Works by Karlsson, Mats O.

Results: 193

Model‐Informed Drug Development for Long‐Acting Injectable Products: Summary of American College of Clinical Pharmacology Symposium.

Published in:

Clinical Pharmacology in Drug Development, 2021, v. 10, n. 3, p. 220, doi. 10.1002/cpdd.928

By:

Sharan, Satish;
Fang, Lanyan;
Lukacova, Viera;
Chen, Xiaomei;
Hooker, Andrew C.;
Karlsson, Mats O.

Publication type:

Article

Rescue therapy with high-dose oral phenobarbitone loading for refractory status epilepticus.

Published in:

Journal of Paediatrics & Child Health, 2010, v. 46, n. 1/2, p. 17, doi. 10.1111/j.1440-1754.2009.01611.x

By:

Wilmshurst, Jo M.;
van der Walt, Jan-Stefan;
Ackermann, Sally;
Karlsson, Mats O.;
Blockman, Marc

Publication type:

Article

In the Cradle of Pharmacometric Methodology: Introducing Population PKPD Modeling, Simultaneous Analysis, and the Effect‐Compartment Model—Commentary on Sheiner et al.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 6, p. 1516, doi. 10.1002/cpt.3663

By:

Karlsson, Mats O.

Publication type:

Article

Model‐Informed Once‐Daily Dosing Strategy for Bedaquiline and Delamanid in Children, Adolescents and Adults with Tuberculosis.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1292, doi. 10.1002/cpt.3536

By:

Lin, Yu‐Jou;
van der Laan, Louvina E.;
Karlsson, Mats O.;
Garcia‐Prats, Anthony J.;
Hesseling, Anneke C.;
Svensson, Elin M.

Publication type:

Article

Longitudinal Analysis of Natural History Progression of Rare and Ultra‐Rare Cerebellar Ataxias Using Item Response Theory.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 6, p. 1593, doi. 10.1002/cpt.3466

By:

Hamdan, Alzahra;
Hendrickx, Niels;
Hooker, Andrew C.;
Chen, Xiaomei;
Comets, Emmanuelle;
Traschütz, Andreas;
Schüle, Rebecca;
Heussen, Nicole Maria;
Hilgers, Ralf‐Dieter;
Klockgether, Thomas;
Ryeznik, Yevgen;
Sverdlov, Oleksandr;
Mentré, France;
Synofzik, Matthis;
Karlsson, Mats O.

Publication type:

Article

Predicting the Long‐Term Effects of Therapeutic Neutralization of Oncostatin M on Human Hematopoiesis.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 703, doi. 10.1002/cpt.3246

By:

Thorsted, Anders;
Zecchin, Chiara;
Berges, Alienor;
Karlsson, Mats O.;
Friberg, Lena E.

Publication type:

Article

Multistate Pharmacometric Model to Define the Impact of Second‐Line Immunotherapies on the Survival Outcome of the IMpower131 Study.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 4, p. 851, doi. 10.1002/cpt.2838

By:

Krishnan, Sreenath M.;
Friberg, Lena E.;
Mercier, François;
Zhang, Rong;
Wu, Ben;
Jin, Jin Y.;
Hoang, Tien;
Ballinger, Marcus;
Bruno, René;
Karlsson, Mats O.

Publication type:

Article

Assessing Prolongation of the Corrected QT Interval with Bedaquiline and Delamanid Coadministration to Predict the Cardiac Safety of Simplified Dosing Regimens.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 4, p. 873, doi. 10.1002/cpt.2685

By:

Tanneau, Lénaïg;
Karlsson, Mats O.;
Rosenkranz, Susan L.;
Cramer, Yoninah S.;
Shenje, Justin;
Upton, Caryn M.;
Morganroth, Joel;
Diacon, Andreas H.;
Maartens, Gary;
Dooley, Kelly E.;
Svensson, Elin M.

Publication type:

Article

A Time‐to‐Event Model Relating Integrated Craving to Risk of Smoking Relapse Across Different Nicotine Replacement Therapy Formulations.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 2, p. 416, doi. 10.1002/cpt.2000

By:

Germovsek, Eva;
Hansson, Anna;
Karlsson, Mats O.;
Westin, Åke;
Soons, Paul A.;
Vermeulen, An;
Kjellsson, Maria C.

Publication type:

Article

Relating Nicotine Plasma Concentration to Momentary Craving Across Four Nicotine Replacement Therapy Formulations.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 1, p. 238, doi. 10.1002/cpt.1595

By:

Germovsek, Eva;
Hansson, Anna;
Kjellsson, Maria C.;
Perez Ruixo, Juan Jose;
Westin, Åke;
Soons, Paul A.;
Vermeulen, An;
Karlsson, Mats O.

Publication type:

Article

Intravenously administered digoxin in patients with acute atrial fibrillation: a population pharmacokinetic/pharmacodynamic analysis based on the Digitalis in Acute Atrial Fibrillation trial.

Published in:

European Journal of Clinical Pharmacology, 2003, v. 58, n. 11, p. 747, doi. 10.1007/s00228-002-0553-3

By:

Hornestam, Björn;
Jerling, Markus;
Karlsson, Mats O.;
Held, Peter

Publication type:

Article

Population pharmacokinetic and pharmacodynamic modelling of artemisinin and mefloquine enantiomers in patients with falciparum malaria.

Published in:

European Journal of Clinical Pharmacology, 2002, v. 58, n. 5, p. 339, doi. 10.1007/s00228-002-0485-y

By:

Svensson, Ulrika S. H.;
Alin, Mohamed Hassan;
Karlsson, Mats O.;
Bergqvist, Yngve;
Ashton, Michael

Publication type:

Article

Physiologically-based pharmacokinetic models versus allometric scaling for prediction of tyrosine-kinase inhibitor exposure from adults to children.

Published in:

Cancer Chemotherapy & Pharmacology, 2024, v. 94, n. 2, p. 297, doi. 10.1007/s00280-024-04678-0

By:

Centanni, Maddalena;
Zaher, Omar;
Elhad, David;
Karlsson, Mats O.;
Friberg, Lena E.

Publication type:

Article

Comparison of Seven Non-Linear Mixed Effect Model-Based Approaches to Test for Treatment Effect.

Published in:

Pharmaceutics, 2023, v. 15, n. 2, p. 460, doi. 10.3390/pharmaceutics15020460

By:

Chasseloup, Estelle;
Karlsson, Mats O.

Publication type:

Article

Improved Confidence in a Confirmatory Stage by Application of Item-Based Pharmacometrics Model: Illustration with a Phase III Active Comparator-Controlled Trial in COPD Patients.

Published in:

Pharmaceutical Research, 2022, v. 39, n. 8, p. 1779, doi. 10.1007/s11095-022-03194-1

By:

Llanos-Paez, Carolina;
Ambery, Claire;
Yang, Shuying;
Beerahee, Misba;
Plan, Elodie L.;
Karlsson, Mats O.

Publication type:

Article

Prediction of exposure-driven myelotoxicity of continuous infusion 5-fluorouracil by a semi-physiological pharmacokinetic-pharmacodynamic model in gastrointestinal cancer patients.

Published in:

2020

By:

Arshad, Usman;
Ploylearmsaeng, Su-arpa;
Karlsson, Mats O.;
Doroshyenko, Oxana;
Langer, Dorothee;
Schömig, Edgar;
Kunze, Sabine;
Güner, Semih A.;
Skripnichenko, Roman;
Ullah, Sami;
Jaehde, Ulrich;
Fuhr, Uwe;
Jetter, Alexander;
Taubert, Max

Publication type:

journal article

Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring.

Published in:

2017

By:

Netterberg, Ida;
Nielsen, Elisabet;
Friberg, Lena;
Karlsson, Mats;
Nielsen, Elisabet I;
Friberg, Lena E;
Karlsson, Mats O

Publication type:

journal article

BSA and ABCB1 polymorphism affect the pharmacokinetics of sunitinib and its active metabolite in Asian mRCC patients receiving an attenuated sunitinib dosing regimen.

Published in:

2016

By:

Chae, Jung-woo;
Teo, Yi;
Ho, Han;
Lee, Jaeyeon;
Back, Hyun-moon;
Yun, Hwi-yeol;
Karlsson, Mats;
Kwon, Kwang-il;
Chan, Alexandre;
Teo, Yi Ling;
Ho, Han Kiat;
Karlsson, Mats O

Publication type:

journal article

Limited inter-occasion variability in relation to inter-individual variability in chemotherapy-induced myelosuppression.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 65, n. 5, p. 839, doi. 10.1007/s00280-009-1089-3

By:

Hansson, Emma K.;
Wallin, Johan E.;
Lindman, Henrik;
Sandström, Marie;
Karlsson, Mats O.;
Friberg, Lena E.

Publication type:

Article

Clinical application of a semimechanistic-physiologic population PK/PD model for neutropenia following pemetrexed therapy.

Published in:

Cancer Chemotherapy & Pharmacology, 2006, v. 57, n. 4, p. 427, doi. 10.1007/s00280-005-0035-2

By:

Latz, Jane E.;
Rusthoven, James J.;
Karlsson, Mats O.;
Ghosh, Atalanta;
Johnson, Robert D.

Publication type:

Article

A semimechanistic-physiologic population pharmacokinetic/pharmacodynamic model for neutropenia following pemetrexed therapy.

Published in:

Cancer Chemotherapy & Pharmacology, 2006, v. 57, n. 4, p. 412, doi. 10.1007/s00280-005-0077-5

By:

Latz, Jane E.;
Karlsson, Mats O.;
Rusthoven, James J.;
Ghosh, Atalanta;
Johnson, Robert D.

Publication type:

Article

Pharmacokinetic modeling of paclitaxel encapsulation in Cremophor EL micelles.

Published in:

Cancer Chemotherapy & Pharmacology, 2001, v. 47, n. 4, p. 309, doi. 10.1007/s002800000215

By:

van Zuylen, Lia;
Karlsson, Mats O.;
Verweij, Jaap;
Brouwer, Eric;
de Bruijn, Peter;
Nooter, Kees;
Stoter, Gerrit;
Sparreboom, Alex

Publication type:

Article

Determination of drug effect on tumour cells, host animal toxicity and drug pharmacokinetics in a hollow-fibre model in rats.

Published in:

2000

By:

Jonsson, Elin;
Friberg, Lena E.;
Karlsson, Mats O.;
Bashir Hassan, Saadia;
Freijs, Agneta;
Hansen, Klaus;
Larsson, Rolf;
Jonsson, E;
Friberg, L E;
Karlsson, M O;
Hassan, S B;
Freijs, A;
Hansen, K;
Larsson, R

Publication type:

journal article

Standard Error of Empirical Bayes Estimate in NONMEM® VI.

Published in:

Korean Journal of Physiology & Pharmacology, 2012, v. 16, n. 2, p. 97, doi. 10.4196/kjpp.2012.16.2.97

By:

Dongwoo Kang;
Kyun-Seop Bae;
Houk, Brett E.;
Savic, Radojka M.;
Karlsson, Mats O.

Publication type:

Article

Comparison of the power and type 1 error of total score models for drug effect detection in clinical trials.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s10928-024-09949-0

By:

Haem, Elham;
Karlsson, Mats O.;
Ueckert, Sebastian

Publication type:

Article

Characterization of anti-drug antibody dynamics using a bivariate mixed hidden-markov model by nonlinear-mixed effects approach.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2024, v. 51, n. 1, p. 65, doi. 10.1007/s10928-023-09890-8

By:

Brekkan, Ari;
Lledo-Garcia, Rocío;
Lacroix, Brigitte;
Jönsson, Siv;
Karlsson, Mats O.;
Plan, Elodie L.

Publication type:

Article

Correction to: Training the next generation of pharmacometric modelers: a multisector perspective.

Published in:

2024

By:

Bonate, Peter L.;
Barrett, Jeffrey S.;
Ait-Oudhia, Sihem;
Brundage, Richard;
Corrigan, Brian;
Duffull, Stephen;
Gastonguay, Marc;
Karlsson, Mats O.;
Kijima, Shinichi;
Krause, Andreas;
Lovern, Mark;
Riggs, Matthew M.;
Neely, Michael;
Ouellet, Daniele;
Plan, Elodie L.;
Rao, Gauri G.;
Standing, Joseph;
Wilkins, Justin;
Zhu, Hao

Publication type:

Correction Notice

Training the next generation of pharmacometric modelers: a multisector perspective.

Published in:

2024

By:

Bonate, Peter L.;
Barrett, Jeffrey S.;
Ait-Oudhia, Sihem;
Brundage, Richard;
Corrigan, Brian;
Duffull, Stephen;
Gastonguay, Marc;
Karlsson, Mats O.;
Kijima, Shinichi;
Krause, Andreas;
Lovern, Mark;
Riggs, Matthew M.;
Neely, Michael;
Ouellet, Daniele;
Plan, Elodie L.;
Rao, Gauri G.;
Standing, Joseph;
Wilkins, Justin;
Zhu, Hao

Publication type:

Letter

Generation and application of avatars in pharmacometric modelling.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2023, v. 50, n. 5, p. 411, doi. 10.1007/s10928-023-09873-9

By:

Chasseloup, Estelle;
Hooker, Andrew C.;
Karlsson, Mats O.

Publication type:

Article

Joint longitudinal model-based meta-analysis of FEV<sub>1</sub> and exacerbation rate in randomized COPD trials.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2023, v. 50, n. 4, p. 297, doi. 10.1007/s10928-023-09853-z

By:

Llanos-Paez, Carolina;
Ambery, Claire;
Yang, Shuying;
Beerahee, Misba;
Plan, Elodie L.;
Karlsson, Mats O.

Publication type:

Article

Improved numerical stability for the bounded integer model.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2021, v. 48, n. 2, p. 241, doi. 10.1007/s10928-020-09727-8

By:

Ueckert, Sebastian;
Karlsson, Mats O.

Publication type:

Article

A general model for cell death and biomarker release from injured tissues.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2021, v. 48, n. 1, p. 69, doi. 10.1007/s10928-020-09720-1

By:

Li, Jingyun;
Karlsson, Mats O.;
Sanhajariya, Suchaya;
Isbister, Geoffrey K.;
Duffull, Stephen B.

Publication type:

Article

Comparison of covariate selection methods with correlated covariates: prior information versus data information, or a mixture of both?

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2020, v. 47, n. 5, p. 485, doi. 10.1007/s10928-020-09700-5

By:

Chasseloup, Estelle;
Yngman, Gunnar;
Karlsson, Mats O.

Publication type:

Article

Performance of longitudinal item response theory models in shortened or partial assessments.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2020, v. 47, n. 5, p. 461, doi. 10.1007/s10928-020-09697-x

By:

Arrington, Leticia;
Ueckert, Sebastian;
Ahamadi, Malidi;
Macha, Sreeraj;
Karlsson, Mats O.

Publication type:

Article

A longitudinal item response model for Aberrant Behavior Checklist (ABC) data from children with autism.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2020, v. 47, n. 3, p. 241, doi. 10.1007/s10928-020-09686-0

By:

Haem, Elham;
Doostfatemeh, Marziyeh;
Firouzabadi, Negar;
Ghazanfari, Nima;
Karlsson, Mats O.

Publication type:

Article

Modeling and simulation of the modified Rankin Scale and National Institutes of Health Stroke Scale neurological endpoints in intracerebral hemorrhage.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2019, v. 46, n. 5, p. 473, doi. 10.1007/s10928-019-09653-4

By:

Schoemaker, Rik;
Nayak, Satyaprakash;
Harnisch, Lutz O.;
Karlsson, Mats O.;
VISTA-ICH Collaboration;
Hanley, Daniel F.;
Butcher, Kenneth S.;
Davis, Stephen;
Gregson, Barbara;
Lees, Kennedy R.;
Lyden, Patrick;
Mayer, Stephan;
Muir, Keith;
Steiner, Thorsten

Publication type:

Article

Development of visual predictive checks accounting for multimodal parameter distributions in mixture models.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2019, v. 46, n. 3, p. 241, doi. 10.1007/s10928-019-09632-9

By:

Arshad, Usman;
Chasseloup, Estelle;
Nordgren, Rikard;
Karlsson, Mats O.

Publication type:

Article

Two bootstrapping routines for obtaining imprecision estimates for nonparametric parameter distributions in nonlinear mixed effects models.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2011, v. 38, n. 1, p. 63, doi. 10.1007/s10928-010-9177-x

By:

Baverel, Paul G.;
Savic, Radojka M.;
Karlsson, Mats O.

Publication type:

Article

A two-compartment effect site model describes the bispectral index after different rates of propofol infusion.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2010, v. 37, n. 3, p. 243, doi. 10.1007/s10928-010-9157-1

By:

Björnsson, Marcus A.;
Norberg, Åke;
Kalman, Sigridur;
Karlsson, Mats O.;
Simonsson, Ulrika S. H.

Publication type:

Article

Multinomial logistic estimation of Markov-chain models for modeling sleep architecture in primary insomnia patients.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2010, v. 37, n. 2, p. 137, doi. 10.1007/s10928-009-9148-2

By:

Bizzotto, Roberto;
Zamuner, Stefano;
De Nicolao, Giuseppe;
Karlsson, Mats O.;
Gomeni, Roberto

Publication type:

Article

Population pharmacokinetics and dosing of dispersible moxifloxacin formulation in children with rifampicin‐resistant tuberculosis.

Published in:

British Journal of Clinical Pharmacology, 2025, v. 91, n. 6, p. 1853, doi. 10.1111/bcp.70005

By:

Palmer, Megan;
Zou, Yuanxi;
Hesseling, Anneke C.;
van der Laan, Louvina;
Courtney, Ingrid;
Kinikar, Aarti A.;
Sonkawade, Naresh;
Paradkar, Mandar;
Kulkarni, Vandana;
Casalme, Dessa Jean O.;
Frias, Melchor V. G.;
Draper, Heather;
Wiesner, Lubbe;
Karlsson, Mats O.;
Denti, Paolo;
Svensson, Elin M.;
Garcia‐Prats, Anthony J.

Publication type:

Article

Population pharmacokinetic and dose–response models of nepadutant, a selective antagonist of the NK<sub>2</sub> receptors, in infants with colic.

Published in:

British Journal of Clinical Pharmacology, 2025, v. 91, n. 2, p. 386, doi. 10.1111/bcp.16230

By:

Jönsson, Siv;
Bouchene, Salim;
Mazzei, Paolo;
Borella, Elisa;
Piana, Chiara;
Tagliavini, Alessia;
Koletzko, Sibylle;
Werkstetter, Katharina;
Capriati, Angela;
Pellacani, Andrea;
Karlsson, Mats O.;
Jonsson, E. Niclas

Publication type:

Article

Understanding the drug exposure–response relationship of bedaquiline to predict efficacy for novel dosing regimens in the treatment of multidrug‐resistant tuberculosis.

Published in:

British Journal of Clinical Pharmacology, 2020, v. 86, n. 5, p. 913, doi. 10.1111/bcp.14199

By:

Tanneau, Lénaïg;
Karlsson, Mats O.;
Svensson, Elin M.

Publication type:

Article

Handling interoccasion variability in model‐based dose individualization using therapeutic drug monitoring data.

Published in:

British Journal of Clinical Pharmacology, 2019, v. 85, n. 6, p. 1326, doi. 10.1111/bcp.13901

By:

Abrantes, João A.;
Jönsson, Siv;
Karlsson, Mats O.;
Nielsen, Elisabet I.

Publication type:

Article

Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers.

Published in:

British Journal of Clinical Pharmacology, 2019, v. 85, n. 3, p. 626, doi. 10.1111/bcp.13840

By:

Duthaler, Urs;
Suenderhauf, Claudia;
Karlsson, Mats O.;
Hussner, Janine;
Meyer zu Schwabedissen, Henriette;
Krähenbühl, Stephan;
Hammann, Felix

Publication type:

Article

The risk of febrile neutropenia in breast cancer patients following adjuvant chemotherapy is predicted by the time course of interleukin-6 and C-reactive protein by modelling.

Published in:

British Journal of Clinical Pharmacology, 2018, v. 84, n. 3, p. 490, doi. 10.1111/bcp.13477

By:

Netterberg, Ida;
Karlsson, Mats O.;
Nielsen, Elisabet I.;
Quartino, Angelica L.;
Lindman, Henrik;
Friberg, Lena E.

Publication type:

Article

Population pharmacokinetics of edoxaban in patients with symptomatic deep-vein thrombosis and/or pulmonary embolism--the Hokusai-VTE phase 3 study.

Published in:

British Journal of Clinical Pharmacology, 2015, v. 80, n. 6, p. 1374, doi. 10.1111/bcp.12727

By:

Niebecker, Ronald;
Jönsson, Siv;
Karlsson, Mats O.;
Miller, Raymond;
Nyberg, Joakim;
Krekels, Elke H. J.;
Simonsson, Ulrika S. H.

Publication type:

Article

Estimation of drug receptor occupancy when non-displaceable binding differs between brain regions - extending the simplified reference tissue model.

Published in:

British Journal of Clinical Pharmacology, 2015, v. 80, n. 1, p. 116, doi. 10.1111/bcp.12558

By:

Kågedal, Matts;
Varnäs, Katarina;
Hooker, Andrew C.;
Karlsson, Mats O.

Publication type:

Article

Characterization of an in vivo concentration-effect relationship for piperaquine in malaria chemoprevention.

Published in:

Science Translational Medicine, 2014, v. 6, n. 260, p. 1, doi. 10.1126/scitranslmed.3005311

By:

Bergstrand, Martin;
Nosten, François;
Lwin, Khin Maung;
Karlsson, Mats O.;
White, Nicholas J.;
Tarning, Joel

Publication type:

Article

Comparison of Two Methods for Determining Item Characteristic Functions and Latent Variable Time-Course for Pharmacometric Item Response Models.

Published in:

AAPS Journal, 2024, v. 26, n. 1, p. 1, doi. 10.1208/s12248-023-00883-6

By:

Arrington, Leticia;
Karlsson, Mats O.

Publication type:

Article