Works by Linhardt, Robert

Results: 287

Characterization of Heparin Interactions With Recombinant Rodent Stabilin‐2/Hyaluronic Acid Receptor for Endocytosis (HARE).

Published in:

Proteoglycan Research, 2025, v. 3, n. 2, p. 1, doi. 10.1002/pgr2.70027

By:

Rohr, Reed A.;
Schroder, Evan A.;
Staab, Joseph D.;
Singh, William P.;
Schroder, Callan J.;
Hatcher, Grant D.;
McWilliams, Joshua T.;
Yang, Jiyuan;
Bopp, Abby E.;
Fatumoju, Linda B.;
Wang, Zhangjie;
Dordick, Jonathan S.;
Linhardt, Robert J.;
Zhang, Fuming;
Liu, Jian;
Harris, Edward N.

Publication type:

Article

Coconut oil-cellulose beaded microfibers by coaxial electrospinning: An eco-model system to study thermoregulation of confined phase change materials.

Published in:

Cellulose, 2019, v. 26, n. 3, p. 1855, doi. 10.1007/s10570-018-2151-2

By:

Udangawa, W. M. Ranodhi N.;
Willard, Charles F.;
Mancinelli, Chiara;
Chapman, Caitlyn;
Linhardt, Robert J.;
Simmons, Trevor John

Publication type:

Article

Antimicrobial mechanism of resveratrol- trans-dihydrodimer produced from peroxidase-catalyzed oxidation of resveratrol.

Published in:

Biotechnology & Bioengineering, 2015, v. 112, n. 12, p. 2417, doi. 10.1002/bit.25686

By:

Mora‐Pale, Mauricio;
Bhan, Namita;
Masuko, Sayaka;
James, Paul;
Wood, Julia;
McCallum, Scott;
Linhardt, Robert J.;
Dordick, Jonathan S.;
Koffas, Mattheos A. G.

Publication type:

Article

An 'omics approach towards CHO cell engineering.

Published in:

Biotechnology & Bioengineering, 2013, v. 110, n. 5, p. 1255, doi. 10.1002/bit.24841

By:

Datta, Payel;
Linhardt, Robert J.;
Sharfstein, Susan T.

Publication type:

Article

Facile pretreatment of lignocellulosic biomass at high loadings in room temperature ionic liquids.

Published in:

Biotechnology & Bioengineering, 2011, v. 108, n. 12, p. 2865, doi. 10.1002/bit.23266

By:

Wu, Hong;
Mora-Pale, Mauricio;
Miao, Jianjun;
Doherty, Thomas V.;
Linhardt, Robert J.;
Dordick, Jonathan S.

Publication type:

Article

Room temperature ionic liquids as emerging solvents for the pretreatment of lignocellulosic biomass.

Published in:

Biotechnology & Bioengineering, 2011, v. 108, n. 6, p. 1229, doi. 10.1002/bit.23108

By:

Mora-Pale, Mauricio;
Meli, Luciana;
Doherty, Thomas V.;
Linhardt, Robert J.;
Dordick, Jonathan S.

Publication type:

Article

E. coli K5 fermentation and the preparation of heparosan, a bioengineered heparin precursor.

Published in:

Biotechnology & Bioengineering, 2010, v. 107, n. 6, p. 964, doi. 10.1002/bit.22898

By:

Wang, Zhenyu;
Ly, Mellisa;
Zhang, Fuming;
Zhong, Weihong;
Suen, Amy;
Hickey, Anne Marie;
Dordick, Jonathan S.;
Linhardt, Robert J.

Publication type:

Article

Ionic liquid-mediated selective extraction of lignin from wood leading to enhanced enzymatic cellulose hydrolysis.

Published in:

Biotechnology & Bioengineering, 2009, v. 102, n. 5, p. 1368, doi. 10.1002/bit.22179

By:

Lee, Sang Hyun;
Doherty, Thomas V.;
Linhardt, Robert J.;
Dordick, Jonathan S.

Publication type:

Article

The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells.

Published in:

Biotechnology & Bioengineering, 2008, v. 100, n. 6, p. 1178, doi. 10.1002/bit.21853

By:

Nam, Jong Hyun;
Zhang, Fuming;
Ermonval, Myriam;
Linhardt, Robert J.;
Sharfstein, Susan T.

Publication type:

Article

The effect of dissolved oxygen (DO) concentration on the glycosylation of recombinant protein produced by the insect cell-baculovirus expression system.

Published in:

Biotechnology & Bioengineering, 2002, v. 77, n. 2, p. 219, doi. 10.1002/bit.10131

By:

Zhang, Fuming;
Saarinen, Mark A.;
Itle, Laura J.;
Lang, Sybil C.;
Murhammer, David W.;
Linhardt, Robert J.

Publication type:

Article

Recombinant Escherichia coli K5 strain with the deletion of waaR gene decreases the molecular weight of the heparosan capsular polysaccharide.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 18, p. 7877, doi. 10.1007/s00253-016-7511-y

By:

Huang, Haichan;
Liu, Xiaobo;
Lv, Shencong;
Zhong, Weihong;
Zhang, Fuming;
Linhardt, Robert

Publication type:

Article

Heparin and related polysaccharides: synthesis using recombinant enzymes and metabolic engineering.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 18, p. 7465, doi. 10.1007/s00253-015-6821-9

By:

Suflita, Matthew;
Fu, Li;
He, Wenqin;
Koffas, Mattheos;
Linhardt, Robert

Publication type:

Article

High cell density cultivation of a recombinant E. coli strain expressing a key enzyme in bioengineered heparin production.

Published in:

Applied Microbiology & Biotechnology, 2013, v. 97, n. 9, p. 3893, doi. 10.1007/s00253-012-4682-z

By:

Restaino, Odile;
Bhaskar, Ujjwal;
Paul, Priscilla;
Li, Lingyun;
Rosa, Mario;
Dordick, Jonathan;
Linhardt, Robert

Publication type:

Article

Engineering of routes to heparin and related polysaccharides.

Published in:

Applied Microbiology & Biotechnology, 2012, v. 93, n. 1, p. 1, doi. 10.1007/s00253-011-3641-4

By:

Bhaskar, Ujjwal;
Sterner, Eric;
Hickey, Anne;
Onishi, Akihiro;
Zhang, Fuming;
Dordick, Jonathan;
Linhardt, Robert

Publication type:

Article

Control of the heparosan N-deacetylation leads to an improved bioengineered heparin.

Published in:

Applied Microbiology & Biotechnology, 2011, v. 91, n. 1, p. 91, doi. 10.1007/s00253-011-3231-5

By:

Wang, Zhenyu;
Yang, Bo;
Zhang, Zhenqing;
Ly, Mellisa;
Takieddin, Majde;
Mousa, Shaker;
Liu, Jian;
Dordick, Jonathan;
Linhardt, Robert

Publication type:

Article

Construction of heparan sulfate microarray for investigating the binding of specific saccharide sequences to proteins.

Published in:

Glycobiology, 2021, v. 31, n. 3, p. 188, doi. 10.1093/glycob/cwaa068

By:

Horton, Maurice;
Su, Guowei;
Yi, Lin;
Wang, Zhangjie;
Xu, Yongmei;
Pagadala, Vijayakanth;
Zhang, Fuming;
Zaharoff, David A;
Pearce, Ken;
Linhardt, Robert J;
Liu, Jian

Publication type:

Article

Elucidating the unusual reaction kinetics of D-glucuronyl C5-epimerase.

Published in:

Glycobiology, 2020, v. 30, n. 11, p. 847, doi. 10.1093/glycob/cwaa035

By:

Vaidyanathan, Deepika;
Paskaleva, Elena;
Vargason, Troy;
Ke, Xia;
McCallum, Scott A;
Linhardt, Robert J;
Dordick, Jonathan S

Publication type:

Article

Structural analysis of urinary glycosaminoglycans from healthy human subjects.

Published in:

Glycobiology, 2020, v. 30, n. 3, p. 143, doi. 10.1093/glycob/cwz088

By:

Han, Xiaorui;
Sanderson, Patience;
Nesheiwat, Sara;
Lin, Lei;
Yu, Yanlei;
Zhang, Fuming;
Amster, I Jonathan;
Linhardt, Robert J

Publication type:

Article

Bottom-up analysis using liquid chromatography–Fourier transform mass spectrometry to characterize fucosylated chondroitin sulfates from sea cucumbers.

Published in:

Glycobiology, 2019, v. 29, n. 11, p. 755, doi. 10.1093/glycob/cwz057

By:

Yan, Lufeng;
Li, Lingyun;
Li, Junhui;
Yu, Yanlei;
Liu, Xinyue;
Ye, Xingqian;
Linhardt, Robert J;
Chen, Shiguo

Publication type:

Article

Specificity and action pattern of heparanase Bp, a β-glucuronidase from Burkholderia pseudomallei.

Published in:

Glycobiology, 2019, v. 29, n. 8, p. 572, doi. 10.1093/glycob/cwz039

By:

Yu, Yanlei;
Williams, Asher;
Zhang, Xing;
Fu, Li;
Xia, Ke;
Xu, Yongmei;
Zhang, Fuming;
Liu, Jian;
Koffas, Mattheos;
Linhardt, Robert J

Publication type:

Article

Identification and characterization of the Streptococcus pneumoniae type 3 capsule-specific glycoside hydrolase of Paenibacillus species 32352.

Published in:

Glycobiology, 2018, v. 28, n. 2, p. 90, doi. 10.1093/glycob/cwx097

By:

Middleton, Dustin R;
Zhang, Xing;
Wantuch, Paeton L;
Ozdilek, Ahmet;
Liu, Xinyue;
LoPilato, Rachel;
Gangasani, Nikhil;
Bridger, Robert;
Wells, Lance;
Linhardt, Robert J

Publication type:

Article

Expanding glycosaminoglycan chemical space: towards the creation of sulfated analogs, novel polymers and chimeric constructs.

Published in:

Glycobiology, 2017, v. 27, n. 7, p. 646, doi. 10.1093/glycob/cwx021

By:

Lane, Rachel S.;
Ange, Kalib St.;
Zolghadr, Behnam;
Xinyue Liu;
Schäffer, Christina;
Linhardt, Robert J.;
DeAngelis, Paul L.

Publication type:

Article

Conformational flexibility of PL12 family heparinases: structure and substrate specificity of heparinase III from Bacteroides thetaiotaomicron (BT4657).

Published in:

Glycobiology, 2017, v. 27, n. 2, p. 176, doi. 10.1093/glycob/cww096

By:

Ulaganathan, ThirumalaiSelvi;
Rong Shi;
Deqiang Yao;
Ruo-Xu Gu;
Garron, Marie-Line;
Cherney, Maia;
Tieleman, D. Peter;
Sterner, Eric;
Guoyun Li;
Lingyun Li;
Linhardt, Robert J.;
Cygler, Miroslaw

Publication type:

Article

Surprising absence of heparin in the intestinal mucosa of baby pigs.

Published in:

Glycobiology, 2017, v. 27, n. 1, p. 57, doi. 10.1093/glycob/cww104

By:

Yanlei Yu;
Yin Chen;
Mikael, Paiyz;
Fuming Zhang;
Stalcup, Apryll M.;
German, Rebecca;
Gould, Francois;
Ohlemacher, Jocelyn;
Hong Zhang;
Linhardt, Robert J.

Publication type:

Article

Keratan sulfate glycosaminoglycan from chicken egg white.

Published in:

Glycobiology, 2016, v. 26, n. 7, p. 693, doi. 10.1093/glycob/cww017

By:

Li Fu;
Xiaojun Sun;
Wenqin He;
Chao Cai;
Onishi, Akihiro;
Fuming Zhang;
Linhardt, Robert J.;
Zhangguo Liu

Publication type:

Article

Bioengineering murine mastocytoma cells to produce anticoagulant heparin.

Published in:

Glycobiology, 2014, v. 24, n. 3, p. 272, doi. 10.1093/glycob/cwt108

By:

Gasimli, Leyla;
Glass, Charles A;
Datta, Payel;
Yang, Bo;
Li, Guoyun;
Gemmill, Trent R;
Baik, Jong Youn;
Sharfstein, Susan T;
Esko, Jeffrey D;
Linhardt, Robert J

Publication type:

Article

Chemoenzymatic synthesis of glycosaminoglycans: Re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains.

Published in:

Glycobiology, 2013, v. 23, n. 7, p. 764, doi. 10.1093/glycob/cwt016

By:

DeAngelis, Paul L;
Liu, Jian;
Linhardt, Robert J

Publication type:

Article

Comamonas testosteronan synthase, a bifunctional glycosyltransferase that produces a unique heparosan polysaccharide analog.

Published in:

Glycobiology, 2011, v. 21, n. 10, p. 1331, doi. 10.1093/glycob/cwr072

By:

Otto, Nigel J;
Solakyildirim, Kemal;
Linhardt, Robert J;
DeAngelis, Paul L

Publication type:

Article

Heparinase 1 selectivity for the 3,6-di-O-sulfo-2-deoxy-2-sulfamido-α-D-glucopyranose (1,4) 2-O-sulfo-α-L-idopyranosyluronic acid (GlcNS3S6S-IdoA2S) linkages.

Published in:

Glycobiology, 2011, v. 21, n. 1, p. 13, doi. 10.1093/glycob/cwq123

By:

Xiao, Zhongping;
Zhao, Wenjing;
Yang, Bo;
Zhang, Zhenqing;
Guan, Huashi;
Linhardt, Robert J

Publication type:

Article

Working group report: the roles of glycans in hemostasis, inflammation and vascular biology.

Published in:

Glycobiology, 2008, v. 18, n. 10, p. 747, doi. 10.1093/glycob/cwn065

By:

Ajit P Varki;
Linda G Baum;
Susan L Bellis;
Richard D Cummings;
Jeffrey D Esko;
Gerald W Hart;
Robert J Linhardt;
John B Lowe;
Rodger P McEver;
Arun Srivastava;
Rita Sarkar

Publication type:

Article

Glyco-Forum.

Published in:

Glycobiology, 2005, v. 15, n. 1, p. 1

By:

Eun Ji Joo;
Gerdy B. ten Dam;
Toin H. van Kuppevelt;
Toshihiko Toida;
Robert J. Linhardt;
Yeong Shik Kim

Publication type:

Article

Determination of the structure of oligosaccharides prepared from acharan sulfate.

Published in:

Glycobiology, 1998, v. 8, n. 9, p. 869, doi. 10.1093/glycob/8.9.869

By:

Kim, Yeong Shik;
Ahn, Mi Young;
Wu, Song Ji;
Kim, Dong‐Hyun;
Toida, Toshihiko;
Teesch, Lynn M.;
Park, Youmie;
Yu, Guyong;
Lin, Jihon;
Linhardt, Robert J.

Publication type:

Article

Characterization and comparative analysis of toxin–antitoxin systems in Acetobacter pasteurianus.

Published in:

Journal of Industrial Microbiology & Biotechnology, 2019, v. 46, n. 6, p. 869, doi. 10.1007/s10295-019-02144-y

By:

Xia, Kai;
Bao, Han;
Zhang, Fuming;
Linhardt, Robert J.;
Liang, Xinle

Publication type:

Article

A simple strategy for the separation and purification of water-soluble polysaccharides from the fresh Spirulina platensis.

Published in:

Separation Science & Technology, 2017, v. 52, n. 3, p. 456, doi. 10.1080/01496395.2016.1244549

By:

Wang, Feng;
Ma, Yong;
Liu, Yanhua;
Cui, Zhenggang;
Ying, Xiaoyan;
Zhang, Fuming;
Linhardt, Robert J.

Publication type:

Article

Mechanism of enhanced oral absorption of akebia saponin D by a self-nanoemulsifying drug delivery system loaded with phospholipid complex.

Published in:

Drug Development & Industrial Pharmacy, 2019, v. 45, n. 1, p. 124, doi. 10.1080/03639045.2018.1526183

By:

Wang, Yuhui;
Shen, Jinyang;
Yang, Xiaolin;
Jin, Ye;
Yang, Zhonglin;
Wang, Rufeng;
Zhang, Fuming;
Linhardt, Robert J.

Publication type:

Article

Implications of Glycosaminoglycans on Viral Zoonotic Diseases.

Published in:

Diseases, 2021, v. 9, n. 4, p. 85, doi. 10.3390/diseases9040085

By:

Bauer, Sarah;
Zhang, Fuming;
Linhardt, Robert J.

Publication type:

Article

Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin.

Published in:

Viruses (1999-4915), 2024, v. 16, n. 2, p. 237, doi. 10.3390/v16020237

By:

Yang, Jiyuan;
Song, Yuefan;
Jin, Weihua;
Xia, Ke;
Burnett, Grace C.;
Qiao, Wanjin;
Bates, John T.;
Pomin, Vitor H.;
Wang, Chunyu;
Qiao, Mingqiang;
Linhardt, Robert J.;
Dordick, Jonathan S.;
Zhang, Fuming

Publication type:

Article

Structural Characteristics of Heparin Binding to SARS-CoV-2 Spike Protein RBD of Omicron Sub-Lineages BA.2.12.1, BA.4 and BA.5.

Published in:

Viruses (1999-4915), 2022, v. 14, n. 12, p. 2696, doi. 10.3390/v14122696

By:

Shi, Deling;
Bu, Changkai;
He, Peng;
Song, Yuefan;
Dordick, Jonathan S.;
Linhardt, Robert J.;
Chi, Lianli;
Zhang, Fuming

Publication type:

Article

Synthesis of Tin(II) Phosphate Open Frameworks Using Isomers of 1,2-Diaminocyclohexane as Template.

Published in:

European Journal of Inorganic Chemistry, 2007, v. 2007, n. 6, p. 858

By:

Xuejun Yuan;
Yi-Zhi Li;
Yan Xu;
Xiaozeng You;
Robert J. Linhardt

Publication type:

Article

Dietary pectic substances enhance gut health by its polycomponent: A review.

Published in:

Comprehensive Reviews in Food Science & Food Safety, 2021, v. 20, n. 2, p. 2015, doi. 10.1111/1541-4337.12723

By:

Wu, Dongmei;
Ye, Xingqian;
Linhardt, Robert J.;
Liu, Xuwei;
Zhu, Kai;
Yu, Chengxiao;
Ding, Tian;
Liu, Donghong;
He, Qiaojun;
Chen, Shiguo

Publication type:

Article

Recovery of High Value‐Added Nutrients from Fruit and Vegetable Industrial Wastewater.

Published in:

Comprehensive Reviews in Food Science & Food Safety, 2019, v. 18, n. 5, p. 1388, doi. 10.1111/1541-4337.12477

By:

Chen, Honglin;
Zhang, Hua;
Tian, Jinhu;
Shi, John;
Linhardt, Robert J.;
Ye, Tian Ding Xingqian;
Chen, Shiguo

Publication type:

Article

Enhancement of heparin and heparin disaccharide absorption by the Phytolacca americana saponins.

Published in:

Archives of Pharmacal Research, 2003, v. 26, n. 12, p. 1102, doi. 10.1007/BF02994765

By:

Cho, So;
Sim, Joon-Soo;
Kang, Sam;
Jeong, Choon-Sik;
Linhardt, Robert;
Kim, Yeong

Publication type:

Article

Enhancement of paracellular transport of heparin disaccharide across Caco-2 cell monolayers.

Published in:

Archives of Pharmacal Research, 2002, v. 25, n. 1, p. 86, doi. 10.1007/BF02975268

By:

Cho, So;
Kim, Jong;
Li, Hong;
Shim, Changkoo;
Linhardt, Robert;
Kim, Yeong

Publication type:

Article

Syntheses and applications of sucrose-based esters.

Published in:

Journal of Surfactants & Detergents, 2001, v. 4, n. 4, p. 415, doi. 10.1007/s11743-001-0196-y

By:

Plat, Tülay;
Linhardt, Robert

Publication type:

Article

On-line capillary electrophoresis/laser-induced fluorescence/mass spectrometry analysis of glycans labeled with Teal™ fluorescent dye using an electrokinetic sheath liquid pump-based nanospray ion source.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2018, v. 32, n. 11, p. 882, doi. 10.1002/rcm.8116

By:

Khan, Shaheer;
Liu, Jenkuei;
Szabo, Zoltan;
Kunnummal, Baburaj;
Han, Xiaorui;
Ouyang, Yilan;
Linhardt, Robert J.;
Xia, Qiangwei

Publication type:

Article

Development of hydrophilic interaction chromatography with quadruple time-of-flight mass spectrometry for heparin and low molecular weight heparin disaccharide analysis.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2016, v. 30, n. 2, p. 277, doi. 10.1002/rcm.7437

By:

Ouyang, Yilan;
Wu, Chengling;
Sun, Xue;
Liu, Jianfen;
Linhardt, Robert J.;
Zhang, Zhenqing

Publication type:

Article

Development of hydrophilic interaction chromatography with quadruple time-of-flight mass spectrometry for heparin and low molecular weight heparin disaccharide analysis.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2016, v. 30, n. 2, p. 277, doi. 10.1002/rcm.7437

By:

Yilan Ouyang;
Chengling Wu;
Xue Sun;
Jianfen Liu;
Linhardt, Robert J.;
Zhenqing Zhang

Publication type:

Article

Mass spectrometry for the characterization of unsulfated chondroitin oligosaccharides from 2-mers to 16-mers. Comparison with hyaluronic acid oligomers.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2008, v. 22, n. 22, p. 3526, doi. 10.1002/rcm.3760

By:

Volpi, Nicola;
Zhang, Zhenqing;
Linhardt, Robert J.

Publication type:

Article

The Loss of Endothelial Glycocalyx in Diabetic Retinopathy.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R3558

By:

Kaur, Gaganpreet;
Song, Yuefan;
Xia, Ke;
Cruz‐Topete, Diana;
McCarthy, Kevin;
Zhang, Fuming;
Linhardt, Robert;
Harris, Norman

Publication type:

Article

Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2018, v. 59, n. 3, p. 363, doi. 10.1165/rcmb.2017-0428OC

By:

Haeger, Sarah M.;
Xinyue Liu;
Xiaorui Han;
McNeil, J. Brennan;
Oshima, Kaori;
McMurtry, Sarah A.;
Yimu Yang;
Yilan Ouyang;
Fuming Zhang;
Nozik-Grayck, Eva;
Zemans, Rachel L.;
Tuder, Rubin M.;
Bastarache, Julie A.;
Linhardt, Robert J.;
Schmidt, Eric P.

Publication type:

Article