Works by Sievers, Philipp

Results: 77

Response to trametinib treatment in progressive pediatric low-grade glioma patients.

Published in:

Journal of Neuro-Oncology, 2020, v. 149, n. 3, p. 499, doi. 10.1007/s11060-020-03640-3

By:

Selt, Florian;
van Tilburg, Cornelis M.;
Bison, Brigitte;
Sievers, Philipp;
Harting, Inga;
Ecker, Jonas;
Pajtler, Kristian W.;
Sahm, Felix;
Bahr, Annabelle;
Simon, Michèle;
Jones, David T. W.;
Well, Lennart;
Mautner, Victor-Felix;
Capper, David;
Hernáiz Driever, Pablo;
Gnekow, Astrid;
Pfister, Stefan M.;
Witt, Olaf;
Milde, Till

Publication type:

Article

CIC/ATXN1‐rearranged tumors in the central nervous system are mainly represented by sarcomas: A comprehensive clinicopathological and epigenetic series.

Published in:

Brain Pathology, 2025, v. 35, n. 2, p. 1, doi. 10.1111/bpa.13303

By:

Tauziède‐Espariat, Arnault;
Ebrahimi, Azadeh;
Boddaert, Nathalie;
Pietsch, Torsten;
Grajkowska, Wieslawa;
Blau, Tobias;
Koch, Arend;
Sievers, Philipp;
Guillemot, Delphine;
Pierron, Gaëlle;
Uro‐Coste, Emmanuelle;
Nicaise, Yvan;
Siegfried, Aurore;
Gilles, Adam;
Bielle, Franck;
Mokhtari, Karima;
Cazals‐Hatem, Dominique;
Iakovlev, Gueorgui;
Lhermitte, Benoît;
Entz‐Werle, Natacha

Publication type:

Article

A comprehensive histomolecular characterization of meningioangiomatosis: Further evidence for a precursor neoplastic lesion.

Published in:

Brain Pathology, 2024, v. 34, n. 6, p. 1, doi. 10.1111/bpa.13259

By:

Tauziède‐Espariat, Arnault;
Masliah‐Planchon, Julien;
Sievers, Philipp;
Sahm, Felix;
Dangouloff‐Ros, Volodia;
Boddaert, Nathalie;
Hasty, Lauren;
Aboubakr, Oumaima;
Métais, Alice;
Chrétien, Fabrice;
Roux, Alexandre;
Pallud, Johan;
Blauwblomme, Thomas;
Beccaria, Kévin;
Bourdeaut, Franck;
Puget, Stéphanie;
Varlet, Pascale

Publication type:

Article

A comprehensive analysis of infantile central nervous system tumors to improve distinctive criteria for infant‐type hemispheric glioma versus desmoplastic infantile ganglioglioma/astrocytoma.

Published in:

Brain Pathology, 2023, v. 33, n. 5, p. 1, doi. 10.1111/bpa.13182

By:

Tauziède‐Espariat, Arnault;
Beccaria, Kévin;
Dangouloff‐Ros, Volodia;
Sievers, Philipp;
Meurgey, Alexandra;
Pissaloux, Daniel;
Appay, Romain;
Saffroy, Raphaël;
Grill, Jacques;
Mariet, Cassandra;
Bourdeaut, Franck;
Hasty, Lauren;
Métais, Alice;
Chrétien, Fabrice;
Blauwblomme, Thomas;
Puget, Stéphanie;
Boddaert, Nathalie;
Varlet, Pascale

Publication type:

Article

Clinical implementation of integrated molecular‐morphologic risk prediction for meningioma.

Published in:

Brain Pathology, 2023, v. 33, n. 3, p. 1, doi. 10.1111/bpa.13132

By:

Hielscher, Thomas;
Sill, Martin;
Sievers, Philipp;
Stichel, Damian;
Brandner, Sebastian;
Jones, David T. W.;
von Deimling, Andreas;
Sahm, Felix;
Maas, Sybren L. N.

Publication type:

Article

Deciphering the genetic and epigenetic landscape of pediatric bithalamic tumors.

Published in:

Brain Pathology, 2022, v. 32, n. 3, p. 1, doi. 10.1111/bpa.13039

By:

Tauziède‐Espariat, Arnault;
Debily, Marie‐Anne;
Castel, David;
Grill, Jacques;
Puget, Stéphanie;
Roux, Alexandre;
Saffroy, Raphaël;
Gauchotte, Guillaume;
Wahler, Ellen;
Hasty, Lauren;
Chrétien, Fabrice;
Lechapt, Emmanuèle;
Dangouloff‐Ros, Volodia;
Boddaert, Nathalie;
Sievers, Philipp;
Varlet, Pascale

Publication type:

Article

An integrative histopathological and epigenetic characterization of primary intracranial mesenchymal tumors, FET:CREB‐fused broadening the spectrum of tumor entities in comparison with their soft tissue counterparts.

Published in:

Brain Pathology, 2022, v. 32, n. 1, p. 1, doi. 10.1111/bpa.13010

By:

Tauziède‐Espariat, Arnault;
Sievers, Philipp;
Larousserie, Frédérique;
Benzakoun, Joseph;
Guillemot, Delphine;
Pierron, Gaëlle;
Duchesne, Mathilde;
Uro‐Coste, Emmanuelle;
Roux, Alexandre;
Vasiljevic, Alexandre;
Fenouil, Tanguy;
Meyronet, David;
Mokhtari, Karima;
Polivka, Marc;
Rousseau, Audrey;
Bost‐Bezeaud, Frédérique;
Akoury, Samir;
Pallud, Johan;
Benevello, Chiara;
Hasty, Lauren

Publication type:

Article

Soft Tissue Undifferentiated Sarcoma Carrying a Novel Onecut1::Nutm1 Fusion.

Published in:

Pediatric Blood & Cancer, 2025, v. 72, n. 1, p. 1, doi. 10.1002/pbc.31427

By:

Filippidou, Maria;
Glentis, Stavros;
Rigatou, Efthymia;
Sievers, Philipp;
Selt, Florian;
Dimitriadis, Efthymios;
Perari, Panagiota;
Binenbaum, Ilona;
Avgerinou, Georgia;
van Tilburg, Cornelis M.;
Jones, David T. W.;
Sahm, Felix;
Milde, Till;
Witt, Olaf;
Pfister, Stefan M.;
Grünewald, Thomas G. P.;
Stefanaki, Kalliopi;
Kattamis, Antonis

Publication type:

Article

Ticagrelor promotes atherosclerotic plaque stability in a mouse model of advanced atherosclerosis.

Published in:

Drug Design, Development & Therapy, 2016, v. 10, p. 2691, doi. 10.2147/DDDT.S105718

By:

Preusch, Michael R.;
Rusnak, Jonas;
Staudacher, Kathrin;
Mogler, Carolin;
Uhlmann, Lorenz;
Sievers, Philipp;
Bea, Florian;
Katus, Hugo A.;
Blessing, Erwin;
Staudacher, Ingo

Publication type:

Article

Combined treatment with olmesartan medoxomil and amlodipine besylate attenuates atherosclerotic lesion progression in a model of advanced atherosclerosis.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 3935, doi. 10.2147/DDDT.S85203

By:

Sievers, Philipp;
Uhlmann, Lorenz;
Korkmaz-Icöz, Sevil;
Fastner, Christian;
Bea, Florian;
Blessing, Erwin;
Katus, Hugo A.;
Preusch, Michael R.

Publication type:

Article

Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow.

Published in:

Journal of Neuro-Oncology, 2023, v. 165, n. 3, p. 467, doi. 10.1007/s11060-023-04500-6

By:

Selt, Florian;
El Damaty, Ahmed;
Schuhmann, Martin U.;
Sigaud, Romain;
Ecker, Jonas;
Sievers, Philipp;
Kocher, Daniela;
Herold-Mende, Christel;
Oehme, Ina;
von Deimling, Andreas;
Pfister, Stefan M.;
Sahm, Felix;
Jones, David T. W.;
Witt, Olaf;
Milde, Till

Publication type:

Article

Efficacy and toxicity of bimodal radiotherapy in WHO grade 2 meningiomas following subtotal resection with carbon ion boost: Prospective phase 2 MARCIE trial.

Published in:

Neuro-Oncology, 2024, v. 26, n. 4, p. 701, doi. 10.1093/neuonc/noad244

By:

Deng, Maximilian Y;
Maas, Sybren L N;
Hinz, Felix;
Karger, Christian P;
Sievers, Philipp;
Eichkorn, Tanja;
Meixner, Eva;
Hoegen-Sassmannshausen, Philipp;
Hörner-Rieber, Juliane;
Lischalk, Jonathan W;
Seidensaal, Katharina;
Bernhardt, Denise;
Jungk, Christine;
Unterberg, Andreas;
Wick, Antje;
Wick, Wolfgang;
Deimling, Andreas von;
Sahm, Felix;
Combs, Stephanie;
Herfarth, Klaus

Publication type:

Article

LOGGIC Core BioClinical Data Bank: Added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients.

Published in:

Neuro-Oncology, 2023, v. 25, n. 11, p. 2087, doi. 10.1093/neuonc/noad078

By:

Hardin, Emily C;
Schmid, Simone;
Sommerkamp, Alexander;
Bodden, Carina;
Heipertz, Anna-Elisa;
Sievers, Philipp;
Wittmann, Andrea;
Milde, Till;
Pfister, Stefan M;
Deimling, Andreas von;
Horn, Svea;
Herz, Nina A;
Simon, Michèle;
Perera, Ashwyn A;
Azizi, Amedeo;
Cruz, Ofelia;
Curry, Sarah;
Damme, An Van;
Garami, Miklos;
Hargrave, Darren

Publication type:

Article

BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma.

Published in:

Neuro-Oncology, 2023, v. 25, n. 4, p. 735, doi. 10.1093/neuonc/noac199

By:

Selt, Florian;
Sigaud, Romain;
Valinciute, Gintvile;
Sievers, Philipp;
Zaman, Julia;
Alcon, Clara;
Schmid, Simone;
Peterziel, Heike;
Tsai, Jessica W;
Guiho, Romain;
Martínez-Barbera, Juan Pedro;
Pusch, Stefan;
Deng, Jing;
Zhai, Yifan;
Tilburg, Cornelis M van;
Schuhman, Martin U;
Damaty, Ahmed El;
Bandopadhayay, Pratiti;
Herold-Mende, Christel;
Deimling, Andreas von

Publication type:

Article

Integrated molecular analysis of adult sonic hedgehog (SHH)-activated medulloblastomas reveals two clinically relevant tumor subsets with VEGFA as potent prognostic indicator.

Published in:

Neuro-Oncology, 2021, v. 23, n. 9, p. 1576, doi. 10.1093/neuonc/noab031

By:

Korshunov, Andrey;
Okonechnikov, Konstantin;
Stichel, Damian;
Ryzhova, Marina;
Schrimpf, Daniel;
Sahm, Felix;
Sievers, Philipp;
Absalyamova, Oksana;
Zheludkova, Olga;
Golanov, Andrey;
Jones, David T W;
Pfister, Stefan M;
Deimling, Andreas von;
Kool, Marcel

Publication type:

Article

A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR.

Published in:

Neuro-Oncology, 2021, v. 23, n. 1, p. 34, doi. 10.1093/neuonc/noaa251

By:

Sievers, Philipp;
Sill, Martin;
Schrimpf, Daniel;
Stichel, Damian;
Reuss, David E;
Sturm, Dominik;
Hench, Jürgen;
Frank, Stephan;
Krskova, Lenka;
Vicha, Ales;
Zapotocky, Michal;
Bison, Brigitte;
Castel, David;
Grill, Jacques;
Debily, Marie-Anne;
Harter, Patrick N;
Snuderl, Matija;
Kramm, Christof M;
Reifenberger, Guido;
Korshunov, Andrey

Publication type:

Article

Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling.

Published in:

Acta Neuropathologica Communications, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40478-024-01921-w

By:

Okonechnikov, Konstantin;
Ghasemi, David R.;
Schrimpf, Daniel;
Tonn, Svenja;
Mynarek, Martin;
Koster, Jan;
Milde, Till;
Zheng, Tuyu;
Sievers, Philipp;
Sahm, Felix;
Jones, David T.W.;
von Deimling, Andreas;
Pfister, Stefan M.;
Kool, Marcel;
Pajtler, Kristian W.;
Korshunov, Andrey

Publication type:

Article

Glioneuronal tumors PATZ1-fused: clinico-molecular and DNA methylation signatures for a variety of morphological and radiological profiles.

Published in:

Acta Neuropathologica Communications, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40478-025-02037-5

By:

Tauziède-Espariat, Arnault;
Dangouloff-Ros, Volodia;
Sievers, Philipp;
Duchesne, Mathilde;
Siegfried, Aurore;
Nicaise, Yvan;
Boddaert, Nathalie;
Hasty, Lauren;
Métais, Alice;
Ngo, Carine;
le Loarer, François;
Bouvier, Corinne;
Fontaine, Alix;
Rousseau, Audrey;
Marguet, Florent;
Beccaria, Kévin;
Blauwblomme, Thomas;
Uro-Coste, Emmanuelle;
Varlet, Pascale

Publication type:

Article

Pediatric high-grade gliomas with concomitant RB1 and SETD2 alterations and Li-Fraumeni syndrome.

Published in:

2025

By:

Tauziède-Espariat, Arnault;
Simbozel, Marie;
Sievers, Philipp;
Dangouloff-Ros, Volodia;
Guida, Lelio;
Blauwblomme, Thomas;
Beccaria, Kévin;
Saffroy, Raphael;
Hasty, Lauren;
Métais, Alice;
Grill, Jacques;
Guerrini-Rousseau, Léa;
Varlet, Pascale

Publication type:

Case Study

Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling.

Published in:

Acta Neuropathologica Communications, 2025, v. 12, n. 1, p. 1, doi. 10.1186/s40478-024-01921-w

By:

Okonechnikov, Konstantin;
Ghasemi, David R.;
Schrimpf, Daniel;
Tonn, Svenja;
Mynarek, Martin;
Koster, Jan;
Milde, Till;
Zheng, Tuyu;
Sievers, Philipp;
Sahm, Felix;
Jones, David T.W.;
von Deimling, Andreas;
Pfister, Stefan M.;
Kool, Marcel;
Pajtler, Kristian W.;
Korshunov, Andrey

Publication type:

Article

A multi-institutional series of a novel, recurrent TRIM24::MET fusion-driven infant-type hemispheric glioma reveals significant clinico-pathological heterogeneity.

Published in:

Acta Neuropathologica Communications, 2024, v. 12, n. 1, p. 1, doi. 10.1186/s40478-024-01817-9

By:

Gorodezki, David;
Chiang, Jason;
Viaene, Angela N.;
Sievers, Philipp;
Schmid, Simone;
Holzer, Ursula;
Paulsen, Frank;
Schuhmann, Martin U.;
Witt, Olaf;
Schittenhelm, Jens;
Ebinger, Martin

Publication type:

Article

CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas.

Published in:

Acta Neuropathologica Communications, 2024, v. 12, n. 1, p. 1, doi. 10.1186/s40478-023-01695-7

By:

Tauziède-Espariat, Arnault;
Nicaise, Yvan;
Sievers, Philipp;
Sahm, Felix;
von Deimling, Andreas;
Guillemot, Delphine;
Pierron, Gaëlle;
Duchesne, Mathilde;
Edjlali, Myriam;
Dangouloff-Ros, Volodia;
Boddaert, Nathalie;
Roux, Alexandre;
Dezamis, Edouard;
Hasty, Lauren;
Lhermitte, Benoît;
Hirsch, Edouard;
Hirsch, Maria Paola Valenti;
Ardellier, François-Daniel;
Karnoub, Mélodie-Anne;
Csanyi, Marie

Publication type:

Article

Refinement of diagnostic criteria for pediatric-type diffuse high-grade glioma, IDH- and H3-wildtype, MYCN-subtype including histopathology, TP53, MYCN and ID2 status.

Published in:

Acta Neuropathologica Communications, 2023, v. 11, n. 1, p. 1, doi. 10.1186/s40478-023-01667-x

By:

Tauziède-Espariat, Arnault;
Uro-Coste, Emmanuelle;
Nicaise, Yvan;
Sievers, Philipp;
von Deimling, Andreas;
Sahm, Felix;
Aboubakr, Oumaima;
Métais, Alice;
Chrétien, Fabrice;
Varlet, Pascale

Publication type:

Article

A case of glioneuronal tumour with ATRX alteration, kinase fusion and anaplastic features showing rapid ependymal and leptomeningeal dissemination.

Published in:

Neuropathology & Applied Neurobiology, 2024, v. 50, n. 4, p. 1, doi. 10.1111/nan.13001

By:

Miele, Evelina;
Barresi, Sabina;
Colafati, Giovanna Stefania;
Pedace, Lucia;
Cardoni, Antonello;
Nardini, Claudia;
Tancredi, Chantal;
Patrizi, Sara;
Del Baldo, Giada;
Megaro, Giacomina;
Muccio, Carmine Franco;
Sievers, Philipp;
Alaggio, Rita;
Mastronuzzi, Angela;
Rossi, Sabrina;
Locatelli, Franco

Publication type:

Article

Rosette‐forming glioneuronal tumours are midline, FGFR1‐mutated tumours.

Published in:

Neuropathology & Applied Neurobiology, 2022, v. 48, n. 5, p. 1, doi. 10.1111/nan.12813

By:

Appay, Romain;
Bielle, Franck;
Sievers, Philipp;
Barets, Doriane;
Fina, Frédéric;
Boutonnat, Jean;
Adam, Clovis;
Gauchotte, Guillaume;
Godfraind, Catherine;
Lhermitte, Benoît;
Maurage, Claude‐Alain;
Meyronet, David;
Mokhtari, Karima;
Rousseau, Audrey;
Tauziède‐Espariat, Arnault;
Tortel, Marie‐Claire;
Uro‐Coste, Emmanuelle;
Burel‐Vandenbos, Fanny;
Chotard, Guillaume;
Pesce, Florian

Publication type:

Article

Accurate calling of KIAA1549‐BRAF fusions from DNA of human brain tumours using methylation array‐based copy number and gene panel sequencing data.

Published in:

Neuropathology & Applied Neurobiology, 2021, v. 47, n. 3, p. 406, doi. 10.1111/nan.12683

By:

Stichel, Damian;
Schrimpf, Daniel;
Sievers, Philipp;
Reinhardt, Annekathrin;
Suwala, Abigail K.;
Sill, Martin;
Reuss, David E.;
Korshunov, Andrey;
Casalini, Belén M.;
Sommerkamp, Alexander C.;
Ecker, Jonas;
Selt, Florian;
Sturm, Dominik;
Gnekow, Astrid;
Koch, Arend;
Simon, Michèle;
Hernáiz Driever, Pablo;
Schüller, Ulrich;
Capper, David;
Tilburg, Cornelis M.

Publication type:

Article

A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45067-8

By:

Hai, Ling;
Hoffmann, Dirk C.;
Wagener, Robin J.;
Azorin, Daniel D.;
Hausmann, David;
Xie, Ruifan;
Huppertz, Magnus-Carsten;
Hiblot, Julien;
Sievers, Philipp;
Heuer, Sophie;
Ito, Jakob;
Cebulla, Gina;
Kourtesakis, Alexandros;
Kaulen, Leon D.;
Ratliff, Miriam;
Mandelbaum, Henriette;
Jung, Erik;
Jabali, Ammar;
Horschitz, Sandra;
Ernst, Kati J.

Publication type:

Article

Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.

Published in:

Theranostics, 2021, v. 11, n. 19, p. 9217, doi. 10.7150/thno.60679

By:

Panitz, Verena;
Končarević, Saša;
Sadik, Ahmed;
Friedel, Dennis;
Bausbacher, Tobias;
Trump, Saskia;
Farztdinov, Vadim;
Schulz, Sandra;
Sievers, Philipp;
Schmidt, Stefan;
Jürgenson, Ina;
Jung, Stephan;
Kuhn, Karsten;
Pflüger, Irada;
Sharma, Suraj;
Wick, Antje;
Pfänder, Pauline;
Selzer, Stefan;
Vollmuth, Philipp;
Sahm, Felix

Publication type:

Article

Identification of a putative molecular subtype of adult-type diffuse astrocytoma with recurrent MAPK pathway alterations.

Published in:

Acta Neuropathologica, 2024, v. 148, n. 1, p. 1, doi. 10.1007/s00401-024-02766-2

By:

Sievers, Philipp;
Bielle, Franck;
Göbel, Kirsten;
Schrimpf, Daniel;
Nichelli, Lucia;
Mathon, Bertrand;
Appay, Romain;
Boldt, Henning B.;
Dohmen, Hildegard;
Selignow, Carmen;
Acker, Till;
Vicha, Ales;
Martinetto, Horacio;
Schweizer, Leonille;
Schüller, Ulrich;
Brandner, Sebastian;
Wesseling, Pieter;
Schmid, Simone;
Capper, David;
Abdullaev, Zied

Publication type:

Article

Clinically unfavorable transcriptome subtypes of non-WNT/non-SHH medulloblastomas are associated with a predominance in proliferating and progenitor-like cell subpopulations.

Published in:

Acta Neuropathologica, 2024, v. 147, n. 1, p. 1, doi. 10.1007/s00401-024-02746-6

By:

Okonechnikov, Konstantin;
Schrimpf, Daniel;
Koster, Jan;
Sievers, Philipp;
Milde, Till;
Sahm, Felix;
Jones, David T. W.;
von Deimling, Andreas;
Pfister, Stefan M.;
Kool, Marcel;
Korshunov, Andrey

Publication type:

Article

PLAG1 fusions extend the spectrum of PLAG(L)-altered CNS tumors.

Published in:

Acta Neuropathologica, 2023, v. 146, n. 6, p. 841, doi. 10.1007/s00401-023-02643-4

By:

Tauziède-Espariat, Arnault;
Siegfried, Aurore;
Nicaise, Yvan;
Dghayem, Delphine;
Laprie, Anne;
Lubrano, Vincent;
Richard, Pomone;
Gauchotte, Guillaume;
Malczuk, Joséphine;
Klein, Olivier;
Hasty, Lauren;
Métais, Alice;
Chrétien, Fabrice;
Dangouloff-Ros, Volodia;
Boddaert, Nathalie;
Sahm, Felix;
Sievers, Philipp;
Varlet, Pascale;
Uro-Coste, Emmanuelle

Publication type:

Article

Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular analysis of EORTC 22042–26042.

Published in:

Acta Neuropathologica, 2023, v. 146, n. 6, p. 837, doi. 10.1007/s00401-023-02642-5

By:

Maas, Sybren L. N.;
Sievers, Philipp;
Weber, Damien C.;
Weller, Michael;
van den Bent, Martin J.;
Mair, Maximilian J.;
Kros, Johan M.;
Carparrotti, Fransesca;
von Deimling, Andreas;
Salvador, Villà Freixa;
Peerdeman, Saskia Marguerite;
Casas-Martin, Jose;
Gorlia, Thierry;
Sahm, Felix;
Preusser, Matthias

Publication type:

Article

Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics.

Published in:

Acta Neuropathologica, 2023, v. 146, n. 6, p. 853, doi. 10.1007/s00401-023-02638-1

By:

Rahmanzade, Ramin;
Pfaff, Elke;
Banan, Rouzbeh;
Sievers, Philipp;
Suwala, Abigail K.;
Hinz, Felix;
Bogumil, Henri;
Cherkezov, Asan;
Kaan, Aras Fuat;
Schrimpf, Daniel;
Friedel, Dennis;
Göbel, Kirsten;
Keller, Felix;
Saenz-Sardà, Xavier;
Lossos, Alexander;
Sill, Martin;
Witt, Olaf;
Sakowitz, Oliver W.;
Korshunov, Andrey;
Reuss, David E.

Publication type:

Article

Transcriptome analysis stratifies second-generation non-WNT/non-SHH medulloblastoma subgroups into clinically tractable subtypes.

Published in:

Acta Neuropathologica, 2023, v. 145, n. 6, p. 829, doi. 10.1007/s00401-023-02575-z

By:

Korshunov, Andrey;
Okonechnikov, Konstantin;
Schrimpf, Daniel;
Tonn, Svenja;
Mynarek, Martin;
Koster, Jan;
Sievers, Philipp;
Milde, Till;
Sahm, Felix;
Jones, David T. W.;
von Deimling, Andreas;
Pfister, Stefan M.;
Kool, Marcel

Publication type:

Article

Correction to: Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.

Published in:

Acta Neuropathologica, 2023, v. 145, n. 4, p. 511, doi. 10.1007/s00401-023-02538-4

By:

Keck, Michaela-Kristina;
Sill, Martin;
Wittmann, Andrea;
Joshi, Piyush;
Stichel, Damian;
Beck, Pengbo;
Okonechnikow, Konstantin;
Sievers, Philipp;
Wefers, Annika K.;
Roncaroli, Federico;
Avula, Shivaram;
McCabe, Martin G.;
Hayden, James T.;
Wesseling, Pieter;
Øra, Ingrid;
Nistér, Monica;
Kranendonk, Mariëtte E. G.;
Tops, Bastiaan B. J.;
Zapotocky, Michal;
Zamecnik, Josef

Publication type:

Article

Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.

Published in:

Acta Neuropathologica, 2023, v. 145, n. 1, p. 49, doi. 10.1007/s00401-022-02516-2

By:

Keck, Michaela-Kristina;
Sill, Martin;
Wittmann, Andrea;
Joshi, Piyush;
Stichel, Damian;
Beck, Pengbo;
Okonechnikow, Konstantin;
Sievers, Philipp;
Wefers, Annika K.;
Roncaroli, Federico;
Avula, Shivaram;
McCabe, Martin G.;
Hayden, James T.;
Wesseling, Pieter;
Øra, Ingrid;
Nistér, Monica;
Kranendonk, Mariëtte E. G.;
Tops, Bastiaan B. J.;
Zapotocky, Michal;
Zamecnik, Josef

Publication type:

Article

Epigenetic profiling reveals a subset of pediatric-type glioneuronal tumors characterized by oncogenic gene fusions involving several targetable kinases.

Published in:

Acta Neuropathologica, 2022, v. 144, n. 5, p. 1049, doi. 10.1007/s00401-022-02492-7

By:

Sievers, Philipp;
Sill, Martin;
Schrimpf, Daniel;
Friedel, Dennis;
Sturm, Dominik;
Gardberg, Maria;
Kurian, Kathreena M.;
Krskova, Lenka;
Vicha, Ales;
Schaller, Tina;
Hagel, Christian;
Abdullaev, Zied;
Aldape, Kenneth;
Jacques, Thomas S.;
Korshunov, Andrey;
Wick, Wolfgang;
Pfister, Stefan M.;
von Deimling, Andreas;
Jones, David T. W.;
Sahm, Felix

Publication type:

Article

Gene expression profiling of Group 3 medulloblastomas defines a clinically tractable stratification based on KIRREL2 expression.

Published in:

Acta Neuropathologica, 2022, v. 144, n. 2, p. 339, doi. 10.1007/s00401-022-02460-1

By:

Korshunov, Andrey;
Okonechnikov, Konstantin;
Stichel, Damian;
Schrimpf, Daniel;
Delaidelli, Alberto;
Tonn, Svenja;
Mynarek, Martin;
Sievers, Philipp;
Sahm, Felix;
Jones, David T. W.;
von Deimling, Andreas;
Pfister, Stefan M.;
Kool, Marcel

Publication type:

Article

Rapid-CNS<sup>2</sup>: rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof-of-concept study.

Published in:

Acta Neuropathologica, 2022, v. 143, n. 5, p. 609, doi. 10.1007/s00401-022-02415-6

By:

Patel, Areeba;
Dogan, Helin;
Payne, Alexander;
Krause, Elena;
Sievers, Philipp;
Schoebe, Natalie;
Schrimpf, Daniel;
Blume, Christina;
Stichel, Damian;
Holmes, Nadine;
Euskirchen, Philipp;
Hench, Jürgen;
Frank, Stephan;
Rosenstiel-Goidts, Violaine;
Ratliff, Miriam;
Etminan, Nima;
Unterberg, Andreas;
Dieterich, Christoph;
Herold-Mende, Christel;
Pfister, Stefan M.

Publication type:

Article

GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types.

Published in:

Acta Neuropathologica, 2021, v. 142, n. 6, p. 1065, doi. 10.1007/s00401-021-02369-1

By:

Sievers, Philipp;
Stichel, Damian;
Sill, Martin;
Schrimpf, Daniel;
Sturm, Dominik;
Selt, Florian;
Ecker, Jonas;
Kazdal, Daniel;
Miele, Evelina;
Kranendonk, Mariëtte E. G.;
Tops, Bastiaan B. J.;
Kohlhof-Meinecke, Patricia;
Beschorner, Rudi;
Kramm, Christof M.;
Hasselblatt, Martin;
Reifenberger, Guido;
Capper, David;
Wesseling, Pieter;
Stenzinger, Albrecht;
Milde, Till

Publication type:

Article

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors.

Published in:

Acta Neuropathologica, 2021, v. 142, n. 5, p. 827, doi. 10.1007/s00401-021-02356-6

By:

Sievers, Philipp;
Henneken, Sophie C.;
Blume, Christina;
Sill, Martin;
Schrimpf, Daniel;
Stichel, Damian;
Okonechnikov, Konstantin;
Reuss, David E.;
Benzel, Julia;
Maaß, Kendra K.;
Kool, Marcel;
Sturm, Dominik;
Zheng, Tuyu;
Ghasemi, David R.;
Kohlhof-Meinecke, Patricia;
Cruz, Ofelia;
Suñol, Mariona;
Lavarino, Cinzia;
Ruf, Viktoria;
Boldt, Henning B.

Publication type:

Article

PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum.

Published in:

Acta Neuropathologica, 2021, v. 142, n. 5, p. 841, doi. 10.1007/s00401-021-02354-8

By:

Alhalabi, Karam T.;
Stichel, Damian;
Sievers, Philipp;
Peterziel, Heike;
Sommerkamp, Alexander C.;
Sturm, Dominik;
Wittmann, Andrea;
Sill, Martin;
Jäger, Natalie;
Beck, Pengbo;
Pajtler, Kristian W.;
Snuderl, Matija;
Jour, George;
Delorenzo, Michael;
Martin, Allison M.;
Levy, Adam;
Dalvi, Nagma;
Hansford, Jordan R.;
Gottardo, Nicholas G.;
Uro-Coste, Emmanuelle

Publication type:

Article

Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas.

Published in:

Acta Neuropathologica, 2021, v. 142, n. 5, p. 873, doi. 10.1007/s00401-021-02351-x

By:

Kirches, Elmar;
Sahm, Felix;
Korshunov, Andrey;
Bluecher, Christina;
Waldt, Natalie;
Kropf, Siegfried;
Schrimpf, Daniel;
Sievers, Philipp;
Stichel, Damian;
Schüller, Ulrich;
Schittenhelm, Jens;
Riemenschneider, Markus J.;
Karajannis, Matthias A.;
Perry, Arie;
Pietsch, Torsten;
Boekhoff, Svenja;
Capper, David;
Beck, Katja;
Paramasivam, Nagarajan;
Schlesner, Matthias

Publication type:

Article

Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1.

Published in:

Acta Neuropathologica, 2021, v. 142, n. 1, p. 179, doi. 10.1007/s00401-021-02302-6

By:

Suwala, Abigail K.;
Stichel, Damian;
Schrimpf, Daniel;
Maas, Sybren L. N.;
Sill, Martin;
Dohmen, Hildegard;
Banan, Rouzbeh;
Reinhardt, Annekathrin;
Sievers, Philipp;
Hinz, Felix;
Blattner-Johnson, Mirjam;
Hartmann, Christian;
Schweizer, Leonille;
Boldt, Henning B.;
Kristensen, Bjarne Winther;
Schittenhelm, Jens;
Wood, Matthew D.;
Chotard, Guillaume;
Bjergvig, Rolf;
Das, Anirban

Publication type:

Article

Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1.

Published in:

Acta Neuropathologica, 2021, v. 141, n. 2, p. 281, doi. 10.1007/s00401-020-02247-2

By:

Sievers, Philipp;
Sill, Martin;
Blume, Christina;
Tauziede-Espariat, Arnault;
Schrimpf, Daniel;
Stichel, Damian;
Reuss, David E.;
Dogan, Helin;
Hartmann, Christian;
Mawrin, Christian;
Hasselblatt, Martin;
Stummer, Walter;
Schick, Uta;
Hench, Jürgen;
Frank, Stephan;
Ketter, Ralf;
Schweizer, Leonille;
Schittenhelm, Jens;
Puget, Stéphanie;
Brandner, Sebastian

Publication type:

Article

CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas.

Published in:

Acta Neuropathologica, 2020, v. 140, n. 3, p. 409, doi. 10.1007/s00401-020-02188-w

By:

Sievers, Philipp;
Hielscher, Thomas;
Schrimpf, Daniel;
Stichel, Damian;
Reuss, David E.;
Berghoff, Anna S.;
Neidert, Marian C.;
Wirsching, Hans-Georg;
Mawrin, Christian;
Ketter, Ralf;
Paulus, Werner;
Reifenberger, Guido;
Lamszus, Katrin;
Westphal, Manfred;
Etminan, Nima;
Ratliff, Miriam;
Herold-Mende, Christel;
Pfister, Stefan M.;
Jones, David T. W.;
Weller, Michael

Publication type:

Article

Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker.

Published in:

Acta Neuropathologica, 2020, v. 139, n. 3, p. 583, doi. 10.1007/s00401-019-02102-z

By:

Korshunov, Andrey;
Okonechnikov, Konstantin;
Sahm, Felix;
Ryzhova, Marina;
Stichel, Damian;
Schrimpf, Daniel;
Ghasemi, David R.;
Pajtler, Kristian W.;
Antonelli, Manila;
Donofrio, Vittoria;
Mastronuzzi, Angela;
Rossi, Sabrina;
Camassei, Francesca Diomedi;
Buccoliero, Anna Maria;
Haberler, Christine;
Slavc, Irene;
Dahiya, Sonika;
Casalini, Belen;
Sievers, Philipp;
Meyer, Jochen

Publication type:

Article

Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation.

Published in:

2020

By:

Sievers, Philipp;
Schrimpf, Daniel;
Stichel, Damian;
Reuss, David E.;
Hasselblatt, Martin;
Hagel, Christian;
Staszewski, Ori;
Hench, Jürgen;
Frank, Stephan;
Brandner, Sebastian;
Korshunov, Andrey;
Wick, Wolfgang;
Pfister, Stefan M.;
Reifenberger, Guido;
von Deimling, Andreas;
Sahm, Felix;
Jones, David T. W.

Publication type:

Letter

YAP1-fusions in pediatric NF2-wildtype meningioma.

Published in:

2020

By:

Sievers, Philipp;
Chiang, Jason;
Schrimpf, Daniel;
Stichel, Damian;
Paramasivam, Nagarajan;
Sill, Martin;
Gayden, Tenzin;
Casalini, Belen;
Reuss, David E.;
Dalton, James;
Pajtler, Kristian W.;
Hänggi, Daniel;
Herold-Mende, Christel;
Rushing, Elisabeth;
Korshunov, Andrey;
Mawrin, Christian;
Weller, Michael;
Schlesner, Matthias;
Wick, Wolfgang;
Jabado, Nada

Publication type:

Letter

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.

Published in:

Acta Neuropathologica, 2020, v. 139, n. 1, p. 193, doi. 10.1007/s00401-019-02078-w

By:

Wefers, Annika K.;
Stichel, Damian;
Schrimpf, Daniel;
Coras, Roland;
Pages, Mélanie;
Tauziède-Espariat, Arnault;
Varlet, Pascale;
Schwarz, Daniel;
Söylemezoglu, Figen;
Pohl, Ute;
Pimentel, José;
Meyer, Jochen;
Hewer, Ekkehard;
Japp, Anna;
Joshi, Abhijit;
Reuss, David E.;
Reinhardt, Annekathrin;
Sievers, Philipp;
Casalini, M. Belén;
Ebrahimi, Azadeh

Publication type:

Article