Works by O'Rahilly, S

Results: 91

Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis.

Published in:

2012

By:

Lowe CE;
Dennis RJ;
Obi U;
O'Rahilly S;
Rochford JJ;
Lowe, C E;
Dennis, R J;
Obi, U;
O'Rahilly, S;
Rochford, J J

Publication type:

journal article

Human obesity as a heritable disorder of the central control of energy balance.

Published in:

2008

By:

O'Rahilly S;
Farooqi IS;
O'Rahilly, S;
Farooqi, I S

Publication type:

journal article

Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution.

Published in:

1997

By:

Montague CT;
Prins JB;
Sanders L;
Digby JE;
O'Rahilly S;
Montague, C T;
Prins, J B;
Sanders, L;
Digby, J E;
O'Rahilly, S

Publication type:

journal article

QUANTITATIVE MODELLING OF ENDOCRINE DISEASES AS EXEMPLIFIED BY DIABETES.

Published in:

Clinical Endocrinology, 1987, v. 26, n. 1, p. 107, doi. 10.1111/j.1365-2265.1987.tb03644.x

By:

TURNER, R. C.;
RUDENSKI, A. S.;
HOLMAN, R. R.;
MATTHEWS, D. R.;
O'RAHILLY, S. P.

Publication type:

Article

Expression of the thermogenic nuclear hormone receptor coactivator PGC-1a is reduced in the adipose tissue of morbidly obese subjects.

Published in:

International Journal of Obesity & Related Metabolic Disorders, 2004, v. 28, n. 1, p. 176, doi. 10.1038/sj.ijo.0802482

By:

Semple, R.K.;
Crowley, V.C.;
Sewter, C.P.;
Laudes, M.;
Christodoulides, C.;
Considine, R.V.;
Vidal-Puig, A.;
O'Rahilly, S.

Publication type:

Article

Adipose depot-specific expression of cIAP2 in human preadipocytes and modulation of expression by serum factors and TNFα.

Published in:

International Journal of Obesity & Related Metabolic Disorders, 2001, v. 25, n. 7, p. 1027, doi. 10.1038/sj.ijo.0801649

By:

Niesler, C U;
Prins, J B;
O'Rahilly, S;
Siddle, K;
Montague, C T

Publication type:

Article

Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population.

Published in:

International Journal of Obesity & Related Metabolic Disorders, 2001, v. 25, n. 4, p. 472, doi. 10.1038/sj.ijo.0801584

By:

Halsall, D J;
Luan, J;
Saker, P;
Huxtable, S;
Farooqi, I S;
Keogh, J;
Wareham, N J;
O'Rahilly, S

Publication type:

Article

A classification of videoconferencing related illness: the Zoomnotic diseases.

Published in:

QJM: An International Journal of Medicine, 2021, v. 114, n. 3, p. 159, doi. 10.1093/qjmed/hcaa316

By:

Rowitch, D H;
O'Rahilly, S;
Smith, G C S

Publication type:

Article

Letter to Editor Response to: Is zoomnosis a human-driven human zoonosis? A call for action.

Published in:

QJM: An International Journal of Medicine, 2021, v. 114, n. 2, p. 143, doi. 10.1093/qjmed/hcab006

By:

Rowitch, D H;
O'Rahilly, S;
Smith, G C S

Publication type:

Article

Depot-related and thiazolidinedione-responsive expression of uncoupling protein 2 (UCP2) in human adipocytes.

Published in:

International Journal of Obesity & Related Metabolic Disorders, 2000, v. 24, n. 5, p. 585, doi. 10.1038/sj.ijo.0801201

By:

Digby, J E;
Crowley, V E F;
Sewter, C P;
Whitehead, J P;
Prins, J B;
O’Rahilly, S

Publication type:

Article

Psychiatric co-morbidities in patients attending specialist obesity services in the UK.

Published in:

QJM: An International Journal of Medicine, 2006, v. 99, n. 5, p. 317, doi. 10.1093/qjmed/hcl041

By:

A. Tuthill;
H. Slawik;
S. O'Rahilly;
N. Finer

Publication type:

Article

The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models.

Published in:

QJM: An International Journal of Medicine, 2000, v. 93, n. 1, p. 7, doi. 10.1093/qjmed/93.1.7

By:

Yeo, G.S.H.;
Farooqi, I.S.;
Challis, B.G.;
Jackson, R.S.;
O'Rahilly, S.

Publication type:

Article

Erratum: Digenic inheritance of severe insulin resistance in a human pedigree.

Published in:

2002

By:

Savage, D B;
Agostini, M;
Barroso, I;
Gurnell, M;
Luan, J;
Meirhaeghe, A;
Harding, A-H;
Ihrke, G;
Rajanayagam, O;
Soos, M A;
George, S;
Berger, D;
Thomas, E L;
Bell, J D;
Meeran, K;
Ross, R J;
Vidal-Puig, A;
Wareham, N J;
O'Rahilly, S

Publication type:

Correction Notice

Mechanistic insights into insulin resistance in the genetic era.

Published in:

Diabetic Medicine, 2011, v. 28, n. 12, p. 1476, doi. 10.1111/j.1464-5491.2011.03463.x

By:

Parker, V. E. R.;
Savage, D. B.;
O'Rahilly, S.;
Semple, R. K.

Publication type:

Article

Severe insulin resistance due to anti-insulin antibodies: response to plasma exchange and immunosuppressive therapy.

Published in:

Diabetic Medicine, 2009, v. 26, n. 1, p. 79, doi. 10.1111/j.1464-5491.2008.02621.x

By:

Greenfield, J. R.;
Tuthill, A.;
Soos, M. A.;
Semple, R. K.;
Halsall, D. J.;
Chaudhry, A.;
O'Rahilly, S.

Publication type:

Article

Functional characterization of a novel insulin receptor mutation contributing to Rabson–Mendenhall syndrome.

Published in:

Clinical Endocrinology, 2007, v. 66, n. 1, p. 21, doi. 10.1111/j.1365-2265.2006.02678.x

By:

Tuthill, A.;
Semple, R. K.;
Day, R.;
Soos, M. A.;
Sweeney, E.;
Seymour, P. J.;
Didi, M.;
O'Rahilly, S.

Publication type:

Article

Associations between body composition, glycaemia and complement C3 in black African and white European men.

Published in:

2022

By:

Reed, R.M.;
Hakim, O.;
Lockhart, S.;
O'Rahilly, S.;
Whyte, M.B.;
Goff, L.M.

Publication type:

Abstract

Plasma adiponectin as a marker of insulin receptor dysfunction: clinical utility in severe insulin resistance.

Published in:

2008

By:

Semple RK;
Cochran EK;
Soos MA;
Burling KA;
Savage DB;
Gorden P;
O'Rahilly S

Publication type:

Journal Article

Identification of the Global Transcriptomic Response of the Hypothalamic Arcuate Nucleus to Fasting and Leptin.

Published in:

Journal of Neuroendocrinology, 2010, v. 22, n. 8, p. 915, doi. 10.1111/j.1365-2826.2010.02026.x

By:

Jovanovic, Z.;
Tung, Y. C. L.;
Lam, B. Y. H.;
O'Rahilly, S.;
Yeo, G. S. H.

Publication type:

Article

The Effects of Neurokinin B upon Gonadotrophin Release in Male Rodents.

Published in:

Journal of Neuroendocrinology, 2010, v. 22, n. 3, p. 181, doi. 10.1111/j.1365-2826.2009.01951.x

By:

Corander, M. P.;
Challis, B. G.;
Thompson, E. L.;
Jovanovic, Z.;
Loraine Tung, Y. C.;
Rimmington, D.;
Huhtaniemi, I. T.;
Murphy, K. G.;
Topaloglu, A. K.;
Yeo, G. S. H.;
O'Rahilly, S.;
Dhillo, W. S.;
Semple, R. K.;
Coll, A. P.

Publication type:

Article

Successful treatment of Type B insulin resistance in a patient with otherwise quiescent systemic lupus erythematosus.

Published in:

2005

By:

Coll AP;
Morganstein D;
Jayne D;
Soos MA;
O'Rahilly S;
Burke J

Publication type:

Journal Article

Letters.

Published in:

2005

By:

Simoens, S.;
Foulon, E.;
Dethier, M.;
Mathieu, C.;
Laekeman, G.;
Brennan, A. M.;
McNamara, B.;
Plant, W. D.;
O'Halloran, D. J.;
Coll, A. P.;
Morganstein, D.;
Jayne, D.;
Soos, M. A.;
O'Rahilly, S.;
Burke, J.

Publication type:

Letter

Genetic variants of insulin receptor substrate-1 (IRS-1) in syndromes of severe insulin resistance. Functional analysis of Ala513Pro and Gly1158Glu IRS-1.

Published in:

Diabetic Medicine, 2002, v. 19, n. 10, p. 804, doi. 10.1046/j.1464-5491.2002.00779.x

By:

Berger, D.;
Barroso, I.;
Soos, M.;
Yeo, G.;
Schafer, A. J.;
O'Rahilly, S.;
Whitehead, J. P.

Publication type:

Article

Is the defect in pro-hormone processing in Type 2 diabetes mellitus restricted to the β cell?

Published in:

Diabetic Medicine, 2001, v. 18, n. 1, p. 17, doi. 10.1046/j.1464-5491.2001.00397.x

By:

Bano, G.;
Rodin, D. A.;
White, A.;
O'rahilly, S.;
Nussey, S. S.

Publication type:

Article

The metabolic syndrome: all in the mind?

Published in:

1999

By:

O'Rahilly, S P

Publication type:

Journal Article

High Prevalence of Hepatitis C Infection in Afro-Caribbean Patients with Type 2 Diabetes and Abnormal Liver Function Tests.

Published in:

Diabetic Medicine, 1995, v. 12, n. 3, p. 244, doi. 10.1111/j.1464-5491.1995.tb00466.x

By:

Gray, H.;
Wreghitt, T.;
Stratton, I.M.;
Alexander, G.J.M.;
Turner, R.C.;
O'Rahilly, S.

Publication type:

Article

The Seventh Annual Meeting of the Anglo-Danish-Dutch Diabetes Group.

Published in:

Diabetic Medicine, 1989, v. 6, n. 9, p. 829, doi. 10.1111/j.1464-5491.1989.tb01290.x

By:

O'Rahilly, S.;
Bilous, R.

Publication type:

Article

The Sixth Annual Meeting of the Anglo-Danish-Dutch Diabetes Group or Fun in Fyn.

Published in:

Diabetic Medicine, 1989, v. 6, n. 3, p. 277, doi. 10.1111/j.1464-5491.1989.tb01161.x

By:

Heller, S. R.;
O'Rahilly, S.

Publication type:

Article

Early-onset Type 2 Diabetes vs Maturity-onset Diabetes of Youth: Evidence for the Existence of Two Discrete Diabetic Syndromes.

Published in:

Diabetic Medicine, 1988, v. 5, n. 3, p. 224, doi. 10.1111/j.1464-5491.1988.tb00974.x

By:

O'Rahilly, S.;
Turner, R. C.

Publication type:

Article

Diabetes Nomenclature: Classification or Grading of Severity?

Published in:

Diabetic Medicine, 1986, v. 3, n. 3, p. 216, doi. 10.1111/j.1464-5491.1986.tb00747.x

By:

Turner, R. C.;
Holman, R. R.;
Matthews, D. R.;
O'Rahilly, S. P.;
Rudenski, A. S.;
Braund, W. J.

Publication type:

Article

Steroid hormones and adipose tissue.

Published in:

European Journal of Clinical Investigation, 1996, v. 26, n. 4, p. 259, doi. 10.1046/j.1365-2362.1996.146269.x

By:

PRINS, J. B.;
O'RAHILLY, S.;
CHATTERJEE, V. K. K.

Publication type:

Article

Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects.

Published in:

Molecular Psychiatry, 2014, v. 19, n. 12, p. 1341, doi. 10.1038/mp.2014.126

By:

Ziauddeen, H;
Chamberlain, S R;
Nathan, P J;
Koch, A;
Maltby, K;
Bush, M;
Tao, W X;
Napolitano, A;
Skeggs, A L;
Brooke, A C;
Cheke, L;
Clayton, N S;
Sadaf Farooqi, I;
O'Rahilly, S;
Waterworth, D;
Song, K;
Hosking, L;
Richards, D B;
Fletcher, P C;
Bullmore, E T

Publication type:

Article

Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects.

Published in:

Molecular Psychiatry, 2013, v. 18, n. 12, p. 1287, doi. 10.1038/mp.2012.154

By:

Ziauddeen, H;
Chamberlain, S R;
Nathan, P J;
Koch, A;
Maltby, K;
Bush, M;
Tao, W X;
Napolitano, A;
Skeggs, A L;
Brooke, A C;
Cheke, L;
Clayton, N S;
Sadaf Farooqi, I;
O'Rahilly, S;
Waterworth, D;
Song, K;
Hosking, L;
Richards, D B;
Fletcher, P C;
Bullmore, E T

Publication type:

Article

Hypoglycemia due to an Insulin Binding Antibody in a Patient with an IgA-κ Myeloma.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2007, v. 92, n. 6, p. 2013, doi. 10.1210/jc.2007-0075

By:

Halsall, D. J.;
Mangi, M.;
Fahie-Wilson, M. N.;
Wark, G.;
Mainwaring-Burton, R.;
O’Rahilly, S.;
Soos, M.

Publication type:

Article

Elevated plasma adiponectin in humans with genetically defective insulin receptors.

Published in:

2006

By:

Semple, R K;
Soos, M A;
Luan, J;
Mitchell, C S;
Wilson, J C;
Gurnell, M;
Cochran, E K;
Gorden, P;
Chatterjee, V K K;
Wareham, N J;
O'Rahilly, S

Publication type:

journal article

Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism.

Published in:

2005

By:

Semple, R K;
Achermann, J C;
Ellery, J;
Farooqi, I S;
Karet, F E;
Stanhope, R G;
O'rahilly, S;
Aparicio, S A

Publication type:

journal article

Severe insulin resistance, diabetes mellitus, hypertriglyceridemia, and pseudoacromegaly.

Published in:

Journal of Clinical Endocrinology & Metabolism, 1996, v. 81, n. 10, p. 3465, doi. 10.1210/jc.81.10.3465

By:

KUMAR, S.;
DURRINGTON, P. N.;
O'RAHILLY, S.;
LAING, I.;
HUMPHREYS, P. J.;
OLUKOGA, A. O.;
BHATNAGAR, D.;
MACKNESS, M. I.;
DAVIS, J. R.;
BOULTON, A. J.

Publication type:

Article

Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance.

Published in:

1993

By:

Flier, J S;
Moller, D E;
Moses, A C;
O'Rahilly, S;
Chaiken, R L;
Grigorescu, F;
Elahi, D;
Kahn, B B;
Weinreb, J E;
Eastman, R

Publication type:

journal article

Ethnic differences in complement system biomarkers and their association with metabolic health in men of Black African and White European ethnicity.

Published in:

Clinical & Experimental Immunology, 2023, v. 212, n. 1, p. 52, doi. 10.1093/cei/uxad011

By:

Goff, L M;
Davies, K;
Zelek, W M;
Kodosaki, E;
Hakim, O;
Lockhart, S;
O'Rahilly, S;
Morgan, B P

Publication type:

Article

Loss of Mfn1 but not Mfn2 enhances adipogenesis.

Published in:

PLoS ONE, 2024, v. 19, n. 12, p. 1, doi. 10.1371/journal.pone.0306243

By:

Mann, Jake P.;
Tábara, Luis Carlos;
Patel, Satish;
Pushpa, Pushpa;
Alvarez-Guaita, Anna;
Dong, Liang;
Haider, Afreen;
Lim, Koini;
Tandon, Panna;
Scurria, Fabio;
Minchin, James E. N.;
O'Rahilly S., Stephen;
Fazakerley, Daniel J.;
Prudent, Julien;
Semple, Robert K.;
Savage, David B.

Publication type:

Article

ob gene mutations and human obesity.

Published in:

1998

By:

Farooqi, S;
Rau, H;
Whitehead, J;
O'Rahilly, S

Publication type:

journal article

Mitochondrial oxidative phosphorylation is impaired in patients with congenital lipodystrophy.

Published in:

2012

By:

Sleigh A;
Stears A;
Thackray K;
Watson L;
Gambineri A;
Nag S;
Campi VI;
Schoenmakers N;
Brage S;
Carpenter TA;
Murgatroyd PR;
O'Rahilly S;
Kemp GJ;
Savage DB;
Sleigh, Alison;
Stears, Anna;
Thackray, Kerrie;
Watson, Laura;
Gambineri, Alessandra;
Nag, Sath

Publication type:

journal article

Loss of NPC1 function in a patient with a co‐inherited novel insulin receptor mutation does not grossly modify the severity of the associated insulin resistance.

Published in:

Journal of Inherited Metabolic Disease, 2010, v. 33, p. 227, doi. 10.1007/s10545-010-9107-5

By:

Kirk, J.;
Porter, K. M.;
Parker, V.;
Barroso, I.;
O'Rahilly, S.;
Hendriksz, C.;
Semple, R. K.

Publication type:

Article

Loss of NPC1 function in a patient with a co-inherited novel insulin receptor mutation does not grossly modify the severity of the associated insulin resistance.

Published in:

Journal of Inherited Metabolic Disease, 2010, v. 33, p. S227, doi. 10.1007/s10545-010-9107-5

By:

Kirk, J.;
Porter, K. M.;
Parker, V.;
Barroso, I.;
O'Rahilly, S.;
Hendriksz, C.;
Semple, R. K.

Publication type:

Article

The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation.

Published in:

Cell Death & Differentiation, 2009, v. 16, n. 5, p. 782, doi. 10.1038/cdd.2009.11

By:

Boyle, K. B.;
Hadaschik, D.;
Virtue, S.;
Cawthorn, W. P;
Ridley, S. H.;
O'Rahilly, S.;
Siddle, K.

Publication type:

Article

FTO expression is regulated by availability of essential amino acids.

Published in:

International Journal of Obesity, 2013, v. 37, n. 5, p. 744, doi. 10.1038/ijo.2012.77

By:

Cheung, M K;
Gulati, P;
O'Rahilly, S;
Yeo, G S H

Publication type:

Article

Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis.

Published in:

International Journal of Obesity, 2012, v. 36, n. 9, p. 1248, doi. 10.1038/ijo.2011.233

By:

Lowe, C E;
Dennis, R J;
Obi, U;
O'Rahilly, S;
Rochford, J J

Publication type:

Article

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent.

Published in:

International Journal of Obesity, 2010, v. 34, n. 1, p. 190, doi. 10.1038/ijo.2009.216

By:

Romeo, S.;
Sentinelli, F.;
Dash, S.;
Yeo, G. S. H.;
Savage, D. B.;
Leonetti, F.;
Capoccia, D.;
Incani, M.;
Maglio, C.;
Iacovino, M.;
O'Rahilly, S.;
Baroni, M. G.

Publication type:

Article

Human obesity as a heritable disorder of the central control of energy balance.

Published in:

International Journal of Obesity, 2008, v. 32, p. S55, doi. 10.1038/ijo.2008.239

By:

O'Rahilly, S.;
Farooqi, I. S.

Publication type:

Article

The NR4A family of orphan nuclear receptors are not required for adipogenesis.

Published in:

International Journal of Obesity, 2008, v. 32, n. 2, p. 388, doi. 10.1038/sj.ijo.0803763

By:

Au, W.-S.;
Payne, V. A.;
O'Rahilly, S.;
Rochford, J. J.

Publication type:

Article