Works about GENE targeting

Results: 5000

利用 CRISPR/Cas 9基因编辑与杂交技术靶向创制灵芝基因位点纯合突变株的方法.

Published in:

Acta Edulis Fungi, 2025, v. 32, n. 3, p. 1, doi. 10.16488/j.cnki.1005-9873.2025.03.001

By:

田佳琳;
董蓓蓓;
唐传红;
周帅;
冯娜;
冯杰;
张劲松;
谭贻

Publication type:

Article

Genetically encoded affinity reagents are a toolkit for visualizing and manipulating endogenous protein function in vivo.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61003-w

By:

Boswell, Curtis W.;
Hoppe, Caroline;
Sherrard, Alice;
Miao, Liyun;
Kojima, Mina L.;
Martino, Pieter;
Zhao, Ning;
Stasevich, Timothy J.;
Nicoli, Stefania;
Giraldez, Antonio J.

Publication type:

Article

The mechanism of Shancigu and its monomer in the development of colorectal cancer based on network pharmacology.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-04795-7

By:

Li, Guiying;
Zhu, Xiuqiong;
Zhao, Ruixia;
Zhang, Xi;
Huang, Cuimei;
Shu, Miaomiao;
Liu, Liangying;
Yuan, Jie

Publication type:

Article

An Engineered RNase P Ribozyme Effectively Reduces Human Coronavirus 229E Gene Expression and Growth in Human Cells.

Published in:

Zoonotic Diseases (2813-0227), 2025, v. 5, n. 2, p. 12, doi. 10.3390/zoonoticdis5020012

By:

Liu, Yujun;
Yan, Bin;
Gong, Hao;
Liu, Fenyong

Publication type:

Article

Baculovirus Variant Detection from Transient CRISPR-Cas9-Mediated Disruption of gp64 at Different Gene Locations.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5805, doi. 10.3390/ijms26125805

By:

Chakraborty, Madhuja;
Nielsen, Lisa;
Nash, Delaney;
Bruder, Mark R.;
Nissimov, Jozef I.;
Charles, Trevor C.;
Aucoin, Marc G.

Publication type:

Article

Bacterial genetics: Hitting the CRISPR target.

Published in:

Nature Reviews Microbiology, 2012, v. 10, n. 6, p. 376, doi. 10.1038/nrmicro2812

By:

Molloy, Sheilagh

Publication type:

Article

How a Blood Cell Intracellular Signal Keeps Blood Flowing.

Published in:

PLoS Biology, 2012, v. 10, n. 8, p. 1, doi. 10.1371/journal.pbio.1001385

By:

Robinson, Richard

Publication type:

Article

Evolutionarily Repurposed Networks Reveal the Well-Known Antifungal Drug Thiabendazole to Be a Novel Vascular Disrupting Agent.

Published in:

PLoS Biology, 2012, v. 10, n. 8, p. 1, doi. 10.1371/journal.pbio.1001379

By:

Hye Ji Cha;
Byrom, Michelle;
Mead, Paul E.;
Ellington, Andrew D.;
Wallingford, John B.;
Marcotte, Edward M.

Publication type:

Article

LAB-1 Targets PP1 and Restricts Aurora B Kinase upon Entrance into Meiosis to Promote Sister Chromatid Cohesion.

Published in:

PLoS Biology, 2012, v. 10, n. 8, p. 1, doi. 10.1371/journal.pbio.1001378

By:

Tzur, Yonatan B.;
De Carvalho, Carlos Egydio;
Nadarajan, Saravanapriah;
Van Bostelen, Ivo;
Gu, Yanjie;
Chu, Diana S.;
Cheeseman, Iain M.;
Colaiácovo, Monica P.

Publication type:

Article

Polymorphic Cis- and Trans-Regulation of Human Gene Expression.

Published in:

PLoS Biology, 2010, v. 8, n. 9, p. 1, doi. 10.1371/journal.pbio.1000480

By:

Cheung, Vivian G.;
Nayak, Renuka R.;
Xiaorong Wang, Isabel;
Elwyn, Susannah;
Cousins, Sarah M.;
Morley, Michael;
Spielman, Richard S.

Publication type:

Article

The Multicopy Gene Sly Represses the Sex Chromosomesin the Male Mouse Germline after Meiosis.

Published in:

PLoS Biology, 2009, v. 7, n. 11, p. 1, doi. 10.1371/journal.pbio.1000244

By:

Cocquet, Julie;
Ellis, Peter J. I.;
Yamauchi, Yasuhiro;
Mahadevaiah, Shantha K.;
Affara, Nabeel A.;
Ward, Monika A.;
Burgoyne, Paul S.

Publication type:

Article

Conservation and Evolution of Cis-Regulatory Systems in Ascomycete Fungi.

Published in:

PLoS Biology, 2004, v. 2, n. 11, p. 1, doi. 10.1371/journal.pbio.0020398

By:

Gasch, Audrey P;
Moses, Alan M;
Chiang, Derek Y;
Fraser, Hunter B;
Berardini, Mark;
Eisen, Michael B

Publication type:

Article

Qualitative and quantitative PCR methods using species-specific primer for detection and identification of wood rot fungi.

Published in:

Journal of Wood Science, 2009, v. 55, n. 2, p. 133, doi. 10.1007/s10086-008-1011-3

By:

Sakae Horisawa;
Yoh Sakuma;
Shuichi Doi

Publication type:

Article

Quantitative analysis of the relationship between induction kinetics of chlorophyll fluorescence and function of genes in the cyanobacterium Synechocystis sp. PCC 6803.

Published in:

Photosynthesis Research, 2009, v. 101, n. 1, p. 47, doi. 10.1007/s11120-009-9462-y

By:

Hiroshi Ozaki;
Kintake Sonoike

Publication type:

Article

Skn7p Is Involved in Oxidative Stress Response and Virulence of Candida glabrata.

Published in:

Mycopathologia, 2010, v. 169, n. 2, p. 81, doi. 10.1007/s11046-009-9233-5

By:

Tomomi Saijo;
Taiga Miyazaki;
Koichi Izumikawa;
Tomo Mihara;
Takahiro Takazono;
Kosuke Kosai;
Yoshifumi Imamura;
Masafumi Seki;
Hiroshi Kakeya;
Yoshihiro Yamamoto

Publication type:

Article

Uptake by human glioma cell lines and biological effects of a peptide-nucleic acids targeting miR-221.

Published in:

Journal of Neuro-Oncology, 2014, v. 118, n. 1, p. 19, doi. 10.1007/s11060-014-1405-6

By:

Brognara, Eleonora;
Fabbri, Enrica;
Bazzoli, Elena;
Montagner, Giulia;
Ghimenton, Claudio;
Eccher, Albino;
Cantù, Cinzia;
Manicardi, Alex;
Bianchi, Nicoletta;
Finotti, Alessia;
Breveglieri, Giulia;
Borgatti, Monica;
Corradini, Roberto;
Bezzerri, Valentino;
Cabrini, Giulio;
Gambari, Roberto

Publication type:

Article

Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme.

Published in:

Journal of Neuro-Oncology, 2014, v. 117, n. 1, p. 125, doi. 10.1007/s11060-014-1362-0

By:

Champ, Colin;
Palmer, Joshua;
Volek, Jeff;
Werner-Wasik, Maria;
Andrews, David;
Evans, James;
Glass, Jon;
Kim, Lyndon;
Shi, Wenyin

Publication type:

Article

PI3K pathway inhibitors for the treatment of brain metastases with a focus on HER2+ breast cancer.

Published in:

Journal of Neuro-Oncology, 2014, v. 117, n. 1, p. 7, doi. 10.1007/s11060-014-1369-6

By:

Peddi, Parvin;
Hurvitz, Sara

Publication type:

Article

Prognostic significance of telomere maintenance mechanisms in pediatric high-grade gliomas.

Published in:

Journal of Neuro-Oncology, 2014, v. 117, n. 1, p. 67, doi. 10.1007/s11060-014-1374-9

By:

Dorris, Kathleen;
Sobo, Matthew;
Onar-Thomas, Arzu;
Panditharatna, Eshini;
Stevenson, Charles;
Gardner, Sharon;
DeWire, Mariko;
Pierson, Christopher;
Olshefski, Randal;
Rempel, Sandra;
Goldman, Stewart;
Miles, Lili;
Fouladi, Maryam;
Drissi, Rachid

Publication type:

Article

CUL4A is overexpressed in human pituitary adenomas and regulates pituitary tumor cell proliferation.

Published in:

Journal of Neuro-Oncology, 2014, v. 116, n. 3, p. 625, doi. 10.1007/s11060-013-1349-2

By:

Xu, Yangyang;
Wang, Yunshan;
Ma, Guangxin;
Wang, Qin;
Wei, Guangwei

Publication type:

Article

MicroRNA-107 inhibits glioma cell migration and invasion by modulating Notch2 expression.

Published in:

Journal of Neuro-Oncology, 2013, v. 112, n. 1, p. 59, doi. 10.1007/s11060-012-1037-7

By:

Chen, Lei;
Chen, Xiang-Rong;
Zhang, Run;
Li, Peng;
Liu, Yi;
Yan, Ke;
Jiang, Xiao-Dan

Publication type:

Article

Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression.

Published in:

Journal of Neuro-Oncology, 2011, v. 103, n. 1, p. 87, doi. 10.1007/s11060-010-0374-7

By:

Chen, Mike;
Clark, Aaron;
Chan, Dana;
Ware, Joy;
Holt, Shawn;
Chidambaram, Archana;
Fillmore, Helen;
Broaddus, William

Publication type:

Article

Receptor activation and inhibition in cellular response to chemotherapeutic combinational mimicries: the concept of divergent targeting.

Published in:

Journal of Neuro-Oncology, 2010, v. 100, n. 3, p. 345, doi. 10.1007/s11060-010-0196-7

By:

Watt, H.;
Rachid, Z.;
Jean-Claude, B.

Publication type:

Article

Tissue expression of PPAR-alpha isoforms in Scophthalmus maximus and transcriptional response of target genes in the heart after exposure to WY-14643.

Published in:

Fish Physiology & Biochemistry, 2013, v. 39, n. 4, p. 1043, doi. 10.1007/s10695-012-9761-7

By:

Urbatzka, R.;
Galante-Oliveira, S.;
Rocha, E.;
Castro, L.;
Cunha, I.

Publication type:

Article

In silico screening of the chicken genome for overlaps between genomic regions: microRNA genes, coding and non-coding transcriptional units, QTL, and genetic variations.

Published in:

Chromosome Research, 2016, v. 24, n. 2, p. 225, doi. 10.1007/s10577-016-9517-9

By:

Zorc, Minja;
Kunej, Tanja

Publication type:

Article

TALEN-mediated genome engineering to generate targeted mice.

Published in:

Chromosome Research, 2015, v. 23, n. 1, p. 43, doi. 10.1007/s10577-014-9457-1

By:

Sommer, Daniel;
Peters, Annika;
Baumgart, Ann-Kathrin;
Beyer, Marc

Publication type:

Article

Boosting transcription by transcription: enhancer-associated transcripts.

Published in:

Chromosome Research, 2013, v. 21, n. 6/7, p. 713, doi. 10.1007/s10577-013-9384-6

By:

Darrow, Emily M.;
Chadwick, Brian P.

Publication type:

Article

Association of modified cytosines and the methylated DNA-binding protein MeCP2 with distinctive structural domains of lampbrush chromatin.

Published in:

Chromosome Research, 2012, v. 20, n. 8, p. 925, doi. 10.1007/s10577-012-9324-x

By:

Morgan, Garry;
Jones, Peter;
Bellini, Michel

Publication type:

Article

Recycling selectable markers via Cre/loxP system for constructing Komagataella phaffii strains co-expressing multiple proteins.

Published in:

Biotechnology Letters, 2024, v. 46, n. 3, p. 399, doi. 10.1007/s10529-024-03466-3

By:

Wang, Weixian;
Han, Minghai;
Zhu, Guofei;
Liu, Xiaohui;
Zhao, Tianming;
Ma, Xiaoyan;
Gong, Xun;
Xu, Cunbin

Publication type:

Article

High-efficiency genetic engineering toolkit for virus based on lambda red-mediated recombination.

Published in:

Biotechnology Letters, 2023, v. 45, n. 10, p. 1327, doi. 10.1007/s10529-023-03412-9

By:

Yi, Jing;
Zhang, Maifei;
Zhu, Lin;
Xu, Changzhi;
Li, Binglin;
Wu, Panpan;
Wu, Hang;
Zhang, Buchang

Publication type:

Article

Characterization of a novel Escherichia coli recombineering selection/counterselection cassette.

Published in:

Biotechnology Letters, 2023, v. 45, n. 2, p. 191, doi. 10.1007/s10529-022-03333-z

By:

Zhang, Guoyi;
Zhang, Qiong;
Wang, Junyu;
Zhang, Jiao;
Shang, Guangdong

Publication type:

Article

Knockout and functional analysis of BSSS-related genes in Acremonium chrysogenum by novel episomal expression vector containing Cas9 and AMA1.

Published in:

Biotechnology Letters, 2022, v. 44, n. 5/6, p. 755, doi. 10.1007/s10529-022-03255-w

By:

Liu, Ling;
Chen, Zhen;
Tian, Xiwei;
Chu, Ju

Publication type:

Article

Circ_0001247 functions as a miR-1270 sponge to accelerate cervical cancer progression by up-regulating ZEB2 expression level.

Published in:

Biotechnology Letters, 2021, v. 43, n. 3, p. 745, doi. 10.1007/s10529-020-03059-w

By:

Wang, Wenshuang;
Xu, Anli;
Zhao, Manyin;
Sun, Jianan;
Gao, Lingyun

Publication type:

Article

A double-locus scarless genome editing system in Escherichia coli.

Published in:

Biotechnology Letters, 2020, v. 42, n. 8, p. 1457, doi. 10.1007/s10529-020-02856-7

By:

Liu, Haiqing;
Hou, Guofeng;
Wang, Peng;
Guo, Guiying;
Wang, Yu;
Yang, Nuo;
Rehman, Muhammad Nafees Ur;
Li, Changlong;
Li, Qian;
Zheng, Jiping;
Zeng, Jifeng;
Li, Shanhu

Publication type:

Article

A simple protocol for transfecting human mesenchymal stem cells.

Published in:

Biotechnology Letters, 2018, v. 40, n. 3, p. 617, doi. 10.1007/s10529-018-2505-8

By:

de Carvalho, Talita Giacomet;
Pellenz, Felipe Matheus;
Laureano, Alvaro;
da Rocha Silla, Lucia Mariano;
Giugliani, Roberto;
Baldo, Guilherme;
Matte, Ursula

Publication type:

Article

Homologous gene targeting of a carotenoids biosynthetic gene in Rhodosporidium toruloides by Agrobacterium-mediated transformation.

Published in:

Biotechnology Letters, 2017, v. 39, n. 7, p. 1001, doi. 10.1007/s10529-017-2324-3

By:

Sun, Wenyi;
Yang, Xiaobing;
Wang, Xueying;
Lin, Xinping;
Wang, Yanan;
Zhang, Sufang;
Luan, Yushi;
Zhao, Zongbao

Publication type:

Article

Gene targeting in amyotrophic lateral sclerosis using causality-based feature selection and machine learning.

Published in:

Molecular Medicine, 2023, v. 29, n. 1, p. 1, doi. 10.1186/s10020-023-00603-y

By:

Founta, Kyriaki;
Dafou, Dimitra;
Kanata, Eirini;
Sklaviadis, Theodoros;
Zanos, Theodoros P.;
Gounaris, Anastasios;
Xanthopoulos, Konstantinos

Publication type:

Article

microRNA-199a-5p regulates epithelial-to-mesenchymal transition in diabetic cataract by targeting SP1 gene.

Published in:

Molecular Medicine, 2020, v. 26, n. 1, p. 1, doi. 10.1186/s10020-020-00250-7

By:

Liu, Xin;
Gong, Qiaoyun;
Yang, Longfei;
Liu, Min;
Niu, Lingzhi;
Wang, Lufei

Publication type:

Article

High-expression of ROCK1 modulates the apoptosis of lens epithelial cells in age-related cataracts by targeting p53 gene.

Published in:

Molecular Medicine, 2020, v. 26, n. 1, p. 1, doi. 10.1186/s10020-020-00251-6

By:

Hu, Shanshan;
Su, Dongmei;
Sun, Lei;
Wang, Zhongying;
Guan, Lina;
Liu, Shanhe;
Zhao, Baowen;
Liu, Yong;
Shi, Cuige;
Yu, Jianbo;
Ma, Xu

Publication type:

Article

Subcellular Localization of a Novel Alternative Splicing of IIIG9 and Colocalization with PPP1gamma Isoforms.

Published in:

Microscopy & Microanalysis, 2008, v. 14, n. S3, p. 141, doi. 10.1017/S143192760808968X

By:

Sousa, C.;
Vintém, A.P.;
Fardilha, M.;
Silva, O. da Cruz e;
Silva, E. da Cruz e

Publication type:

Article

Evaluation of DNMT1 gene expression profile and methylation of its promoter region in patients with ankylosing spondylitis.

Published in:

Clinical Rheumatology, 2016, v. 35, n. 11, p. 2723, doi. 10.1007/s10067-016-3403-x

By:

Aslani, Saeed;
Mahmoudi, Mahdi;
Garshasbi, Masoud;
Jamshidi, Ahmad;
Karami, Jafar;
Nicknam, Mohammad

Publication type:

Article

Optimizing vector application for gene transfer into human hepatoblastoma cells.

Published in:

2006

By:

Warmann, Steven;
Armeanu, Sorin;
Heitmann, Heike;
Ruck, Peter;
Seitz, Guido;
Wessels, Johannes;
Lemken, Marie-Luise;
Lauer, Ulrich;
Fuchs, Jörg;
Bitzer, Michael;
Warmann, Steven W;
Wessels, Johannes T;
Lauer, Ulrich M;
Fuchs, Jörg

Publication type:

journal article

In vitro gene targeting in human hepatoblastoma.

Published in:

2006

By:

Warmann, Steven W.;
Armeanu, Sorin;
Frank, Heike;
Buck, Heike;
Graepler, Florian;
Lemken, Marie-Luise;
Heitmann, Heike;
Seitz, Guido;
Lauer, Ulrich M.;
Bitzer, Michael;
Fuchs, Jörg;
Fuchs, Jörg

Publication type:

journal article

Magnesium transport in the aglomerular kidney of the Gulf toadfish (Opsanus beta).

Published in:

Journal of Comparative Physiology B: Biochemical, Systemic & Environmental Physiology, 2021, v. 191, n. 5, p. 865, doi. 10.1007/s00360-021-01392-8

By:

Hansen, Nina G. Walker;
Madsen, Steffen S.;
Brauckhoff, Melanie;
Heuer, Rachael M.;
Schlenker, Lela S.;
Engelund, Morten B.;
Grosell, Martin

Publication type:

Article

Ecdysone-responsive transcription factors determine the expression region of target cuticular protein genes in the epidermis of Bombyx mori.

Published in:

Development Genes & Evolution, 2012, v. 222, n. 2, p. 89, doi. 10.1007/s00427-012-0392-x

By:

Ali, Md.;
Iwanaga, Masashi;
Kawasaki, Hideki

Publication type:

Article

Insertion orientation within the cassette affects gene-targeting success during ends-out recombination in the yeast Saccharomyces cerevisiae.

Published in:

Current Genetics, 2022, v. 68, n. 5/6, p. 551, doi. 10.1007/s00294-022-01246-y

By:

Mitrikeski, Petar Tomev

Publication type:

Article

Homology length dictates the requirement for Rad51 and Rad52 in gene targeting in the Basidiomycota yeast Naganishia liquefaciens.

Published in:

Current Genetics, 2021, v. 67, n. 6, p. 919, doi. 10.1007/s00294-021-01201-3

By:

Palihati, Maierdan;
Tsubouchi, Hideo;
Argunhan, Bilge;
Kajitani, Rei;
Bakenova, Omirgul;
Han, Yong-Woon;
Murayama, Yasuto;
Itoh, Takehiko;
Iwasaki, Hiroshi

Publication type:

Article

Genetic characteristics and phylogenetic analysis of Brazilian clinical strains of Pseudomonas aeruginosa harboring CRISPR/Cas systems.

Published in:

Current Genetics, 2021, v. 67, n. 4, p. 663, doi. 10.1007/s00294-021-01173-4

By:

de Oliveira Luz, Ana Carolina;
da Silva Junior, Wilson José;
do Nascimento Junior, José Bandeira;
da Silva, Julia Mariana Assis;
de Queiroz Balbino, Valdir;
Leal-Balbino, Tereza Cristina

Publication type:

Article

A conserved role for transcription factor sumoylation in binding-site selection.

Published in:

Current Genetics, 2019, v. 65, n. 6, p. 1307, doi. 10.1007/s00294-019-00992-w

By:

Rosonina, Emanuel

Publication type:

Article

Ubiquitin-like activating enzymes BcAtg3 and BcAtg7 participate in development and pathogenesis of Botrytis cinerea.

Published in:

Current Genetics, 2018, v. 64, n. 4, p. 919, doi. 10.1007/s00294-018-0810-3

By:

Ren, Weichao;
Sang, Chengwei;
Shi, Dongya;
Song, Xiushi;
Zhou, Mingguo;
Chen, Changjun

Publication type:

Article