Works by Petrucelli, Leonard

Results: 181
    1

    Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight.

    Published in:
    Genome Biology, 2019, v. 20, n. 1, p. N.PAG, doi. 10.1186/s13059-019-1707-2
    By:
    • Ebbert, Mark T. W.;
    • Jensen, Tanner D.;
    • Jansen-West, Karen;
    • Sens, Jonathon P.;
    • Reddy, Joseph S.;
    • Ridge, Perry G.;
    • Kauwe, John S. K.;
    • Belzil, Veronique;
    • Pregent, Luc;
    • Carrasquillo, Minerva M.;
    • Keene, Dirk;
    • Larson, Eric;
    • Crane, Paul;
    • Asmann, Yan W.;
    • Ertekin-Taner, Nilufer;
    • Younkin, Steven G.;
    • Ross, Owen A.;
    • Rademakers, Rosa;
    • Petrucelli, Leonard;
    • Fryer, John D.
    Publication type:
    Article
    2
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    Clinical Performance of Plasma Aβ<sub>42</sub>/Aβ<sub>40</sub>, p‐tau217 and Neurofilament Light in Sporadic Frontotemporal Dementia Spectrum Disorders with subsequent comparison of pathology.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S2, p. 1, doi. 10.1002/alz.091873
    By:
    • Rajbanshi, Binita;
    • Heuer, Hilary W.;
    • VandeVrede, Lawren;
    • Ljubenkov, Peter A.;
    • Lago, Argentina Lario;
    • Araujo, Igor Prufer Q C;
    • Staffaroni, Adam M.;
    • Petrucelli, Leonard;
    • Gendron, Tania F;
    • Rosen, Howard J.;
    • Boeve, Brad F.;
    • Bateman, Randall J.;
    • Rojas, Julio C.;
    • Boxer, Adam L.
    Publication type:
    Article
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    GDF15 as a Prognostic Biomarker of Cognitive Decline in Frontotemporal Dementia.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S2, p. 1, doi. 10.1002/alz.089335
    By:
    • Chen, Coty;
    • Paolillo, Emily W.;
    • Saloner, Rowan;
    • VandeBunte, Anna M.;
    • Cadwallader, Claire J.;
    • Lee, Shannon Y.;
    • Lago, Argentina Lario;
    • Gendron, Tania F;
    • Petrucelli, Leonard;
    • Webb, Julia D;
    • Staffaroni, Adam M.;
    • Heuer, Hilary W.;
    • Boeve, Brad;
    • Forsberg, Leah K.;
    • Rosen, Howard J.;
    • Rojas, Julio C.;
    • Kramer, Joel H.;
    • Boxer, Adam L.;
    • Casaletto, Kaitlin B.
    Publication type:
    Article
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    Global platform trial design for tau (MAPT) mutation carriers.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078640
    By:
    • Staffaroni, Adam M.;
    • Quintana, Melanie;
    • Wendelberger, Barbara;
    • Tartaglia, Carmela;
    • Heuer, Hilary W.;
    • Russell, Lucy L.;
    • Gendron, Tania F;
    • Petrucelli, Leonard;
    • Heller, Carolin;
    • Wolf, Amy;
    • Cobigo, Yann;
    • Sanderson‐Cimino, Mark E.;
    • Forsberg, Leah K.;
    • Kornak, John;
    • Cash, David M;
    • Boeve, Brad F.;
    • Rosen, Howard J.;
    • Rohrer, Jonathan D.;
    • Boxer, Adam L.
    Publication type:
    Article
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    Association of Physical Activity With Neurofilament Light Chain Trajectories in Autosomal Dominant Frontotemporal Lobar Degeneration Variant Carriers.

    Published in:
    JAMA Neurology, 2023, v. 80, n. 1, p. 82, doi. 10.1001/jamaneurol.2022.4178
    By:
    • Casaletto, Kaitlin B.;
    • Kornack, John;
    • Paolillo, Emily W.;
    • Rojas, Julio C.;
    • VandeBunte, Anna;
    • Staffaroni, Adam S.;
    • Lee, Shannon;
    • Heuer, Hilary;
    • Forsberg, Leah;
    • Ramos, Eliana M.;
    • Miller, Bruce L.;
    • Kramer, Joel H.;
    • Yaffe, Kristine;
    • Petrucelli, Leonard;
    • Boxer, Adam;
    • Boeve, Brad;
    • Gendron, Tania F.;
    • Rosen, Howard
    Publication type:
    Article
    13

    Association of Apolipoprotein E ε4 With Transactive Response DNA-Binding Protein 43.

    Published in:
    JAMA Neurology, 2018, v. 75, n. 11, p. 1347, doi. 10.1001/jamaneurol.2018.3139
    By:
    • Wennberg, Alexandra M.;
    • Tosakulwong, Nirubol;
    • Lesnick, Timothy G.;
    • Murray, Melissa E.;
    • Whitwell, Jennifer L.;
    • Liesinger, Amanda M.;
    • Petrucelli, Leonard;
    • Boeve, Bradley F.;
    • Parisi, Joseph E.;
    • Knopman, David S.;
    • Petersen, Ronald C.;
    • Dickson, Dennis W.;
    • Josephs, Keith A.
    Publication type:
    Article
    14
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    Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD.

    Published in:
    Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30387-4
    By:
    • Krishnan, Gopinath;
    • Raitcheva, Denitza;
    • Bartlett, Daniel;
    • Prudencio, Mercedes;
    • McKenna-Yasek, Diane M.;
    • Douthwright, Catherine;
    • Oskarsson, Björn E.;
    • Ladha, Shafeeq;
    • King, Oliver D.;
    • Barmada, Sami J.;
    • Miller, Timothy M.;
    • Bowser, Robert;
    • Watts, Jonathan K.;
    • Petrucelli, Leonard;
    • Brown, Robert H.;
    • Kankel, Mark W.;
    • Gao, Fen-Biao
    Publication type:
    Article
    16
    17

    FTDP-17 with Pick body-like inclusions associated with a novel tau mutation, p.E372G.

    Published in:
    Brain Pathology, 2017, v. 27, n. 5, p. 612, doi. 10.1111/bpa.12428
    By:
    • Tacik, Pawel;
    • DeTure, Michael A.;
    • Carlomagno, Yari;
    • Lin, Wen‐Lang;
    • Murray, Melissa E.;
    • Baker, Matthew C.;
    • Josephs, Keith A.;
    • Boeve, Bradley F.;
    • Wszolek, Zbigniew K.;
    • Graff‐Radford, Neill R.;
    • Parisi, Joseph E.;
    • Petrucelli, Leonard;
    • Rademakers, Rosa;
    • Isaacson, Richard S.;
    • Heilman, Kenneth M.;
    • Petersen, Ronald C.;
    • Dickson, Dennis W.;
    • Kouri, Naomi
    Publication type:
    Article
    18
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    Deletion of the Ubiquitin Ligase CHIP Leads to the Accumulation, But Not the Aggregation, of Both Endogenous Phospho- and Caspase-3-Cleaved Tau Species.

    Published in:
    Journal of Neuroscience, 2006, v. 26, n. 26, p. 6985, doi. 10.1523/JNEUROSCI.0746-06.2006
    By:
    • Dickey, Chad A.;
    • Mei Yue;
    • Wen-Lang Lin;
    • Dickson, Dennis W.;
    • Dunmore, Judith H.;
    • Lee, Wing C.;
    • Zehr, Cynthia;
    • West, Gemma;
    • Songsong Cao;
    • Clark, Amber M. K.;
    • Caldwell, Guy A.;
    • Caldwell, Kim A.;
    • Eckman, Christopher;
    • Patterson, Cam;
    • Hutton, Michael;
    • Petrucelli, Leonard
    Publication type:
    Article
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    Long-read sequencing across the C9orf72 ‘GGGGCC’ repeat expansion: implications for clinical use and genetic discovery efforts in human disease.

    Published in:
    Molecular Neurodegeneration, 2018, v. 13, n. 1, p. N.PAG, doi. 10.1186/s13024-018-0274-4
    By:
    • Ebbert, Mark T. W.;
    • Farrugia, Stefan L.;
    • Sens, Jonathon P.;
    • Jansen-West, Karen;
    • Gendron, Tania F.;
    • Prudencio, Mercedes;
    • McLaughlin, Ian J.;
    • Bowman, Brett;
    • Seetin, Matthew;
    • DeJesus-Hernandez, Mariely;
    • Jackson, Jazmyne;
    • Brown, Patricia H.;
    • Dickson, Dennis W.;
    • van Blitterswijk, Marka;
    • Rademakers, Rosa;
    • Petrucelli, Leonard;
    • Fryer, John D.
    Publication type:
    Article
    24

    Replication of progressive supranuclear palsy genome-wide association study identifies <italic>SLCO1A2</italic> and <italic>DUSP10</italic> as new susceptibility loci.

    Published in:
    Molecular Neurodegeneration, 2018, v. 13, n. 1, p. N.PAG, doi. 10.1186/s13024-018-0267-3
    By:
    • Sanchez-Contreras, Monica Y.;
    • Kouri, Naomi;
    • Cook, Casey N.;
    • Serie, Daniel J.;
    • Heckman, Michael G.;
    • Finch, NiCole A.;
    • Caselli, Richard J.;
    • Uitti, Ryan J.;
    • Wszolek, Zbigniew K.;
    • Graff-Radford, Neill;
    • Petrucelli, Leonard;
    • Wang, Li-San;
    • Schellenberg, Gerard D.;
    • Dickson, Dennis W.;
    • Rademakers, Rosa;
    • Ross, Owen A.
    Publication type:
    Article
    25

    The lysosomal protein cathepsin L is a progranulin protease.

    Published in:
    Molecular Neurodegeneration, 2017, v. 12, p. 1, doi. 10.1186/s13024-017-0196-6
    By:
    • Lee, Chris W.;
    • Stankowski, Jeannette N.;
    • Jeannie Chew;
    • Cook, Casey N.;
    • Ying-Wai Lam;
    • Almeida, Sandra;
    • Carlomagno, Yari;
    • Kwok-Fai Lau;
    • Prudencio, Mercedes;
    • Fen-Biao Gao;
    • Bogyo, Matthew;
    • Dickson, Dennis W.;
    • Petrucelli, Leonard
    Publication type:
    Article
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    Progranulin regulates neuronal outgrowth independent of Sortilin.

    Published in:
    Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 33, doi. 10.1186/1750-1326-7-33
    By:
    • Gass, Jennifer;
    • Lee, Wing C;
    • Cook, Casey;
    • Finch, Nicole;
    • Stetler, Caroline;
    • Jansen-West, Karen;
    • Lewis, Jada;
    • Link, Christopher D;
    • Rademakers, Rosa;
    • Nykijaer, Anders;
    • Petrucelli, Leonard
    Publication type:
    Article
    29
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    The role of tau in neurodegeneration.

    Published in:
    Molecular Neurodegeneration, 2009, v. 4, p. 1, doi. 10.1186/1750-1326-4-13
    By:
    • Gendron, Tania F.;
    • Petrucelli, Leonard
    Publication type:
    Article
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    Symptomatic progression of frontotemporal dementia with the TARDBP I383V variant.

    Published in:
    2024
    By:
    • Pressman, Peter S.;
    • Carter, Danelle J.;
    • Ramos, Eliana Marisa;
    • Molden, Joie;
    • Smith, Kaitlin;
    • Dino, Francesca;
    • McMillan, Corey;
    • Irwin, David;
    • Rascovsky, Katya;
    • Ghoshal, Nupur;
    • Knudtson, Marguerite;
    • Rademakers, Rosa;
    • Geschwind, Daniel;
    • Gendron, Tania;
    • Petrucelli, Leonard;
    • Heuer, Hilary;
    • Boeve, Bradley F.;
    • Barmada, Sami;
    • Boxer, Adam;
    • Tempini, Maria Luisa Gorno
    Publication type:
    Case Study
    34

    Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis.

    Published in:
    Journal of Neurology, 2023, v. 270, n. 7, p. 3315, doi. 10.1007/s00415-023-11768-1
    By:
    • Abdelhak, Ahmed;
    • Barba, Lorenzo;
    • Romoli, Michele;
    • Benkert, Pascal;
    • Conversi, Francesco;
    • D'Anna, Lucio;
    • Masvekar, Ruturaj R.;
    • Bielekova, Bibiana;
    • Prudencio, Mercedes;
    • Petrucelli, Leonard;
    • Meschia, James F.;
    • Erben, Young;
    • Furlan, Roberto;
    • De Lorenzo, Rebecca;
    • Mandelli, Alessandra;
    • Sutter, Raoul;
    • Hert, Lisa;
    • Epple, Varenka;
    • Marastoni, Damiano;
    • Sellner, Johann
    Publication type:
    Article
    35
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    Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant.

    Published in:
    Acta Neuropathologica Communications, 2019, v. 7, n. 1, p. N.PAG, doi. 10.1186/s40478-019-0661-2
    By:
    • Carlomagno, Yari;
    • Chung, Dah-eun Chloe;
    • Yue, Mei;
    • Kurti, Aishe;
    • Avendano, Nicole M.;
    • Castanedes-Casey, Monica;
    • Hinkle, Kelly M.;
    • Jansen-West, Karen;
    • Daughrity, Lillian M.;
    • Tong, Jimei;
    • Phillips, Virginia;
    • Rademakers, Rosa;
    • DeTure, Michael;
    • Fryer, John D.;
    • Dickson, Dennis W.;
    • Petrucelli, Leonard;
    • Cook, Casey
    Publication type:
    Article
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    An autoradiographic evaluation of AV-1451 Tau PET in dementia.

    Published in:
    Acta Neuropathologica Communications, 2016, v. 4, p. 1, doi. 10.1186/s40478-016-0315-6
    By:
    • Lowe, Val J.;
    • Curran, Geoffry;
    • Fang, Ping;
    • Liesinger, Amanda M.;
    • Josephs, Keith A.;
    • Parisi, Joseph E.;
    • Kantarci, Kejal;
    • Boeve, Bradley F.;
    • Pandey, Mukesh K.;
    • Bruinsma, Tyler;
    • Knopman, David S.;
    • Jones, David T.;
    • Petrucelli, Leonard;
    • Cook, Casey N.;
    • Graff-Radford, Neill R.;
    • Dickson, Dennis W.;
    • Petersen, Ronald C.;
    • Jack Jr., Clifford R.;
    • Murray, Melissa E.
    Publication type:
    Article
    40

    CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.

    Published in:
    Human Molecular Genetics, 2004, v. 13, n. 7, p. 703, doi. 10.1093/hmg/ddh083
    By:
    • Petrucelli, Leonard;
    • Dickson, Dennis;
    • Kehoe, Kathryn;
    • Taylor, Julie;
    • Snyder, Heather;
    • Grover, Andrew;
    • De Lucia, Michael;
    • McGowan, Eileen;
    • Lewis, Jada;
    • Prihar, Guy;
    • Kim, Jungsu;
    • Dillmann, Wolfgang H.;
    • Browne, Susan E.;
    • Hall, Alexis;
    • Voellmy, Richard;
    • Tsuboi, Yoshio;
    • Dawson, Ted M.;
    • Wolozin, Benjamin;
    • Hardy, John;
    • Hutton, Mike
    Publication type:
    Article
    41

    Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion.

    Published in:
    Science Translational Medicine, 2013, v. 5, n. 208, p. 1, doi. 10.1126/scitranslmed.3007529
    By:
    • Sareen, Dhruv;
    • O'Rourke, Jacqueline G.;
    • Meera, Pratap;
    • Muhammad, A. K. M. G.;
    • Grant, Sharday;
    • Simpkinson, Megan;
    • Bell, Shaughn;
    • Carmona, Sharon;
    • Ornelas, Loren;
    • Sahabian, Anais;
    • Gendron, Tania;
    • Petrucelli, Leonard;
    • Baughn, Michael;
    • Ravits, John;
    • Harms, Matthew B.;
    • Rigo, Frank;
    • Bennett, C. Frank;
    • Otis, Thomas S.;
    • Svendsen, Clive N.;
    • Baloh, Robert H.
    Publication type:
    Article
    42

    Cover Image, Volume 177B, Number 1, January 2018.

    Published in:
    American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 2018, v. 177, n. 1, p. i, doi. 10.1002/ajmg.b.32617
    By:
    • Farhan, Sali M. K.;
    • Gendron, Tania F.;
    • Petrucelli, Leonard;
    • Hegele, Robert A.;
    • Strong, Michael J.
    Publication type:
    Article
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    Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue.

    Published in:
    Autophagy, 2024, v. 20, n. 9, p. 2076, doi. 10.1080/15548627.2024.2356490
    By:
    • Watzlawik, Jens O.;
    • Hou, Xu;
    • Richardson, Tyrique;
    • Lewicki, Szymon L.;
    • Siuda, Joanna;
    • Wszolek, Zbigniew K.;
    • Cook, Casey N.;
    • Petrucelli, Leonard;
    • DeTure, Michael;
    • Dickson, Dennis W.;
    • Antico, Odetta;
    • Muqit, Miratul M. K.;
    • Fishman, Jordan B.;
    • Pirani, Karima;
    • Kumaran, Ravindran;
    • Polinski, Nicole K.;
    • Fiesel, Fabienne C.;
    • Springer, Wolfdieter
    Publication type:
    Article
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    Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice.

    Published in:
    Journal of Neuroscience, 2010, v. 30, n. 32, p. 10851, doi. 10.1523/JNEUROSCI.1630-10.2010
    By:
    • Ya-Fei Xu;
    • Gendron, Tania F.;
    • Yong-Jie Zhang;
    • Wen-Lang Lin;
    • D'Alton, Simon;
    • Hong Sheng;
    • Casey, Monica Castanedes;
    • Jimei Tong;
    • Knight, Joshua;
    • Xin Yu;
    • Rademakers, Rosa;
    • Boylan, Kevin;
    • Hutton, Mike;
    • McGowan, Eileen;
    • Dickson, Dennis W.;
    • Lewis, Jada;
    • Petrucelli, Leonard
    Publication type:
    Article
    47

    Proteasome inhibition and Parkinson's disease modeling.

    Published in:
    Annals of Neurology, 2006, v. 60, n. 2, p. 260
    By:
    • Jordi Bové;
    • Chun Zhou;
    • Vernice Jackson‐Lewis;
    • Julie Taylor;
    • Yaping Chu;
    • Hardy J. Rideout;
    • Du‐Chu Wu;
    • Jeffrey H. Kordower;
    • Leonard Petrucelli;
    • Serge Przedborski
    Publication type:
    Article
    48

    Lewy bodies and parkinsonism in families with parkin mutations.

    Published in:
    2001
    By:
    • Farrer, Matt;
    • Chan, Piu;
    • Chen, Rong;
    • Tan, Louis;
    • Lincoln, Sarah;
    • Hernandez, Dena;
    • Forno, Lysia;
    • Gwinn-Hardy, Katrina;
    • Petrucelli, Leonard;
    • Hussey, Jennifer;
    • Singleton, Andrew;
    • Tanner, Caroline;
    • Hardy, John;
    • Langston, J. William;
    • Farrer, M;
    • Chan, P;
    • Chen, R;
    • Tan, L;
    • Lincoln, S;
    • Hernandez, D
    Publication type:
    journal article
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