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Disposition of Oral Nalbuphine and Its Metabolites in Healthy Subjects and Subjects with Hepatic Impairment: Preliminary Modeling Results Using a Continuous Intestinal Absorption Model with Enterohepatic Recirculation.
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- Metabolites (2218-1989), 2024, v. 14, n. 9, p. 471, doi. 10.3390/metabo14090471
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- Article
Screening a Compound Library to Identify Additives That Boost Cytochrome P450 Enzyme Function in Vascularised Liver Spheres.
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- Cells (2073-4409), 2024, v. 13, n. 18, p. 1594, doi. 10.3390/cells13181594
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- Article
CYP3A-Mediated Carbon–Carbon Bond Cleavages in Drug Metabolism.
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- Biomolecules (2218-273X), 2024, v. 14, n. 9, p. 1125, doi. 10.3390/biom14091125
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- Article
Metabolic mediators: microbialderived metabolites as key regulators of anti-tumor immunity, immunotherapy, and chemotherapy.
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- Frontiers in Immunology, 2024, p. 01, doi. 10.3389/fimmu.2024.1456030
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- Article
Correction: Kovács et al. ABT-333 (Dasabuvir) Increases Action Potential Duration and Provokes Early Afterdepolarizations in Canine Left Ventricular Cells via Inhibition of I Kr. Pharmaceuticals 2023, 16 , 488.
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- 2024
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- Correction Notice
Development and Evaluation of Ontogeny Functions of the Major UDP‐Glucuronosyltransferase Enzymes to Underwrite Physiologically Based Pharmacokinetic Modeling in Pediatric Populations.
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- Journal of Clinical Pharmacology, 2024, v. 64, n. 10, p. 1222, doi. 10.1002/jcph.2484
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- Article
Advanced Liver-on-a-Chip Model for Evaluating Drug Metabolism and Hepatotoxicity.
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- Biosensors (2079-6374), 2024, v. 14, n. 9, p. 435, doi. 10.3390/bios14090435
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- Article
Comparison of Mitochondrial and Antineoplastic Effects of Amiodarone and Desethylamiodarone in MDA-MB-231 Cancer Line.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 18, p. 9781, doi. 10.3390/ijms25189781
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- Article
A critical review of the effects of inhaled corticosteroids on growth.
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- Allergy & Asthma Proceedings, 2013, v. 34, n. 5, p. 391, doi. 10.2500/aap.2013.34.3689
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- Article
Role of microbes, metabolites and effector compounds in host–microbiota interaction: a pharmacological outlook.
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- Environmental Chemistry Letters, 2019, v. 17, n. 4, p. 1801, doi. 10.1007/s10311-019-00914-9
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- Article
DPYD and UGT1A1 Pharmacogenetic Testing in Patients with Gastrointestinal Malignancies: An Overview of the Evidence and Considerations for Clinical Implementation.
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- Pharmacotherapy, 2020, v. 40, n. 11, p. 1108, doi. 10.1002/phar.2463
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- Article
CYP2D6 Genetic Polymorphisms and Risperidone Pharmacokinetics: A Systematic Review and Meta‐analysis.
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- Pharmacotherapy, 2020, v. 40, n. 7, p. 632, doi. 10.1002/phar.2434
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- Article
Potential Implications of Gut Microbiota in Drug Pharmacokinetics and Bioavailability.
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- Pharmacotherapy, 2020, v. 40, n. 7, p. 704, doi. 10.1002/phar.2428
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- Article
Addition of Allopurinol for Altering Thiopurine Metabolism to Optimize Therapy in Patients with Inflammatory Bowel Disease.
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- Pharmacotherapy, 2018, v. 38, n. 2, p. 259, doi. 10.1002/phar.2067
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- Article
Pharmacokinetics of Ceftazidime-Avibactam in Two Patients With KPC-Producing Klebsiella pneumoniae Bacteremia and Renal Impairment.
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- Pharmacotherapy, 2016, v. 36, n. 11, p. e172, doi. 10.1002/phar.1840
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- Article
Pharmacokinetics of Vancomycin in Extremely Obese Patients with Suspected or Confirmed Staphylococcus aureus Infections.
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- Pharmacotherapy, 2015, v. 35, n. 2, p. 127, doi. 10.1002/phar.1531
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- Article
Comparison of an assumption-free Bayesian approach with Optimal Sampling Schedule to a maximum a posteriori Approach for Personalizing Cyclophosphamide Dosing.
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- Pharmacotherapy, 2014, v. 34, n. 4, p. 330, doi. 10.1002/phar.1346
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- Article
In Vivo Alterations in Drug Metabolism and Transport Pathways in Patients with Chronic Kidney Diseases.
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- Pharmacotherapy, 2014, v. 34, n. 2, p. 114, doi. 10.1002/phar.1347
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- Article
The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?
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- Pharmacotherapy, 2013, v. 33, n. 2, p. 210, doi. 10.1002/phar.1194
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- Article
Optimal Prevention of Seizures Induced by High-Dose Busulfan.
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- Pharmacotherapy, 2008, v. 28, n. 12, p. 1502, doi. 10.1592/phco.28.12.1502
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- Article
Safety and Efficacy of Eletriptan in the Treatment of Acute Migraine.
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- Pharmacotherapy, 2006, v. 26, n. 1, p. 115, doi. 10.1592/phco.2006.26.1.115
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- Article
The effect of polymeric films of hydroxypropyl methylcellulose (HPMC)/chitosan on ofloxacin release, diffusion, and biological activity.
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- Polymer Engineering & Science, 2023, v. 63, n. 9, p. 2871, doi. 10.1002/pen.26411
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- Article
Herbal Medicine and Drug Interactions.
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- Innovation, 2006, v. 6, n. 2, p. 44
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- Article
Continuous Production of Highly Functional Vascularized Hepatobiliary Organoids from Human Pluripotent Stem Cells using a Scalable Microfluidic Platform.
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- Advanced Functional Materials, 2023, v. 33, n. 49, p. 1, doi. 10.1002/adfm.202210233
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- Article
Predicting reactivity to drug metabolism: beyond P450s—modelling FMOs and UGTs.
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- Journal of Computer-Aided Molecular Design, 2021, v. 35, n. 4, p. 541, doi. 10.1007/s10822-020-00321-1
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- Article
Time dependent analysis of assay comparability: a novel approach to understand intra- and inter-site variability over time.
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- Journal of Computer-Aided Molecular Design, 2015, v. 29, n. 9, p. 795, doi. 10.1007/s10822-015-9836-5
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- Article
An integrated suite of modeling tools that empower scientists in structure- and property-based drug design.
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- Journal of Computer-Aided Molecular Design, 2015, v. 29, n. 6, p. 511, doi. 10.1007/s10822-015-9845-4
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- Article
Combined use of pharmacophoric models together with drug metabolism and genotoxicity 'in silico' studies in the hit finding process.
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- Journal of Computer-Aided Molecular Design, 2013, v. 27, n. 1, p. 79, doi. 10.1007/s10822-012-9627-1
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- Article
A support vector machine approach to classify human cytochrome P450 3A4 inhibitors.
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- Journal of Computer-Aided Molecular Design, 2005, v. 19, n. 3, p. 189, doi. 10.1007/s10822-005-3785-3
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- Article
Evaluation of hepatic drug-metabolism for glioblastoma using liver-brain chip.
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- Biotechnology Letters, 2021, v. 43, n. 2, p. 383, doi. 10.1007/s10529-020-03043-4
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- Article
Drug metabolism in microorganisms.
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- Biotechnology Letters, 2015, v. 37, n. 1, p. 19, doi. 10.1007/s10529-014-1653-8
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- Article
Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species.
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- Biotechnology Letters, 2011, v. 33, n. 2, p. 321, doi. 10.1007/s10529-010-0425-3
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- Article
Modulating the pharmacokinetics of therapeutic antibodies.
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- Biotechnology Letters, 2010, v. 32, n. 5, p. 609, doi. 10.1007/s10529-010-0214-z
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- Article
Psychotropic drug metabolism in the cancer patient: clinical aspects of management of potential drug interactions.
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- Psycho-Oncology, 1998, v. 7, n. 4, p. 307, doi. 10.1002/(SICI)1099-1611(199807/08)7:4<307::AID-PON366>3.0.CO;2-3
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- Article
Effect of polymorphisms on the pharmacokinetics, pharmacodynamics, and safety of risperidone in healthy volunteers.
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- Human Psychopharmacology: Clinical & Experimental, 2014, v. 29, n. 5, p. 459, doi. 10.1002/hup.2420
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- Article
Plasma fluvoxamine levels and OCD symptoms/response in adult patients.
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- Human Psychopharmacology: Clinical & Experimental, 2012, v. 27, n. 4, p. 397, doi. 10.1002/hup.2240
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- Article
In vitro microsomal metabolism of imipramine under conditions mimicking the in vivo steady-state situation.
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- Human Psychopharmacology: Clinical & Experimental, 2004, v. 19, n. 1, p. 31, doi. 10.1002/hup.550
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- Article
Psychiatry, Psychopharmacology and P-450s.
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- Human Psychopharmacology: Clinical & Experimental, 1996, v. 11, n. 2, p. 97, doi. 10.1002/(SICI)1099-1077(199603)11:2<97::AID-HUP759>3.0.CO;2-7
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- Article
New Anticonvulsant Drugs and the Role of Clobazam as Adjunctive Therapy.
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- Human Psychopharmacology: Clinical & Experimental, 1995, v. 10, p. 65, doi. 10.1002/hup.470100706
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- Article
The Sixth International Conference on Phenothiazines and Structurally Related Psychotropic Compounds.
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- Human Psychopharmacology: Clinical & Experimental, 1990, v. 5, n. 2, p. 180, doi. 10.1002/hup.470050214
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- Article
Grundprinzipien der Therapie mit Neuropsychopharmaka.
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- Der Nervenarzt, 2012, v. 83, n. 9, p. 1193, doi. 10.1007/s00115-012-3554-1
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- Article
Formation of functional, extended bile canaliculi, and increased bile acid production in sandwich-cultured human cryopreserved hepatocytes using commercially available culture medium.
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- Archives of Toxicology, 2024, v. 98, n. 8, p. 2605, doi. 10.1007/s00204-024-03757-8
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- Article
Effects of marine biotoxins on drug-metabolizing cytochrome P450 enzymes and their regulation in mammalian cells.
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- Archives of Toxicology, 2024, v. 98, n. 5, p. 1311, doi. 10.1007/s00204-024-03694-6
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- Article
Single-cell RNA sequencing to reveal non-parenchymal cell heterogeneity and immune network of acetaminophen-induced liver injury in mice.
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- Archives of Toxicology, 2023, v. 97, n. 7, p. 1979, doi. 10.1007/s00204-023-03513-4
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- Article
Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions.
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- Archives of Toxicology, 2022, v. 96, n. 8, p. 2145, doi. 10.1007/s00204-022-03304-3
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- Article
Extending the viability of human precision-cut intestinal slice model for drug metabolism studies.
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- Archives of Toxicology, 2022, v. 96, n. 6, p. 1815, doi. 10.1007/s00204-022-03295-1
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- Article
Generation of Caco-2 cells stably expressing CYP3A4·POR·UGT1A1 and CYP3A4·POR·UGT1A1*6 using a PITCh system.
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- Archives of Toxicology, 2022, v. 96, n. 2, p. 499, doi. 10.1007/s00204-021-03175-0
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- Publication type:
- Article
Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification.
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- Archives of Toxicology, 2021, v. 95, n. 7, p. 2413, doi. 10.1007/s00204-021-03075-3
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- Article
Cross-species analysis of hepatic cytochrome P450 and transport protein expression.
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- Archives of Toxicology, 2021, v. 95, n. 1, p. 117, doi. 10.1007/s00204-020-02939-4
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- Article
Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism.
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- Archives of Toxicology, 2021, v. 95, n. 1, p. 11, doi. 10.1007/s00204-020-02916-x
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- Article