Works about DRUG repositioning

Results: 1940

Genetic Architecture of Idiopathic Inflammatory Myopathies From Meta‐Analyses.

Published in:

Arthritis & Rheumatology, 2025, v. 77, n. 6, p. 750, doi. 10.1002/art.43088

By:

Zhu, Catherine;
Han, Younghun;
Byun, Jinyoung;
Xiao, Xiangjun;
Rothwell, Simon;
Miller, Frederick W.;
Lundberg, Ingrid E.;
Gregersen, Peter K.;
Vencovsky, Jiri;
Shaw, Vikram R.;
McHugh, Neil;
Limaye, Vidya;
Selva‐O'Callaghan, Albert;
Hanna, Michael G.;
Machado, Pedro M.;
Pachman, Lauren M.;
Reed, Ann M.;
Rider, Lisa G.;
Molberg, Øyvind;
Benveniste, Olivier

Publication type:

Article

Purposeful Drug Repurposing.

Published in:

2025

By:

Nagele, Peter;
Conway, Charles R.;
Zorumski, Charles F.

Publication type:

Opinion

Repurposing of CNS accumulating drugs Gemfibrozil and Doxylamine for enhanced sensitization of glioblastoma cells through modulation of autophagy.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-05054-5

By:

Dey, Smita;
Mathur, Prerika;
Mukherjee, Sudeshna;
Chowdhury, Rajdeep;
Majumder, Syamantak;
Roy, Aniruddha;
Chowdhury, Shibasish

Publication type:

Article

An example of drug repurposing: ebastine in combination with docetaxel as a treatment for metastatic castration-resistant prostate cancer–the EXUROC prostate study, a clinical trial protocol.

Published in:

BMC Urology, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12894-025-01837-0

By:

Ørum, Katrine;
Stormoen, Dag R.;
Lauritsen, Jakob;
Rohde, Mikkel;
Jäättelä, Marja;
Pappot, Helle

Publication type:

Article

Drug Repurposing for Targeting ISL LIM Homeobox 2 in Treatment of Endometriosis: A Computational Study.

Published in:

International Journal of Fertility & Sterility, 2025, v. 19, n. 3, p. 277, doi. 10.22074/ijfs.2025.2009299.1516

By:

Mahdian, Soodeh;
Favaedi, Raha;
Mikaeeli, Gelareh;
Moini, Ashraf;
Shahhoseini, Maryam

Publication type:

Article

In-silico drug repositioning studies of Candida albicans Nitrogen permease reactivator 1 (Npr1) kinase.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-08148-2

By:

Das, Sanjib;
Bagchi, Arka;
Bera, Analava;
Biswas, Arunima;
Roy, Analabha;
Ganguly, Rik;
Mondal, Amalesh;
Chattopadhyay, Deepanjan;
Mondal, Paromita Saha;
Mondal, Tanushree;
Samanta, Subhasree;
Goswami, Achintya Mohan;
Saha, Tanima

Publication type:

Article

The hormonal nexus in PIK3CA-mutated meningiomas: implications for targeted therapy and clinical trial design.

Published in:

Journal of Neuro-Oncology, 2025, v. 174, n. 2, p. 329, doi. 10.1007/s11060-025-05082-1

By:

Abikenari, Matthew;
Regev, Amit;
Himic, Vratko;
Choi, John;
Jeyaretna, Sanjeeva;
Fountain, Daniel M.;
Lim, Michael

Publication type:

Article

Empagliflozin Repurposing for Lafora Disease: A Pilot Clinical Trial and Preclinical Investigation of Novel Therapeutic Targets.

Published in:

Methods & Protocols, 2025, v. 8, n. 3, p. 48, doi. 10.3390/mps8030048

By:

d'Orsi, Giuseppe;
Liantonio, Antonella;
Imbrici, Paola;
Gambacorta, Nicola;
Dinoi, Giorgia;
Altomare, Cosimo Damiano;
Carella, Massimo

Publication type:

Article

Dapagliflozin and Silymarin Ameliorate Cisplatin-Induced Nephrotoxicity via Nrf2/HO-1 Upregulation: A Preclinical Mechanistic Study.

Published in:

Sci (2413-4155), 2025, v. 7, n. 2, p. 59, doi. 10.3390/sci7020059

By:

Satyam, Shakta Mani;
Bairy, Laxminarayana Kurady;
Rehman, Abdul;
Nair, Anuradha Asokan;
Farook, Mohamed;
Binu, Nirmal Nachiketh;
Khan, Sofiya;
Yehya, Mohamed;
Khan, Mohammed Moin

Publication type:

Article

Remdesivir is active in vitro against tick-borne encephalitis virus and selects for resistance mutations in the viral RNA-dependent RNA polymerase.

Published in:

Infectious Diseases, 2025, v. 57, n. 7, p. 628, doi. 10.1080/23744235.2025.2468510

By:

Nyström, Kristina;
Trybala, Edward;
Said, Joanna;
Roth, Anette;
Patzi Churqui, Marianela;
Kärmander, Ambjörn;
Cihlar, Tomas;
Bilello, John P.;
Bergström, Tomas;
Lagging, Martin

Publication type:

Article

Histamine H<sub>3</sub> receptor: an emerging target for cancer therapy?

Published in:

Inflammation Research, 2025, v. 74, n. 1, p. 1, doi. 10.1007/s00011-025-02054-z

By:

Lauretta, Paolo;
Martinez Vivot, Rocio;
Velazco, Agueda;
Medina, Vanina A.

Publication type:

Article

Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer.

Published in:

Medical Sciences, 2025, v. 13, n. 2, p. 47, doi. 10.3390/medsci13020047

By:

Hunt, Sunny;
Thyagarajan, Anita;
Sahu, Ravi P.

Publication type:

Article

Beyond Transgenic Mice: Emerging Models and Translational Strategies in Alzheimer's Disease.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5541, doi. 10.3390/ijms26125541

By:

Alexandra Lopes, Paula;
Guil-Guerrero, José L.

Publication type:

Article

Development and Application of a Senolytic Predictor for Discovery of Novel Senolytic Compounds and Herbs.

Published in:

Molecules, 2025, v. 30, n. 12, p. 2653, doi. 10.3390/molecules30122653

By:

Li, Jinjun;
Zhao, Kai;
Yang, Guotai;
Lv, Haohao;
Zhang, Renxin;
Li, Shuhan;
Chen, Zhiyuan;
Xu, Min;
Yang, Naixue;
Dai, Shaoxing

Publication type:

Article

Identification and Evaluation of Besifloxacin as Repurposed Antifungal Drug in Combination With Fluconazole Against Candida albicans.

Published in:

Chemical Biology & Drug Design, 2025, v. 105, n. 6, p. 1, doi. 10.1111/cbdd.70138

By:

Chakraborty, Shuvechha;
Pawaskar, Ameya;
Metkari, Siddhanath;
Madan, Taruna;
Idicula‐Thomas, Susan

Publication type:

Article

Drug repurposing candidates for amyotrophic lateral sclerosis using common and rare genetic variants Open Access.

Published in:

Brain Communications, 2025, v. 7, n. 3, p. 1, doi. 10.1093/braincomms/fcaf184

By:

Gerring, Zachary F;
Bhalala, Oneil G;
Fearnley, Liam G;
Oikari, Lotta E;
White, Anthony R;
Derks, Eske M;
Watson, Rosie;
Yassi, Nawaf;
Bahlo, Melanie;
Reay, William R

Publication type:

Article

Bioadhesive Eudragit RL ® 100 Nanocapsules for Melanoma Therapy: A Repurposing Strategy for Propranolol.

Published in:

Pharmaceutics, 2025, v. 17, n. 6, p. 718, doi. 10.3390/pharmaceutics17060718

By:

Mieres, Naomi Gerzvolf;
Simião, Soraia de Oliveira;
Cruz, Luiza Stolz;
Melo, Rafaela Cirillo de;
Khalil, Najeh Maissar;
Bonini, Juliana Sartori;
Rego, Fabiane Gomes de Moraes;
Sari, Marcel Henrique Marcondes;
Pontarolo, Roberto;
Lazo, Raul Edison Luna;
Reolon, Jéssica Brandão;
Ferreira, Luana Mota

Publication type:

Article

In Silico Investigation of TATA-Binding Protein as a Therapeutic Target for Chagas Disease: Insights into FDA Drug Repositioning.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 6, p. 845, doi. 10.3390/ph18060845

By:

Gaona-López, Carlos;
Méndez-Álvarez, Domingo;
Gonzalez-Gonzalez, Alonzo;
Avalos-Navarro, Guadalupe;
Paz-González, Alma D.;
Moreno-Rodríguez, Adriana;
Nogueda-Torres, Benjamín;
Rivera, Gildardo

Publication type:

Article

Incretins: How we got here, where we're at and what is coming next.

Published in:

Journal of Diabetes Nursing, 2024, v. 28, n. 1, p. 1

By:

Morris, David

Publication type:

Article

基于SPO 语义三元组的自闭症谱系障碍药物知识发现.

Published in:

Chinese Nursing Research, 2024, v. 38, n. 5, p. 796, doi. 10.12102/j.issn.1009-6493.2024.05.007

By:

吕艳华;
赵宏霞;
李琦;
梁傲雪;
于琦

Publication type:

Article

Potential drug repurposing of ruxolitinib to inhibit the JAK/STAT pathway for the treatment of patients with epithelial ovarian cancer.

Published in:

Journal of Obstetrics & Gynaecology Research, 2023, v. 49, n. 11, p. 2563, doi. 10.1111/jog.15761

By:

Yunianto, Irfan;
Currie, Margaret;
Chitcholtan, Kenny;
Sykes, Peter

Publication type:

Article

Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion.

Published in:

Molecular Medicine, 2023, v. 29, n. 1, p. 1, doi. 10.1186/s10020-023-00664-z

By:

Wilk, Elizabeth J.;
Howton, Timothy C.;
Fisher, Jennifer L.;
Oza, Vishal H.;
Brownlee, Ryan T.;
McPherson, Kasi C.;
Cleary, Hannah L.;
Yoder, Bradley K.;
George, James F.;
Mrug, Michal;
Lasseigne, Brittany N.

Publication type:

Article

Modular networks and genomic variation during progression from stable angina pectoris through ischemic cardiomyopathy to chronic heart failure.

Published in:

Molecular Medicine, 2022, v. 28, n. 1, p. 1, doi. 10.1186/s10020-022-00569-3

By:

Chen, Lin;
Yu, Ya-Nan;
Liu, Jun;
Chen, Yin-ying;
Wang, Bo;
Qi, Yi-Fei;
Guan, Shuang;
Liu, Xi;
Li, Bing;
Zhang, Ying-Ying;
Hu, Yuanhui;
Wang, Zhong

Publication type:

Article

Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients' treatment.

Published in:

NPJ Aging, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41514-024-00138-4

By:

Lelarge, V.;
Capelle, R.;
Oger, F.;
Mathieu, T.;
Le Calvé, B.

Publication type:

Article

Biomarker repurposing: opportunities and challenges in the evolving field of laboratory medicine.

Published in:

2025

By:

Gruson, Damien;
Menghoun, Nassiba;
Pouleur, Anne-Catherine;
Bayes Genis, Antoni

Publication type:

Letter

Repurposing of nervous system drugs for cancer treatment: recent advances, challenges, and future perspectives.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02067-4

By:

Wang, Zixun;
Xu, Chen;
Wang, Qi;
Wang, Yudong

Publication type:

Article

Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-01763-5

By:

Niwata, Chieko;
Nakagawa, Takayuki;
Naruse, Takako;
Sakuma, Miyuki;
Yamakado, Nao;
Akagi, Misaki;
Ono, Shigehiro;
Tobiume, Kei;
Gao, Jing;
Jimi, Eijiro;
Ohta, Kouji;
Aikawa, Tomonao

Publication type:

Article

Structural Insights and Drug Repurposing of FDA-Approved Molecules against Human Agmatinase in Cancer Therapy.

Published in:

Journal of Computational Biophysics & Chemistry, 2025, v. 24, n. 6, p. 767, doi. 10.1142/S2737416524500820

By:

Khan, Zeeshan;
Ikram, Saima;
Ahmad, Jamshaid;
Ur Rehman, Irshad;
Ahsan, Hina;
Ullah, Amin;
Alshaya, Dalal Sulaiman;
Fayad, Eman;
Hassan, Hesham M.;
Eldeen, Muhammad Alaa

Publication type:

Article

Editorial: Special Issue on Graph Representation Learning in Drug Repositioning.

Published in:

2025

By:

Hu, Lun;
Hu, Pengwei;
Huang, Yu-An

Publication type:

Editorial

Machine Learning-Based Drug Repositioning of Novel Human Aromatase Inhibitors Utilizing Molecular Docking and Molecular Dynamic Simulation.

Published in:

Journal of Computational Biophysics & Chemistry, 2025, v. 24, n. 3, p. 371, doi. 10.1142/S2737416524410035

By:

Bodun, Damilola Samuel;
Abdulwahab, Adeniyi Ayinde;
Adegbenro, Temitope Ibukunoluwa;
Chidinma, Emidun Olayinka;
Osunnaya, Samuel Aduramurewa;
Alonge, Mary Oluwatominsin;
Diyaolu, Zainab Olaide;
Abdulazeez, Muhammad Temitope;
Abolade, Rachael Oluwakamiye

Publication type:

Article

A Graph Deep Learning-Based Framework for Drug–Disease Association Identification with Chemical Structure Similarities.

Published in:

Journal of Computational Biophysics & Chemistry, 2025, v. 24, n. 3, p. 331, doi. 10.1142/S2737416523410053

By:

Zhao, Bo-Wei;
Su, Xiao-Rui;
Li, Dong-Xu;
Li, Guo-Dong;
Hu, Peng-Wei;
Zhao, Yong-Gang;
Hu, Lun

Publication type:

Article

An Ensemble Approach for Prioritizing Antivirals Against COVID-19 via Heterogeneous Network Inference-Based Inductive Matrix Completion.

Published in:

Journal of Computational Biophysics & Chemistry, 2025, v. 24, n. 3, p. 319, doi. 10.1142/S2737416523410041

By:

Aruna, A. S.;
Remesh Babu, K. R.;
Deepthi, K.

Publication type:

Article

Repurposing FDA-Approved Drugs as Potential Inhibitors of SARS-CoV-2 PLpro: A Comprehensive Computational Study.

Published in:

Journal of Computational Biophysics & Chemistry, 2024, v. 23, n. 9, p. 1209, doi. 10.1142/S273741652450039X

By:

Metwaly, Ahmed M.;
Elkaeed, Eslam B.;
Alsfouk, Aisha A.;
Ibrahim, Ibrahim M.;
Soliman, Omar A.;
Elkady, Hazem;
Eissa, Ibrahim H.

Publication type:

Article

Understanding the Binding Mode of Losartan Upon GPVI via a Molecular Simulation Study.

Published in:

Journal of Computational Biophysics & Chemistry, 2022, v. 21, n. 1, p. 23, doi. 10.1142/S2737416522500028

By:

Zheng, Zhichao;
Jin, Jing;
Liu, Lei;
Meng, Xiaoyan;
Li, Lingjun;
Wei, Qunchao;
Meng, Fancui

Publication type:

Article

Targeting Epigenetic Regulators Using Machine Learning: Potential Sirtuin 2 Inhibitors.

Published in:

Journal of Computational Biophysics & Chemistry, 2021, v. 20, n. 8, p. 841, doi. 10.1142/S2737416521500526

By:

Kessler, Andrew;
Kouznetsova, Valentina L.;
Tsigelny, Igor F.

Publication type:

Article

Colchicine as a potential HDAC inhibitor: comparative binding energies and prospects for cancer therapy repurposing.

Published in:

Journal of Research in Pharmacy, 2024, v. 28, n. 5, p. 1812, doi. 10.29228/jrp.853

By:

BURAN, Kerem

Publication type:

Article

In vitro, in silico and in vivo screening of non-oncology drugs for repurposing in osteosarcoma.

Published in:

Journal of Research in Pharmacy, 2023, v. 27, n. 2, p. 712, doi. 10.29228/jrp.354

By:

DESAI, Sujit;
MANJAPPA, Arehalli;
KHULBE, Preeti;
CHOUDHARİ, Prafulla;
KUMBHAR, Popat

Publication type:

Article

A spatial hierarchical network learning framework for drug repositioning allowing interpretation from macro to micro scale.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07107-3

By:

Ren, Zhonghao;
Zeng, Xiangxiang;
Lao, Yizhen;
Zheng, Heping;
You, Zhuhong;
Xiang, Hongxin;
Zou, Quan

Publication type:

Article

COMPUTATIONAL REPURPOSING OF FDA-APPROVED DRUGS AGAINST SPECIFIC MASTITIS-CAUSING PATHOGENS.

Published in:

Acta Scientiarum Polonorum seria Zootechnica, 2021, v. 20, n. 4, p. 5, doi. 10.21005/asp.2021.20.4.02

By:

Ghafoor, Naeem Abdul;
Sitkowska, Beata

Publication type:

Article

Insights on the crosstalk among different cell death mechanisms.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02328-9

By:

Eskander, Georgette;
Abdelhamid, Sherihan G.;
Wahdan, Sara A.;
Radwan, Sara M.

Publication type:

Article

Integrative Analysis of Drug Co-Prescriptions in Peritoneal Dialysis Reveals Molecular Targets and Novel Strategies for Intervention.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 11, p. 3733, doi. 10.3390/jcm14113733

By:

Evgeniou, Michail;
Perco, Paul;
Eibensteiner, Fabian;
Unterwurzacher, Markus;
Vychytil, Andreas;
Herzog, Rebecca;
Kratochwill, Klaus

Publication type:

Article

Repurposing Antiepileptic Drugs for Cancer: A Promising Therapeutic Strategy.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 8, p. 2673, doi. 10.3390/jcm14082673

By:

Tarawneh, Noor;
Hussein, Shaymaa A.;
Abdalla, Shtaywy

Publication type:

Article

Potential Ototoxicity of Insulin-like Growth Factor 1 Receptor Signaling Inhibitors: An In Silico Drug Repurposing Study of the Regenerating Cochlear Neuron Transcriptome.

Published in:

Journal of Clinical Medicine, 2023, v. 12, n. 10, p. 3485, doi. 10.3390/jcm12103485

By:

Bertagnoli, Lino E.;
Seist, Richard;
Batts, Shelley;
Stankovic, Konstantina M.

Publication type:

Article

Text-Mining Approach to Identify Hub Genes of Cancer Metastasis and Potential Drug Repurposing to Target Them.

Published in:

Journal of Clinical Medicine, 2022, v. 11, n. 8, p. 2130, doi. 10.3390/jcm11082130

By:

Detroja, Trishna Saha;
Gil-Henn, Hava;
Samson, Abraham O.

Publication type:

Article

A Multicenter, Randomized, Double-Blinded, Parallel-Group, Placebo-Controlled Phase I/IIa Study to Evaluate the Efficacy and Safety of a Single Intra-Articular Injection of YYD302 in Patients with Knee Osteoarthritis.

Published in:

Journal of Clinical Medicine, 2022, v. 11, n. 6, p. 1482, doi. 10.3390/jcm11061482

By:

In, Yong;
Ha, Chul-Won

Publication type:

Article

RNA-TARGETED DRUG REPURPOSING PIPELINE FOR AEROSPACE MEDICINE.

Published in:

Aerospace Medicine & Human Performance, 2024, v. 95, n. 8, p. 532

By:

Cerqueira, Bianca;
Reese, Justin;
Galeano, Diego;
Beheshti, Afshin;
Cappelletti, Luca;
Cates, Kim;
Caufield, Harry;
Smith, Timothy;
Chapapas, Holly;
Robinson, Meghan;
Sherman, Paul

Publication type:

Article

Interpretability and accessibility of machine learning in selected food processing, agriculture and health applications.

Published in:

Journal of the National Science Foundation of Sri Lanka, 2022, v. 50, p. 263, doi. 10.4038/jnsfsr.v50i0.11249

By:

Ranasinghe, N.;
Ramanan, A.;
Fernando, S.;
Hameed, P. N.;
Herath, D.;
Malepathirana, T.;
Suganthan, P.;
Niranjan, M.;
Halgamuge, S.

Publication type:

Article

Graph Neural Network-Based Modeling with Subcategory Exploration for Drug Repositioning.

Published in:

Electronics (2079-9292), 2024, v. 13, n. 19, p. 3835, doi. 10.3390/electronics13193835

By:

Lu, Rong;
Liang, Yong;
Lin, Jiatai;
Chen, Yuqiang

Publication type:

Article

Evaluation of Additive Neuroprotective Effect of Combination Therapy for Parkinson's Disease Using In Vitro Models.

Published in:

Antioxidants, 2025, v. 14, n. 4, p. 396, doi. 10.3390/antiox14040396

By:

Shtilbans, Alexander;
Esneault, Elise;
Simon, Florian;
Mazzulli, Joseph R.;
Quiriconi, Drew J.;
Rom, Dror;
Reintsch, Wolfgang E.;
Krahn, Andrea I.;
Durcan, Thomas M.

Publication type:

Article

Synergistic Dual Targeting of Thioredoxin and Glutathione Systems Irrespective of p53 in Glioblastoma Stem Cells.

Published in:

Antioxidants, 2024, v. 13, n. 10, p. 1201, doi. 10.3390/antiox13101201

By:

Jamali, Fatemeh;
Lan, Katherine;
Daniel, Paul;
Petrecca, Kevin;
Sabri, Siham;
Abdulkarim, Bassam

Publication type:

Article