Works matching DE "DRUG design"

Results: 5000

Pharmaceutical Innovation Through Computational Drug Design: A Comprehensive Exploration.

Published in:

Makara Journal of Science, 2025, v. 29, n. 2, p. 216, doi. 10.7454/mss.v29i2.2629

By:

Chandramouli, Manasa;
Surendra, Madhusudhan Heggadadevanakote

Publication type:

Article

Prevalence of symptomatic toxicities for novel therapies in adult oncology trials: a scoping review Open Access.

Published in:

JNCI Cancer Spectrum, 2025, v. 9, n. 3, p. 1, doi. 10.1093/jncics/pkaf036

By:

King, Amanda L;
Vasilj, Tamara;
Cooper, Diane;
Vera, Elizabeth;
Berhanu, Sefanit;
Johnson, Morgan;
Locke, Ciara;
Mciver, Bennett;
Basch, Ethan;
Cappelleri, Joseph C;
Dueck, Amylou;
Gilbert, Mark R;
Jones, Lee;
Li, Yuelin;
Minasian, Lori M;
Reeve, Bryce B;
Armstrong, Terri S;
Mendoza, Tito

Publication type:

Article

Molecular dynamics in pharmaceutical nanotechnology: simulating interactions and advancing applications.

Published in:

Journal of Biomaterials Science -- Polymer Edition, 2025, v. 36, n. 10, p. 1502, doi. 10.1080/09205063.2025.2450150

By:

Mundada, Anand Badrivishal;
Pradhan, Pankaj;
Raju, Rajapandi;
Sujitha, Y. Sarah;
Kulkarni, Parag Arun;
Mundada, Pooja Anand;
Tiwari, Ruchi;
Sharma, Pankaj

Publication type:

Article

A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61083-8

By:

Li, Kan;
Rudy, Michael J.;
Hu, Yanmei;
Tan, Haozhou;
Lambrinidis, George;
Wu, Xiangmeng;
Georgiou, Kyriakos;
Tan, Bin;
Frost, Joshua;
Wilson, Courtney;
Clarke, Penny;
Kolocouris, Antonios;
Zhang, Qing-yu;
Tyler, Kenneth L.;
Wang, Jun

Publication type:

Article

Identification of nanomolar adenosine A<sub>2A</sub> receptor ligands using reinforcement learning and structure-based drug design.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60629-0

By:

Thomas, Morgan;
Matricon, Pierre G.;
Gillespie, Robert J.;
Napiórkowska, Maja;
Neale, Hannah;
Mason, Jonathan S.;
Brown, Jason;
Harwood, Kaan;
Fieldhouse, Charlotte;
Swain, Nigel A.;
Geng, Tian;
O'Boyle, Noel M.;
Deflorian, Francesca;
Bender, Andreas;
de Graaf, Chris

Publication type:

Article

Protein-protein interaction prediction using bidirectional GRUs with explicit ensemble.

Published in:

PLoS ONE, 2025, v. 20, n. 7, p. 1, doi. 10.1371/journal.pone.0326960

By:

Lan, Qiuhong;
Zheng, Zhongtuan;
Tang, Zhen;
Qiu, Xuehua;
Yin, Zhixiang

Publication type:

Article

INTRODUCTION.

Published in:

Jordan Journal of Pharmaceutical Sciences, 2025, v. 18, n. 2, p. ix

By:

Alabbadi, Ibrahim

Publication type:

Article

Safety concerns associated with BACE1 inhibitors – past, present, and future.

Published in:

Expert Opinion on Drug Safety, 2025, v. 24, n. 7, p. 767, doi. 10.1080/14740338.2025.2467811

By:

Naidu, Aniketh;
Silverglate, Bret;
Silverglate, Mary;
Grossberg, George T.

Publication type:

Article

Recent developments in the utilization of pyridones as privileged scaffolds in drug discovery.

Published in:

Expert Opinion on Drug Discovery, 2025, v. 20, n. 7, p. 873, doi. 10.1080/17460441.2025.2507377

By:

Li, Zheyu;
Ma, Wenbo;
Gu, Linghui;
Xie, Jiayuan;
Yang, Kui;
Lin, Shibo

Publication type:

Article

Role of PE family of proteins in mycobacterial virulence: Potential on anti-TB vaccine and drug design.

Published in:

International Reviews of Immunology, 2025, v. 44, n. 4, p. 213, doi. 10.1080/08830185.2025.2455161

By:

Dahiya, Priyanka;
Bisht, Manoj Kumar;
Mukhopadhyay, Sangita

Publication type:

Article

Unlocking the potential of tumor-targeting peptides in precision oncology.

Published in:

Oncology Research, 2025, v. 33, n. 7, p. 1547, doi. 10.32604/or.2025.062197

By:

REHMAN, HAFIZ MUHAMMAD;
AHMAD, SIDRA;
SARWAR, AZEEM;
BASHIR, HAMID

Publication type:

Article

Structural insights into full‐length human fascin1: a target for cancer treatment.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2025, v. 81, n. 7, p. 319, doi. 10.1107/S2053230X25005254

By:

Giraldo-Ruiz, Lucía;
Quereda-Moraleda, Isabel;
Grieco, Alice;
Ruiz-Sanz, Javier;
Luque, Irene;
Martin-Garcia, Jose Manuel

Publication type:

Article

Mannigfaltiges Molecular Modelling in Erlangen.

Published in:

Nachrichten aus der Chemie, 2025, v. 73, n. 7, p. 81, doi. 10.1002/nadc.20254151706

By:

Horn, Anselm

Publication type:

Article

Improving Ex Vivo Nasal Mucosa Experimental Design for Drug Permeability Assessments: Correcting Mucosal Thickness Interference and Reevaluating Fluorescein Sodium as an Integrity Marker for Chemically Induced Mucosal Injury.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 6, p. 889, doi. 10.3390/ph18060889

By:

Zhao, Shengnan;
Zuo, Jieyu;
Mallillin III, Marlon C.;
Tang, Ruikun;
Doschak, Michael R.;
Davies, Neal M.;
Löbenberg, Raimar

Publication type:

Article

On the Symmetry and Domination Integrity of Some Bidegreed Graphs.

Published in:

Symmetry (20738994), 2025, v. 17, n. 6, p. 953, doi. 10.3390/sym17060953

By:

Ganesan, Balaraman;
Raman, Sundareswaran

Publication type:

Article

Insulin delegation and other strategies to reduce the load on stretched services.

Published in:

Journal of Diabetes Nursing, 2021, v. 25, n. 5, p. 1

By:

Down, Su

Publication type:

Article

Sequencing parasite populations.

Published in:

Nature Reviews Microbiology, 2012, v. 10, n. 2, p. 85, doi. 10.1038/nrmicro2738

By:

Sanchez-Flores, Alejandro

Publication type:

Article

Viral shape-shifting: norovirus evasion of the human immune system.

Published in:

Nature Reviews Microbiology, 2010, v. 8, n. 3, p. 231, doi. 10.1038/nrmicro2296

By:

Donaldson, Eric F.;
Lindesmith, Lisa C.;
LoBue, Anna D.;
Baric, Ralph S.

Publication type:

Article

INDEPENDENT DRUG TESTING TO ENSURE DRUG SAFETY AND EFFICACY.

Published in:

Journal of Health Care Law & Policy, 2015, v. 18, n. 1, p. 45

By:

RODWIN, MARC A.

Publication type:

Article

Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design.

Published in:

PLoS Biology, 2010, v. 8, n. 4, p. 1, doi. 10.1371/journal.pbio.1000355

By:

Mazella, Jean;
Pétrault, Olivier;
Lucas, Guillaume;
Deval, Emmanuel;
Béraud-Dufour, Sophie;
Gandin, Carine;
El-Yacoubi, Malika;
Widmann, Catherine;
Guyon, Alice;
Chevet, Eric;
Taouji, Said;
Conductier, Grégory;
Corinus, Alain;
Coppola, Thierry;
Gobbi, Gabriella;
Nahon, Jean-Louis;
Heurteaux, Catherine;
Borsotto, Marc

Publication type:

Article

Translating DNA into Synthetic Molecules.

Published in:

PLoS Biology, 2004, v. 2, n. 7, p. 1, doi. 10.1371/journal.pbio.0020223

By:

Liu, David R

Publication type:

Article

How do gynecologists face to social problems among women cancer survivors?

Published in:

Journal of Obstetrics & Gynaecology Research, 2021, v. 47, n. 5, p. 1651, doi. 10.1111/jog.14703

By:

Endo, Motoki

Publication type:

Article

Establishment of a patient‐derived xenograft model and cell line of malignant transformation of mature cystic teratoma of the ovary.

Published in:

Journal of Obstetrics & Gynaecology Research, 2021, v. 47, n. 2, p. 713, doi. 10.1111/jog.14596

By:

Tamauchi, Satoshi;
Suzuki, Shiro;
Xuboya, Chang;
Yoshihara, Masato;
Yoshida, Kosuke;
Ikeda, Yoshiki;
Yoshikawa, Nobuhisa;
Kajiyama, Hiroaki;
Kikkawa, Fumitaka

Publication type:

Article

Extended‐release guanfacine improves symptoms in adults with ADHD.

Published in:: Brown University Psychopharmacology Update, 2020, v. 31, n. 8, p. 3, doi. 10.1002/pu.30604
Publication type:: Article

Protecting the Public's Health: Critical Functions of the Section 317 Immunization Program--A Report of the National Vaccine Advisory Committee.

Published in:: Public Health Reports, 2013, v. 128, n. 2, p. 78, doi. 10.1177/003335491312800203
Publication type:: Article

NTU Researchers Make Significant Findings about Protein Architecture.

Published in:: Innovation, 2011, v. 10, n. 1, p. 75
Publication type:: Article

Stimuli-Responsive Materials for Controlled Release of Theranostic Agents.

Published in:

Advanced Functional Materials, 2014, v. 24, n. 27, p. 4206, doi. 10.1002/adfm.201400279

By:

Wang, Yucai;
Shim, Min Suk;
Levinson, Nathanael S.;
Sung, Hsing‐Wen;
Xia, Younan

Publication type:

Article

Updating Corneofungimetry: A Bioassay Exploring Dermatomycoses and Antifungal Susceptibility.

Published in:

Mycopathologia, 2010, v. 169, n. 1, p. 27

By:

Gérald Piérard;
Claudine Piérard-Franchimont;
Pascale Quatresooz

Publication type:

Article

Many are called, few are chosen: the role of science in drug development decisions.

Published in:

Journal of Technology Transfer, 2024, v. 49, n. 2, p. 492, doi. 10.1007/s10961-022-09982-6

By:

Colen, Linde;
Belderbos, René;
Kelchtermans, Stijn;
Leten, Bart

Publication type:

Article

Phase I trial of verubulin (MPC-6827) plus carboplatin in patients with relapsed glioblastoma multiforme.

Published in:

Journal of Neuro-Oncology, 2012, v. 110, n. 2, p. 257, doi. 10.1007/s11060-012-0964-7

By:

Grossmann, Kenneth;
Colman, Howard;
Akerley, Wallace;
Glantz, Michael;
Matsuoko, Yuko;
Beelen, Andrew;
Yu, Margaret;
Groot, John;
Aiken, Robert;
Olsen, Jeffery;
Evans, Brent;
Jensen, Randy

Publication type:

Article

Methodological issues in designing and reporting health-related quality of life in cancer clinical trials: the challenge of brain cancer studies.

Published in:

Journal of Neuro-Oncology, 2012, v. 108, n. 2, p. 221, doi. 10.1007/s11060-012-0819-2

By:

Efficace, Fabio;
Taphoorn, Martin

Publication type:

Article

A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: a Pediatric Brain Tumor Consortium study.

Published in:

Journal of Neuro-Oncology, 2012, v. 106, n. 3, p. 643, doi. 10.1007/s11060-011-0709-z

By:

Warren, Katherine;
Gururangan, Sri;
Geyer, J.;
McLendon, Roger;
Poussaint, Tina;
Wallace, Dana;
Balis, Frank;
Berg, Stacey;
Packer, Roger;
Goldman, Stewart;
Minturn, Jane;
Pollack, Ian;
Boyett, James;
Kun, Larry

Publication type:

Article

Three-dimensional (3D) printed tablets using ethyl cellulose and hydroxypropyl cellulose to achieve zero order sustained release profile.

Published in:

Cellulose, 2020, v. 27, n. 3, p. 1573, doi. 10.1007/s10570-019-02881-4

By:

Homaee Borujeni, Shiva;
Mirdamadian, Seyedeh Zahra;
Varshosaz, Jaleh;
Taheri, Azade

Publication type:

Article

Antifungal effects of lycorine on Botrytis cinerea and possible mechanisms.

Published in:

Biotechnology Letters, 2021, v. 43, n. 7, p. 1503, doi. 10.1007/s10529-021-03128-8

By:

Zhao, Shixue;
Guo, Yanhua;
Wang, Qiannan;
An, Bang

Publication type:

Article

Developing a Comprehensive CryoEM Cross-Facility Training Curriculum That Adheres to Best Practices Across Diverse Settings.

Published in:

Microscopy & Microanalysis, 2024, v. 30, p. 1, doi. 10.1093/mam/ozae044.443

By:

Aragon, Mahira;
Carpen, Dianne;
Castello, Cathleen;
Chua, Eugene Y D;
Marco, Alex de;
Dubbeldam, Charlie;
Eng, Edward T;
Kieft, Jeffrey S;
Kopylov, Elina;
Owji, Aaron P;
Zimanyi, Christina M

Publication type:

Article

Exploring the anticancer potential of new 3‐cyanopyridine derivatives bearing N‐acylhydrazone motif: Synthesis, DFT calculations, cytotoxic evaluation, molecular modeling, and antioxidant properties.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 9, p. 1, doi. 10.1002/jbt.23819

By:

Kadi, Ibtissem;
Şekerci, Güldeniz;
Boulebd, Houssem;
Zebbiche, Zineddine;
Tekin, Suat;
Benarous, Khedidja;
Serseg, Talia;
Küçükbay, Fatümetüzzehra;
Küçükbay, Hasan;
Boumoud, Taoues

Publication type:

Article

Therapeutic properties, biological effects, antiliver cancer, and anticolon cancer effects of some natural compounds: A biochemical approach.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 1, p. 1, doi. 10.1002/jbt.23573

By:

Li, Long;
Zhu, Yu;
Huang, Ying‐Guang;
Hou, De‐Zhi;
Ahmed Zaki, Mohamed Samir;
Sideeg, Abulqasim M.;
Mohammed, Heitham;
El‐kott, Attalla F.;
Al‐Saeed, Fatimah A.;
Ling, Ping

Publication type:

Article

Vinyl functionalized 5,6‐dimethylbenzimidazolium salts: Synthesis and biological activities.

Published in:

Journal of Biochemical & Molecular Toxicology, 2023, v. 37, n. 2, p. 1, doi. 10.1002/jbt.23255

By:

Karaca, Emine Ö.;
Bingöl, Zeynebe;
Gürbüz, Nevin;
Özdemir, İsmail;
Gülçin, İlhami

Publication type:

Article

Inhibition profiles of Voriconazole against acetylcholinesterase, α‐glycosidase, and human carbonic anhydrase I and II isoenzymes.

Published in:

Journal of Biochemical & Molecular Toxicology, 2019, v. 33, n. 10, p. N.PAG, doi. 10.1002/jbt.22385

By:

Topal, Fevzi

Publication type:

Article

Divergent Synthesis of Trifluoromethyl Ketones via Photoredox Activation of Halotrifluoroacetones.

Published in:

Helvetica Chimica Acta, 2024, v. 107, n. 10, p. 1, doi. 10.1002/hlca.202400125

By:

Giri, Rahul;
Kissling, Mathias;
Zhilin, Egor;
Fernandes, Anthony J.;
Ordan, Quentin E. L.;
Katayev, Dmitry

Publication type:

Article

Carbohydrate‐Derived Dienes as Building Blocks for Pharmaceutically Relevant Molecules.

Published in:

Helvetica Chimica Acta, 2023, v. 106, n. 1, p. 1, doi. 10.1002/hlca.202200135

By:

Dubbu, Sateesh;
Santhi, Jampani;
Hevey, Rachel

Publication type:

Article

A Practical Route to Cyclobutanols and Fluorocyclobutanes.

Published in:

Helvetica Chimica Acta, 2021, v. 104, n. 9, p. 1, doi. 10.1002/hlca.202100106

By:

Revil‐Baudard, Vincent L.;
Zard, Samir Z.

Publication type:

Article

A novel isothermal microcalorimetry tool to assess drug effects on Ancylostoma ceylanicum and Necator americanus.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 2, p. 837, doi. 10.1007/s00253-015-7081-4

By:

Flores, Dayana;
Panic, Gordana;
Braissant, Olivier;
Keiser, Jennifer

Publication type:

Article

Advances in applications, metabolism, and biotechnological production of L-xylulose.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 2, p. 535, doi. 10.1007/s00253-015-7087-y

By:

Meng, Qing;
Zhang, Tao;
Jiang, Bo;
Mu, Wanmeng;
Miao, Ming

Publication type:

Article

Prediction of T cell epitopes of Brucella abortus and evaluation of their protective role in mice.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 18, p. 7625, doi. 10.1007/s00253-015-6787-7

By:

Afley, Prachiti;
Dohre, Sudhir;
Prasad, G.;
Kumar, Subodh

Publication type:

Article

MODEL-BASED IDENTIFICATION AND ADAPTIVE CONTROL OF THE CORE MODULE IN A TYPICAL CELL CYCLE PATHWAY VIA NETWORK AND SYSTEM CONTROL THEORIES.

Published in:

Advances in Complex Systems, 2009, v. 12, n. 1, p. 21, doi. 10.1142/S0219525909002076

By:

BINHUA TANG;
LI HE;
QING JING;
BAIRONG SHEN

Publication type:

Article

Open-Label Phase II Evaluation of Imatinib in Primary Inoperable or Incompletely Resected and Recurrent Glioblastoma.

Published in:

Oncology, 2020, v. 98, n. 1, p. 16, doi. 10.1159/000502483

By:

Sautter, Lisa;
Hofheinz, Ralf;
Tuettenberg, Jochen;
Grimm, Mario;
Vajkoczy, Peter;
Groden, Christoph;
Schmieder, Kirsten;
Hochhaus, Andreas;
Wenz, Frederik;
Giordano, Frank A.

Publication type:

Article

When Clinical Trial Participation Is Not an Option in the Era of Personalized Medicine: The Case of Two Patients.

Published in:

Oncology, 2017, v. 92, n. 1, p. 55, doi. 10.1159/000450712

By:

Verschraegen, Claire F.;
Rehman, Hibba;
Pulluri, Bhargavi;
DeKay, James;
Barry, Maura;
Folefac, Edmund;
Dittus, Kim;
Holmes, Chris;
Sprague, Julian;
Ades, Steve;
Gibson, Pam C.

Publication type:

Article

Effects of exogenous prostacyclin on placental blood flow, placental weight and fetal weight in normotensive and spontaneously hypertensive rats.

Published in:

1992

By:

Furuhashi, N.;
Tsujiei, M.;
Kimura, H.;
Yajima, A.

Publication type:

journal article

Ovine fetal breathing and swallowing activity in response to plasma glucose changes.

Published in:

1991

By:

Schreyer, Peter;
Sherman, Dan J.;
Ervin, M. Gore;
Day, Linda;
Ross, Michael G.;
Schreyer, P;
Sherman, D J;
Ervin, M G;
Day, L;
Ross, M G

Publication type:

journal article