
Li, Jinlong;
Li, Honglin;
Wang, Haozhen;
Zhu, Xiaoyang;
Xu, Yawen;
Zhao, Yong;
Hu, Qianfeng;
Liu, Ruiqi;
Pan, Yinghua;
Li, Danting;
Wang, Wensheng;
Xu, Jianlong;
Sun, Xingming;
Li, Jinjie;
Zhang, Hongliang;
Li, Zichao;
Zhang, Zhanying

Publication type:

Article

Whole-genome sequencing of 1,060 Brettanomyces bruxellensis isolates reveals significant phenotypic impact of acquired subgenomes in allopolyploids.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60706-4

By:

Loegler, Victor;
Runge, Jan-Niklas;
Eberlein, Chris;
Peltier, Émilien;
Harrouard, Jules;
Miot-Sertier, Cécile;
Albertin, Warren;
Friedrich, Anne;
Schacherer, Joseph

Publication type:

Article

DrFARM: identification of pleiotropic genetic variants in genome-wide association studies.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60439-4

By:

Chan, Lap Sum;
Li, Gen;
Fauman, Eric B.;
Yin, Xianyong;
Laakso, Markku;
Boehnke, Michael;
Song, Peter X. K.

Publication type:

Article

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60431-y

By:

Sharapov, Sodbo;
Timoshchuk, Anna;
Zaytseva, Olga;
Maslov, Denis E.;
Soplenkova, Anna;
Elgaeva, Elizaveta E.;
Tiys, Evgeny S.;
Mangino, Massimo;
Wittenbecher, Clemens;
Karssen, Lennart;
Timofeeva, Maria;
Nostaeva, Arina;
Vuckovic, Frano;
Trbojević-Akmačić, Irena;
Štambuk, Tamara;
Feoktistova, Sofya;
Potapova, Nadezhda A.;
Voroshilova, Viktoria;
Williams, Frances;
Primorac, Dragan

Publication type:

Article

Feature selection and aggregation for antibiotic resistance GWAS in Mycobacterium tuberculosis : a comparative study.

Published in:

Frontiers in Microbiology, 2025, p. 1, doi. 10.3389/fmicb.2025.1586476

By:

Reshetnikov, Kirill;
Bykova, Daria;
Kuleshov, Konstantin;
Chukreev, Konstantin;
Guguchkin, Egor;
Neverov, Alexey;
Fedonin, Gennady

Publication type:

Article

Data simulation to optimize frameworks for genome-wide association studies in diverse populations.

Published in:

Frontiers in Genetics, 2025, p. 1, doi. 10.3389/fgene.2025.1559496

By:

Mugo, Jacquiline W.;
Mulder, Nicola;
Chimusa, Emile R.

Publication type:

Article

Identification of circulating inflammation cytokines as a mediator of gut microbiota and type 2 diabetes mellitus: a Mendelian randomization study.

Published in:

Diabetology & Metabolic Syndrome, 2025, v. 17, n. 1, p. 1, doi. 10.1186/s13098-025-01792-8

By:

Zhou, Xin;
Zheng, Wenbin;
Kong, Wen;
Zeng, Tianshu

Publication type:

Article

Leveraging genome-wide association analyses with chip and imputed data emerges potential pleiotropic region for four duck growth traits.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-08852-z

By:

Tarsani, Eirini;
Matika, Oswald;
McIntosh, Kiah;
Desire, Suzanne;
Dunn, Ian C.;
Talenti, Andrea;
Rae, Anne M.;
Kranis, Andreas;
Watson, Kellie A.

Publication type:

Article

Causal role of immunophenotypes in HIV-1 acquisition: insights from Mendelian randomization analysis.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-07962-y

By:

Li, Nan;
He, Chuan

Publication type:

Article

Multiple genome analysis of Staphylococcus aureus from wild ungulates renders new insights into the links between genetic diversity and biofilm formation.

Published in:

Journal of Applied Microbiology, 2025, v. 136, n. 6, p. 1, doi. 10.1093/jambio/lxaf126

By:

Teixeira, Sara;
Ramos, Beatriz;
Cunha, Mónica V

Publication type:

Article

Genome-wide epistasis analysis reveals significant epistatic signals associated with Parkinson's disease risk.

Published in:

Brain: A Journal of Neurology, 2025, v. 148, n. 6, p. 2060, doi. 10.1093/brain/awae398

By:

Cisterna-Garcia, Alejandro;
Bustos, Bernabe I;
Bandres-Ciga, Sara;
Leal, Thiago P;
Sarihan, Elif I;
Jok, Christie;
Krainc, Dimitri;
Mata, Ignacio F;
Lubbe, Steven J;
Botia, Juan A

Publication type:

Article

Multi‐ancestry genome‐wide association study of topiramate's effects on heavy alcohol use.

Published in:

Alcohol, Clinical & Experimental Research, 2025, v. 49, n. 6, p. 1197, doi. 10.1111/acer.70069

By:

Davis, Christal N.;
Jinwala, Zeal;
Justice, Amy C.;
Rentsch, Christopher T.;
Kranzler, Henry R.

Publication type:

Article

Moderation of treatment outcomes by polygenic risk for alcohol‐related traits in placebo‐controlled trials of topiramate.

Published in:

Alcohol, Clinical & Experimental Research, 2025, v. 49, n. 6, p. 1297, doi. 10.1111/acer.70052

By:

Kranzler, Henry R.;
Jinwala, Zeal;
Davis, Christal N.;
Xu, Heng;
Biernacka, Joanna M.;
Zhou, Hang;
Kember, Rachel L.;
Gelernter, Joel;
Feinn, Richard

Publication type:

Article

Identification of comorbid genes between type 2 diabetes and migraine through peripheral blood single-cell and Mendelian randomization analysis.

Published in:

Journal of Headache & Pain, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s10194-025-02090-4

By:

Yuan, Bobo;
Li, Jianrui;
Shu, Qing;
Wang, Xiaoye;
Luo, Guogang;
Ma, Ranran

Publication type:

Article

What does a migraine aura look like?—A systematic review.

Published in:

Journal of Headache & Pain, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s10194-025-02080-6

By:

Joppeková, Ľubica;
Pinto, Maria João;
da Costa, Mariana Dias;
Boček, Richard;
Berman, Gabriele;
Salim, Yones;
Akhtanova, Dinara;
Abzalbekova, Aizhana;
MaassenVanDenBrink, Antoinette;
Lampl, Christian

Publication type:

Article

Integrating Agronomic and Molecular Advancements to Enhance Nitrogen Use Efficiency (NUE) and Promote Sustainable Rice Production.

Published in:

Nitrogen (2504-3129), 2025, v. 6, n. 2, p. 34, doi. 10.3390/nitrogen6020034

By:

Kunwar, Uttam Bahadur;
Manzoor, Nazer;
Wen, Jiancheng;
Pandit, Naba Raj

Publication type:

Article

Assessing the suitability of formalin-fixed paraffin-embedded (FFPE) tissue for genome-wide association studies (GWAS).

Published in:

BMC Research Notes, 2025, v. 18, n. 1, p. 1, doi. 10.1186/s13104-025-07306-z

By:

Reingruber, Julian;
Krämer, Maximilian J.;
Bigge, Jessica;
Dasmeh, Pouria;
Grover, Sandeep;
Heilmann-Heimbach, Stefanie;
Nöthen, Markus M.;
Kreuser, Nicole;
Gockel, Ines;
Veits, Lothar;
Vieth, Michael;
Jank, Paul;
Denkert, Carsten;
Maj, Carlo;
Hess, Timo;
Schumacher, Johannes

Publication type:

Article

Woolf et al's "GWAS by subtraction" is not useful for cross-generational Mendelian randomization studies.

Published in:

BMC Research Notes, 2025, v. 18, n. 1, p. 1, doi. 10.1186/s13104-025-07326-9

By:

Evans, David M;
Smith, George Davey;
Moen, Gunn-Helen

Publication type:

Article

Monoamine neurotransmitter-related gene-based genome-wide association study of low-dose ketamine in patients with treatment-resistant depression.

Published in:

Journal of Psychopharmacology, 2025, v. 39, n. 6, p. 593, doi. 10.1177/02698811251326939

By:

Kao, Chung-Feng;
Tsai, Shih-Jen;
Su, Tung-Ping;
Li, Cheng-Ta;
Lin, Wei-Chen;
Hong, Chen-Jee;
Bai, Ya-Mei;
Tu, Pei-Chi;
Chen, Mu-Hong

Publication type:

Article

Genome-wide association study of Northern corn leaf blight (NCLB) resistance using temperate and subtropical maize recombinant inbred lines.

Published in:

BMC Genomics, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s12864-025-11806-4

By:

Gong, Xiaodong;
Jiang, Fuyan;
Shaw, Ranjan K.;
Sun, Jiachen;
Dai, Tao;
Bi, Yaqi;
Pan, Yanhui;
Kong, Jiao;
Zong, Haiyang;
Yang, Xiaoping;
Ijaz, Babar;
Fan, Xingming

Publication type:

Article

Coconut: covariate-assisted composite null hypothesis testing with applications to replicability analysis of high-throughput experimental data.

Published in:

BMC Bioinformatics, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s12859-025-06163-8

By:

Li, Yan;
Li, Yanmei;
Ma, Han;
Yue, Zitong;
Zhang, Xin

Publication type:

Article

Polygenic Risk Score Analysis of Antidepressant Treatment Outcomes: A CAN-BIND-1 Study Report: Analyse des résultats du traitement antidépresseur à l'aide des scores de risque polygéniques : Rapport sur l'étude CAN-BIND-1.

Published in:

Canadian Journal of Psychiatry, 2025, v. 70, n. 7, p. 552, doi. 10.1177/07067437251329073

By:

Magarbeh, Leen;
Elsheikh, Samar S. M.;
Islam, Farhana;
Marshe, Victoria S.;
Men, Xiaoyu;
Tavakoli, Emytis;
Kronenbuerger, Martin;
Kloiber, Stefan;
Frey, Benicio N.;
Milev, Roumen;
Soares, Claudio N.;
Parikh, Sagar V.;
Placenza, Franca;
Hassel, Stefanie;
Taylor, Valerie H.;
Leri, Francesco;
Blier, Pierre;
Uher, Rudolf;
Farzan, Faranak;
Lam, Raymond W.

Publication type:

Article

Map-based cloning and characterization reveal that an R2R3 MYB gene confers red glume in wheat.

Published in:

Crop Journal (2095-5421), 2025, v. 13, n. 3, p. 887, doi. 10.1016/j.cj.2024.03.002

By:

Weiwei Mao;
Xiaobo Wang;
Yongming Chen;
Yongfa Wang;
Liang Ma;
Xiaoming Xie;
Xiaojia Wu;
Jin Xu;
Yuqi Zhang;
Yue Zhao;
Xuejun Tian;
Weilong Guo;
Zhaorong Hu;
Mingming Xin;
Yingyin Yao;
Zhongfu Ni;
Qixin Sun;
Huiru Peng

Publication type:

Article

Rethinking Newborn Screening: A Case of GALM Deficiency.

Published in:

International Journal of Neonatal Screening (IJNS), 2025, v. 11, n. 2, p. 25, doi. 10.3390/ijns11020025

By:

van Konijnenburg, Eva M. M. Hoytema;
Radenkovic, Silvia;
Koop, Klaas;
Prinsen, Hubertus C. M. T.;
de Sain-van der Velden, Monique

Publication type:

Article

Genome-Wide Identification of Wheat Gene Resources Conferring Resistance to Stripe Rust.

Published in:

Plants (2223-7747), 2025, v. 14, n. 12, p. 1883, doi. 10.3390/plants14121883

By:

Ma, Qiaoyun;
Yan, Dong;
Pang, Binshuang;
Bai, Jianfang;
Yang, Weibing;
Gao, Jiangang;
Chen, Xianchao;
Hou, Qiling;
Zhang, Honghong;
Tian, Li;
Li, Yahui;
Jia, Jizeng;
Zhang, Lei;
Chen, Zhaobo;
Gao, Lifeng;
Liao, Xiangzheng

Publication type:

Article

Gene Localization and Functional Validation of GmPDH1 in Soybean Against Cyst Nematode Race 4.

Published in:

Plants (2223-7747), 2025, v. 14, n. 12, p. 1877, doi. 10.3390/plants14121877

By:

Dai, Yuehua;
Zhang, Yue;
Li, Chuhui;
Wan, Kun;
Chen, Yan;
Nie, Mengen;
Zhang, Haiping

Publication type:

Article

Single- and Multi-Locus GWAS Unravels Novel Genomic Regions Related to Low-Phosphate Stress in Cotton Seedlings.

Published in:

Plants (2223-7747), 2025, v. 14, n. 12, p. 1803, doi. 10.3390/plants14121803

By:

Wei, Xianxu;
Yao, Siyu;
Di, Jiangnuo;
Guan, Jiaxin;
Wang, Aohan;
Yang, Jie;
Zhang, Luyao;
Liu, Yang;
Liang, Mengyao;
Niu, Zhihao;
Zhang, Xuan;
Xue, Jiarui;
Shen, Mengxue;
Li, Lin;
Su, Yao;
Sun, Zhengwen

Publication type:

Article

Physiologic, Genetic and Epigenetic Determinants of Water Deficit Tolerance in Fruit Trees.

Published in:

Plants (2223-7747), 2025, v. 14, n. 12, p. 1769, doi. 10.3390/plants14121769

By:

Bonnin, Marie;
Diop, Khadidiatou;
Cavelier, Gabriel;
Crastes, Mathieu;
Groenewald, Renel;
Nguyen, Hong Thu;
Morillon, Raphaël;
Pontvianne, Frédéric

Publication type:

Article

Incorporating Real‐World Variability in Clinical IBD Research.

Published in:

Journal of Evaluation in Clinical Practice, 2025, v. 31, n. 4, p. 1, doi. 10.1111/jep.70117

By:

te Velde, Anje A.

Publication type:

Article

Editorial: Adrenal insufficiency: diagnostic approaches, treatments, and outcomes, volume II.

Published in:

Frontiers in Endocrinology, 2025, p. 1, doi. 10.3389/fendo.2025.1629881

By:

Pazderska, Agnieszka;
Malchoff, Carl D.;
Valassi, Elena

Publication type:

Article

A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer's disease.

Published in:

Science Signaling, 2025, v. 18, n. 893, p. 1, doi. 10.1126/scisignal.adv0970

By:

Gauron, Maria Celeste;
Prokopenko, Dmitry;
Lee, Sanghun;
Wolfe, Sarah A.;
Hecker, Julian;
Willett, Julian;
Waqas, Mohammad;
Lordén, Gema;
Yang, Yimin;
Mayfield, Joshua E.;
Castanho, Isabel;
Mullin, Kristina;
Morgan, Sarah;
Hahn, Georg;
Demeo, Dawn L.;
Hide, Winston;
Bertram, Lars;
Lange, Christoph;
Newton, Alexandra C.;
Tanzi, Rudolph E.

Publication type:

Article

Integrated multi-omics and machine learning reveals immune-metabolic signatures in osteoarthritis: from bulk RNA-seq to single-cell resolution.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1599930

By:

He, Hui;
Zhao, Xiumei;
Zhang, Bo;
Zhao, Shijian;
Wu, Yinteng

Publication type:

Article

Causal relationship between COVID-19, vaccination, and 20 digestive diseases: a comprehensive two-sample Mendelian randomization study.

Published in:

Virology Journal, 2025, v. 22, n. 1, p. 1, doi. 10.1186/s12985-025-02847-y

By:

Zeng, Xin;
Li, Xiang;
Fu, Yansong;
Chen, Jie;
Yang, Keyi;
Qin, Hong

Publication type:

Article

Identification of Advantaged Genes for Low-Nitrogen-Tolerance-Related Traits in Rice Using a Genome-Wide Association Study.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5749, doi. 10.3390/ijms26125749

By:

Zhang, Zhiyuan;
Zhai, Laiyuan;
Liu, Yuzhuo;
Tian, Lin;
Zhu, Shuangbing;
Shen, Congcong;
Jia, Juqing;
Chen, Kai;
Xu, Jianlong

Publication type:

Article

Genome-Wide Association Study for Drought Tolerance in Cowpea (Vigna unguiculata (L.) Walp.) at Seedling Stage Using a Whole Genome Resequencing Approach.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5478, doi. 10.3390/ijms26125478

By:

Ravelombola, Waltram;
Xiong, Haizheng;
Bhattarai, Gehendra;
Manley, Aurora;
Cason, John;
Pham, Hanh;
Zia, Bazgha;
Mou, Beiquan;
Shi, Ainong

Publication type:

Article

Uridine, a Therapeutic Nucleoside, Exacerbates Alcoholic Liver Disease via SRC Kinase Activation: A Network Toxicology and Molecular Dynamics Perspective.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5473, doi. 10.3390/ijms26125473

By:

Liu, Zhenyu;
Wang, Zhihao;
Wang, Jie;
Xu, Shiquan;
Zhang, Tong

Publication type:

Article

Novel Shared Heritable Candidate Risk Loci of Breast and Endometrial Cancer—A Swedish Haplotype Genome-Wide Association Study.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5461, doi. 10.3390/ijms26125461

By:

Barnekow, Elin;
Liu, Wen;
Franko, Mikael Andersson;
von Wachenfeldt, Anna;
Wendt, Camilla;
Tham, Emma;
Mints, Miriam;
O'Mara, Tracy A.;
Hall, Per;
Margolin, Sara;
Lindblom, Annika

Publication type:

Article

Exploring the shared genetic architecture between testosterone traits and major depressive disorder.

Published in:

BMC Psychiatry, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12888-025-07096-5

By:

Lu, Wen;
He, Xiaoyan;
Peng, Huan;
Lei, Pu;
Liu, Jing;
Ding, Yuanyuan;
Yan, Bin;
Ma, Xiancang;
Yang, Jian

Publication type:

Article