Works matching DE "DRUG target"

Results: 5000

RESEARCH OF PHYSICOCHEMICAL, PHARMACOKINETIC AND DRUGLIKENESS PARAMETERS OF A SERIES OF 5-ARYLIDENE DERIVATIVES OF 3-(BENZO[d]THIAZOL-2-YLAMINO)-2-THIOXOTHIAZOLIDIN-4-ONE).

Published in:

Issues of Chemistry & Chemical Technology / Voprosy Khimii & Khimicheskoi Tekhnologii, 2025, n. 3, p. 4, doi. 10.32434/0321-4095-2025-160-3-4-12

By:

Mosula, L. M.;
Chudinovych, K. S.

Publication type:

Article

Viral hijacking of host DDX60 promotes Crimean-Congo haemorrhagic fever virus replication via G-quadruplex unwinding.

Published in:

PLoS Pathogens, 2025, v. 21, n. 6, p. 1, doi. 10.1371/journal.ppat.1013278

By:

Sui, Yutong;
Xu, Qi;
Liu, Mingsheng;
Liu, Xiaomei;
Liu, Xinpeng;
Wang, Yujie;
Meng, Xiangyuan;
Liu, Zinan;
Li, Quanshun;
Liu, Jinyu

Publication type:

Article

Biological Susceptibility of Patients with Schizophrenia to Metabolic Syndrome: A Review.

Published in:

Alpha Psychiatry, 2025, v. 26, n. 2, p. 1, doi. 10.31083/AP39896

By:

Jun Ma;
Zhengyuan Huang;
Jing Chen;
Gaohua Wang

Publication type:

Article

Targeting the Liver Serine Protease TMPRSS6 Ameliorates Steatosis and Attenuates Fibrosis in Experimental MASLD.

Published in:

Liver International, 2025, v. 45, n. 7, p. 1, doi. 10.1111/liv.70163

By:

Pettinato, Mariateresa;
Furiosi, Valeria;
Carleo, Rossana;
Bavuso Volpe, Letizia;
Guo, Shuling;
Mannella, Valeria;
Musco, Giovanna;
Gilberti, Enrica;
De Palma, Giuseppe;
Federico, Giorgia;
Carlomagno, Francesca;
Cherubini, Alessandro;
Pelusi, Serena;
Dano, Anxhela;
Nai, Antonella;
Valenti, Luca;
Altamura, Sandro;
Pagani, Alessia;
Silvestri, Laura

Publication type:

Article

Microplastics as Emerging Contaminants and Human Health: Exploring Functional Nutrition in Gastric–Colon–Brain Axis Cancer.

Published in:

Toxics, 2025, v. 13, n. 6, p. 438, doi. 10.3390/toxics13060438

By:

Scuto, Maria;
Lombardo, Cinzia Maria Grazia;
Lo Sasso, Bruna;
Di Fatta, Eleonora;
Ferri, Raffaele;
Trovato Salinaro, Angela

Publication type:

Article

Novel Antischistosomal Drug Targets: Identification of Alkaloid Inhibitors of SmTGR via Integrated In Silico Methods.

Published in:

Pathogens, 2025, v. 14, n. 6, p. 591, doi. 10.3390/pathogens14060591

By:

Paixão, Valéria V. M.;
Santos, Yria J. A.;
Fernandes, Adriana O.;
Conceição, Elaine S.;
Rodrigues, Ricardo P.;
Chagas-Paula, Daniela A.;
Dolabella, Silvio S.;
Oliveira, Tiago B.

Publication type:

Article

Inflammatory Bowel Disease in the Post-STRIDE II Era: Epidemiology and Long-Term Clinical Outcomes from a Population-Based Study.

Published in:

Medical Sciences, 2025, v. 13, n. 2, p. 55, doi. 10.3390/medsci13020055

By:

Ingravalle, Fabio;
Valvano, Marco;
Barbara, Andrea;
Bardhi, Dorian;
Latella, Giovanni;
Viscido, Angelo;
Campanale, Mariachiara;
Vinci, Antonio;
Viora, Carlo;
Bulfone, Giampiera;
Mazzotta, Rocco;
Maurici, Massimo

Publication type:

Article

Recent Advancements in Understanding the Role and Mechanisms of Angiopoietin-like Proteins in Diabetic Retinopathy.

Published in:

Metabolites (2218-1989), 2025, v. 15, n. 6, p. 352, doi. 10.3390/metabo15060352

By:

Zhang, Xinling;
Liu, Dongang;
Qiu, Yuting;
Hu, Ruiyao;
Chen, Shiyu;
Xu, Yue;
Qian, Chenyan;
Du, Lailing;
Yuan, Jinghua;
Li, Xiaoping

Publication type:

Article

Thienopyrimidine: Unveiling the Versatile Potential of a Promising Heterocyclic Scaffold in Drug Discovery.

Published in:

Chemical Biology & Drug Design, 2025, v. 105, n. 6, p. 1, doi. 10.1111/cbdd.70146

By:

Nadar, Sahaya;
Borkar, Maheshkumar;
Khan, Tabassum

Publication type:

Article

Impaired splicing machinery in craniopharyngiomas unveils PRPF8 and RAVER1 as novel biomarkers and therapeutic targets.

Published in:

Acta Neuropathologica Communications, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40478-025-02040-w

By:

Fuentes-Fayos, Antonio C.;
G-García, Miguel E.;
Sánchez-Medianero, Teresa;
Apps, John;
Flores-Martínez, Álvaro;
De la Rosa-Herencia, Ana S.;
Gil-Duque, Ignacio;
Otto, Georg;
Venegas-Moreno, Eva;
Ruiz-Valdepeñas, Eugenio Cárdenas;
Herrera-Martínez, Aura D.;
Solivera, Juan;
Gahete, Manuel D.;
Cano, David A.;
Ortega, Rosa;
Soto-Moreno, Alfonso;
Gálvez-Moreno, María A.;
Martínez-Barberá, Juan Pedro;
Luque, Raúl M.

Publication type:

Article

Medulloblastoma: Molecular Targets and Innovative Theranostic Approaches.

Published in:

Pharmaceutics, 2025, v. 17, n. 6, p. 736, doi. 10.3390/pharmaceutics17060736

By:

Foti, Alice;
Allia, Fabio;
Briglia, Marilena;
Malaguarnera, Roberta;
Tamburrini, Gianpiero;
Cecconi, Francesco;
Pagliarini, Vittoria;
Nazio, Francesca;
Graziano, Adriana Carol Eleonora

Publication type:

Article

Beyond ADME: The Endogenous Functions of Drug Transporters and Its Impact on Human Disease.

Published in:

Pharmaceutics, 2025, v. 17, n. 6, p. 685, doi. 10.3390/pharmaceutics17060685

By:

Blaze, Christine;
Shu, Yan

Publication type:

Article

Cardiovascular and Renal Outcomes Following Repeated Naringenin Exposure in Normotensive and Hypertensive Rats.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 6, p. 873, doi. 10.3390/ph18060873

By:

Dada, Anelize;
Vilhena da Silva, Rita de Cássia;
Zanovello, Mariana;
Macarini, Anelise Felício;
Boeing, Thaise;
Cechinel Filho, Valdir;
de Souza, Priscila

Publication type:

Article

SPHK1 - S1p Signaling Drives Fibrocyte-Mediated Pulmonary Fibrosis: Mechanistic Insights and Therapeutic Potential.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 6, p. 859, doi. 10.3390/ph18060859

By:

Lu, Fei;
Wang, Gaoming;
Yang, Xiangzhe;
Luo, Jing;
Ma, Haitao;
Pan, Liangbin;
Yao, Yu;
Xie, Kai

Publication type:

Article

Multitarget Compounds Designed for Alzheimer, Parkinson, and Huntington Neurodegeneration Diseases.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 6, p. 831, doi. 10.3390/ph18060831

By:

Katsoulaki, Eleftheria-Emmanouela;
Dimopoulos, Dimitrios;
Hadjipavlou-Litina, Dimitra

Publication type:

Article

Progress in the Genetics of Myelodysplastic Syndromes with a Latin American Perspective.

Published in:

Genes, 2025, v. 16, n. 6, p. 687, doi. 10.3390/genes16060687

By:

Basquiera, Ana Lisa;
Andreoli, Verónica;
Grille, Sofía;
Belli, Carolina Bárbara

Publication type:

Article

The Complex Role of the miR-17-92 Cluster in Stroke: Mechanistic Insights and Biomarker Potential.

Published in:

Genes, 2025, v. 16, n. 6, p. 665, doi. 10.3390/genes16060665

By:

Braicu, Cornelia;
Molnar, Mihaela;
Isachesku, Ekaterina;
Pană, Adrian;
Mureșanu, Dafin;
Strilciuc, Stefan

Publication type:

Article

Systems virology: host-directed approaches to viral pathogenesis and drug targeting.

Published in:

Nature Reviews Microbiology, 2013, v. 11, n. 7, p. 455, doi. 10.1038/nrmicro3036

By:

Law, G. Lynn;
Korth, Marcus J.;
Benecke, Arndt G.;
Katze, Michael G.

Publication type:

Article

Transdisciplinary research and clinical priorities for better health.

Published in:

2021

By:

Fontana, Luigi;
Fasano, Alessio;
Chong, Yap Seng;
Vineis, Paolo;
Willett, Walter C.

Publication type:

journal article

Nanomaterials in Cerebrovascular Disease Diagnose and Treatment.

Published in:

Particle & Particle Systems Characterization, 2021, v. 38, n. 5, p. 1, doi. 10.1002/ppsc.202000311

By:

Luo, Yin;
Wang, Yanting;
Fu, Jie

Publication type:

Article

Capillary electrophoresis integrated immobilized enzyme reactor for kinetic and inhibition assays of β‐secretase as the Alzheimer's disease drug target.

Published in:

Journal of Separation Science, 2019, v. 42, n. 5, p. 1067, doi. 10.1002/jssc.201800947

By:

Schejbal, Jan;
Šefraná, Šárka;
Řemínek, Roman;
Glatz, Zdeněk

Publication type:

Article

Multiplatform profiling of meningioma provides molecular insight and prioritization of drug targets for rational clinical trial design.

Published in:

Journal of Neuro-Oncology, 2018, v. 139, n. 2, p. 469, doi. 10.1007/s11060-018-2891-8

By:

Everson, Richard G.;
Hashimoto, Yuuri;
Freeman, Jacob L.;
Hodges, Tiffany R.;
Huse, Jason;
Zhou, Shouhao;
Xiu, Joanne;
Spetzler, David;
Sanai, Nader;
Kim, Lyndon;
Kesari, Santosh;
Brenner, Andrew;
De Monte, Franco;
Heimberger, Amy;
Raza, Shaan M.

Publication type:

Article

Breaking resistance: in silico subtractive and comparative genomics approaches for drug targeting in Bacteroides fragilis.

Published in:

Biotechnology Letters, 2024, v. 46, n. 6, p. 1249, doi. 10.1007/s10529-024-03537-5

By:

Zia, Tehreem;
Khan, Kanwal;
Aghayeva, Saltanat;
Uddin, Reaz

Publication type:

Article

Network pharmacological evaluation of strigolactones efficacy as potential inhibitors against therapeutic targets of hepatocellular carcinoma.

Published in:

Biotechnology Letters, 2022, v. 44, n. 7, p. 879, doi. 10.1007/s10529-022-03266-7

By:

Amod, Ayush;
Pahal, Sonu;
Choudhary, Princy;
Gupta, Ayushi;
Singh, Sangeeta

Publication type:

Article

Integrated bioinformatics based subtractive genomics approach to decipher the therapeutic function of hypothetical proteins from Salmonella typhi XDR H-58 strain.

Published in:

Biotechnology Letters, 2022, v. 44, n. 2, p. 279, doi. 10.1007/s10529-021-03219-6

By:

Khan, Kanwal;
Uddin, Reaz

Publication type:

Article

Repurposing a drug targeting peptide for targeting antimicrobial peptides against Staphylococcus.

Published in:

Biotechnology Letters, 2020, v. 42, n. 2, p. 287, doi. 10.1007/s10529-019-02779-y

By:

Choudhury, Ankan;
Islam, S. M. Ashiqul;
Ghidey, Meron R.;
Kearney, Christopher Michel

Publication type:

Article

Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion.

Published in:

Molecular Medicine, 2023, v. 29, n. 1, p. 1, doi. 10.1186/s10020-023-00664-z

By:

Wilk, Elizabeth J.;
Howton, Timothy C.;
Fisher, Jennifer L.;
Oza, Vishal H.;
Brownlee, Ryan T.;
McPherson, Kasi C.;
Cleary, Hannah L.;
Yoder, Bradley K.;
George, James F.;
Mrug, Michal;
Lasseigne, Brittany N.

Publication type:

Article

Correction: Identification of kukoamine a as an anti-osteoporosis drug target using network pharmacology and experiment verification.

Published in:

2023

By:

Luo, Liying;
Guan, Zhiyuan;
Jin, Xiao;
Guan, Zhiqiang;
Jiang, Yanyun

Publication type:

Correction Notice

Identification of kukoamine a as an anti-osteoporosis drug target using network pharmacology and experiment verification.

Published in:

Molecular Medicine, 2023, v. 29, n. 1, p. 1, doi. 10.1186/s10020-023-00625-6

By:

Luo, Liying;
Guan, Zhiyuan;
Jin, Xiao;
Guan, Zhiqiang;
Jiang, Yanyun

Publication type:

Article

Relevance of the pyroptosis-related inflammasome drug targets in the Chuanxiong to improve diabetic nephropathy.

Published in:

Molecular Medicine, 2022, v. 28, n. 1, p. 1, doi. 10.1186/s10020-022-00567-5

By:

Li, ChangYan;
Ma, JingYuan;
Mali, Niroj;
Zhang, Le;
Wei, Tao;
Shi, LuYao;
Liu, Fang;
WenXing, Fan;
Yang, Jing

Publication type:

Article

Role of long non-coding RNA H19 in the development of osteoporosis.

Published in:

Molecular Medicine, 2021, v. 27, n. 1, p. 1, doi. 10.1186/s10020-021-00386-0

By:

Chen, Senxiang;
Liu, Da;
Zhou, Zimo;
Qin, Sen

Publication type:

Article

Macrophages and cancer stem cells: a malevolent alliance.

Published in:

Molecular Medicine, 2021, v. 27, n. 1, p. 1, doi. 10.1186/s10020-021-00383-3

By:

Allavena, Paola;
Digifico, Elisabeth;
Belgiovine, Cristina

Publication type:

Article

MicroRNA regulation of the proliferation and apoptosis of Leydig cells in diabetes.

Published in:

Molecular Medicine, 2021, v. 27, n. 1, p. 1, doi. 10.1186/s10020-021-00370-8

By:

Hu, Li;
Wei, Shaochai;
Wu, Yuqi;
Li, Shulin;
Zhu, Pei;
Wang, Xiangwei

Publication type:

Article

Visualizing Epigenetics: A Review of Microscopy Techniques for Investigating DNA Methylation Patterns, Chromatin Structure, and Gene Expression.

Published in:

Microscopy & Microanalysis, 2025, v. 31, n. 2, p. 1, doi. 10.1093/mam/ozaf017

By:

Thompson, Anna-Lee C;
Wopereis, Judith L M;
Tekle, Yonas I;
Katz, Laura A

Publication type:

Article

Lessons Taught and Lessons Learned from Teaching Cryo-EM Courses.

Published in:

Microscopy & Microanalysis, 2024, v. 30, p. 1, doi. 10.1093/mam/ozae044.436

By:

Lander, Gabriel C

Publication type:

Article

Delivering Consistent and Efficient Imaging for SPA with HexAuFoil<sup>®</sup> Sample Supports.

Published in:

Microscopy & Microanalysis, 2024, v. 30, p. 1, doi. 10.1093/mam/ozae044.370

By:

Naylor, Claire;
Vandekerckhove, Herve

Publication type:

Article

From Crystals to Cells: Freezing Challenging Biological Targets With The VitroJet.

Published in:

Microscopy & Microanalysis, 2024, v. 30, p. 1, doi. 10.1093/mam/ozae044.359

By:

Yang, Jie E;
Sibert, Bryan;
Larson, Matt;
Wright, Elizabeth R

Publication type:

Article

Resveratrol Alleviates Liver Fibrosis by Targeting Cross‐Talk Between TLR2/MyD88/ERK and NF‐κB/NLRP3 Inflammasome Pathways in Macrophages.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 3, p. 1, doi. 10.1002/jbt.70208

By:

Lei, Jin‐qing;
Xie, Qing‐li;
Li, Qing‐ping;
Qin, Shan‐yu;
Wu, Jiao‐hua;
Jiang, Hai‐xing;
Yu, Bing;
Luo, Wei

Publication type:

Article

Mechanistic Insight of Pharmacological Aspects of Violacein: Recent Trends and Advancements.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 2, p. 1, doi. 10.1002/jbt.70114

By:

Chauhan, Abhishek;
Mathkor, Darin Mansor;
Joshi, Hemant;
Chauhan, Ritu;
Sharma, Ujjawal;
Sharma, Vikas;
Kumar, Manoj;
Saini, Reena V.;
Saini, Adesh K.;
Tuli, Hardeep Singh;
Kaur, Damandeep;
Haque, Shafiul

Publication type:

Article

Study on the Role of microRNA‐138‐5p Through Sorbin and SH3 Domain‐Containing Protein 2 in Breast Cancer.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 12, p. 1, doi. 10.1002/jbt.70081

By:

Zhang, LiGong;
Zhu, Chao;
Guo, Chenxu;
Yin, FaXiang;
Xie, Qiang;
Tao, Min

Publication type:

Article

Targeted therapy: P2X3 receptor silencing in bone cancer pain relief.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 11, p. 1, doi. 10.1002/jbt.70026

By:

Jiang, Yuge;
Liu, Xuan;
Zhang, Hong;
Xu, Longhe

Publication type:

Article

Exploring the anticancer potential of new 3‐cyanopyridine derivatives bearing N‐acylhydrazone motif: Synthesis, DFT calculations, cytotoxic evaluation, molecular modeling, and antioxidant properties.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 9, p. 1, doi. 10.1002/jbt.23819

By:

Kadi, Ibtissem;
Şekerci, Güldeniz;
Boulebd, Houssem;
Zebbiche, Zineddine;
Tekin, Suat;
Benarous, Khedidja;
Serseg, Talia;
Küçükbay, Fatümetüzzehra;
Küçükbay, Hasan;
Boumoud, Taoues

Publication type:

Article

Luteolin: Nature's promising warrior against Alzheimer's and Parkinson's disease.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 1, p. 1, doi. 10.1002/jbt.23619

By:

Goyal, Ahsas;
Solanki, Kunal;
Verma, Aanchal

Publication type:

Article

Circ‐ERBB2 knockdown sensitized colorectal cancer cells to 5‐FU via miR‐181a‐5p/PTEN/Akt pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2023, v. 37, n. 4, p. 1, doi. 10.1002/jbt.23297

By:

Zhang, Yueli;
Wang, Xinchun;
Wang, Shuyun;
Liu, Jia;
Li, Ruijia;
Li, Xiaoxia;
Zhang, Rui

Publication type:

Article

Exploring genetic links between blood metabolites and gout susceptibility.

Published in:

Clinical Rheumatology, 2024, v. 43, n. 12, p. 3901, doi. 10.1007/s10067-024-07215-9

By:

Zeng, Wenxing;
Hu, Minhua;
Zhou, Lin;
Cun, Dejun;
Ma, Luyao;
Zhang, Jingtao;
Huang, Feng;
Jiang, Ziwei

Publication type:

Article

Prioritizing drug targets in systemic lupus erythematosus from a genetic perspective: a druggable genome-wide Mendelian randomization study.

Published in:

Clinical Rheumatology, 2024, v. 43, n. 9, p. 2843, doi. 10.1007/s10067-024-07059-3

By:

Gao, Yuan;
Zhou, Youtao;
Lin, Zikai;
Chen, Fengzhen;
Wu, Haiyang;
Peng, Chusheng;
Xie, Yingying

Publication type:

Article

Genetically proxied therapeutic inhibition of lipid-lowering drug targets and risk of rheumatoid arthritis disease: a Mendelian randomization study.

Published in:

Clinical Rheumatology, 2024, v. 43, n. 3, p. 939, doi. 10.1007/s10067-023-06837-9

By:

Qiao, Liang;
Lv, Shun;
Meng, Kai;
Yang, Jianmei

Publication type:

Article

Synovial biopsies in clinical practice and research: current developments and perspectives.

Published in:

Clinical Rheumatology, 2021, v. 40, n. 7, p. 2593, doi. 10.1007/s10067-020-05512-7

By:

Johnsson, Hanna;
Najm, Aurélie

Publication type:

Article

Potential of miRNA as Imaging Targets for PET.

Published in:

Helvetica Chimica Acta, 2024, v. 107, n. 8, p. 1, doi. 10.1002/hlca.202400014

By:

Zientek, Simon H.;
Thompson, Stephen;
Aigbirhio, Franklin I.;
Sephton, Selena Milicevic

Publication type:

Article

Endometriosis, the Silent Disease: Molecular Targets, Active Principles, and Drug Delivery Systems.

Published in:

Helvetica Chimica Acta, 2023, v. 106, n. 1, p. 1, doi. 10.1002/hlca.202200132

By:

Teworte, Sarah;
Luciani, Paola

Publication type:

Article