Works by Wengel, Jesper

Results: 116

Evaluation of Gene Expression Knock‐Down by Chemically and Structurally Modified Gapmer Antisense Oligonucleotides.

Published in:

ChemBioChem, 2022, v. 23, n. 15, p. 1, doi. 10.1002/cbic.202200168

By:

Lisowiec‐Wąchnicka, Jolanta;
Danielsen, Mathias B.;
Nader, Eugenie Abi;
Jørgensen, Per T.;
Wengel, Jesper;
Pasternak, Anna

Publication type:

Article

Development of an Efficient G-Quadruplex-Stabilised Thrombin-Binding Aptamer Containing a Three-Carbon Spacer Molecule.

Published in:

ChemBioChem, 2017, v. 18, n. 8, p. 755, doi. 10.1002/cbic.201600654

By:

Aaldering, Lukas J.;
Poongavanam, Vasanthanathan;
Langkjær, Niels;
Murugan, N. Arul;
Jørgensen, Per Trolle;
Wengel, Jesper;
Veedu, Rakesh N.

Publication type:

Article

Unlocked Nucleic Acids with a Pyrene-Modified Uracil: Synthesis, Hybridization Studies, Fluorescent Properties and i-Motif Stability.

Published in:

ChemBioChem, 2014, v. 15, n. 1, p. 146, doi. 10.1002/cbic.201300567

By:

Perlíková, Pavla;
Karlsen, Kasper K.;
Pedersen, Erik B.;
Wengel, Jesper

Publication type:

Article

Photoinduzierter reduktiver Elektronentransfer in LNA:DNA-Hybriden: Kompromiss aus Konformation und Basenstapelung.

Published in:

Angewandte Chemie, 2012, v. 124, n. 40, p. 10168, doi. 10.1002/ange.201204901

By:

Wenge, Ulrike;
Wengel, Jesper;
Wagenknecht, Hans-Achim

Publication type:

Article

Functionalization of 2"-C-(Piperazinomethyl)-2',3'-BcNA (Bicyclic Nucleic Acids) with Pyren-1-ylcarbonyl Units.

Published in:

Helvetica Chimica Acta, 2014, v. 97, n. 9, p. 1204

By:

Jørgensen, Per Trolle;
Wengel, Jesper;
Hansen, Morten Borre;
Raunkjær, Michael;
Andersen, Nicolai Krog

Publication type:

Article

Application of locked nucleic acid-based probes in fluorescence in situ hybridization.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 13, p. 5897, doi. 10.1007/s00253-016-7429-4

By:

Fontenete, Sílvia;
Carvalho, Daniel;
Guimarães, Nuno;
Madureira, Pedro;
Figueiredo, Céu;
Wengel, Jesper;
Azevedo, Nuno

Publication type:

Article

Mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 9, p. 3961, doi. 10.1007/s00253-015-6389-4

By:

Silvia, Fontenete;
Joana, Barros;
Pedro, Madureira;
Céu, Figueiredo;
Jesper, Wengel;
Filipe, Azevedo

Publication type:

Article

Erratum to: Mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids.

Published in:

2015

By:

Fontenete, Silvia;
Barros, Joana;
Madureira, Pedro;
Figueiredo, Céu;
Wengel, Jesper;
Azevedo, Nuno

Publication type:

Erratum

The conformations of locked nucleic acids (LNA).

Published in:

Journal of Molecular Recognition, 2000, v. 13, n. 1, p. 44, doi. 10.1002/(SICI)1099-1352(200001/02)13:1<44::AID-JMR486>3.0.CO;2-6

By:

Petersen, Michael;
Nielsen, Christina B.;
Nielsen, Katrine E.;
Jensen, Gitte A.;
Bondensgaard, Kent;
Singh, Sanjay K.;
Rajwanshi, Vivek K.;
Koshkin, Alexei A.;
Dahl, Britta M.;
Wengel, Jesper;
Jacobsen, Jens Peter

Publication type:

Article

Polyamine‐Functionalized 2′‐Amino‐LNA in Oligonucleotides: Facile Synthesis of New Monomers and High‐Affinity Binding towards ssDNA and dsDNA.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 4, p. 1416, doi. 10.1002/chem.202004495

By:

Danielsen, Mathias B.;
Christensen, Niels Johan;
Jørgensen, Per T.;
Jensen, Knud J.;
Wengel, Jesper;
Lou, Chenguang

Publication type:

Article

Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA.

Published in:

Nucleic Acids Research, 2013, v. 41, n. 5, p. 3257, doi. 10.1093/nar/gkt007

By:

Moreno, Pedro M. D.;
Geny, Sylvain;
Pabon, Y. Vladimir;
Bergquist, Helen;
Zaghloul, Eman M.;
Rocha, Cristina S. J.;
Oprea, Iulian I.;
Bestas, Burcu;
Andaloussi, Samir EL;
Jørgensen, Per T.;
Pedersen, Erik B.;
Lundin, Karin E.;
Zain, Rula;
Wengel, Jesper;
Smith, C. I. Edvard

Publication type:

Article

In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 10, p. 4653, doi. 10.1093/nar/gks033

By:

Schyth, Brian Dall;
Bramsen, Jesper Bertram;
Pakula, Malgorzata Maria;
Larashati, Sekar;
Kjems, Jørgen;
Wengel, Jesper;
Lorenzen, Niels

Publication type:

Article

Synthesis and structural characterization of piperazino-modified DNA that favours hybridization towards DNA over RNA.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 5, p. 1953, doi. 10.1093/nar/gkq1123

By:

Skov, Joan;
Bryld, Torsten;
Lindegaard, Dorthe;
Nielsen, Katrine E.;
Højland, Torben;
Wengel, Jesper;
Petersen, Michael

Publication type:

Article

Optimizing anti-gene oligonucleotide ‘Zorro-LNA’ for improved strand invasion into duplex DNA.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 3, p. 1142, doi. 10.1093/nar/gkq835

By:

Zaghloul, Eman M.;
Madsen, Andreas S.;
Moreno, Pedro M. D.;
Oprea, Iulian I.;
El-Andaloussi, Samir;
Bestas, Burcu;
Gupta, Pankaj;
Pedersen, Erik B.;
Lundin, Karin E.;
Wengel, Jesper;
Smith, C. I. Edvard

Publication type:

Article

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 3, p. 1155, doi. 10.1093/nar/gkq823

By:

Pasternak, Anna;
Hernandez, Frank J.;
Rasmussen, Lars M.;
Vester, Birte;
Wengel, Jesper

Publication type:

Article

Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides.

Published in:

Nucleic Acids Research, 2010, v. 38, n. 19, p. 6697, doi. 10.1093/nar/gkq561

By:

Pasternak, Anna;
Wengel, Jesper

Publication type:

Article

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.

Published in:

Nucleic Acids Research, 2010, v. 38, n. 17, p. 5761, doi. 10.1093/nar/gkq341

By:

Bramsen, Jesper B.;
Pakula, Malgorzata M.;
Hansen, Thomas B.;
Bus, Claus;
Langkjær, Niels;
Odadzic, Dalibor;
Smicius, Romualdas;
Wengel, Suzy L.;
Chattopadhyaya, Jyoti;
Engels, Joachim W.;
Herdewijn, Piet;
Wengel, Jesper;
Kjems, Jørgen

Publication type:

Article

Improved silencing properties using small internally segmented interfering RNAs.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 17, p. 5886, doi. 10.1093/nar/gkm548

By:

Bramsen, Jesper B.;
Laursen, Maria B.;
Damgaard, Christian K.;
Lena, Suzy W.;
Ravindra Babu, B.;
Wengel, Jesper;
Kjems, Jørgen

Publication type:

Article

Intercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities.

Published in:

Nucleic Acids Research, 2005, v. 33, n. 13, p. 4223, doi. 10.1093/nar/gki726

By:

Brunet, Erika;
Corgnali, Maddalena;
Perrouault, Loïc;
Roig, Victoria;
Asseline, Ulysse;
Sørensen, Mads D.;
Babu, B. Ravindra;
Wengel, Jesper;
Giovannangeli, Carine

Publication type:

Article

Transcription factor decoy oligonucleotides modified with locked nucleic acids: an in vitro study to reconcile biostability with binding affinity.

Published in:

Nucleic Acids Research, 2004, v. 32, n. 6, p. 1874, doi. 10.1093/nar/gkh503

By:

Crinelli, Rita;
Bianchi, Marzia;
Gentilini, Lucia;
Palma, Linda;
Sørensen, Mads D.;
Bryld, Torsten;
Babu, Ravindra B.;
Arar, Khalil;
Wengel, Jesper;
Magnani, Mauro

Publication type:

Article

Chirality transmission in macromolecular domains.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-021-27708-4

By:

Pandey, Shankar;
Mandal, Shankar;
Danielsen, Mathias Bogetoft;
Brown, Asha;
Hu, Changpeng;
Christensen, Niels Johan;
Kulakova, Alina Vitaliyivna;
Song, Shixi;
Brown, Tom;
Jensen, Knud J.;
Wengel, Jesper;
Lou, Chenguang;
Mao, Hanbin

Publication type:

Article

Polyamine–Oligonucleotide Conjugates: 2′- O Me-Triazole-Linked 1,4,7,10-Tetraazacyclododecane and Intercalating Dyes and Their Effect on the Thermal Stability of DNA Duplexes.

Published in:

Pharmaceutics, 2022, v. 14, n. 1, p. 66, doi. 10.3390/pharmaceutics14010066

By:

Tomczyk, Mateusz D.;
Zalewski, Mariusz;
Jørgensen, Per T.;
Wengel, Jesper;
Walczak, Krzysztof

Publication type:

Article

Intramuscular Evaluation of Chimeric Locked Nucleic Acid/2′ O Methyl-Modified Antisense Oligonucleotides for Targeted Exon 23 Skipping in Mdx Mice.

Published in:

Pharmaceuticals (14248247), 2021, v. 14, n. 11, p. 1113, doi. 10.3390/ph14111113

By:

Georgiadou, Michaella;
Christou, Melina;
Sokratous, Kleitos;
Wengel, Jesper;
Michailidou, Kyriaki;
Kyriacou, Kyriacos;
Koutsoulidou, Andrie;
Mastroyiannopoulos, Nikolaos P.;
Phylactou, Leonidas A.

Publication type:

Article

MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells.

Published in:

RNA Biology, 2018, v. 15, n. 10, p. 1273, doi. 10.1080/15476286.2018.1526536

By:

Ferino, Annalisa;
Miglietta, Giulia;
Picco, Raffaella;
Vogel, Stefan;
Wengel, Jesper;
Xodo, Luigi E.

Publication type:

Article

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 9, p. 4067, doi. 10.1172/JCI76175

By:

Bestas, Burcu;
Moreno, Pedro M. D.;
Blomberg, K. Emelie M.;
Mohammad, Dara K.;
Saleh, Amer F.;
Sutlu, Tolga;
Nordin, Joel Z.;
Guterstam, Peter;
Gustafsson, Manuela O.;
Kharazi, Shabnam;
Piatosa, Barbara;
Roberts, Thomas C.;
Behlke, Mark A.;
Wood, Matthew J. A.;
Gait, Michael J.;
Lundin, Karin E.;
Andaloussi, Samir El;
Månsson, Robert;
Berglöf, Anna;
Wengel, Jesper

Publication type:

Article

Electrochemistry of Single Metalloprotein and DNA-Based Molecules at Au(111) Electrode Surfaces.

Published in:

ChemPhysChem, 2013, v. 14, n. 10, p. 2101, doi. 10.1002/cphc.201300299

By:

Salvatore, Princia;
Zeng, Dongdong;
Karlsen, Kasper K.;
Chi, Qijin;
Wengel, Jesper;
Ulstrup, Jens

Publication type:

Article

Novel assemblies based on oligonucleotides containing intercalating nucleic acid monomers.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2020, v. 39, n. 1-3, p. 82, doi. 10.1080/15257770.2019.1683188

By:

Abdelrahman, Asmaa;
Gouda, Alaa S.;
Jørgensen, Per T.;
Wengel, Jesper

Publication type:

Article

Selective Biocatalytic Acylation Studies on 5′- O -(4,4′-Dimethoxytrityl)-2′,3′-Secouridine: An Efficient Synthesis of UNA Monomer.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2012, v. 31, n. 12, p. 831, doi. 10.1080/15257770.2012.734424

By:

Singh, SunilK.;
Reddy, L.Chandrashekhar;
Srivastava, Smriti;
Olsen, CarlE.;
Sanghvi, YogeshS.;
Langkjær, Niels;
Wengel, Jesper;
Parmar, VirinderS.;
Prasad, AshokK.

Publication type:

Article

Dual-Probe System Using Pyrenylmethyl-Modified Amino-Lna for Mismatch Detection.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2007, v. 26, n. 10-12, p. 1261, doi. 10.1080/15257770701528255

By:

Umemoto, Tadashi;
Hrdlicka, PatrickJ.;
Babu, B.Ravindra;
Wengel, Jesper

Publication type:

Article

Synthesis and Biophysical Studies of N2'-Functionalized 2'-Amino-α-L-LNA.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2007, v. 26, n. 10-12, p. 1403, doi. 10.1080/15257770701538841

By:

Kumar, T.Santhosh;
Madsen, AndreasS.;
Wengel, Jesper;
Hrdlicka, PatrickJ.

Publication type:

Article

Pyrene-Functionalized 2 '-Amino-α-L-LNA as Potential Diagnostic Probes.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2007, v. 26, n. 10-12, p. 1407, doi. 10.1080/15257770701538908

By:

Kumar, T.Santhosh;
Wengel, Jesper;
Hrdlicka, PatrickJ.

Publication type:

Article

Triplex-Forming Ability of Modified Oligonucleotides.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2007, v. 26, n. 10-12, p. 1411, doi. 10.1080/15257770701539047

By:

Højland, Torben;
Babu, B.Ravindra;
Bryld, Torsten;
Wengel, Jesper

Publication type:

Article

N2'-Functionalized 2'-Amino-α-L-LNA Adenine Derivatives - Efficient Targeting of Single Stranded DNA.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2007, v. 26, n. 10-12, p. 1415, doi. 10.1080/15257770701539153

By:

Andersen, NicolaiK.;
Wengel, Jesper;
Hrdlicka, PatrickJ.

Publication type:

Article

In Vitro Incorporation of LNA Nucleotides.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2007, v. 26, n. 8/9, p. 1207, doi. 10.1080/15257770701527844

By:

Veedu, RakeshN.;
Vester, Birte;
Wengel, Jesper

Publication type:

Article

Novel Selective Biocatalytic Deacylation Studies on Key Precursors for Bicyclonucleosides.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2007, v. 26, n. 10-12, p. 1517, doi. 10.1080/15257770701544302

By:

Prasad, AshokK.;
Singh, SunilK.;
Kalra, Neerja;
Singhal, Nidhi;
Wengel, Jesper;
Parmar, VirinderS.

Publication type:

Article

Synthesis of a 2′-Amino- α -l-LNA-T Phosphoramidite.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2005, v. 24, n. 5-7, p. 1101, doi. 10.1080/15257770500276866

By:

Hrdlicka, Patrick J.;
Kumar, T. Santhosh;
Wengel, Jesper

Publication type:

Article

DNA Self-Assembling Systems: Branched Oligonucleotides as Building Blocks and Monitoring by Pyrene Excimer Band Formation.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2005, v. 24, n. 5-7, p. 679, doi. 10.1081/NCN-200060247

By:

Lindegaard, Dorthe;
Babu, B. Ravindra;
Wengel, Jesper

Publication type:

Article

Synthesis and Biological Evaluation of Conformationally Restricted and Nucleobase-Modified Analogs of the Anticancer Compound 3′-C-Ethynylcytidine (ECYD).

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2005, v. 24, n. 5-7, p. 397, doi. 10.1081/NCN-200059821

By:

Hrdlicka, Patrick J.;
Jepsen, Jan S.;
Wengel, Jesper

Publication type:

Article

Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria?

Published in:

Antibiotics (2079-6382), 2021, v. 10, n. 4, p. 379, doi. 10.3390/antibiotics10040379

By:

Pereira, Sara;
Yao, Ruwei;
Gomes, Mariana;
Jørgensen, Per Trolle;
Wengel, Jesper;
Azevedo, Nuno Filipe;
Sobral Santos, Rita

Publication type:

Article

Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model.

Published in:

PLoS ONE, 2016, v. 11, n. 2, p. 1, doi. 10.1371/journal.pone.0148353

By:

Fontenete, Sílvia;
Leite, Marina;
Cappoen, Davie;
Santos, Rita;
Ginneken, Chris Van;
Figueiredo, Céu;
Wengel, Jesper;
Cos, Paul;
Azevedo, Nuno Filipe

Publication type:

Article

Photoinduced Reductive Electron Transfer in LNA:DNA Hybrids: A Compromise between Conformation and Base Stacking.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 40, p. 10026, doi. 10.1002/anie.201204901

By:

Wenge, Ulrike;
Wengel, Jesper;
Wagenknecht, Hans-Achim

Publication type:

Article

Alpha-l-Locked Nucleic Acid-Modified Antisense Oligonucleotides Induce Efficient Splice Modulation In Vitro.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 7, p. 2434, doi. 10.3390/ijms21072434

By:

Raguraman, Prithi;
Wang, Tao;
Ma, Lixia;
Jørgensen, Per Trolle;
Wengel, Jesper;
Veedu, Rakesh N.

Publication type:

Article

Structural Studies of LNA:RNA Duplexes by NMR: Conformations and Implications for RNase H Activity.

Published in:

Chemistry - A European Journal, 2000, v. 6, n. 15, p. 2687, doi. 10.1002/1521-3765(20000804)6:15<2687::AID-CHEM2687>3.0.CO;2-U

By:

Bondensgaard, Kent;
Petersen, Michael;
Singh, Sanjay K.;
Rajwanshi, Vivek K.;
Kumar, Ravindra;
Wengel, Jesper;
Jacobsen, Jens Peter

Publication type:

Article

LNA and α-L-LNA: Towards Therapeutic Applications.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2003, v. 22, n. 5-8, p. 601, doi. 10.1081/NCN-120021963

By:

Wengel, Jesper;
Vester, Birte;
Lundberg, Lars Bo;
Douthwaite, Stephen;
Sørensen, Mads D.;
Ravindra Babu, B.;
Gait, Michael J.;
Arzumanov, Andrey;
Petersen, Michael;
Nielsen, Jakob T.

Publication type:

Article

Synthesis of an Asymmetrically Substituted AZA Crown Ether as Metal and Amino Acid Binding Site in DNA Conjugates.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2003, v. 22, n. 5-8, p. 1039, doi. 10.1081/NCN-120022730

By:

Vogel, Stefan;
Rohr, Katja;
Dahl, Otto;
Wengel, Jesper

Publication type:

Article

Improved Synthesis of 2′-Amino-LNA.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2003, v. 22, n. 5-8, p. 1131, doi. 10.1081/NCN-120022818

By:

Christensen, Signe M.;
Rosenbohm, Christoph;
Sørensen, Mads;
Larsen, Lotte-Emilie;
Wengel, Jesper;
Koch, Troels

Publication type:

Article

xylo-Configured Oligonucleotides (XNA, Xylo Nucleic Acids): Synthesis and Hybridization Studies.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2003, v. 22, n. 5-8, p. 1147, doi. 10.1081/NCN-120022822

By:

Poopeiko, Nicolai E.;
Dahl, Britta M.;
Wengel, Jesper

Publication type:

Article

Synthesis of a Base-Protected α-L-LNA Guanine Nucleoside.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2003, v. 22, n. 5-8, p. 1155, doi. 10.1081/NCN-120022824

By:

Gaubert, Gilles;
Wengel, Jesper

Publication type:

Article

Synthesis and Hybridization Properties of Oligodeoxynucleotides Containing 3′-Deoxy-3′-C-methyleneuridine.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2003, v. 22, n. 5-8, p. 1159, doi. 10.1081/NCN-120022825

By:

Lindegaard, Dorthe;
Wengel, Jesper

Publication type:

Article

Synthesis of a Base-Protected xylo-LNA Adenine Nucleoside.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2003, v. 22, n. 5-8, p. 1163, doi. 10.1081/NCN-120022826

By:

Bryld, Torsten;
Wengel, Jesper

Publication type:

Article