Works by Leissring, Malcolm A.

Results: 33

Aβ-Degrading Proteases: Therapeutic Potential in Alzheimer Disease.

Published in:

2016

By:

Leissring, Malcolm;
Leissring, Malcolm A

Publication type:

journal article

Multiphoton-evoked color change of DsRed as an optical highlighter for cellular and subcellular labeling.

Published in:

Nature Biotechnology, 2001, v. 19, n. 7, p. 645, doi. 10.1038/90249

By:

Marchant, Jonathan S.;
Stutzmann, Grace E.;
Leissring, Malcolm A.;
LaFerla, Frank M.;
Parker, Ian

Publication type:

Article

Structural biology: Enzyme target to latch on to.

Published in:

Nature, 2006, v. 443, n. 7113, p. 761, doi. 10.1038/nature05210

By:

Leissring, Malcolm A.;
Selkoe, Dennis J.

Publication type:

Article

Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme.

Published in:

Biomedicines, 2021, v. 9, n. 1, p. 86, doi. 10.3390/biomedicines9010086

By:

González-Casimiro, Carlos M.;
Merino, Beatriz;
Casanueva-Álvarez, Elena;
Postigo-Casado, Tamara;
Cámara-Torres, Patricia;
Fernández-Díaz, Cristina M.;
Leissring, Malcolm A.;
Cózar-Castellano, Irene;
Perdomo, Germán

Publication type:

Article

5′ DREDGE: Direct Repeat-Enabled Downregulation of Gene Expression via the 5′ UTR of Target Genes.

Published in:

Cells (2073-4409), 2025, v. 14, n. 12, p. 866, doi. 10.3390/cells14120866

By:

Parikh, Sagar J.;
Terron, Heather M.;
Burgard, Luke A.;
Butler, Dylan D.;
LaFerla, Frank M.;
Lane, Shelley;
Leissring, Malcolm A.

Publication type:

Article

Targeted Control of Gene Expression Using CRISPR-Associated Endoribonucleases.

Published in:

Cells (2073-4409), 2025, v. 14, n. 7, p. 543, doi. 10.3390/cells14070543

By:

Parikh, Sagar J.;
Terron, Heather M.;
Burgard, Luke A.;
Maranan, Derek S.;
Butler, Dylan D.;
Wiseman, Abigail;
LaFerla, Frank M.;
Lane, Shelley;
Leissring, Malcolm A.

Publication type:

Article

Effects of Fasting and Feeding on Transcriptional and Posttranscriptional Regulation of Insulin-Degrading Enzyme in Mice.

Published in:

Cells (2073-4409), 2021, v. 10, n. 9, p. 2446, doi. 10.3390/cells10092446

By:

González-Casimiro, Carlos M.;
Cámara-Torres, Patricia;
Merino, Beatriz;
Diez-Hermano, Sergio;
Postigo-Casado, Tamara;
Leissring, Malcolm A.;
Cózar-Castellano, Irene;
Perdomo, Germán

Publication type:

Article

Insulin-Degrading Enzyme: Paradoxes and Possibilities.

Published in:

Cells (2073-4409), 2021, v. 10, n. 9, p. 2445, doi. 10.3390/cells10092445

By:

Leissring, Malcolm A.

Publication type:

Article

Identification of BACE2 as an avid β-amyloid-degrading protease.

Published in:

Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 46, doi. 10.1186/1750-1326-7-46

By:

Abdul-Hay, Samer O.;
Sahara, Tomoko;
McBride, Melinda;
Kang, Dongcheul;
Leissring, Malcolm A.

Publication type:

Article

A Dual-Function "TRE-Lox" System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 7, p. 6745, doi. 10.3390/ijms24076745

By:

Terron, Heather M.;
Maranan, Derek S.;
Burgard, Luke A.;
LaFerla, Frank M.;
Lane, Shelley;
Leissring, Malcolm A.

Publication type:

Article

Targeting Insulin-Degrading Enzyme in Insulin Clearance.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 5, p. 2235, doi. 10.3390/ijms22052235

By:

Leissring, Malcolm A.;
González-Casimiro, Carlos M.;
Merino, Beatriz;
Suire, Caitlin N.;
Perdomo, Germán;
Gastaldelli, Amalia

Publication type:

Article

Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis.

Published in:

Alzheimer's Research & Therapy, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13195-024-01443-6

By:

Terron, Heather M.;
Parikh, Sagar J.;
Abdul-Hay, Samer O.;
Sahara, Tomoko;
Kang, Dongcheul;
Dickson, Dennis W.;
Saftig, Paul;
LaFerla, Frank M.;
Lane, Shelley;
Leissring, Malcolm A.

Publication type:

Article

Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display.

Published in:

PLoS ONE, 2018, v. 13, n. 2, p. 1, doi. 10.1371/journal.pone.0193101

By:

Suire, Caitlin N.;
Nainar, Sarah;
Fazio, Michael;
Kreutzer, Adam G.;
Paymozd-Yazdi, Tara;
Topper, Caitlyn L.;
Thompson, Caroline R.;
Leissring, Malcolm A.

Publication type:

Article

Correction to: Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation.

Published in:

2024

By:

Merino, Beatriz;
Casanueva-Álvarez, Elena;
Quesada, Iván;
González-Casimiro, Carlos M.;
Fernández-Díaz, Cristina M.;
Postigo-Casado, Tamara;
Leissring, Malcolm A.;
Kaestner, Klaus H.;
Perdomo, Germán;
Cózar-Castellano, Irene

Publication type:

Correction Notice

Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation.

Published in:

Diabetologia, 2022, v. 65, n. 8, p. 1375, doi. 10.1007/s00125-022-05729-y

By:

Merino, Beatriz;
Casanueva-Álvarez, Elena;
Quesada, Iván;
González-Casimiro, Carlos M.;
Fernández-Díaz, Cristina M.;
Postigo-Casado, Tamara;
Leissring, Malcolm A.;
Kaestner, Klaus H.;
Perdomo, Germán;
Cózar-Castellano, Irene

Publication type:

Article

Alzheimer's Presenilin-1 Mutation Potentiates Inositol 1,4,5- Trisphosphate-Mediated Calcium Signaling in Xenopus Oocytes.

Published in:

Journal of Neurochemistry, 1999, v. 72, n. 3, p. 1061, doi. 10.1046/j.1471-4159.1999.0721061.x

By:

Leissring, Malcolm A.;
Paul, Brooke A.;
Parker, Ian;
Cotman, Carl W.;
LaFerla, Frank M.

Publication type:

Article

Aβ degradation—the inside story.

Published in:

Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00229

By:

Leissring, Malcolm A.

Publication type:

Article

Regional hypomyelination and dysplasia in transgenic mice with astrocyte-directed expression of interferon-γ.

Published in:

Journal of Molecular Neuroscience, 2000, v. 15, n. 1, p. 45, doi. 10.1385/JMN:15:1:45

By:

LaFerla, Frank;
Sugarman, Michael;
Lane, Thomas;
Leissring, Malcolm

Publication type:

Article

Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance.

Published in:

PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0020818

By:

Abdul-Hay, Samer O.;
Kang, Dongcheul;
McBride, Melinda;
Li, Lilin;
Ji Zhao;
Leissring, Malcolm A.

Publication type:

Article

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin.

Published in:

PLoS ONE, 2010, v. 5, n. 5, p. 1, doi. 10.1371/journal.pone.0010504

By:

Leissring, Malcolm A.;
Malito, Enrico;
Hedouin, Sabrine;
Reinstatler, Lael;
Sahara, Tomoko;
Abdul-Hay, Samer O.;
Choudhry, Shakeel;
Maharvi, Ghulam M.;
Fauq, Abdul H.;
Huzarska, Malwina;
May, Philip S.;
Sungwoon Choi;
Logan, Todd P.;
Turk, Benjamin E.;
Cantley, Lewis C.;
Manolopoulou, Marika;
Wei-Jen Tang;
Stein, Ross L.;
Cuny, Gregory D.;
Selkoe, Dennis J.

Publication type:

Article

Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening.

Published in:

PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005274

By:

Cabrol, Christelle;
Huzarska, Malwina A.;
Dinolfo, Christopher;
Rodriguez, Maria C.;
Reinstatler, Lael;
Ni, Jake;
Li-An Yeh;
Cuny, Gregory D.;
Stein, Ross L.;
Selkoe, Dennis J.;
Leissring, Malcolm A.

Publication type:

Article

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.

Published in:

Nature, 2014, v. 511, n. 7507, p. 94, doi. 10.1038/nature13297

By:

Maianti, Juan Pablo;
McFedries, Amanda;
Foda, Zachariah H.;
Kleiner, Ralph E.;
Du, Xiu Quan;
Leissring, Malcolm A.;
Tang, Wei-Jen;
Charron, Maureen J.;
Seeliger, Markus A.;
Saghatelian, Alan;
Liu, David R.

Publication type:

Article

Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40.

Published in:

Alzheimer's Research & Therapy, 2020, v. 12, n. 1, p. 1, doi. 10.1186/s13195-020-00649-8

By:

Suire, Caitlin N.;
Abdul-Hay, Samer O.;
Sahara, Tomoko;
Kang, Dongcheul;
Brizuela, Monica K.;
Saftig, Paul;
Dickson, Dennis W.;
Rosenberry, Terrone L.;
Leissring, Malcolm A.

Publication type:

Article

Hydroxypyridinethione Inhibitors of Human Insulin‐Degrading Enzyme.

Published in:

ChemMedChem, 2021, v. 16, n. 11, p. 1775, doi. 10.1002/cmdc.202100111

By:

Adamek, Rebecca N.;
Suire, Caitlin N.;
Stokes, Ryjul W.;
Brizuela, Monica K.;
Cohen, Seth M.;
Leissring, Malcolm A.

Publication type:

Article

Functional cDNA screening identifies BACE-2 as a principal beta-amyloid degrading protease

Published in:

2011

By:

Abdul-Hay, Samer;
Leissring, Malcolm;
Sahara, Tomoko;
McBride, Melinda;
Kang, Dongcheul

Publication type:

Abstract

Identification of secretase-independent beta-amyloid-lowering agents via ultra-high throughput compound screening

Published in:

2011

By:

Leissring, Malcolm

Publication type:

Abstract

Correlation between insulin-degrading enzyme levels and neuropathology in control versus Alzheimer brains with and without cerebral amyloid angiopathy

Published in:

2010

By:

DelleDonne, Anthony;
Miles, Richard J.;
Dickson, Dennis W.;
Abdul-Hay, Samer O.;
Ertekin-Taner, Nilufer;
Leissring, Malcolm A.

Publication type:

Abstract

Characterization of brain region- and disease-specific IDE expression in Alzheimer patients and controls

Published in:

2010

By:

Miles, Richard J.;
DelleDonne, Anthony;
Zou, Fanggeng;
Murray, Melissa;
Ma, Li;
Nguyen, Thuy;
Bisceglio, Gina;
Dickson, Dennis W.;
Younkin, Steven;
Leissring, Malcolm A.;
Ertekin-Taner, Nilufer

Publication type:

Abstract

Association of a missense cathepsin D (CTSD) SNP with risk of Alzheimer's disease

Published in:

2009

By:

Burgess, Jeremy;
Leissring, Malcolm A.;
Ma, Li;
Younkin, Linda H.;
Reinstatler, Lael;
Crook, Julia E.;
Pankratz, V. Shane;
Dickson, Dennis W.;
Peterson, Ronald C.;
Graff-Radford, Neill R.;
Younkin, Steven G.;
Ertekin-Taner, Nilufer

Publication type:

Abstract

Cathepsin D knockout mice harbor large and highly selective increases in cerebral Aß42 and tau: Implications for Alzheimer's disease pathogenesis

Published in:

2009

By:

Leissring, Malcolm A.;
Reinstatler, Lael;
Sahara, Tomoko;
Sevlever, Daniel;
Roman, Robert;
Ji, Zhao;
Li, Lilin;
Lu, Qun;
Säftig, Paul;
Levites, Yona;
Golde, Todd E.;
Burgess, Jeremy;
Ertekin-Taner, Nilufer;
Eckman, Elizabeth A.

Publication type:

Abstract

P1-391: Monomeric Aβ peptides bearing the Flemish A21G mutation are less readily degraded by neprilysin than wild type Aβ

Published in:

2006

By:

Betts, Vicki;
Leissring, Malcolm A.;
Selkoe, Dennis J.;
Walsh, Dominic M.

Publication type:

Abstract

P1-391: Monomeric Aβ peptides bearing the Flemish A21G mutation are less readily degraded by neprilysin than wild type Aβ

Published in:

2006

By:

Betts, Vicki;
Leissring, Malcolm A.;
Selkoe, Dennis J.;
Walsh, Dominic M.

Publication type:

Abstract

Regulation of distinct pools of amyloid β-protein by multiple cellular proteases.

Published in:

Alzheimer's Research & Therapy, 2013, v. 5, n. 4, p. 1, doi. 10.1186/alzrt194

By:

Leissring, Malcolm A.;
Turner, Anthony J.

Publication type:

Article