Works matching AU van der Graaf, Piet H.

Results: 91

Combining mechanistic modeling with machine learning as a strategy to predict inflammatory bowel disease clinical scores.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1479666

By:

Shim, Jaehee V.;
Rehberg, Markus;
Wagenhuber, Britta;
van der Graaf, Piet H.;
Chung, Douglas W.

Publication type:

Article

Estimation of binding rate constants using a simultaneous mixed-effects method: application to monoamine transporter reuptake inhibitor reboxetine.

Published in:

2010

By:

Benson, Neil;
Snelder, Nelleke;
Ploeger, Bart;
Napier, Carolyn;
Sale, Harriet;
JM Birdsall, Nigel;
Butt, Richard P;
Van Der Graaf, Piet H;
Birdsall, Nigel J M

Publication type:

journal article

Standing on the Shoulders of Giants: 125th Anniversary of the American Society for Clinical Pharmacology & Therapeutics.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 6, p. 1481, doi. 10.1002/cpt.3666

By:

van der Graaf, Piet H.;
Gerding, Alethea B.

Publication type:

Article

Progress in Clinical Pharmacology in China: An Ongoing Evolution.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 3, p. 609, doi. 10.1002/cpt.3549

By:

Zhao, Liang;
van der Graaf, Piet H.

Publication type:

Article

Quantitative Systems Pharmacology‐Based Digital Twins Approach Supplements Clinical Trial Data for Enzyme Replacement Therapies in Pompe Disease.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 2, p. 579, doi. 10.1002/cpt.3498

By:

Kaddi, Chanchala;
Tao, Mengdi;
Bergeler, Silke;
George, Kelly;
Geerts, Hugo;
van der Graaf, Piet H.;
Batista, Julie L.;
Foster, Meredith;
Ortemann‐Renon, Catherine;
Zaher, Atef;
An Haack, Kristina;
Zaph, Susana

Publication type:

Article

First‐in‐Human Dose Selection for T‐Cell Engaging Bispecific Antibodies.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 1, p. 11, doi. 10.1002/cpt.3487

By:

van der Graaf, Piet H.

Publication type:

Article

Therapeutic Orphan No More: Role for Clinical Pharmacology and Translational Science in Developing Therapeutics for Rare and Neglected Diseases.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 6, p. 1363, doi. 10.1002/cpt.3474

By:

Ramamoorthy, Anuradha;
Younis, Islam;
Wen, Ya‐Feng;
Mehanna, Mai;
Giacomini, Kathleen M.;
van der Graaf, Piet H.

Publication type:

Article

Is Pharmacogenetic Testing a Vital Tool for Enhancing Therapeutic Management of Patients Worldwide?

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 4, p. 885, doi. 10.1002/cpt.3404

By:

Giacomini, Kathleen M.;
van der Graaf, Piet H.

Publication type:

Article

Getting the Dosage Right: A Vital Role for Clinical Pharmacology in the Era of Precision Medicine.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 491, doi. 10.1002/cpt.3375

By:

Minichmayr, Iris K.;
Shebley, Mohamad;
van der Graaf, Piet H.;
Venkatakrishnan, Karthik

Publication type:

Article

Reflections on Model‐Informed Drug Development.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 2, p. 267, doi. 10.1002/cpt.3335

By:

Lesko, Lawrence J.;
van der Graaf, Piet H.

Publication type:

Article

Discovery and Model‐Informed Drug Development of a Controlled‐Release Formulation of Nonracemic Amisulpride that Reduces Plasma Exposure but Achieves Pharmacodynamic Bioequivalence in the Brain.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 2, p. 460, doi. 10.1002/cpt.3311

By:

Hopkins, Seth C.;
Toongsuwan, Siriporn;
Corriveau, Taryn J.;
Watanabe, Takao;
Tsushima, Yuki;
Asada, Takumi;
Lew, Robert;
Shi, Lei;
Zann, Vanessa;
Snowden, Thomas J.;
van der Graaf, Piet H.;
Darpo, Borje;
Searle, Graham E.;
Rabiner, Eugenii A.;
Wilding, Ian;
Szabo, Steven T.;
Galluppi, Gerald R.;
Koblan, Kenneth S.

Publication type:

Article

Weaning off Thorough QT Studies.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 1, p. 11, doi. 10.1002/cpt.3294

By:

Mehanna, Mai;
van der Graaf, Piet H.

Publication type:

Article

Moving the Needle for Oncology Dose Optimization: A Call for Action.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 6, p. 1187, doi. 10.1002/cpt.3263

By:

Venkatakrishnan, Karthik;
Jayachandran, Priya;
Seo, Shirley K.;
van der Graaf, Piet H.;
Wagner, John A.;
Gupta, Neeraj

Publication type:

Article

Best Practices for Pharmacokinetic Studies of New Chemical Entities.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 5, p. 917, doi. 10.1002/cpt.3231

By:

Wen, Ya‐Feng;
van der Graaf, Piet H.

Publication type:

Article

Artificial Intelligence/Machine Learning: The New Frontier of Clinical Pharmacology and Precision Medicine.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 4, p. 637, doi. 10.1002/cpt.3198

By:

Liu, Qi;
Joshi, Amita;
Standing, Joseph F.;
van der Graaf, Piet H.

Publication type:

Article

Subcutaneous Biologics: Clinical Pharmacology and Drug Development.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 3, p. 385, doi. 10.1002/cpt.3179

By:

Ait‐Oudhia, Sihem;
Chen, Joseph;
Li, Junyi;
van der Graaf, Piet H.

Publication type:

Article

Progress in Clinical Pharmacology in China: A Randomized Controlled Study to Advance Genotype‐Guided Precision Medicine.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 2, p. 169, doi. 10.1002/cpt.3126

By:

Zhao, Liang;
Giacomini, Kathleen M.;
van der Graaf, Piet H.

Publication type:

Article

No Recipe for Quantitative Systems Pharmacology Model Validation, but a Balancing Act Between Risk and Cost.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 1, p. 25, doi. 10.1002/cpt.3082

By:

Lemaire, Vincent;
Hu, Chuanpu;
van der Graaf, Piet H.;
Chang, Steve;
Wang, Weirong

Publication type:

Article

Ensuring Transparency and Quality of Clinical Trial Reporting in Clinical Pharmacology & Therapeutics: Prospective Trial Registration and Compliance with Reporting Guidelines Are Required for all Clinical Trials.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 6, p. 1153, doi. 10.1002/cpt.3070

By:

Smith, D. Max;
Minichmayr, Iris K.;
Standing, Joseph F.;
Giacomini, Kathleen M.;
van der Graaf, Piet H.;
Peck, Richard W.

Publication type:

Article

Novel Therapeutic Modalities: The Future is Now.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 3, p. 493, doi. 10.1002/cpt.2996

By:

Choi, Yewon;
Vinks, Alexander A.;
van der Graaf, Piet H.

Publication type:

Article

Trends in Clinical Pharmacology and Therapeutics.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 1, p. 11, doi. 10.1002/cpt.2931

By:

Minichmayr, Iris K.;
Smith, D. Max;
Giacomini, Kathleen M.;
van der Graaf, Piet H.

Publication type:

Article

Clinical Significance of Therapeutic Peptide and Protein Drug Interactions: A Call to Action.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 6, p. 1173, doi. 10.1002/cpt.2899

By:

van der Graaf, Piet H.

Publication type:

Article

Mush Room for Improving Therapeutic Approaches in Psychiatry.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 4, p. 757, doi. 10.1002/cpt.2859

By:

van der Graaf, Piet H.

Publication type:

Article

Diversity, Equity, and Inclusion: Translating Clinical Pharmacology for All.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 3, p. 457, doi. 10.1002/cpt.2853

By:

Venkatakrishnan, Karthik;
Brown, Karen E.;
Giacomini, Kathleen M.;
van der Graaf, Piet H.

Publication type:

Article

How a Pandemic Simultaneously Strengthened Existing Fundamentals and Drove New Innovations in Clinical Pharmacology.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 6, p. 1141, doi. 10.1002/cpt.2758

By:

Seo, Shirley K.;
van der Graaf, Piet H.

Publication type:

Article

Toward Project Optimus for Oncology Precision Medicine: Multi‐Dimensional Dose Optimization Enabled by Quantitative Clinical Pharmacology.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 5, p. 927, doi. 10.1002/cpt.2742

By:

Venkatakrishnan, Karthik;
van der Graaf, Piet H.

Publication type:

Article

Roadmap to 2030 for Drug Evaluation in Older Adults.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 2, p. 210, doi. 10.1002/cpt.2452

By:

Liu, Qi;
Schwartz, Janice B.;
Slattum, Patricia W.;
Lau, S.W. Johnny;
Guinn, Daphne;
Madabushi, Rajanikanth;
Burckart, Gilbert;
Califf, Robert;
Cerreta, Francesca;
Cho, Carolyn;
Cook, Jack;
Gamerman, Jamie;
Goldsmith, Paul;
van der Graaf, Piet H.;
Gurwitz, Jerry H.;
Haertter, Sebastian;
Hilmer, Sarah;
Huang, Shiew‐Mei;
Inouye, Sharon K.;
Kanapuru, Bindu

Publication type:

Article

Quantitative Clinical Pharmacology of CAR T‐Cell Therapy.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 1, p. 11, doi. 10.1002/cpt.2631

By:

Holstein, Sarah A.;
Venkatakrishnan, Karthik;
van der Graaf, Piet H.

Publication type:

Article

Therapeutic Innovations in Neuroscience: What's New on the Horizon?

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 4, p. 715, doi. 10.1002/cpt.2547

By:

Minichmayr, Iris K.;
Ravenstijn, Paulien;
van der Graaf, Piet H.;
Vamvakas, Spiros

Publication type:

Article

The Pandemic as a Catalyst for Disruptive Innovation in Clinical Pharmacology.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 3, p. 529, doi. 10.1002/cpt.2519

By:

Giacomini, Kathleen M.;
van der Graaf, Piet H.

Publication type:

Article

BIA 10‐2474: Some Lessons are Clear but Important Questions Remain Unanswered.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 2, p. 343, doi. 10.1002/cpt.2495

By:

Peck, Richard W.;
Holstein, Sarah A.;
van der Graaf, Piet H.

Publication type:

Article

Themes in Clinical Pharmacology and Therapeutics.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 6, p. 1413, doi. 10.1002/cpt.2436

By:

van der Graaf, Piet H.;
Gerding, Alethea B.

Publication type:

Article

Model‐Informed Drug Development: Connecting the Dots With a Totality of Evidence Mindset to Advance Therapeutics.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 5, p. 1147, doi. 10.1002/cpt.2422

By:

Venkatakrishnan, Karthik;
van der Graaf, Piet H.

Publication type:

Article

Mechanistic Quantitative Pharmacology Strategies for the Early Clinical Development of Bispecific Antibodies in Oncology.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 3, p. 528, doi. 10.1002/cpt.1961

By:

Betts, Alison;
van der Graaf, Piet H.

Publication type:

Article

COVID-19: A Defining Moment for Clinical Pharmacology?

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 1, p. 11, doi. 10.1002/cpt.1876

By:

van der Graaf, Piet H.;
Giacomini, Kathleen M.

Publication type:

Article

Design principles of collateral sensitivity-based dosing strategies.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25927-3

By:

Aulin, Linda B. S.;
Liakopoulos, Apostolos;
van der Graaf, Piet H.;
Rozen, Daniel E.;
van Hasselt, J. G. Coen

Publication type:

Article

Evaluation of a Cardiovascular Systems Model for Design and Analysis of Hemodynamic Safety Studies.

Published in:

Pharmaceutics, 2023, v. 15, n. 4, p. 1175, doi. 10.3390/pharmaceutics15041175

By:

Fu, Yu;
Snelder, Nelleke;
Guo, Tingjie;
van der Graaf, Piet H.;
van Hasselt, Johan. G. C.

Publication type:

Article

A Review of Quantitative Systems Pharmacology Models of the Coagulation Cascade: Opportunities for Improved Usability.

Published in:

Pharmaceutics, 2023, v. 15, n. 3, p. 918, doi. 10.3390/pharmaceutics15030918

By:

Chung, Douglas;
Bakshi, Suruchi;
van der Graaf, Piet H.

Publication type:

Article

Using a Network-Based Analysis Approach to Investigate the Involvement of S. aureus in the Pathogenesis of Granulomatosis with Polyangiitis.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 3, p. 1822, doi. 10.3390/ijms24031822

By:

Rowland, Gregory;
Kronbichler, Andreas;
Smith, Rona;
Jayne, David;
van der Graaf, Piet H.;
Chelliah, Vijayalakshmi

Publication type:

Article

Computational neurosciences and quantitative systems pharmacology: a powerful combination for supporting drug development in neurodegenerative diseases.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2024, v. 51, n. 5, p. 563, doi. 10.1007/s10928-023-09876-6

By:

Geerts, Hugo;
Bergeler, Silke;
Lytton, William W.;
van der Graaf, Piet H.

Publication type:

Article

A system pharmacology Boolean network model for the TLR4-mediated inflammatory response in early sepsis.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2022, v. 49, n. 6, p. 645, doi. 10.1007/s10928-022-09828-6

By:

Liu, Feiyan;
Aulin, Linda B. S.;
Kossen, Sebastiaan S. A.;
Cathalina, Julius;
Bremmer, Marlotte;
Foks, Amanda C.;
van der Graaf, Piet H.;
Moerland, Matthijs;
van Hasselt, Johan G. C.

Publication type:

Article

Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM1.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2020, v. 47, n. 5, p. 513, doi. 10.1007/s10928-020-09702-3

By:

Betts, Alison;
Clark, Tracey;
Jasper, Paul;
Tolsma, John;
van der Graaf, Piet H.;
Graziani, Edmund I.;
Rosfjord, Edward;
Sung, Matthew;
Ma, Dangshe;
Barletta, Frank

Publication type:

Article

Quantification of the endogenous growth hormone and prolactin lowering effects of a somatostatin-dopamine chimera using population PK/PD modeling.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2020, v. 47, n. 3, p. 229, doi. 10.1007/s10928-020-09683-3

By:

van Esdonk, Michiel J.;
Burggraaf, Jacobus;
Dehez, Marion;
van der Graaf, Piet H.;
Stevens, Jasper

Publication type:

Article

Correction to: Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models.

Published in:

2018

By:

de Witte, Wilhelmus E. A.;
Rottschäfer, Vivi;
Danhof, Meindert;
van der Graaf, Piet H.;
Peletier, Lambertus A.;
de Lange, Elizabeth C. M.

Publication type:

Correction Notice

Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2018, v. 45, n. 4, p. 621, doi. 10.1007/s10928-018-9593-x

By:

de Witte, Wilhelmus E. A.;
Rottschäfer, Vivi;
Danhof, Meindert;
van der Graaf, Piet H.;
Peletier, Lambertus A.;
de Lange, Elizabeth C. M.

Publication type:

Article

Model reduction in mathematical pharmacology.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2018, v. 45, n. 4, p. 537, doi. 10.1007/s10928-018-9584-y

By:

Snowden, Thomas J.;
van der Graaf, Piet H.;
Tindall, Marcus J.

Publication type:

Article

A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability.

Published in:

Bulletin of Mathematical Biology, 2022, v. 84, n. 3, p. 1, doi. 10.1007/s11538-021-00982-5

By:

Sher, Anna;
Niederer, Steven A.;
Mirams, Gary R.;
Kirpichnikova, Anna;
Allen, Richard;
Pathmanathan, Pras;
Gavaghan, David J.;
van der Graaf, Piet H.;
Noble, Denis

Publication type:

Article

Correction to: Mathematical Modelling of Alternative Pathway of Complement System.

Published in:

2022

By:

Bakshi, Suruchi;
Cunningham, Fraser;
Nichols, Eva-Maria;
Biedzka-Sarek, Marta;
Neisen, Jessica;
Petit-Frere, Sebastien;
Bessant, Christina;
Bansal, Loveleena;
Peletier, Lambertus A.;
Zamuner, Stefano;
van der Graaf, Piet H.

Publication type:

Correction Notice

Mathematical Modelling of Alternative Pathway of Complement System.

Published in:

Bulletin of Mathematical Biology, 2020, v. 82, n. 2, p. 1, doi. 10.1007/s11538-020-00708-z

By:

Bakshi, Suruchi;
Cunningham, Fraser;
Nichols, Eva-Maria;
Biedzka-Sarek, Marta;
Neisen, Jessica;
Petit-Frere, Sebastien;
Bessant, Christina;
Bansal, Loveleena;
Peletier, Lambertus A.;
Zamuner, Stefano;
van der Graaf, Piet H.

Publication type:

Article

Model‐based dose optimization framework for bedaquiline, pretomanid and linezolid for the treatment of drug‐resistant tuberculosis.

Published in:

British Journal of Clinical Pharmacology, 2024, v. 90, n. 2, p. 463, doi. 10.1111/bcp.15925

By:

Mehta, Krina;
Guo, Tingjie;
van der Graaf, Piet H.;
van Hasselt, J. G. Coen

Publication type:

Article