Works about DOUBLE-strand DNA breaks

Results: 2224

Nuclear deformability increases PARPi sensitivity in BRCA1-deficient cells by increasing microtubule-dependent DNA break mobility.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60756-8

By:

Faustini, Elena;
dello Stritto, Angela;
Panza, Andrea;
Doksani, Ylli;
Lottersberger, Francisca

Publication type:

Article

DNA Polymerase Theta Regulates the Growth and Development of Fusarium acuminatum and Its Virulence on Alfalfa.

Published in:

Agriculture; Basel, 2025, v. 15, n. 11, p. 1128, doi. 10.3390/agriculture15111128

By:

Jing, Yuqing;
Yang, Jian;
Ma, Renyi;
Lan, Bo;
Li, Siyang;
Zhang, Qian;
Du, Fang K.;
Guo, Qianqian;
Yin, Kangquan

Publication type:

Article

HSP110 Regulates the Assembly of the SWI/SNF Complex.

Published in:

Cells (2073-4409), 2025, v. 14, n. 11, p. 849, doi. 10.3390/cells14110849

By:

Pointeau, Océane;
Paccagnini, Manon;
Borges-Bonan, Natalia;
Biziorek, Léo;
Causse, Sébastien;
Garrido, Carmen;
Dubrez, Laurence

Publication type:

Article

Effect of X-Ray Energy on the Quantitative Yield of γH2AX and 53BP1 Foci in Human Mesenchymal Stem Cells.

Published in:

Bulletin of Experimental Biology & Medicine, 2025, v. 178, n. 6, p. 717, doi. 10.1007/s10517-025-06404-z

By:

Ignatov, M. A.;
Chigasova, A. K.;
Osipov, A. A.;
Fedotov, Yu. A.;
Vorobyeva, N. Yu.;
Osipov, A. N.

Publication type:

Article

Advances in DNA repair systems in human diseases and emerging therapeutic opportunities.

Published in:

Minerva Biotechnology & Biomolecular Research, 2025, v. 37, n. 2, p. 59, doi. 10.23736/S2724-542X.25.03280-8

By:

FAGOONEE, Sharmila;
WEISKIRCHEN, Ralf

Publication type:

Article

Significantly increased load of hereditary cancer-linked germline variants in infertile men Open Access.

Published in:

Human Reproduction Open, 2025, v. 2025, n. 2, p. 1, doi. 10.1093/hropen/hoaf008

By:

Valkna, Anu;
Juchnewitsch, Anna-Grete;
Põlluaas, Lisanna;
Lillepea, Kristiina;
Tjagur, Stanislav;
Dutta, Avirup;
Pomm, Kristjan;
Punab, Margus;
Laan, Maris

Publication type:

Article

Antioxidants Ameliorates Ionizing Radiation-Induced Microcephaly in Cerebral Organoid Derived from Human-induced Pluripotent Stem Cells.

Published in:

Radiation Research, 2025, v. 203, n. 6, p. 410, doi. 10.1667/RADE-25-00017.1

By:

Shimada, Mikio;
Matsumoto, Yoshihisa

Publication type:

Article

Correlation Between DNA Double-Strand Break Distribution in 3D Genome and Ionizing Radiation-Induced Cell Death.

Published in:

Radiation Research, 2025, v. 203, n. 6, p. 421, doi. 10.1667/RADE-24-00277.1

By:

Hu, Ankang;
Zhou, Wanyi;
Luo, Xiyu;
Qiu, Rui;
Li, Junli

Publication type:

Article

Selective targeting of genome amplifications and repeat elements by CRISPR-Cas9 nickases to promote cancer cell death.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60160-2

By:

Hanlon, Matthew B.;
Shohet, Jason M.;
Wolfe, Scot A.

Publication type:

Article

circ_0002456/FUS interaction inhibits NF-κB signaling to attenuate DNA damage and inflammatory responses in hDPSCs.

Published in:

Stem Cell Research & Therapy, 2025, v. 16, n. 1, p. 1, doi. 10.1186/s13287-025-04391-6

By:

Lin, Liecong;
Dong, Huixian;
Lai, Feng;
Zhang, Jingkun;
Wang, Bingtao;
Lv, Xiaohui;
Lin, Li;
Hong, Kehuan;
Zhao, Yuxuan;
Jiang, Qianzhou

Publication type:

Article

Fluorescent reporter mouse models for genome editing: choices and challenges.

Published in:

Mammalian Genome, 2025, v. 36, n. 2, p. 372, doi. 10.1007/s00335-024-10079-8

By:

Walkey, Christopher J.

Publication type:

Article

Trans-cinnamaldehyde fumigation inhibits Escherichia coli by affecting the mechanism of intracellular biological macromolecules.

Published in:

Natural Product Research, 2025, v. 39, n. 11, p. 3160, doi. 10.1080/14786419.2024.2331611

By:

Huang, Yuqiang;
Zhang, Tong;
Hu, Huiying;
Duan, Xuejuan;
Wu, Kegang;
Chai, Xianghua;
He, Dong

Publication type:

Article

The Interplay Between DNA Repair and the Immune Microenvironment in Pancreatic Cancer.

Published in:

Biomedicines, 2025, v. 13, n. 5, p. 1031, doi. 10.3390/biomedicines13051031

By:

Ciner, Aaron;
Hosein, Peter J.;
Jiang, Yixing;
Rassool, Feyruz

Publication type:

Article

Effects of Cisplatin on the Radiation Response and DNA Damage Markers in Peripheral Blood Lymphocytes Ex Vivo.

Published in:

Cells (2073-4409), 2025, v. 14, n. 10, p. 682, doi. 10.3390/cells14100682

By:

Zahnreich, Sebastian;
Bhatti, Aisha;
Ahmad, Barea;
Drabke, Sophia;
Kaufmann, Justus;
Schmidberger, Heinz

Publication type:

Article

Progress in CRISPR Technology for Antiviral Treatments: Genome Editing as a Potential Cure for Chronic Viral Infections.

Published in:

Microbiology Research, 2025, v. 16, n. 5, p. 104, doi. 10.3390/microbiolres16050104

By:

Nouri, Fatemeh;
Alibabaei, Farnaz;
Forouzanmehr, Behina;
Tahmasebi, Hamed;
Oksenych, Valentyn;
Eslami, Majid

Publication type:

Article

Skin Fibroblasts from Individuals Self-Diagnosed as Electrosensitive Reveal Two Distinct Subsets with Delayed Nucleoshuttling of the ATM Protein in Common.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4792, doi. 10.3390/ijms26104792

By:

Sonzogni, Laurène;
Al-Choboq, Joëlle;
Combemale, Patrick;
Massardier-Pilonchéry, Amélie;
Bouchet, Audrey;
May, Philippe;
Doré, Jean-François;
Debouzy, Jean-Claude;
Bourguignon, Michel;
Dréan, Yves Le;
Foray, Nicolas

Publication type:

Article

Acorus calamus L. Essential Oil Induces Oxidative Stress and DNA Replication Disruptions in Root Meristem Cells of Two Fabaceae and Two Brassicaceae Species.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4715, doi. 10.3390/ijms26104715

By:

Wróblewski, Mateusz;
Krajewski, Konrad;
Gocek, Natalia;
Żabka, Aneta;
Polit, Justyna T.

Publication type:

Article

C1QBP Modulates DNA Damage Response and Radiosensitivity in Hepatocellular Carcinoma by Regulating NF-κB Activity.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4513, doi. 10.3390/ijms26104513

By:

Zhou, Haitao;
Wu, Yanjin;
Meng, Jiahui;
Zhao, Xiaotong;
Hou, Yujia;
Wang, Qin;
Liu, Yang

Publication type:

Article

The DNA double-strand break repair proteins γH2AX, RAD51, BRCA1, RPA70, KU80, and XRCC4 exhibit follicle-specific expression differences in the postnatal mouse ovaries from early to older ages.

Published in:

Journal of Assisted Reproduction & Genetics, 2024, v. 41, n. 9, p. 2419, doi. 10.1007/s10815-024-03189-4

By:

Talibova, Gunel;
Bilmez, Yesim;
Tire, Betul;
Ozturk, Saffet

Publication type:

Article

Various repair events following CRISPR/Cas9-based mutational correction of an infertility-related mutation in mouse embryos.

Published in:

Journal of Assisted Reproduction & Genetics, 2024, v. 41, n. 6, p. 1605, doi. 10.1007/s10815-024-03095-9

By:

Bekaert, B.;
Boel, A.;
Rybouchkin, A.;
Cosemans, G.;
Declercq, S.;
Chuva de Sousa Lopes, S. M.;
Parrington, J.;
Stoop, D.;
Coucke, P.;
Menten, B.;
Heindryckx, B.

Publication type:

Article

Continuing the search for sperm-based determinants of early mammalian development.

Published in:

Journal of Assisted Reproduction & Genetics, 2023, v. 40, n. 4, p. 695, doi. 10.1007/s10815-023-02826-8

By:

Albertini, David F.

Publication type:

Article

Double strand DNA breaks in sperm: the bad guy in the crowd.

Published in:

Journal of Assisted Reproduction & Genetics, 2023, v. 40, n. 4, p. 745, doi. 10.1007/s10815-023-02748-5

By:

Alvarez, Juan G.;
García-Peiró, Agustin;
Barros, Alberto;
Ferraz, Luís;
Sousa, Mário;
Sakkas, Denny

Publication type:

Article

Comparison of open and a novel closed vitrification system with slow freezing for human ovarian tissue cryopreservation.

Published in:

Journal of Assisted Reproduction & Genetics, 2021, v. 38, n. 10, p. 2723, doi. 10.1007/s10815-021-02297-9

By:

Sugishita, Yodo;
Taylan, Enes;
Kawahara, Tai;
Shahmurzada, Bunyad;
Suzuki, Nao;
Oktay, Kutluk

Publication type:

Article

Sperm selection during ICSI treatments reduces single- but not double-strand DNA break values compared to the semen sample.

Published in:

Journal of Assisted Reproduction & Genetics, 2021, v. 38, n. 5, p. 1187, doi. 10.1007/s10815-021-02129-w

By:

Lara-Cerrillo, Sandra;
Ribas-Maynou, Jordi;
Rosado-Iglesias, Candela;
Lacruz-Ruiz, Tania;
Benet, Jordi;
García-Peiró, Agustín

Publication type:

Article

DNA damage control then and now: a matter of life or death.

Published in:

2020

By:

Albertini, David F.

Publication type:

Editorial

The canine RAD51 mutation leads to the attenuation of interaction with PALB2.

Published in:

Veterinary & Comparative Oncology, 2020, v. 18, n. 2, p. 247, doi. 10.1111/vco.12542

By:

Uemura, Mitsuki;
Ochiai, Kazuhiko;
Morimatsu, Masami;
Michishita, Masaki;
Onozawa, Eri;
Azakami, Daigo;
Uno, Yumiko;
Yoshikawa, Yasunaga;
Sasaki, Takanori;
Watanabe, Masami;
Omi, Toshinori

Publication type:

Article

The Rapid Synthesis of Colibactin Warhead Model Compounds Using New Metal‐Free Photocatalytic Cyclopropanation Reactions Facilitates the Investigation of Biological Mechanisms.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 56, p. 1, doi. 10.1002/chem.202301713

By:

Bosveli, Artemis;
Griboura, Nefeli;
Kampouropoulos, Ioannis;
Kalaitzakis, Dimitris;
Montagnon, Tamsyn;
Vassilikogiannakis, Georgios

Publication type:

Article

Capturing a Pentacyclic Fragment‐Based Library Derived from Perophoramidine: Their Design, Synthesis and Evaluation as Anticancer Compounds by DNA Double‐Strand Breaks (DSB) and PARP‐1 Inhibition.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 63, p. 1, doi. 10.1002/chem.202202405

By:

Guha, Souvik;
Yussif El‐Deeb, Ibrahim;
Yadav, Shalini;
Das, Ranajit;
Dutta Dubey, Kshatresh;
Baruah, Mousumi;
Gremaud, Ludovic;
Sen, Subhabrata

Publication type:

Article

p53-deficient cancer cells hyperactivate DNA double-strand break repair pathways to overcome chemotherapeutic damage and augment survival.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10434-1

By:

Dsouza, Rebecca;
Jain, Meghna;
Khattar, Ekta

Publication type:

Article

Role of TRIP13 in human cancer development.

Published in:

Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-10012-x

By:

Chen, Chaohu;
Li, Pan;
Fan, Guangrui;
Yang, Enguang;
Jing, Suoshi;
Shi, Yibo;
Gong, Yuwen;
Zhang, Luyang;
Wang, Zhiping

Publication type:

Article

Alternative end-joining originates stable chromosome aberrations induced by etoposide during targeted inhibition of DNA-PKcs in ATM-deficient tumor cells.

Published in:

Chromosome Research, 2022, v. 30, n. 4, p. 459, doi. 10.1007/s10577-022-09700-w

By:

de Campos Nebel, Marcelo;
Palmitelli, Micaela;
Pérez Maturo, Josefina;
González-Cid, Marcela

Publication type:

Article

Intragenic meiotic recombination in Schizosaccharomyces pombe is sensitive to environmental temperature changes.

Published in:

Chromosome Research, 2020, v. 28, n. 2, p. 195, doi. 10.1007/s10577-020-09632-3

By:

Brown, Simon D.;
Audoynaud, Charlotte;
Lorenz, Alexander

Publication type:

Article

DNA double-strand breaks: a potential therapeutic target for neurodegenerative diseases.

Published in:

Chromosome Research, 2019, v. 27, n. 4, p. 345, doi. 10.1007/s10577-019-09617-x

By:

Thadathil, Nidheesh;
Hori, Roderick;
Xiao, Jianfeng;
Khan, Mohammad Moshahid

Publication type:

Article

DIBI, a novel 3-hydroxypyridin-4-one chelator iron-binding polymer, inhibits breast cancer cell growth and functions as a chemosensitizer by promoting S-phase DNA damage.

Published in:

BioMetals, 2019, v. 32, n. 6, p. 909, doi. 10.1007/s10534-019-00222-3

By:

Greenshields, Anna L.;
Power Coombs, Melanie R.;
Fernando, Wasundara;
Holbein, Bruce E.;
Hoskin, David W.

Publication type:

Article

Zinc deficiency alters the susceptibility of pancreatic beta cells (INS-1) to arsenic exposure.

Published in:

BioMetals, 2019, v. 32, n. 6, p. 845, doi. 10.1007/s10534-019-00217-0

By:

Cao, Annie L.;
Beaver, Laura M.;
Wong, Carmen P.;
Hudson, Laurie G.;
Ho, Emily

Publication type:

Article

The past 20 years of Medicinal Research Reviews.

Published in:

Medicinal Research Reviews, 2020, v. 40, n. 1, p. 5, doi. 10.1002/med.21655

By:

Wang, Binghe

Publication type:

Article

Genome damage accumulated in seed ageing leads to plant genome instability and growth inhibition.

Published in:

Biochemical Journal, 2023, v. 480, n. 7, p. 461, doi. 10.1042/BCJ20230006

By:

Waterworth, Wanda M.;
West, Christopher E.

Publication type:

Article

Divergent binding mode for a protozoan BRC repeat to RAD51.

Published in:

Biochemical Journal, 2022, v. 479, n. 10, p. 1031, doi. 10.1042/BCJ20220141

By:

Pantelejevs, Teodors;
Hyvönen, Marko

Publication type:

Article

Temporal modulation of the NF-κB RelA network in response to different types of DNA damage.

Published in:

Biochemical Journal, 2021, v. 478, n. 3, p. 533, doi. 10.1042/BCJ20200627

By:

Campbell, Amy E.;
Franco, Catarina Ferraz;
Su, Ling-I;
Corbin, Emma K.;
Perkins, Simon;
Kalyuzhnyy, Anton;
Jones, Andrew R.;
Brownridge, Philip J.;
Perkins, Neil D.;
Eyers, Claire E.

Publication type:

Article

Structural insights into DNA double-strand break signaling.

Published in:

Biochemical Journal, 2021, v. 478, n. 1, p. 135, doi. 10.1042/BCJ20200066

By:

Panigrahi, Rashmi;
Glover, J. N. Mark

Publication type:

Article

The Tricarboxylic Acid Cycle as a Central Regulator of the Rate of Aging: Implications for Metabolic Interventions.

Published in:

Advanced Biology, 2023, v. 7, n. 7, p. 1, doi. 10.1002/adbi.202300095

By:

Borkum, Jonathan M.

Publication type:

Article

Determining Prostate Cancer-Related Pathways and the Role of the RPH3AL Gene.

Published in:

Experimed, 2024, v. 14, n. 3, p. 215, doi. 10.26650/experimed.1505817

By:

Seven, Didem;
Bayrak, Omer Faruk

Publication type:

Article

Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer.

Published in:

NPJ Precision Oncology, 2025, v. 9, n. 1, p. 1, doi. 10.1038/s41698-025-00800-4

By:

Sishc, Brock J.;
Saha, Janapriya;
Alves, Elizabeth M.;
Ding, Lianghao;
Lu, Huiming;
Wang, Shih-Ya;
Swancutt, Katy L.;
Nicholson, James H.;
Facoetti, Angelica;
Pompos, Arnold;
Ciocca, Mario;
Aguilera, Todd A.;
Story, Michael D.;
Davis, Anthony J.

Publication type:

Article

Secrets of DNA-PKcs beyond DNA repair.

Published in:

NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-024-00655-1

By:

Camfield, Sydney;
Chakraborty, Sayan;
Dwivedi, Shailendra Kumar Dhar;
Pramanik, Pijush Kanti;
Mukherjee, Priyabrata;
Bhattacharya, Resham

Publication type:

Article

A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency.

Published in:

NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-024-00610-0

By:

Kohsaka, Shinji;
Yagishita, Shigehiro;
Shirai, Yukina;
Matsuno, Yusuke;
Ueno, Toshihide;
Kojima, Shinya;
Ikeuchi, Hiroshi;
Ikegami, Masachika;
Kitada, Rina;
Yoshioka, Ken-ichi;
Toshimitsu, Kohta;
Tabata, Kimiyo;
Yokoi, Akira;
Doi, Toshihiko;
Yamamoto, Noboru;
Owa, Takashi;
Hamada, Akinobu;
Mano, Hiroyuki

Publication type:

Article

Temperature sensitivity of DNA double-strand break repair underpins heat-induced meiotic failure in mouse spermatogenesis.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03449-y

By:

Hirano, Kodai;
Nonami, Yuta;
Nakamura, Yoshiaki;
Sato, Toshiyuki;
Sato, Takuya;
Ishiguro, Kei-ichiro;
Ogawa, Takehiko;
Yoshida, Shosei

Publication type:

Article

Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03312-0

By:

Asada-Utsugi, Megumi;
Uemura, Kengo;
Ayaki, Takashi;
T. Uemura, Maiko;
Minamiyama, Sumio;
Hikiami, Ryota;
Morimura, Toshifumi;
Shodai, Akemi;
Ueki, Takatoshi;
Takahashi, Ryosuke;
Kinoshita, Ayae;
Urushitani, Makoto

Publication type:

Article

HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02671-4

By:

Tanaka, Hikari;
Kondo, Kanoh;
Fujita, Kyota;
Homma, Hidenori;
Tagawa, Kazuhiko;
Jin, Xiaocen;
Jin, Meihua;
Yoshioka, Yuki;
Takayama, Sumire;
Masuda, Hitomi;
Tokuyama, Rie;
Nakazaki, Yukoh;
Saito, Takashi;
Saido, Takaomi;
Murayama, Shigeo;
Ikura, Teikichi;
Ito, Nobutoshi;
Yamamori, Yu;
Tomii, Kentaro;
Bianchi, Marco E.

Publication type:

Article

Tag-seq: a convenient and scalable method for genome-wide specificity assessment of CRISPR/Cas nucleases.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02351-3

By:

Huang, Hongxin;
Hu, Yongfei;
Huang, Guanjie;
Ma, Shufeng;
Feng, Jianqi;
Wang, Dong;
Lin, Ying;
Zhou, Jiajian;
Rong, Zhili

Publication type:

Article

THERAPEUTICAL TARGETS IN BREAST CANCER: ESR1 AND BRCA1 MUTATIONS.

Published in:

Genetics & Applications, 2023, p. 73

By:

Dalila, Žilić;
Amina, Kurtović-Kozarić

Publication type:

Article