Works matching AU Hiroshi Tomoda

Results: 133

A Mixture of Atropisomers Enhances Neutral Lipid Degradation in Mammalian Cells with Autophagy Induction.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-30679-0

By:

Kobayashi, Keisuke;
Ohte, Satoshi;
Ohshiro, Taichi;
Ugaki, Narihiro;
Tomoda, Hiroshi

Publication type:

Article

Biosynthesis of mercapturic acid derivative of the labdane-type diterpene, cyslabdan that potentiates imipenem activity against methicillin-resistant Staphylococcus aureus: cyslabdan is generated by mycothiol-mediated xenobiotic detoxification.

Published in:

Journal of Industrial Microbiology & Biotechnology, 2016, v. 43, n. 2/3, p. 325, doi. 10.1007/s10295-015-1694-6

By:

Ikeda, Haruo;
Shin-ya, Kazuo;
Nagamitsu, Tohru;
Tomoda, Hiroshi

Publication type:

Article

Monapinone Coupling Enzyme Produces Non-Natural Heterodimers.

Published in:

Catalysts (2073-4344), 2021, v. 11, n. 8, p. 1015, doi. 10.3390/catal11081015

By:

Ohte, Satoshi;
Toyoda, Masayuki;
Kobayashi, Keisuke;
Fujii, Isao;
Ohshiro, Taichi;
Tomoda, Hiroshi

Publication type:

Article

The Nonantibiotic Small Molecule Cyslabdan Enhances the Potency of β-Lactams against MRSA by Inhibiting Pentaglycine Interpeptide Bridge Synthesis.

Published in:

PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0048981

By:

Koyama, Nobuhiro;
Tokura, Yuriko;
Münch, Daniela;
Sahl, Hans-Georg;
Schneider, Tanja;
Shibagaki, Yoshio;
Ikeda, Haruo;
Tomoda, Hiroshi

Publication type:

Article

Antibiotic production by an endophytic Streptomyces isolated from the medicinal plant Poikilospermum suaveolens.

Published in:

Biodiversitas: Journal of Biological Diversity, 2024, v. 25, n. 5, p. 2221, doi. 10.13057/biodiv/d250540

By:

ALI, ALIMUDDIN;
PASSITTA, MUHARRAM;
RANTE, HERLINA;
WAHYUDIN, ELLY;
NATSIR DJIDE, NANA JUNIARTI;
POLITAN, ROLAND JANSEN;
NUR, ELYZA AIMAN;
SHIGENO, SATORU;
OHTE, SATOSHI;
KOBAYASHI, KEISUKE;
HOSODA, KANJI;
TOMODA, HIROSHI;
OHSHIRO, TAICHI

Publication type:

Article

Synthesis of Chiloscyphones and the Biological Activities of Their Synthetic Intermediates Against Methicillin-Resistant Staphylococcus aureus (MRSA).

Published in:

European Journal of Organic Chemistry, 2006, v. 2006, n. 10, p. 2362, doi. 10.1002/ejoc.200500928

By:

Junichi Shiina;
Rika Obata;
Hiroshi Tomoda;
Shigeru Nishiyama

Publication type:

Article

Correction: New potentiators of amphotericin B activity, shodoamides A to C produced by Pseudophialophora sp. BF-0158.

Published in:

2025

By:

Yagi, Akiho;
Kashima, Masahiro;
Ishijima, Hiroyuki;
Tomoda, Hiroshi;
Uchida, Ryuji

Publication type:

Correction Notice

Celludinone C, a new dihydroisobenzofuran isolated from Talaromyces cellulolyticus BF-0307.

Published in:

Journal of Antibiotics, 2025, v. 78, n. 1, p. 26, doi. 10.1038/s41429-024-00785-5

By:

Seki, Reiko;
Nagai, Kenichiro;
Kobayashi, Keisuke;
Shigeno, Satoru;
Shirahata, Tatsuya;
Kobayashi, Yoshinori;
Ohshiro, Taichi;
Tomoda, Hiroshi

Publication type:

Article

Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase.

Published in:

Journal of Antibiotics, 2024, v. 77, n. 12, p. 837, doi. 10.1038/s41429-024-00774-8

By:

Nur, Elyza Aiman Azizah;
Kobayashi, Keisuke;
Tejima, Rio;
Katada, Yosuke;
Tomoda, Hiroshi;
Ohshiro, Taichi

Publication type:

Article

Paranazzamides A and B, new cyclic dipeptides containing a C7-prenylated tryptophan, produced by pathogenic reptile fungi Paranannizziopsis sp. UH-21.

Published in:

Journal of Antibiotics, 2024, v. 77, n. 7, p. 403, doi. 10.1038/s41429-024-00725-3

By:

Kobayashi, Keisuke;
Tejima, Rio;
Nagai, Kenichiro;
Seki, Reiko;
Hosoya, Tsuyoshi;
Une, Yumi;
Shigeno, Satoru;
Tomoda, Hiroshi;
Ohshiro, Taichi

Publication type:

Article

Simaomicin α, a polycyclic xanthone, induces G<sub>1</sub> arrest with suppression of retinoblastoma protein phosphorylation.

Published in:

Cancer Science, 2009, v. 100, n. 2, p. 322, doi. 10.1111/j.1349-7006.2008.01033.x

By:

Koizumi, Yukio;
Tomoda, Hiroshi;
Kumagai, Ayako;
Zhou, Xiao-ping;
Koyota, Souichi;
Sugiyama, Toshihiro

Publication type:

Article

p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.

Published in:

2005

By:

Mashima, Tetsuo;
Oh-hara, Tomoko;
Sato, Shigeo;
Mochizuki, Mikiko;
Sugimoto, Yoshikazu;
Yamazaki, Kanami;
Hamada, Jun-ichi;
Tada, Mitsuhiro;
Moriuchi, Tetsuya;
Ishikawa, Yuichi;
Kato, Yo;
Tomoda, Hiroshi;
Yamori, Takao;
Tsuruo, Takashi

Publication type:

journal article

Structure-Activity Analysis of Gram-positive Bacterium-producing Lasso Peptides with Anti-mycobacterial Activity.

Published in:

Scientific Reports, 2016, p. 30375, doi. 10.1038/srep30375

By:

Inokoshi, Junji;
Koyama, Nobuhiro;
Miyake, Midori;
Shimizu, Yuji;
Tomoda, Hiroshi

Publication type:

Article

Screening for microbial potentiators of neutral lipid degradation in CHO-K1 cells.

Published in:

Drug Discoveries & Therapeutics, 2022, v. 16, n. 6, p. 273, doi. 10.5582/ddt.2022.01087

By:

Nur, Elyza Aiman Azizah;
Keisuke Kobayashi;
Satoshi Ohte;
Hiroshi Tomoda;
Taichi Ohshiro

Publication type:

Article

Binding of phenochalasin A, an inhibitor of lipid droplet formation in mouse macrophages, on G-actin.

Published in:

Drug Discoveries & Therapeutics, 2022, v. 16, n. 4, p. 148, doi. 10.5582/ddt.2022.01053

By:

Keisuke Kobayashi;
Daisuke Matsuda;
Hiroshi Tomoda;
Taichi Ohshiro

Publication type:

Article

Development of an in vivo-mimic silkworm infection model with Mycobacterium avium complex.

Published in:

Drug Discoveries & Therapeutics, 2020, v. 14, n. 6, p. 287, doi. 10.5582/ddt.2020.03099

By:

Akiho Yagi;
Hiroyuki Yamazaki;
Takeshi Terahara;
Taehui Yang;
Hiroshi Hamamoto;
Chiaki Imada;
Hiroshi Tomoda;
Ryuji Uchida

Publication type:

Article

Therapeutic effects of three trichothecenes in the silkworm infection assay with Candida albicans.

Published in:

Drug Discoveries & Therapeutics, 2016, v. 10, n. 1, p. 44, doi. 10.5582/ddt.2016.01013

By:

Ryuji Uchida;
Shingo Namiguchi;
Hiroyuki Ishijima;
Hiroshi Tomoda

Publication type:

Article

In vitro and in vivo anti-MRSA activities of nosokomycins.

Published in:

Drug Discoveries & Therapeutics, 2014, v. 8, n. 6, p. 249, doi. 10.5582/ddt.2014.01050

By:

Uchida, Ryuji;
Hanaki, Hideaki;
Matsui, Hidenori;
Hamamoto, Hiroshi;
Sekimizu, Kazuhisa;
Iwatsuki, Masato;
Yong-Pil Kim;
Tomoda, Hiroshi

Publication type:

Article

Complete Inhibition of Mouse Macrophage-Derived Foam Cell Formation by Triacsin C1.

Published in:

Journal of Biochemistry, 1999, v. 125, n. 2, p. 319, doi. 10.1093/oxfordjournals.jbchem.a022289

By:

Namatame, Ichiji;
Tomoda, Hiroshi;
Arai, Hiroyuki;
Inoue, Keizo;
Õmura, Satoshi

Publication type:

Article

New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239.

Published in:

Journal of Antibiotics, 2024, v. 77, n. 5, p. 265, doi. 10.1038/s41429-024-00710-w

By:

Shigeno, Satoru;
Kadowaki, Miyu;
Nagai, Kenichiro;
Hosoda, Kanji;
Terahara, Takeshi;
Nishimura, Tomoyasu;
Hasegawa, Naoki;
Tomoda, Hiroshi;
Ohshiro, Taichi

Publication type:

Article

Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity.

Published in:

Journal of Antibiotics, 2024, v. 77, n. 4, p. 214, doi. 10.1038/s41429-023-00700-4

By:

Nagai, Kenichiro;
Kobayashi, Keisuke;
Miyake, Ryosuke;
Sato, Yukino;
Seki, Reiko;
Fukuda, Takashi;
Yagi, Akiho;
Uchida, Ryuji;
Ohshiro, Taichi;
Tomoda, Hiroshi

Publication type:

Article

Haneummycin, a new 22-membered macrolide lactam antibiotic, produced by marine-derived Streptomyces sp. KM77-8.

Published in:

Journal of Antibiotics, 2023, v. 76, n. 11, p. 650, doi. 10.1038/s41429-023-00648-5

By:

Uemura, Moeka;
Kobayashi, Keisuke;
Sato, Noriko;
Nagai, Kenichiro;
Seki, Reiko;
Kamio, Michiya;
Fukuda, Takashi;
Tsubouchi, Taishi;
Tomoda, Hiroshi;
Ohshiro, Taichi;
Kobayashi, Takeshi;
Terahara, Takeshi

Publication type:

Article

New potentiators of amphotericin B activity, shodoamides A to C produced by Pseudophialophora sp. BF-0158.

Published in:

Journal of Antibiotics, 2023, v. 76, n. 10, p. 579, doi. 10.1038/s41429-023-00642-x

By:

Yagi, Akiho;
Kashima, Masahiro;
Ishijima, Hiroyuki;
Tomoda, Hiroshi;
Uchida, Ryuji

Publication type:

Article

Discovery of prescopranone, a key intermediate in scopranone biosynthesis.

Published in:

Journal of Antibiotics, 2022, v. 75, n. 6, p. 305, doi. 10.1038/s41429-022-00521-x

By:

Demachi, Ayumu;
Ohte, Satoshi;
Uchida, Ryuji;
Shin-ya, Kazuo;
Ohshiro, Taichi;
Tomoda, Hiroshi;
Ikeda, Haruo

Publication type:

Article

Kimidinomycin, a new antibiotic against Mycobacterium avium complex, produced by Streptomyces sp. KKTA-0263.

Published in:

Journal of Antibiotics, 2022, v. 75, n. 2, p. 72, doi. 10.1038/s41429-021-00494-3

By:

Hikima, Ayumi;
Asamizu, Shumpei;
Onaka, Hiroyasu;
Zhang, Huiping;
Tomoda, Hiroshi;
Koyama, Nobuhiro

Publication type:

Article

Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440.

Published in:

Journal of Antibiotics, 2020, v. 73, n. 11, p. 748, doi. 10.1038/s41429-020-0327-0

By:

Ohshiro, Taichi;
Morita, Haruka;
Nur, Elyza Aiman Azizah;
Hosoda, Kanji;
Uchida, Ryuji;
Tomoda, Hiroshi

Publication type:

Article

Special issue dedicated to William Fenical: a pioneer in marine/marine-derived microbial chemistry.

Published in:

2020

By:

Tomoda, Hiroshi;
McAlpine, James B.

Publication type:

Editorial

A new diketopiperazine-like inhibitor of bone morphogenetic protein-induced osteoblastic differentiation produced by marine-derived Aspergillus sp. BFM-0085.

Published in:

Journal of Antibiotics, 2020, v. 73, n. 8, p. 554, doi. 10.1038/s41429-020-0316-3

By:

Ohte, Satoshi;
Shiokawa, Takehiro;
Koyama, Nobuhiro;
Katagiri, Takenobu;
Imada, Chiaki;
Tomoda, Hiroshi

Publication type:

Article

2-Epi-anthracimycin, a new cytotoxic agent from the marine-derived actinomycete Streptomyces sp. OPMA00631.

Published in:

Journal of Antibiotics, 2020, v. 73, n. 8, p. 548, doi. 10.1038/s41429-020-0309-2

By:

Fukuda, Takashi;
Nagai, Kenichiro;
Kanamoto, Akihiko;
Tomoda, Hiroshi

Publication type:

Article

Steffimycin E, a new anti-mycobacterial agent against Mycobacterium avium complex, produced by Streptomyces sp. OPMA02852.

Published in:

Journal of Antibiotics, 2020, v. 73, n. 8, p. 581, doi. 10.1038/s41429-020-0290-9

By:

Koyama, Nobuhiro;
Shigeno, Satoru;
Kanamoto, Akihiko;
Tomoda, Hiroshi

Publication type:

Article

Polyketide glycosides phialotides A to H, new potentiators of amphotericin B activity, produced by Pseudophialophora sp. BF-0158.

Published in:

Journal of Antibiotics, 2020, v. 73, n. 4, p. 211, doi. 10.1038/s41429-019-0276-7

By:

Yagi, Akiho;
Uchida, Ryuji;
Kobayashi, Keisuke;
Tomoda, Hiroshi

Publication type:

Article

Simpotentin, a new potentiator of amphotericin B activity against Candida albicans, produced by Simplicillium minatense FKI-4981.

Published in:

Journal of Antibiotics, 2019, v. 72, n. 3, p. 134, doi. 10.1038/s41429-018-0128-x

By:

Uchida, Ryuji;
Kondo, Ariko;
Yagi, Akiho;
Nonaka, Kenichi;
Masuma, Rokurou;
Kobayashi, Keisuke;
Tomoda, Hiroshi

Publication type:

Article

MS network-based screening for new antibiotics discovery.

Published in:

Journal of Antibiotics, 2019, v. 72, n. 1, p. 54, doi. 10.1038/s41429-018-0109-0

By:

Koyama, Nobuhiro;
Tomoda, Hiroshi

Publication type:

Article

Helvamide, a new inhibitor of sterol O-acyltransferase produced by the fungus Aspergillus nidulans BF-0142.

Published in:

Journal of Antibiotics, 2019, v. 72, n. 1, p. 8, doi. 10.1038/s41429-018-0101-8

By:

Fukuda, Takashi;
Furukawa, Takun;
Kobayashi, Keisuke;
Nagai, Kenichiro;
Uchida, Ryuji;
Tomoda, Hiroshi

Publication type:

Article

Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 12, p. 1000, doi. 10.1038/s41429-018-0097-0

By:

Ohshiro, Taichi;
Seki, Reiko;
Fukuda, Takashi;
Uchida, Ryuji;
Tomoda, Hiroshi

Publication type:

Article

Anti-Rhizopus activity of tanzawaic acids produced by the hot spring-derived fungus Penicillium sp. BF-0005.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 7, p. 626, doi. 10.1038/s41429-018-0049-8

By:

Tominaga, Takehiro;
Uchida, Ryuji;
Koyama, Nobuhiro;
Tomoda, Hiroshi

Publication type:

Article

Winners of the 2016 JA Medals for excellence.

Published in:

Journal of Antibiotics, 2017, v. 70, n. 12, p. 1085, doi. 10.1038/ja.2017.133

By:

Tomoda, Hiroshi;
Yoshida, Minoru

Publication type:

Article

Isomethoxyneihumicin, a new cytotoxic agent produced by marine Nocardiopsis alba KM6-1.

Published in:

Journal of Antibiotics, 2017, v. 70, n. 5, p. 590, doi. 10.1038/ja.2016.152

By:

Fukuda, Takashi;
Takahashi, Misaki;
Nagai, Kenichiro;
Harunari, Enjuro;
Imada, Chiaki;
Tomoda, Hiroshi

Publication type:

Article

Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis.

Published in:

Journal of Antibiotics, 2017, v. 70, n. 5, p. 685, doi. 10.1038/ja.2017.23

By:

Yagi, Akiho;
Uchida, Ryuji;
Hamamoto, Hiroshi;
Sekimizu, Kazuhisa;
Kimura, Ken-ichi;
Tomoda, Hiroshi

Publication type:

Article

Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities.

Published in:

Journal of Antibiotics, 2017, v. 70, n. 5, p. 562, doi. 10.1038/ja.2017.28

By:

Fukumoto, Atsushi;
Kim, Yong-Pil;
Matsumoto, Atsuko;
Takahashi, Yoko;
Suzuki, Makoto;
Onodera, Hideyuki;
Tomoda, Hiroshi;
Matsui, Hidehito;
Hanaki, Hideaki;
Iwatsuki, Masato;
Ōmura, Satoshi;
Shiomi, Kazuro

Publication type:

Article

Pseudopyronine B, an inhibitor of sterol O-acyltransferase, produced by Pseudomonas sp. BYK11209.

Published in:

Journal of Antibiotics, 2017, v. 70, n. 1, p. 96, doi. 10.1038/ja.2016.46

By:

Suzuki, Aika;
Fukuda, Takashi;
Kobayashi, Keisuke;
Ohshiro, Taichi;
Tomoda, Hiroshi

Publication type:

Article

Inhibition of bacterial undecaprenyl pyrophosphate synthase by small fungal molecules.

Published in:

Journal of Antibiotics, 2016, v. 69, n. 11, p. 798, doi. 10.1038/ja.2016.35

By:

Inokoshi, Junji;
Nakamura, Yuichiro;
Komada, Saori;
Komatsu, Katsuichiro;
Umeyama, Hideaki;
Tomoda, Hiroshi

Publication type:

Article

7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007.

Published in:

Journal of Antibiotics, 2016, v. 69, n. 8, p. 647, doi. 10.1038/ja.2016.27

By:

Uchida, Ryuji;
Nakajyo, Kento;
Kobayashi, Keisuke;
Ohshiro, Taichi;
Terahara, Takeshi;
Imada, Chiaki;
Tomoda, Hiroshi

Publication type:

Article

Diketopiperazines, inhibitors of sterol O-acyltransferase, produced by a marine-derived Nocardiopsis sp. KM2-16.

Published in:

Journal of Antibiotics, 2015, v. 68, n. 10, p. 638, doi. 10.1038/ja.2015.38

By:

Kobayashi, Keisuke;
Fukuda, Takashi;
Terahara, Takeshi;
Harunari, Enjuro;
Imada, Chiaki;
Tomoda, Hiroshi

Publication type:

Article

Graphiumins, new thiodiketopiperazines from the marine-derived fungus Graphium sp. OPMF00224.

Published in:

Journal of Antibiotics, 2015, v. 68, n. 10, p. 620, doi. 10.1038/ja.2015.41

By:

Fukuda, Takashi;
Shinkai, Minori;
Sasaki, Eri;
Nagai, Kenichiro;
Kurihara, Yuko;
Kanamoto, Akihiko;
Tomoda, Hiroshi

Publication type:

Article

Clonoamide, a new inhibitor of sterol O-acyltransferase, produced by Clonostachys sp. BF-0131.

Published in:

Journal of Antibiotics, 2015, v. 68, n. 10, p. 615, doi. 10.1038/ja.2015.37

By:

Kobayashi, Keisuke;
Tsukasaki, Nobuaki;
Uchida, Ryuji;
Yamaguchi, Yuichi;
Tomoda, Hiroshi

Publication type:

Article

Bafilomycin L, a new inhibitor of cholesteryl ester synthesis in mammalian cells, produced by marine-derived Streptomyces sp. OPMA00072.

Published in:

Journal of Antibiotics, 2015, v. 68, n. 2, p. 126, doi. 10.1038/ja.2014.100

By:

Kobayashi, Keisuke;
Fukuda, Takashi;
Usui, Takeo;
Kurihara, Yuko;
Kanamoto, Akihiko;
Tomoda, Hiroshi

Publication type:

Article

In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites.

Published in:

Journal of Antibiotics, 2015, v. 68, n. 1, p. 27, doi. 10.1038/ja.2014.91

By:

Matsuda, Daisuke;
Ohshiro, Taichi;
Ohtawa, Masaki;
Yamazaki, Hiroyuki;
Nagamitsu, Tohru;
Tomoda, Hiroshi

Publication type:

Article

Habiterpenol, a novel abrogator of bleomycin-induced G2 arrest in Jurkat cells, produced by Phytohabitans suffuscus 3787_5.

Published in:

Journal of Antibiotics, 2014, v. 67, n. 11, p. 777, doi. 10.1038/ja.2014.62

By:

Uchida, Ryuji;
Yokota, Sayaka;
Matsuda, Daisuke;
Matsumoto, Atsuko;
Iwamoto, Susumu;
Onodera, Hideyuki;
Takahashi, Yoko;
Tomoda, Hiroshi

Publication type:

Article

Structure elucidation of meroterpenoid habiterpenol, a novel abrogator of bleomycin-induced G2 arrest in Jurkat cells, produced by Phytohabitans suffuscus 3787_5.

Published in:

Journal of Antibiotics, 2014, v. 67, n. 11, p. 783, doi. 10.1038/ja.2014.71

By:

Uchida, Ryuji;
Yokota, Sayaka;
Tomoda, Hiroshi

Publication type:

Article