Works by Ye, Keqiang

Results: 115

Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus.

Published in:

2020

By:

Seong Su Kang;
Xia Liu;
Eun Hee Ahn;
Jie Xiang;
Manfredsson, Fredric P.;
Xifei Yang;
Luo, Hongbo R.;
Liles, L. Cameron;
Weinshenker, David;
Keqiang Ye;
Kang, Seong Su;
Liu, Xia;
Ahn, Eun Hee;
Xiang, Jie;
Yang, Xifei;
Ye, Keqiang

Publication type:

journal article

Tumor Necrosis Factor-α Promotes Phosphoinositide 3-Kinase Enhancer A and AMP-Activated Protein Kinase Interaction to Suppress Lipid Oxidation in Skeletal Muscle.

Published in:

2017

By:

Chui Ling Tse, Margaret;
Herlea-Pana, Oana;
Brobst, Daniel;
Xiuying Yang;
Wood, John;
Xiang Hu;
Zhixue Liu;
Chi Wai Lee;
Aung Moe Zaw;
Chow, Billy K. C.;
Keqiang Ye;
Chi Bun Chan;
Ling Tse, Margaret Chui;
Yang, Xiuying;
Hu, Xiang;
Liu, Zhixue;
Lee, Chi Wai;
Zaw, Aung Moe;
Ye, Keqiang;
Chan, Chi Bun

Publication type:

journal article

NQO1 Is Regulated by PTEN in Glioblastoma, Mediating Cell Proliferation and Oxidative Stress.

Published in:

Oxidative Medicine & Cellular Longevity, 2018, p. 1, doi. 10.1155/2018/9146528

By:

Luo, Shilin;
Lei, Kecheng;
Xiang, Daxiong;
Ye, Keqiang

Publication type:

Article

C/EBPβ/AEP Signaling Drives Alzheimer's Disease Pathogenesis.

Published in:

Neuroscience Bulletin, 2023, v. 39, n. 7, p. 1173, doi. 10.1007/s12264-023-01025-w

By:

Xiong, Jing;
Zhang, Zhentao;
Ye, Keqiang

Publication type:

Article

Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease.

Published in:

Journal of Neuroscience, 2019, v. 39, n. 37, p. 7291, doi. 10.1523/JNEUROSCI.0625-19.2019

By:

Shilin Luo;
Seong Su Kang;
Zhi-Hao Wang;
Xia Liu;
Julia X. Day;
Zhiping Wu;
Junmin Peng;
Daxiong Xiang;
Springer, Wolfdieter;
Keqiang Ye

Publication type:

Article

Fine Particulate Matter Triggers α-Synuclein Fibrillization and Parkinson-like Neurodegeneration.

Published in:

2022

By:

Yuan, Xin;
Yang, Yingxu;
Liu, Chaoyang;
Tian, Ye;
Xia, Danhao;
Liu, Zehua;
Pan, Lina;
Xiong, Min;
Xiong, Jing;
Meng, Lanxia;
Zhang, Zhaohui;
Ye, Keqiang;
Jiang, Haiqiang;
Zhang, Zhentao

Publication type:

journal article

Development of Positron Emission Tomography Radiotracers for Imaging α-Synuclein Aggregates.

Published in:

Cells (2073-4409), 2025, v. 14, n. 12, p. 907, doi. 10.3390/cells14120907

By:

Guo, Xiaodi;
Xiang, Jie;
Ye, Keqiang;
Zhang, Zhentao

Publication type:

Article

Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases.

Published in:

Expert Opinion on Therapeutic Targets, 2016, v. 20, n. 10, p. 1237, doi. 10.1080/14728222.2016.1182990

By:

Zhang, Zhentao;
Xie, Manling;
Ye, Keqiang

Publication type:

Article

Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus.

Published in:

Journal of Clinical Investigation, 2020, v. 130, n. 1, p. 422, doi. 10.1172/JCI130513

By:

Seong Su Kang;
Xia Liu;
Eun Hee Ahn;
Jie Xiang;
Manfredsson, Fredric P.;
Xifei Yang;
Luo, Hongbo R.;
Liles, L. Cameron;
Weinshenker, David;
Keqiang Ye

Publication type:

Article

Proteinase 3-dependent caspase-3 cleavage modulates neutrophil death and inflammation.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 10, p. 4445, doi. 10.1172/JCI76246

By:

Loison, Fabien;
Haiyan Zhu;
Kutay Karatepe;
Anongnard Kasorn;
Peng Liu;
Keqiang Ye;
Jiaxi Zhou;
Shannan Cao;
Haiyan Gong;
Jenne, Dieter E.;
Remold-O'Donnell, Eileen;
Yuanfu Xu;
Hongbo R. Luo

Publication type:

Article

Transgenic Mice Expressing Human α-Synuclein 1-103 Fragment as a Novel Model of Parkinson's Disease.

Published in:

Frontiers in Aging Neuroscience, 2021, v. 13, p. 1, doi. 10.3389/fnagi.2021.760781

By:

Tian, Ye;
He, Mingyang;
Pan, Lina;
Yuan, Xin;
Xiong, Min;
Meng, Lanxia;
Yao, Zhaohui;
Yu, Zhui;
Ye, Keqiang;
Zhang, Zhentao

Publication type:

Article

Age-related attenuation of cortical synaptic tagging in the ACC is rescued by BDNF or a TrkB receptor agonist in both sex of mice.

Published in:

Molecular Brain, 2023, p. 1, doi. 10.1186/s13041-022-00992-x

By:

Zhou, Si-Bo;
Xue, Man;
Liu, Weiqi;
Chen, Yu-Xin;
Chen, Qi-Yu;
Lu, Jing-Shan;
Wang, Jinjun;
Ye, Keqiang;
Li, Xu-Hui;
Zhuo, Min

Publication type:

Article

Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator‐Induced Brain Hemorrhagic Transformation After Ischemic Stroke.

Published in:

CNS Neuroscience & Therapeutics, 2025, v. 31, n. 3, p. 1, doi. 10.1111/cns.70345

By:

Xie, Guanfeng;
Jiang, Gege;
Huang, Liqin;
Sun, Shangqi;
Li, Xiaoyi;
Wu, Bingjie;
Wang, Hualong;
Zhang, Zhentao;
Ye, Keqiang;
Yu, Ying;
Xiong, Jing

Publication type:

Article

Oral Treatments With the TrkB Ligand Prodrug, R13, Promote Enhanced Axon Regeneration Following Peripheral Nerve Injury.

Published in:

Frontiers in Cellular Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fncel.2022.857664

By:

English, Arthur W.;
Carrasco, Dario;
Hoffman, Dustin;
Isaacson, Robin;
Kang, Seong Su;
Khan, Samia;
Liu, Xia;
Ye, Keqiang

Publication type:

Article

PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death.

Published in:

Journal of Cellular & Molecular Medicine, 2007, v. 11, n. 1, p. 39, doi. 10.1111/j.1582-4934.2007.00014.x

By:

Chi Bun Chan;
Keqiang Ye

Publication type:

Article

Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease.

Published in:

Experimental & Molecular Medicine EMM, 2020, v. 52, n. 8, p. 1275, doi. 10.1038/s12276-020-00494-7

By:

Kang, Seong Su;
Ahn, Eun Hee;
Ye, Keqiang

Publication type:

Article

The roles of PIKE in tumorigenesis.

Published in:

Acta Pharmacologica Sinica, 2013, v. 34, n. 8, p. 991, doi. 10.1038/aps.2013.71

By:

Qi, Qi;
Ye, Keqiang

Publication type:

Article

Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth.

Published in:

Acta Pharmacologica Sinica, 2013, v. 34, n. 7, p. 930, doi. 10.1038/aps.2013.40

By:

Qi, Qi;
Liu, Xia;
Li, Shiyong;
Joshi, Harish C;
Ye, Keqiang

Publication type:

Article

Asparaginyl endopeptidase cleaves TDP-43 in brain.

Published in:

Proteomics, 2012, v. 12, n. 15/16, p. 2455, doi. 10.1002/pmic.201200006

By:

Herskowitz, Jeremy H.;
Gozal, Yair M.;
Duong, Duc M.;
Dammer, Eric B.;
Gearing, Marla;
Ye, Keqiang;
Lah, James J.;
Peng, Junmin;
Levey, Allan I.;
Seyfried, Nicholas T.

Publication type:

Article

Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer's disease.

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2019, v. 46, n. 5, p. 1152, doi. 10.1007/s00259-018-4242-6

By:

Leuzy, Antoine;
Chiotis, Konstantinos;
Lemoine, Laetitia;
Saint-Aubert, Laure;
Nordberg, Agneta;
Cicognola, Claudia;
Blennow, Kaj;
Höglund, Kina;
Zetterberg, Henrik;
Andreasen, Niels;
Ye, Keqiang

Publication type:

Article

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances.

Published in:

Signal Transduction & Targeted Therapy, 2025, v. 10, n. 1, p. 1, doi. 10.1038/s41392-025-02145-7

By:

Jiang, Qiu;
Liu, Jie;
Huang, Shan;
Wang, Xuan-Yue;
Chen, Xiaowei;
Liu, Guang-Hui;
Ye, Keqiang;
Song, Weihong;
Masters, Colin L.;
Wang, Jun;
Wang, Yan-Jiang

Publication type:

Article

7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.64872

By:

Fan Xue;
Zhenlei Zhao;
Yanpei Gu;
Jianxin Han;
Keqiang Ye;
Ying Zhang

Publication type:

Article

Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.65301

By:

Xingyu Zhang;
Li Zou;
Lanxia Meng;
Min Xiong;
Lina Pan;
Guiqin Chen;
Yongfa Zheng;
Jing Xiong;
Zhihao Wang;
Duc M. Duong;
Zhaohui Zhang;
Xuebing Cao;
Tao Wang;
Li Tang;
Keqiang Ye;
Zhentao Zhang

Publication type:

Article

Nuclear Functions of the Arf Guanine Nucleotide Exchange Factor BRAG2.

Published in:

Traffic, 2007, v. 8, n. 6, p. 661, doi. 10.1111/j.1600-0854.2007.00561.x

By:

Dunphy, Jillian L.;
Ye, Keqiang;
Casanova, James E.

Publication type:

Article

A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32435-5

By:

Xiong, Jing;
Liao, Jianming;
Liu, Xia;
Zhang, Zhaohui;
Adams, Jonathan;
Pacifici, Roberto;
Ye, Keqiang

Publication type:

Article

CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals.

Published in:

Alzheimer's Research & Therapy, 2022, v. 14, n. 1, p. 1, doi. 10.1186/s13195-022-01142-0

By:

Simrén, Joel;
Brum, Wagner S.;
Ashton, Nicholas J.;
Benedet, Andrea L.;
Karikari, Thomas K.;
Kvartsberg, Hlin;
Sjons, Emma;
Lussier, Firoza Z.;
Chamoun, Mira;
Stevenson, Jenna;
Hopewell, Robert;
Pallen, Vanessa;
Ye, Keqiang;
Pascoal, Tharick A.;
Zetterberg, Henrik;
Rosa-Neto, Pedro;
Blennow, Kaj

Publication type:

Article

Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia.

Published in:

Science Translational Medicine, 2018, v. 10, n. 435, p. 1, doi. 10.1126/scitranslmed.aal4045

By:

Hou, Qingming;
Liu, Fei;
Chakraborty, Anutosh;
Jia, Yonghui;
Prasad, Amit;
Yu, Hongbo;
Zhao, Li;
Ye, Keqiang;
Snyder, Solomon H.;
Xu, Yuanfu;
Luo, Hongbo R.

Publication type:

Article

Sex differences in brain-derived neurotrophic factor signaling and functions.

Published in:

Journal of Neuroscience Research, 2017, v. 95, n. 1/2, p. 328, doi. 10.1002/jnr.23863

By:

Chan, Chi Bun;
Ye, Keqiang

Publication type:

Article

Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice.

Published in:

Autophagy, 2022, v. 18, n. 6, p. 1367, doi. 10.1080/15548627.2021.1985257

By:

Ahuja, Palak;
Ng, Chun Fai;
Pang, Brian Pak Shing;
Chan, Wing Suen;
Tse, Margaret Chui Ling;
Bi, Xinyi;
Kwan, Hiu-Lam Rachel;
Brobst, Daniel;
Herlea-Pana, Oana;
Yang, Xiuying;
Du, Guanhua;
Saengnipanthkul, Suchaorn;
Noh, Hye Lim;
Jiao, Baowei;
Kim, Jason K.;
Lee, Chi Wai;
Ye, Keqiang;
Chan, Chi Bun

Publication type:

Article

Protection of Spiral Ganglion Neurons from Degeneration Using Small-Molecule TrkB Receptor Agonists.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 32, p. 13042, doi. 10.1523/JNEUROSCI.0854-13.2013

By:

Qing Yu;
Qing Chang;
Xia Liu;
Yunfeng Wang;
Huawei Li;
Shusheng Gong;
Keqiang Ye;
Xi Lin

Publication type:

Article

SRPK2 Phosphorylates Tau and Mediates the Cognitive Defects in Alzheimer's Disease.

Published in:

Journal of Neuroscience, 2012, v. 32, n. 48, p. 17262, doi. 10.1523/JNEUROSCI.3300-12.2012

By:

Yi Hong;
Chi Bun Chan;
Il-Sun Kwon;
Xuekun Li;
Song, Mingke;
Hyun-Pil Lee;
Xia Liu;
Sompol, Pradoldej;
Peng Jin;
Hyoung-gon Lee;
Shan Ping Yu;
Keqiang Ye

Publication type:

Article

Phosphoinositide 3-Kinase Enhancer Regulates Neuronal Dendritogenesis and Survival in Neocortex.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 22, p. 8083, doi. 10.1523/JNEUROSCI.1129-11.2011

By:

Chi Bun Chan;
Xia Liu;
Pradoldej, Sompol;
Chunhai Hao;
Jie An;
Yepes, Manuel;
Luo, Hongbo R.;
Keqiang Ye

Publication type:

Article

Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome.

Published in:

Journal of Neuroscience, 2010, v. 30, n. 32, p. 10624, doi. 10.1523/JNEUROSCI.0402-10.2010

By:

Gross, Christina;
Nakamoto, Mika;
Xiaodi Yao;
Chi-Bun Chan;
Yim, So Y.;
Keqiang Ye;
Warren, Stephen T.;
Bassell, Gary J.

Publication type:

Article

Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer's disease.

Published in:

EMBO Journal, 2021, v. 40, n. 17, p. 1, doi. 10.15252/embj.2020106320

By:

Chen, Chun;
Zhou, Yunzhe;
Wang, Hualong;
Alam, Ashfaqul;
Kang, Seong Su;
Ahn, Eun Hee;
Liu, Xia;
Jia, Jianping;
Ye, Keqiang

Publication type:

Article

Netrin‐1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features.

Published in:

EMBO Journal, 2021, v. 40, n. 3, p. 1, doi. 10.15252/embj.2020105537

By:

Jasmin, Mélissa;
Ahn, Eun Hee;
Voutilainen, Merja H;
Fombonne, Joanna;
Guix, Catherine;
Viljakainen, Tuulikki;
Kang, Seong Su;
Yu, Li‐ying;
Saarma, Mart;
Mehlen, Patrick;
Ye, Keqiang

Publication type:

Article

α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease.

Published in:

EMBO Journal, 2018, v. 37, n. 12, p. 1, doi. 10.15252/embj.201798878

By:

Kang, Seong Su;
Ahn, Eun Hee;
Zhang, Zhentao;
Liu, Xia;
Manfredsson, Fredric P.;
Sandoval, Ivette M.;
Dhakal, Susov;
Iuvone, P. Michael;
Cao, Xuebing;
Ye, Keqiang

Publication type:

Article

PIKE/nuclear PI 3‐kinase signaling in preventing programmed cell death.

Published in:

Journal of Cellular Biochemistry, 2005, v. 96, n. 3, p. 463, doi. 10.1002/jcb.20549

By:

Keqiang Ye

Publication type:

Article

7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer's Disease.

Published in:

Neuropsychopharmacology, 2014, v. 39, n. 3, p. 638, doi. 10.1038/npp.2013.243

By:

Zhang, Zhentao;
Liu, Xia;
Schroeder, Jason P;
Chan, Chi-Bun;
Song, Mingke;
Yu, Shan Ping;
Weinshenker, David;
Ye, Keqiang

Publication type:

Article

N-Acetylserotonin: Neuroprotection, Neurogenesis, and the Sleepy Brain.

Published in:

Neuroscientist, 2012, v. 18, n. 6, p. 645, doi. 10.1177/1073858412446634

By:

Tosini, Gianluca;
Ye, Keqiang;
Iuvone, P. Michael

Publication type:

Article

FSH and ApoE4 contribute to Alzheimer's disease-like pathogenesis via C/EBPβ/δ-secretase in female mice.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42282-7

By:

Xiong, Jing;
Kang, Seong Su;
Wang, Mengmeng;
Wang, Zhihao;
Xia, Yiyuan;
Liao, Jianming;
Liu, Xia;
Yu, Shan-Ping;
Zhang, Zhaohui;
Ryu, Vitaly;
Yuen, Tony;
Zaidi, Mone;
Ye, Keqiang

Publication type:

Article

Bacteroides Fragilis in the gut microbiomes of Alzheimer's disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41283-w

By:

Xia, Yiyuan;
Xiao, Yifan;
Wang, Zhi-Hao;
Liu, Xia;
Alam, Ashfaqul M.;
Haran, John P.;
McCormick, Beth A.;
Shu, Xiji;
Wang, Xiaochuan;
Ye, Keqiang

Publication type:

Article

Netrin-1 signaling pathway mechanisms in neurodegenerative diseases.

Published in:

Neural Regeneration Research, 2025, v. 20, n. 4, p. 960, doi. 10.4103/NRR.NRR-D-23-01573

By:

Kedong Zhu;
Hualong Wang;
Keqiang Ye;
Guiqin Chen;
Zhaohui Zhang

Publication type:

Article

CK2 Phosphorylating I<sub>2</sub><sup>PP2A</sup>/SET Mediates Tau Pathology and Cognitive Impairment.

Published in:

Frontiers in Molecular Neuroscience, 2018, p. 1, doi. 10.3389/fnmol.2018.00146

By:

Zhang, Qing;
Xia, Yiyuan;
Wang, Yongjun;
Shentu, Yangping;
Zeng, Kuan;
Mahaman, Yacoubou A. R.;
Huang, Fang;
Wu, Mengjuan;
Ke, Dan;
Wang, Qun;
Zhang, Bin;
Liu, Rong;
Wang, Jian-Zhi;
Ye, Keqiang;
Wang, Xiaochuan

Publication type:

Article

Inhibition of IκB kinase in Notch signaling activates FOXO3a.

Published in:

Cell Cycle, 2012, v. 11, n. 13, p. 2417, doi. 10.4161/cc.21067

By:

Keqiang Ye

Publication type:

Article

Phosphorylation of Merlin Regulates its Stability and Tumor Suppressive Activity.

Published in:

Cell Adhesion & Migration, 2007, v. 1, n. 4, p. 196, doi. 10.4161/cam.1.4.5192

By:

Ye, Keqiang

Publication type:

Article

Fyn Regulates Adipogenesis by Promoting PIKE-A/STAT5a Interaction.

Published in:

Molecular & Cellular Biology, 2013, v. 33, n. 9, p. 1797, doi. 10.1128/MCB.01410-12

By:

Chui Ling Tse, Margaret;
Xia Liu;
Seran Yang;
Keqiang Ye;
Chi Bun Chan

Publication type:

Article

Inhibition of Mammalian Target of Rapamycin Induces Phosphatidylinositol 3-Kinase-Dependent and Mnk-Mediated Eukaryotic Translation Initiation Factor 4E Phosphorylation.

Published in:

Molecular & Cellular Biology, 2007, v. 27, n. 21, p. 5, doi. 10.1128/MCB.00760-07

By:

Xuerong Wang;
Ping Yue;
Chi-Bun Chan;
Keqiang Ye;
Ueda, Takeshi;
Watanabe-Fukunaga, Rie;
Fukunaga, Rikiro;
Haian Fu;
Khuri, Fadlo R.;
Shi-Yong Sun

Publication type:

Article

Interaction between ROCK II and Nucleophosmin/B23 in the Regulation of Centrosome Duplication.

Published in:

Molecular & Cellular Biology, 2006, v. 26, n. 23, p. 30, doi. 10.1128/MCB.01383-06

By:

Zhiyong Ma;
Kanai, Masayuki;
Kawamura, Kenji;
Kaibuchi, Kozo;
Keqiang Ye;
Fukasawa, Kenji

Publication type:

Article

Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses.

Published in:

Cancer Immunology, Immunotherapy, 2000, v. 49, n. 4/5, p. 217, doi. 10.1007/s002620000109

By:

Ke, Yong;
Ye, Keqiang;
Grossniklaus, Hans E.;
Archer, David R.;
Joshi, Harish C.;
Kapp, Judith A.

Publication type:

Article

O-Methylated Metabolite of 7,8-Dihydroxyflavone Activates TrkB Receptor and Displays Antidepressant Activity.

Published in:

Pharmacology, 2013, v. 91, n. 3/4, p. 185, doi. 10.1159/000346920

By:

Liu, Xia;
Qi, Qi;
Xiao, Ge;
Li, Jingyu;
Luo, Hongbo R.;
Ye, Keqiang

Publication type:

Article