Works by Simard, J Marc

Results: 91

Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis.

Published in:

2017

By:

Gerzanich, Volodymyr;
Min Seong Kwon;
Stokum, Jesse A.;
Seung Kyoon Woo;
Ivanova, Svetlana;
Ivanov, Alexander;
Simard, J. Marc;
Makar, Tapas K.;
Bever, Christopher T.;
Reddy Guda, Poornachander;
Brooke Morris, Alexandra;
Mehta, Rupal I.;
Bryan, Joseph;
Guda, Poornachander Reddy;
Kwon, Min Seong;
Woo, Seung Kyoon;
Morris, Alexandra Brooke;
Marc Simard, J

Publication type:

journal article

Does inhibiting Sur1 complement rt-PA in cerebral ischemia?

Published in:

Annals of the New York Academy of Sciences, 2012, v. 1268, n. 1, p. 95, doi. 10.1111/j.1749-6632.2012.06705.x

By:

Simard, J. Marc;
Geng, Zhihua;
Silver, Frank L.;
Sheth, Kevin N.;
Kimberly, W. Taylor;
Stern, Barney J.;
Colucci, Mario;
Gerzanich, Volodymyr

Publication type:

Article

Correlation of HIV-Induced Neuroinflammation and Synaptopathy with Impairment of Learning and Memory in Mice with HAND.

Published in:

Journal of Clinical Medicine, 2023, v. 12, n. 16, p. 5169, doi. 10.3390/jcm12165169

By:

Keledjian, Kaspar;
Makar, Tapas;
Zhang, Chenyu;
Zhang, Jiantao;
Shim, Bosung;
Davis, Harry;
Bryant, Joseph;
Gerzanich, Volodymyr;
Simard, J. Marc;
Zhao, Richard Y.

Publication type:

Article

Brief Suppression of Abcc8 Prevents Autodestruction of Spinal Cord After Trauma.

Published in:

Science Translational Medicine, 2010, v. 2, n. 28, p. 1, doi. 10.1126/scitranslmed.3000522

By:

Marc Simard, J.;
Woo, S. Kyoon;
Norenberg, Michael D.;
Tosun, Cigdem;
Zheng Chen;
Ivanova, Svetlana;
Tsymbalyuk, Orest;
Bryan, Joseph;
Landsman, Douglas;
Gerzanich, Volodymyr

Publication type:

Article

HMGB1 is a Potential Mediator of Astrocytic TLR4 Signaling Activation following Acute and Chronic Focal Cerebral Ischemia.

Published in:

Neurology Research International, 2020, p. 1, doi. 10.1155/2020/3929438

By:

Famakin, Bolanle M.;
Tsymbalyuk, Orest;
Tsymbalyuk, Natalia;
Ivanova, Svetlana;
Woo, Seung Kyoon;
Kwon, Min Seong;
Gerzanich, Volodymyr;
Simard, J. Marc

Publication type:

Article

Unruptured cerebral aneurysms in elderly patients: key challenges and management.

Published in:

Annals of Medicine, 2021, v. 53, n. 1, p. 1839, doi. 10.1080/07853890.2021.1990393

By:

Caffes, Nicholas;
Wenger, Nicole;
Cannarsa, Gregory;
Oliver, Jeffrey;
Onwukwe, Chimdiya;
Gandhi, Dheeraj;
Simard, J. Marc

Publication type:

Article

Unruptured cerebral aneurysms in elderly patients: key challenges and management.

Published in:

Annals of Medicine, 2021, v. 53, n. 1, p. 1839, doi. 10.1080/07853890.2021.1990393

By:

Caffes, Nicholas;
Wenger, Nicole;
Cannarsa, Gregory;
Oliver, Jeffrey;
Onwukwe, Chimdiya;
Gandhi, Dheeraj;
Simard, J. Marc

Publication type:

Article

Early pathophysiological changes in cerebral vessels predisposing to stroke.

Published in:

Clinical Hemorheology & Microcirculation, 2003, v. 29, n. 3-4, p. 291

By:

Volodymyr Gerzanich, Bob;
Svetlana Ivanova;
J. Marc Simard

Publication type:

Article

Canagliflozin, an Inhibitor of the Na + -Coupled D-Glucose Cotransporter, SGLT2, Inhibits Astrocyte Swelling and Brain Swelling in Cerebral Ischemia.

Published in:

Cells (2073-4409), 2023, v. 12, n. 18, p. 2221, doi. 10.3390/cells12182221

By:

Shim, Bosung;
Stokum, Jesse A.;
Moyer, Mitchell;
Tsymbalyuk, Natalya;
Tsymbalyuk, Orest;
Keledjian, Kaspar;
Ivanova, Svetlana;
Tosun, Cigdem;
Gerzanich, Volodymyr;
Simard, J. Marc

Publication type:

Article

Region-Specific Homeostatic Identity of Astrocytes Is Essential for Defining Their Response to Pathological Insults.

Published in:

Cells (2073-4409), 2023, v. 12, n. 17, p. 2172, doi. 10.3390/cells12172172

By:

Makarava, Natallia;
Mychko, Olga;
Molesworth, Kara;
Chang, Jennifer Chen-Yu;
Henry, Rebecca J.;
Tsymbalyuk, Natalya;
Gerzanich, Volodymyr;
Simard, J. Marc;
Loane, David J.;
Baskakov, Ilia V.

Publication type:

Article

Glibenclamide for the Treatment of Acute CNS Injury.

Published in:

Pharmaceuticals (14248247), 2013, v. 6, n. 10, p. 1287, doi. 10.3390/ph6101287

By:

Kurland, David B.;
Tosun, Cigdem;
Pampori, Adam;
Karimy, Jason K.;
Caffes, Nicholas M.;
Gerzanich, Volodymyr;
Marc Simard, J.

Publication type:

Article

An update on the pharmacological management and prevention of cerebral edema: current therapeutic strategies.

Published in:

Expert Opinion on Pharmacotherapy, 2021, v. 22, n. 8, p. 1025, doi. 10.1080/14656566.2021.1876663

By:

Pergakis, Melissa;
Badjatia, Neeraj;
Simard, J. Marc

Publication type:

Article

Survival of Patient With Hemorrhagic Meningitis Associated With Inhalation Anthrax.

Published in:

Clinical Infectious Diseases, 2022, v. 75, p. S364, doi. 10.1093/cid/ciac531

By:

Espinosa, Evelyn Lombarte;
Usón, María Cruz Villuendas;
García, Jorge Arribas;
García, Isabel Jado;
Lacunza, Rafael Huarte;
Chug, Paola Zárate;
Vega, Luis Manuel Claraco;
Andrés, María Jesús Santed;
Ríos, María Jiménez;
Cook, Rachel;
Simard, J Marc;
Boyer, Anne E;
Rezusta, Antonio

Publication type:

Article

Anthrax Meningoencephalitis and Intracranial Hemorrhage.

Published in:

Clinical Infectious Diseases, 2022, v. 75, p. S451, doi. 10.1093/cid/ciac521

By:

Caffes, Nicholas;
Hendricks, Katherine;
Bradley, John S;
Twenhafel, Nancy A;
Simard, J Marc

Publication type:

Article

Functional Coupling between Sulfonylurea Receptor Type 1 and a Nonselective Cation Channel in Reactive Astrocytes from Adult Rat Brain.

Published in:

Journal of Neuroscience, 2003, v. 23, n. 24, p. 8568, doi. 10.1523/JNEUROSCI.23-24-08568.2003

By:

Mingkui Chen;
Yafeng Dong;
Simard, J. Marc

Publication type:

Article

Potential of glyburide to reduce intracerebral edema in brain metastases.

Published in:

Expert Review of Neurotherapeutics, 2014, v. 14, n. 4, p. 379, doi. 10.1586/14737175.2014.890891

By:

Boggs, Drexell Hunter;
Simard, J Marc;
Steven, Andrew;
Mehta, Minesh P

Publication type:

Article

A large portion of the astrocyte proteome is dedicated to perivascular endfeet, including critical components of the electron transport chain.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2021, v. 41, n. 10, p. 2546, doi. 10.1177/0271678X211004182

By:

Stokum, Jesse A;
Shim, Bosung;
Huang, Weiliang;
Kane, Maureen;
Smith, Jesse A;
Gerzanich, Volodymyr;
Simard, J Marc

Publication type:

Article

Molecular pathophysiology of cerebral edema.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2016, v. 36, n. 3, p. 513, doi. 10.1177/0271678X15617172

By:

Stokum, Jesse A.;
Gerzanich, Volodymyr;
Simard, J. Marc

Publication type:

Article

Sulfonylurea receptor 1 in central nervous system injury: a focused review.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2012, v. 32, n. 9, p. 1699, doi. 10.1038/jcbfm.2012.91

By:

Simard, J Marc;
Woo, S Kyoon;
Schwartzbauer, Gary T;
Gerzanich, Volodymyr

Publication type:

Article

Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury.

Published in:

2007

By:

Simard, J Marc;
Tsymbalyuk, Orest;
Ivanov, Alexander;
Ivanova, Svetlana;
Bhatta, Sergei;
Geng, Zhihua;
Woo, S Kyoon;
Gerzanich, Volodymyr

Publication type:

journal article

Endothelial sulfonylurea receptor 1-regulated NCCa-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury.

Published in:

Journal of Clinical Investigation, 2007, v. 117, n. 8, p. 2105, doi. 10.1172/JCI32041

By:

Marc Simard, J.;
Tsymbalyuk, Orest;
Ivanov, Alexander;
Ivanova, Svetlana;
Bhatta, Sergei;
Zhihua Geng;
Kyoon Woo, S.;
Gerzanich, Volodymyr

Publication type:

Article

The NCX1 calcium exchanger is implicated in delayed axotomy after peripheral nerve stretch injury.

Published in:

Journal of the Peripheral Nervous System, 2024, v. 29, n. 4, p. 555, doi. 10.1111/jns.12663

By:

Wilhelmy, Bradley;
Gerzanich, Volodymyr;
Simard, J. Marc;
Stokum, Jesse A.

Publication type:

Article

Immunomodulatory therapy with glatiramer acetate reduces endoplasmic reticulum stress and mitochondrial dysfunction in experimental autoimmune encephalomyelitis.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-29852-x

By:

Makar, Tapas K.;
Guda, Poornachander R.;
Ray, Sugata;
Andhavarapu, Sanketh;
Keledjian, Kaspar;
Gerzanich, Volodymyr;
Simard, J. Marc;
Nimmagadda, Vamshi K. C.;
Bever Jr, Christopher T.

Publication type:

Article

High Compliance with Scheduled Nimodipine Is Associated with Better Outcome in Aneurysmal Subarachnoid Hemorrhage Patients Cotreated with Heparin Infusion.

Published in:

Frontiers in Neurology, 2017, p. 1, doi. 10.3389/fneur.2017.00268

By:

Wessell, Aaron;
Kole, Matthew J.;
Badjatia, Neeraj;
Parikh, Gunjan;
Albrecht, Jennifer S.;
Schreibman, David L.;
Simard, J. Marc

Publication type:

Article

Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date.

Published in:

Drug Design, Development & Therapy, 2018, v. 12, p. 2539, doi. 10.2147/DDDT.S150043

By:

King, Zachary A;
Sheth, Kevin N;
Kimberly, W Taylor;
Simard, J Marc

Publication type:

Article

Cerebral microbleeds in a neonatal rat model.

Published in:

PLoS ONE, 2017, v. 12, n. 2, p. 1, doi. 10.1371/journal.pone.0171163

By:

Carusillo Theriault, Brianna;
Woo, Seung Kyoon;
Karimy, Jason K.;
Keledjian, Kaspar;
Stokum, Jesse A.;
Sarkar, Amrita;
Coksaygan, Turhan;
Ivanova, Svetlana;
Gerzanich, Volodymyr;
Simard, J. Marc

Publication type:

Article

BIIB093 (IV glibenclamide): an investigational compound for the prevention and treatment of severe cerebral edema.

Published in:

Expert Opinion on Investigational Drugs, 2019, v. 28, n. 12, p. 1031, doi. 10.1080/13543784.2019.1681967

By:

Pergakis, Melissa;
Badjatia, Neeraj;
Chaturvedi, Seemant;
Cronin, Carolyn A.;
Kimberly, W. Taylor;
Sheth, Kevin N.;
Simard, J. Marc

Publication type:

Article

Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 21, p. 11899, doi. 10.3390/ijms222111899

By:

Jha, Ruchira M.;
Rani, Anupama;
Desai, Shashvat M.;
Raikwar, Sudhanshu;
Mihaljevic, Sandra;
Munoz-Casabella, Amanda;
Kochanek, Patrick M.;
Catapano, Joshua;
Winkler, Ethan;
Citerio, Giuseppe;
Hemphill, J. Claude;
Kimberly, W. Taylor;
Narayan, Raj;
Sahuquillo, Juan;
Sheth, Kevin N.;
Simard, J. Marc

Publication type:

Article

When the Blood Hits Your Brain: The Neurotoxicity of Extravasated Blood.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 10, p. 5132, doi. 10.3390/ijms22105132

By:

Stokum, Jesse A.;
Cannarsa, Gregory J.;
Wessell, Aaron P.;
Shea, Phelan;
Wenger, Nicole;
Simard, J. Marc;
Balla, József;
Andjelkovic, Anuska V.

Publication type:

Article

Role of Sulfonylurea Receptor 1 and Glibenclamide in Traumatic Brain Injury: A Review of the Evidence.

Published in:

2020

By:

Jha, Ruchira M.;
Bell, Josh;
Citerio, Giuseppe;
Hemphill, J. Claude;
Kimberly, W. Taylor;
Narayan, Raj K.;
Sahuquillo, Juan;
Sheth, Kevin N.;
Simard, J. Marc

Publication type:

Literature Review

Bursting at the Seams: Molecular Mechanisms Mediating Astrocyte Swelling.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 2, p. 330, doi. 10.3390/ijms20020330

By:

Lafrenaye, Audrey D.;
Simard, J. Marc

Publication type:

Article

Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review.

Published in:

International Journal of Molecular Sciences, 2016, v. 17, n. 4, p. 497, doi. 10.3390/ijms17040497

By:

Lucke-Wold, Brandon P.;
Logsdon, Aric F.;
Manoranjan, Branavan;
Turner, Ryan C.;
McConnell, Evan;
Vates, George Edward;
Huber, Jason D.;
Rosen, Charles L.;
Simard, J. Marc

Publication type:

Article

Methemoglobin Is an Endogenous Toll-Like Receptor 4 Ligand--Relevance to Subarachnoid Hemorrhage.

Published in:

International Journal of Molecular Sciences, 2015, v. 16, n. 3, p. 5028, doi. 10.3390/ijms16035028

By:

Min Seong Kwon;
Seung Kyoon Woo;
Kurland, David B.;
Sung Hwan Yoon;
Palmer, Andre F.;
Banerjee, Uddyalok;
Iqbal, Sana;
Ivanova, Svetlana;
Gerzanich, Volodymyr;
Simard, J. Marc

Publication type:

Article

Glibenclamide for the Treatment of Ischemic and Hemorrhagic Stroke.

Published in:

International Journal of Molecular Sciences, 2015, v. 16, n. 3, p. 4973, doi. 10.3390/ijms16034973

By:

Caffes, Nicholas;
Kurland, David B.;
Gerzanich, Volodymyr;
Simard, J. Marc

Publication type:

Article

Interactions of Scorpion Toxins with the Sodium Channel.

Published in:

Annals of the New York Academy of Sciences, 1986, v. 479, n. 1, p. 113, doi. 10.1111/j.1749-6632.1986.tb15565.x

By:

MEVES, HANS;
SIMARD, J. MARC;
WATT, DEAN D.

Publication type:

Article

SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling.

Published in:

Glia (0894-1491), 2018, v. 66, n. 1, p. 108, doi. 10.1002/glia.23231

By:

Stokum, Jesse A.;
Kwon, Min S.;
Woo, Seung K.;
Tsymbalyuk, Orest;
Vennekens, Rudi;
Gerzanich, Volodymyr;
Simard, J. Marc

Publication type:

Article

Inward rectifier K+ channel Kir2.3 (IRK3) in reactive astrocytes from adult rat brain.

Published in:

Glia (0894-1491), 2000, v. 31, n. 2, p. 181, doi. 10.1002/1098-1136(200008)31:2<181::AID-GLIA90>3.0.CO;2-8

By:

Perillán, Pablo R.;
Li, Xing;
Potts, Eric A.;
Chen, Mingkui;
Bredt, David S.;
Simard, J. Marc

Publication type:

Article

K+ inward rectifier currents in reactive astrocytes from adult rat brain.

Published in:

Glia (0894-1491), 1999, v. 27, n. 3, p. 213, doi. 10.1002/(SICI)1098-1136(199909)27:3<213::AID-GLIA3>3.0.CO;2-1

By:

Perillán, Pablo R.;
Li, Xing;
Simard, J. Marc

Publication type:

Article

Heterogeneity of aquaporin-4 localization and expression after focal cerebral ischemia underlies differences in white versus grey matter swelling.

Published in:

Acta Neuropathologica Communications, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40478-015-0239-6

By:

Stokum, Jesse A.;
Mehta, Rupal I.;
Ivanova, Svetlana;
Yu, Edward;
Gerzanich, Volodymyr;
Simard, J. Marc

Publication type:

Article

Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle.

Published in:

Journal of Physiology, 2006, v. 570, n. 1, p. 73, doi. 10.1113/jphysiol.2005.100883

By:

Ivanov, Alexander;
Gerzanich, Volodymyr;
Ivanova, Svetlana;
DenHaese, Ryan;
Tsymbalyuk, Orest;
Simard, J. Marc

Publication type:

Article

SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells.

Published in:

PLoS ONE, 2018, v. 13, n. 4, p. 1, doi. 10.1371/journal.pone.0195526

By:

Gerzanich, Volodymyr;
Kwon, Min Seong;
Woo, Seung Kyoon;
Ivanov, Alexander;
Simard, J. Marc

Publication type:

Article

Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.

Published in:

PLoS ONE, 2017, v. 12, n. 9, p. 1, doi. 10.1371/journal.pone.0184261

By:

Hashiguchi, Hiroshi;
Sheng, Zhenyu;
Routh, Vanessa;
Gerzanich, Volodymyr;
Simard, J. Marc;
Bryan, Joseph

Publication type:

Article

Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer.

Published in:

PLoS ONE, 2017, v. 12, n. 3, p. 1, doi. 10.1371/journal.pone.0174557

By:

Connolly, Nina P.;
Stokum, Jesse A.;
Schneider, Craig S.;
Ozawa, Tatsuya;
Xu, Su;
Galisteo, Rebeca;
Castellani, Rudolph J.;
Kim, Anthony J.;
Simard, J. Marc;
Winkles, Jeffrey A.;
Holland, Eric C.;
Woodworth, Graeme F.

Publication type:

Article

Silencing of Abcc8 or inhibition of newly upregulated Sur1-Trpm4 reduce inflammation and disease progression in experimental autoimmune encephalomyelitis.

Published in:

2015

By:

Makar, Tapas K.;
Gerzanich, Volodymyr;
Nimmagadda, Vamshi K. C.;
Jain, Rupal;
Lam, Kristal;
Mubariz, Fahad;
Trisler, David;
Ivanova, Svetlana;
Seung KyoonWoo;
Min Seong Kwon;
Bryan, Joseph;
Bever, Christopher T.;
Simard, J. Marc;
Woo, Seung Kyoon;
Kwon, Min Seong

Publication type:

journal article

Biomarkers as outcome predictors in subarachnoid hemorrhage - a systematic review.

Published in:

Biomarkers, 2014, v. 19, n. 2, p. 95, doi. 10.3109/1354750X.2014.881418

By:

Hong, Caron M.;
Tosun, Cigdem;
Kurland, David B.;
Gerzanich, Volodymyr;
Schreibman, David;
Simard, J. Marc

Publication type:

Article

Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke.

Published in:

Science Signaling, 2023, v. 16, n. 788, p. 1, doi. 10.1126/scisignal.add6364

By:

Stokum, Jesse A.;
Shim, Bosung;
Negoita, Serban;
Tsymbalyuk, Natalya;
Tsymbalyuk, Orest;
Ivanova, Svetlana;
Keledjian, Kaspar;
Bryan, Joseph;
Blaustein, Mordecai P.;
Jha, Ruchira M.;
Kahle, Kristopher T.;
Gerzanich, Volodymyr;
Simard, J. Marc

Publication type:

Article

Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis.

Published in:

Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02692-2

By:

Cummings, Jessica;
Wu, Yijen L.;
Dixon, C. Edward;
Henchir, Jeremy;
Simard, J. Marc;
Panigrahy, Ashok;
Kochanek, Patrick M.;
Jha, Ruchira M.;
Aneja, Rajesh K.

Publication type:

Article

Traumatic brain injury alters dendritic cell differentiation and distribution in lymphoid and non-lymphoid organs.

Published in:

Journal of Neuroinflammation, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12974-022-02609-5

By:

Tsymbalyuk, Orest;
Gerzanich, Volodymyr;
Simard, J. Marc;
Rathinam, Chozha Vendan

Publication type:

Article

SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury.

Published in:

Molecular Pain, 2021, v. 17, p. 1, doi. 10.1177/17448069211006603

By:

Tsymbalyuk, Orest;
Gerzanich, Volodymyr;
Mumtaz, Aaida;
Andhavarapu, Sanketh;
Ivanova, Svetlana;
Makar, Tapas K;
Sansur, Charles A;
Keller, Asaf;
Nakamura, Yumiko;
Bryan, Joseph;
Simard, J Marc

Publication type:

Article

SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury.

Published in:

Molecular Pain, 2021, p. 1, doi. 10.1177/17448069211006603

By:

Tsymbalyuk, Orest;
Gerzanich, Volodymyr;
Mumtaz, Aaida;
Andhavarapu, Sanketh;
Ivanova, Svetlana;
Makar, Tapas K;
Sansur, Charles A;
Keller, Asaf;
Nakamura, Yumiko;
Bryan, Joseph;
Simard, J Marc

Publication type:

Article