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Subgroup identification in clinical trials via the predicted individual treatment effect.
- Published in:
- PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0205971
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- Article
Performance of different clinical trial designs to evaluate treatments during an epidemic.
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- PLoS ONE, 2018, v. 13, n. 9, p. 1, doi. 10.1371/journal.pone.0203387
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- Article
Determining the minimum duration of treatment in tuberculosis: An order restricted non‐inferiority trial design.
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- Pharmaceutical Statistics, 2023, v. 22, n. 5, p. 938, doi. 10.1002/pst.2320
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- Article
A dose‐finding design for dual‐agent trials with patient‐specific doses for one agent with application to an opiate detoxification trial.
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- Pharmaceutical Statistics, 2022, v. 21, n. 2, p. 476, doi. 10.1002/pst.2181
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- Article
Assessing goodness‐of‐fit for evaluation of dose‐proportionality.
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- Pharmaceutical Statistics, 2021, v. 20, n. 2, p. 272, doi. 10.1002/pst.2074
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- Article
A critical review of graphics for subgroup analyses in clinical trials.
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- Pharmaceutical Statistics, 2020, v. 19, n. 5, p. 541, doi. 10.1002/pst.2012
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- Article
Bayesian sequential integration within a preclinical pharmacokinetic and pharmacodynamic modeling framework: Lessons learned.
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- Pharmaceutical Statistics, 2019, v. 18, n. 4, p. 486, doi. 10.1002/pst.1941
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- Article
Response to comments on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharm Stat 17(5):593‐606, Sep/Oct 2018., DOI:https://doi.org/10.1002/pst.1873
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- Pharmaceutical Statistics, 2019, v. 18, n. 3, p. 284, doi. 10.1002/pst.1942
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- Article
Dose‐escalation strategies which use subgroup information.
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- Pharmaceutical Statistics, 2018, v. 17, n. 5, p. 414, doi. 10.1002/pst.1860
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- Article
Bayesian adaptive dose-escalation designs for simultaneously estimating the optimal and maximum safe dose based on safety and efficacy.
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- Pharmaceutical Statistics, 2017, v. 16, n. 6, p. 396, doi. 10.1002/pst.1818
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- Article
Why are two mistakes not worse than one? A proposal for controlling the expected number of false claims.
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- Pharmaceutical Statistics, 2016, v. 15, n. 4, p. 362, doi. 10.1002/pst.1751
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- Article
Bayesian adaptive dose-escalation procedures for binary and continuous responses utilizing a gain function.
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- Pharmaceutical Statistics, 2015, v. 14, n. 6, p. 479, doi. 10.1002/pst.1706
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- Article
Multiplicity: discussion points from the Statisticians in the Pharmaceutical Industry multiplicity expert group.
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- Pharmaceutical Statistics, 2013, v. 12, n. 5, p. 255, doi. 10.1002/pst.1584
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- Article
Estimation of pharmacokinetic parameters with the R package PK.
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- Pharmaceutical Statistics, 2011, v. 10, n. 3, p. 284, doi. 10.1002/pst.449
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- Article
Confidence intervals for ratios of AUCs in the case of serial sampling: a comparison of seven methods.
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- Pharmaceutical Statistics, 2009, v. 8, n. 1, p. 12, doi. 10.1002/pst.321
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- Article
TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy
- Published in:
- Clinical Infectious Diseases, 2020, v. 79, n. 10, p. 2062, doi. 10.1093/cid/ciz589
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- Article
Recurrent events modelling of haemophilia bleeding events.
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- Journal of the Royal Statistical Society: Series C (Applied Statistics), 2021, v. 70, n. 2, p. 351, doi. 10.1111/rssc.12462
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- Article
Subgroup analysis of treatment effects for misclassified biomarkers with time‐to‐event data.
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- Journal of the Royal Statistical Society: Series C (Applied Statistics), 2019, v. 68, n. 5, p. 1447, doi. 10.1111/rssc.12364
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- Article
An information theoretic phase I–II design for molecularly targeted agents that does not require an assumption of monotonicity.
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- Journal of the Royal Statistical Society: Series C (Applied Statistics), 2019, v. 68, n. 2, p. 347, doi. 10.1111/rssc.12293
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- Article
Backfilling cohorts in phase I dose-escalation studies.
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- Clinical Trials, 2023, v. 20, n. 3, p. 261, doi. 10.1177/17407745231160092
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- Article
Endpoints for randomized controlled clinical trials for COVID-19 treatments.
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- Clinical Trials, 2020, v. 17, n. 5, p. 472, doi. 10.1177/1740774520939938
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- Article
A comparison of phase I dose-finding designs in clinical trials with monotonicity assumption violation.
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- Clinical Trials, 2020, v. 17, n. 5, p. 522, doi. 10.1177/1740774520932130
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- Article
Designing and evaluating dose-escalation studies made easy: The MoDEsT web app.
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- Clinical Trials, 2020, v. 17, n. 2, p. 147, doi. 10.1177/1740774519890146
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- Publication type:
- Article
Uptake of novel statistical methods for early-phase clinical studies in the UK public sector.
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- Clinical Trials, 2013, v. 10, n. 2, p. 344, doi. 10.1177/1740774512474375
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- Article
Differential Effects of Parental Controls on Adolescent Substance Use: For Whom is the Family Most Important?
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- Journal of Quantitative Criminology, 2013, v. 29, n. 3, p. 347, doi. 10.1007/s10940-012-9183-9
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- Article
A multi‐arm multi‐stage platform design that allows preplanned addition of arms while still controlling the family‐wise error.
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- Statistics in Medicine, 2024, v. 43, n. 19, p. 3613, doi. 10.1002/sim.10135
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- Article
Adding experimental treatment arms to multi‐arm multi‐stage platform trials in progress.
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- Statistics in Medicine, 2024, v. 43, n. 18, p. 3447, doi. 10.1002/sim.10090
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- Article
A comparison of Bayesian information borrowing methods in basket trials and a novel proposal of modified exchangeability‐nonexchangeability method.
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- Statistics in Medicine, 2023, v. 42, n. 24, p. 4392, doi. 10.1002/sim.9867
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- Article
A Bayesian multi‐arm multi‐stage clinical trial design incorporating information about treatment ordering.
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- Statistics in Medicine, 2023, v. 42, n. 16, p. 2841, doi. 10.1002/sim.9752
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- Article
Online error rate control for platform trials.
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- Statistics in Medicine, 2023, v. 42, n. 14, p. 2475, doi. 10.1002/sim.9733
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- Article
Point estimation for adaptive trial designs II: Practical considerations and guidance.
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- Statistics in Medicine, 2023, v. 42, n. 14, p. 2496, doi. 10.1002/sim.9734
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- Article
Point estimation for adaptive trial designs I: A methodological review.
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- Statistics in Medicine, 2023, v. 42, n. 2, p. 122, doi. 10.1002/sim.9605
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- Article
Practical implementation of the partial ordering continual reassessment method in a Phase I combination‐schedule dose‐finding trial.
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- Statistics in Medicine, 2022, v. 41, n. 30, p. 5789, doi. 10.1002/sim.9594
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- Article
Dose finding studies for therapies with late‐onset toxicities: A comparison study of designs.
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- Statistics in Medicine, 2022, v. 41, n. 30, p. 5767, doi. 10.1002/sim.9593
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- Article
An order restricted multi‐arm multi‐stage clinical trial design.
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- Statistics in Medicine, 2022, v. 41, n. 9, p. 1613, doi. 10.1002/sim.9314
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- Article
Optimizing subgroup selection in two-stage adaptive enrichment and umbrella designs.
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- 2021
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- Publication type:
- journal article
Estimation of treatment effects following a sequential trial of multiple treatments.
- Published in:
- 2020
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- Publication type:
- journal article
Improving safety of the continual reassessment method via a modified allocation rule.
- Published in:
- Statistics in Medicine, 2020, v. 39, n. 7, p. 906, doi. 10.1002/sim.8450
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- Article
Improving safety of the continual reassessment method via a modified allocation rule.
- Published in:
- 2019
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- journal article
An alternative method to analyse the biomarker-strategy design.
- Published in:
- 2018
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- Publication type:
- journal article
Design and estimation in clinical trials with subpopulation selection.
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- 2018
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- Publication type:
- journal article
Simultaneous confidence regions for multivariate bioequivalence.
- Published in:
- Statistics in Medicine, 2017, v. 36, n. 29, p. 4585, doi. 10.1002/sim.7446
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- Article
Comparing sampling methods for pharmacokinetic studies using model averaged derived parameters.
- Published in:
- 2017
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- Publication type:
- journal article
Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs.
- Published in:
- 2020
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- Publication type:
- journal article
Editorial for the MCP 2017 Special Issue.
- Published in:
- Biometrical Journal, 2019, v. 61, n. 1, p. 7, doi. 10.1002/bimj.201800364
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- Article
Confidence regions for treatment effects in subgroups in biomarker stratified designs.
- Published in:
- Biometrical Journal, 2019, v. 61, n. 1, p. 27, doi. 10.1002/bimj.201700303
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- Article
Assessing Systemic Drug Exposure in Repeated Dose Toxicity Studies in the Case of Complete and Incomplete Sampling.
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- Biometrical Journal, 2009, v. 51, n. 6, p. 1017, doi. 10.1002/bimj.200900151
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- Article
Bayesian sample size determination in basket trials borrowing information between subsets.
- Published in:
- Biostatistics, 2023, v. 24, n. 4, p. 1000, doi. 10.1093/biostatistics/kxac033
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- Article
A benchmark for dose-finding studies with unknown ordering.
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- 2022
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- Publication type:
- journal article
A benchmark for dose finding studies with continuous outcomes.
- Published in:
- 2020
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- Publication type:
- journal article