Works by Fischetti, Vincent A.

Results: 61

Lytic enzyme discovery through multigenomic sequence analysis in Clostridium perfringens.

Published in:

Applied Microbiology & Biotechnology, 2011, v. 89, n. 6, p. 1783, doi. 10.1007/s00253-010-2982-8

By:

Schmitz, Jonathan E.;
Ossiprandi, Maria Cristina;
Rumah, Kareem R.;
Fischetti, Vincent A.

Publication type:

Article

Mutagenesis of a bacteriophage lytic enzyme PlyGBS significantly increases its antibacterial activity against group B streptococci.

Published in:

Applied Microbiology & Biotechnology, 2007, v. 74, n. 6, p. 1284, doi. 10.1007/s00253-006-0771-1

By:

Qi Cheng;
Fischetti, Vincent A.

Publication type:

Article

Quantifying how much host, pathogen, and other factors affect human protective adaptive immune responses.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1330253

By:

Sela, Uri;
Corrêa da Rosa, Joel M.;
Fischetti, Vincent A.;
Cohen, Joel E.

Publication type:

Article

Oral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringens.

Published in:

Frontiers in Cellular & Infection Microbiology, 2017, v. 7, p. 1, doi. 10.3389/fcimb.2017.00011

By:

Rumah, Kareem R.;
Vartanian, Timothy K.;
Fischetti, Vincent A.

Publication type:

Article

Development of Phage Lysins as Novel Therapeutics: A Historical Perspective.

Published in:

2018

By:

Fischetti, Vincent A.

Publication type:

Other

Reinventing phage therapy: are the parts greater than the sum?

Published in:

Nature Biotechnology, 2006, v. 24, n. 12, p. 1508, doi. 10.1038/nbt1206-1508

By:

Fischetti, Vincent A.;
Nelson, Daniel;
Schuch, Raymond

Publication type:

Article

Phage antibacterials make a comeback.

Published in:

Nature Biotechnology, 2001, v. 19, n. 8, p. 734, doi. 10.1038/90777

By:

Fischetti, Vincent A.

Publication type:

Article

PlyC, a novel bacteriophage lysin for compartment- dependent proteomics of group A streptococci.

Published in:

Proteomics, 2008, v. 8, n. 1, p. 140, doi. 10.1002/pmic.200700001

By:

Köller, Thomas;
Nelson, Daniel;
Nakata, Masanobu;
Kreutzer, Michael;
Fischetti, Vincent A.;
Glocker, Michael O.;
Podbielski, Andreas;
Kreikemeyer, Bernd

Publication type:

Article

Streptococcus-related glomerulonephritis.

Published in:

Kidney International, 1973, v. 3, n. 1, p. 100, doi. 10.1038/ki.1973.16

By:

Zabriskie, John B.;
Utermohlen, Virginia;
Read, Stanley E.;
Fischetti, Vincent A.

Publication type:

Article

Conformational characteristics of the complete cequence of group A streptococcal M6 protein.

Published in:

Proteins, 1988, v. 3, n. 1, p. 60, doi. 10.1002/prot.340030106

By:

Fischetti, Vincent A.;
Parry, David A. D.;
Trus, Benes L.;
Hollingshead, Susan K.;
Scott, June R.;
Manjula, Belur N.

Publication type:

Article

Characterization of recombinant Streptococcus mitis-derived human platelet aggregation factor.

Published in:

APMIS, 2012, v. 120, n. 1, p. 56, doi. 10.1111/j.1600-0463.2011.02813.x

By:

OHKUNI, HISASHI;
NAGAMUNE, HIDEAKI;
OZAKI, NANA;
TABATA, ATSUSHI;
TODOME, YUKO;
WATANABE, YUKINO;
TAKAHASHI, HIDEMI;
OHKURA, KAZUTO;
KOURAI, HIROKI;
OHTSUKA, HIROKI;
FISCHETTI, VINCENT A.;
ZABRISKIE, JOHN B.

Publication type:

Article

Engineered Lysin-Derived Peptide as a Potent Antimicrobial for Acne Vulgaris.

Published in:

Antibiotics (2079-6382), 2025, v. 14, n. 4, p. 344, doi. 10.3390/antibiotics14040344

By:

Sela, Uri;
Heselpoth, Ryan D.;
Fischetti, Vincent A.

Publication type:

Article

Determining bacteriophage endopeptidase activity using either fluorophore-quencher labeled peptides combined with liquid chromatography-mass spectrometry (LC-MS) or Förster resonance energy transfer (FRET) assays.

Published in:

PLoS ONE, 2017, v. 12, n. 3, p. 1, doi. 10.1371/journal.pone.0173919

By:

Lood, Rolf;
Molina, Henrik;
Fischetti, Vincent A.

Publication type:

Article

The Phage Lysin PlySs2 Decolonizes Streptococcus suis from Murine Intranasal Mucosa.

Published in:

PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0169180

By:

Gilmer, Daniel B.;
Schmitz, Jonathan E.;
Thandar, Mya;
Euler, Chad W.;
Fischetti, Vincent A.

Publication type:

Article

Targeted Curing of All Lysogenic Bacteriophage from Streptococcus pyogenes Using a Novel Counter-selection Technique.

Published in:

PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0146408

By:

Euler, Chad W.;
Juncosa, Barbara;
Ryan, Patricia A.;
Deutsch, Douglas R.;
McShan, W. Michael;
Fischetti, Vincent A.

Publication type:

Article

Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses.

Published in:

PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0146412

By:

Sela, Uri;
Park, Chae Gyu;
Park, Andrew;
Olds, Peter;
Wang, Shu;
Steinman, Ralph M.;
Fischetti, Vincent A.

Publication type:

Article

Strains of bacterial species induce a greatly varied acute adaptive immune response: The contribution of the accessory genome.

Published in:

PLoS Pathogens, 2018, v. 14, n. 1, p. 1, doi. 10.1371/journal.ppat.1006726

By:

Sela, Uri;
Euler, Chad W.;
Correa da Rosa, Joel;
Fischetti, Vincent A.

Publication type:

Article

Non-M protein(s) on the cell wall and membrane of group A streptococci induce(s) IFN-γ production by dermal CD4+ T cells in psoriasis.

Published in:

Archives of Dermatological Research, 2001, v. 293, n. 4, p. 165, doi. 10.1007/s004030100218

By:

Brown, Dean W.;
Baker, B. S.;
Ovigne, J.-M.;
Fischetti, Vincent A.;
Hardman, Catherine;
Powles, Anne V.;
Fry, Lionel

Publication type:

Article

A structural basis for the allosteric regulation of non-hydrolysing UDP-GlcNAc 2-epimerases.

Published in:

EMBO Reports, 2008, v. 9, n. 12, p. 1251, doi. 10.1038/embor.2008.206

By:

Velloso, Lucas M;
Bhaskaran, Shyam S;
Schuch, Raymond;
Fischetti, Vincent A;
Stebbins, C Erec

Publication type:

Article

A structural basis for the allosteric regulation of non-hydrolysing UDP-GlcNAc 2-epimerases.

Published in:

EMBO Reports, 2008, v. 9, n. 2, p. 199, doi. 10.1038/sj.embor.7401154

By:

Velloso, Lucas M;
Bhaskaran, Shyam S;
Schuch, Raymond;
Fischetti, Vincent A;
Stebbins, C Erec

Publication type:

Article

Why Have Group A Streptococci Remained Susceptible to Penicillin? Report on a Symposium.

Published in:

Clinical Infectious Diseases, 1998, v. 26, n. 6, p. 1341

By:

Horn, David L.;
Zabriskie, John B.;
Austrian, Robert;
Cleary, P. Patrick;
Ferretti, Joseph J.;
Fischetti, Vincent A.;
Gotschlich, Emil;
Kaplan, Edward L.;
McCarty, Maclyn;
Opal, Steven M.;
Roberts, Richard B.;
Tomasz, Alexander;
Wachtfogel, Yanina

Publication type:

Article

Novel Algorithms Reveal Streptococcal Transcriptomes and Clues about Undefined Genes.

Published in:

PLoS Computational Biology, 2007, v. 3, n. 7, p. e132, doi. 10.1371/journal.pcbi.0030132

By:

Ryan, Patricia A.;
Kirk, Brian W.;
Euler, Chad W.;
Schuch, Raymond;
Fischetti, Vincent A.

Publication type:

Article

The global emergence of a novel Streptococcus suis clade associated with human infections.

Published in:

EMBO Molecular Medicine, 2021, v. 13, n. 7, p. 1, doi. 10.15252/emmm.202013810

By:

Dong, Xingxing;
Chao, Yanjie;
Zhou, Yang;
Zhou, Rui;
Zhang, Wei;
Fischetti, Vincent A.;
Wang, Xiaohong;
Feng, Ye;
Li, Jinquan

Publication type:

Article

The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin.

Published in:

PLoS Pathogens, 2015, v. 11, n. 5, p. 1, doi. 10.1371/journal.ppat.1004896

By:

Rumah, Kareem Rashid;
Ma, Yinghua;
Linden, Jennifer R.;
Oo, Myat Lin;
Anrather, Josef;
Schaeren-Wiemers, Nicole;
Alonso, Miguel A.;
Fischetti, Vincent A.;
McClain, Mark S.;
Vartanian, Timothy

Publication type:

Article

Novel Strategy to Prevent Otitis Media Caused by Colonizing Streptococcus pneumoniae.

Published in:

2007

By:

McCullers, Jonathan A.;
Karlström, Åsa;
Iverson, Amy R.;
Loeffler, Jutta M.;
Fischetti, Vincent A.

Publication type:

Editorial

Letter to the Editor concerning "Bacteria: back pain, leg pain and Modic sign: a surgical multicenter comparative study" by Fritzell, P., Welinder-Olsson, C., Jönsson, B. et al. Eur Spine J (2019).

Published in:

2020

By:

Capoor, Manu N.;
McDowell, Andrew;
Birkenmaier, Christof;
Ahmed, Fahad S.;
Coscia, Erin;
Raz, Assaf;
Mavrommatis, Konstantinos;
Fischetti, Vincent A.;
Slaby, Ondrej

Publication type:

Letter

A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue.

Published in:

2019

By:

Capoor, Manu N.;
Birkenmaier, Christof;
Wang, Jeffrey C.;
McDowell, Andrew;
Ahmed, Fahad S.;
Brüggemann, Holger;
Coscia, Erin;
Davies, David G.;
Ohrt-Nissen, Soren;
Raz, Assaf;
Ruzicka, Filip;
Schmitz, Jonathan E.;
Fischetti, Vincent A.;
Slaby, Ondrej

Publication type:

journal article

Regulatory control of the Streptococcus mutans HdrRM LytTR Regulatory System functions via a membrane sequestration mechanism.

Published in:

Molecular Microbiology, 2020, v. 114, n. 4, p. 681, doi. 10.1111/mmi.14576

By:

Xie, Zhoujie;
Zou, Zhengzhong;
Raz, Assaf;
Qin, Hua;
Fischetti, Vincent;
Zhang, Shan;
Kreth, Jens;
Merritt, Justin

Publication type:

Article

Cellular aspects of the distinct M protein and SfbI anchoring pathways in Streptococcus pyogenes.

Published in:

Molecular Microbiology, 2012, v. 84, n. 4, p. 631, doi. 10.1111/j.1365-2958.2012.08047.x

By:

Raz, Assaf;
Talay, Susanne R.;
Fischetti, Vincent A.

Publication type:

Article

Comprehensive analysis of antibody responses to streptococcal and tissue antigens in patients with acute rheumatic fever.

Published in:

International Immunology, 2008, v. 20, n. 3, p. 445, doi. 10.1093/intimm/dxn004

By:

Thomas B. Martins;
James L. Hoffman;
Nancy H. Augustine;
Amit R. Phansalkar;
Vincent A. Fischetti;
John B. Zabriskie;
Patrick P. Cleary;
James M. Musser;
L. George Veasy;
Harry R. Hill

Publication type:

Article

Clostridium perfringens Epsilon Toxin Binds to and Kills Primary Human Lymphocytes.

Published in:

Toxins, 2023, v. 15, n. 7, p. 423, doi. 10.3390/toxins15070423

By:

Shetty, Samantha V.;
Mazzucco, Michael R.;
Winokur, Paige;
Haigh, Sylvia V.;
Rumah, Kareem Rashid;
Fischetti, Vincent A.;
Vartanian, Timothy;
Linden, Jennifer R.

Publication type:

Article

Genotypic differences between strains of the opportunistic pathogen Corynebacterium bovis isolated from humans, cows, and rodents.

Published in:

PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0209231

By:

Cheleuitte-Nieves, Christopher;
Gulvik, Christopher A.;
McQuiston, John R.;
Humrighouse, Ben W.;
Bell, Melissa E.;
Villarma, Aaron;
Fischetti, Vincent A.;
Westblade, Lars F.;
Lipman, Neil S.

Publication type:

Article

Importance of Propionibacterium acnes hemolytic activity in human intervertebral discs: A microbiological study.

Published in:

PLoS ONE, 2018, v. 13, n. 11, p. 1, doi. 10.1371/journal.pone.0208144

By:

Capoor, Manu N.;
Ruzicka, Filip;
Sandhu, Gurpreet;
Rollason, Jess;
Mavrommatis, Konstantinos;
Ahmed, Fahad S.;
Schmitz, Jonathan E.;
Raz, Assaf;
Brüggemann, Holger;
Lambert, Peter A.;
Fischetti, Vincent A.;
Slaby, Ondrej

Publication type:

Article

Novel Method to Control Pathogenic Bacteria on Human Mucous Membranes.

Published in:

Annals of the New York Academy of Sciences, 2003, v. 987, n. 1, p. 207, doi. 10.1111/j.1749-6632.2003.tb06050.x

By:

FISCHETTI, VINCENT A.

Publication type:

Article

Gram‐negative anaerobes elicit a robust keratinocytes immune response with potential insights into HS pathogenesis.

Published in:

Experimental Dermatology, 2024, v. 33, n. 5, p. 1, doi. 10.1111/exd.15087

By:

Williams, Samuel C.;
Garcet, Sandra;
Hur, Hong;
Miura, Shunsuke;
Gonzalez, Juana;
Navrazhina, Kristina;
Yamamura‐Murai, Mika;
Yamamura, Kazuhiko;
Li, Xuan;
Frew, John;
Fischetti, Vincent A.;
Sela, Uri;
Krueger, James G.

Publication type:

Article

Combination therapy with lysin CF-301 and antibiotic is superior to antibiotic alone for treating methicillin-resistant Staphylococcus aureus-induced murine bacteremia.

Published in:

2014

By:

Schuch, Raymond;
Lee, Han M;
Schneider, Brent C;
Sauve, Karen L;
Law, Christina;
Khan, Babar K;
Rotolo, Jimmy A;
Horiuchi, Yuki;
Couto, Daniel E;
Raz, Assaf;
Fischetti, Vincent A;
Huang, David B;
Nowinski, Robert C;
Wittekind, Michael

Publication type:

journal article

Combination Therapy With Lysin CF-301 and Antibiotic Is Superior to Antibiotic Alone for Treating Methicillin-Resistant Staphylococcus aureus–Induced Murine Bacteremia.

Published in:

Journal of Infectious Diseases, 2014, v. 209, n. 9, p. 1469, doi. 10.1093/infdis/jit637

By:

Schuch, Raymond;
Lee, Han M.;
Schneider, Brent C.;
Sauve, Karen L.;
Law, Christina;
Khan, Babar K.;
Rotolo, Jimmy A.;
Horiuchi, Yuki;
Couto, Daniel E.;
Raz, Assaf;
Fischetti, Vincent A.;
Huang, David B.;
Nowinski, Robert C.;
Wittekind, Michael

Publication type:

Article

A bacteriolytic agent that detects and kills Bacillys anthracis.

Published in:

Nature, 2002, v. 418, n. 6900, p. 884, doi. 10.1038/nature01026

By:

Schuch, Raymond;
Nelson, Daniel;
Fischetti, Vincent A.

Publication type:

Article

Molecular basis for recognition of the Group A Carbohydrate backbone by the PlyC streptococcal bacteriophage endolysin.

Published in:

Biochemical Journal, 2021, v. 478, n. 12, p. 2385, doi. 10.1042/BCJ20210158

By:

King, Harley;
Castro, Sowmya Ajay;
Pohane, Amol Arunrao;
Scholte, Cynthia M.;
Fischetti, Vincent A.;
Korotkova, Natalia;
Nelson, Daniel C.;
Dorfmueller, Helge C.

Publication type:

Article

Extra-Chromosomal DNA Sequencing Reveals Episomal Prophages Capable of Impacting Virulence Factor Expression in <italic>Staphylococcus aureus</italic>.

Published in:

Frontiers in Microbiology, 2018, p. N.PAG, doi. 10.3389/fmicb.2018.01406

By:

Deutsch, Douglas R.;
Utter, Bryan;
Verratti, Kathleen J.;
Sichtig, Heike;
Tallon, Luke J.;
Fischetti, Vincent A.

Publication type:

Article

Elimination of Chromosomal Island SpyCIM1 from Streptococcus pyogenes Strain SF370 Reverses the Mutator Phenotype and Alters Global Transcription.

Published in:

PLoS ONE, 2015, v. 10, n. 12, p. 1, doi. 10.1371/journal.pone.0145884

By:

Hendrickson, Christina;
Euler, Chad W.;
Nguyen, Scott V.;
Rahman, Maliha;
McCullor, Kimberly A.;
King, Catherine J.;
Fischetti, Vincent A.;
McShan, W. Michael

Publication type:

Article

Streptococcus pyogenes Sortase Mutants Are Highly Susceptible to Killing by Host Factors Due to Aberrant Envelope Physiology.

Published in:

PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0140784

By:

Raz, Assaf;
Tanasescu, Ana-Maria;
Zhao, Anna M.;
Serrano, Anna;
Alston, Tricia;
Sol, Asaf;
Bachrach, Gilad;
Fischetti, Vincent A.

Publication type:

Article

Prothrombin Time and Activated Partial Thromboplastin Time Testing: A Comparative Effectiveness Study in a Million-Patient Sample.

Published in:

PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0133317

By:

Capoor, Manu N.;
Stonemetz, Jerry L.;
Baird, John C.;
Ahmed, Fahad S.;
Awan, Ahsan;
Birkenmaier, Christof;
Jr.Inchiosa, Mario A.;
Magid, Steven K.;
McGoldrick, Kathryn;
Molmenti, Ernesto;
Naqvi, Sajjad;
Parker, Stephen D.;
Pothula, S. M.;
Shander, Aryeh;
Steen, R. Grant;
Urban, Michael K.;
Wall, Judith;
Fischetti, Vincent A.

Publication type:

Article

Beyond the Chromosome: The Prevalence of Unique Extra-Chromosomal Bacteriophages with Integrated Virulence Genes in Pathogenic Staphylococcus aureus.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0100502

By:

Utter, Bryan;
Deutsch, Douglas R.;
Schuch, Raymond;
Winer, Benjamin Y.;
Verratti, Kathleen;
Bishop-Lilly, Kim;
Sozhamannan, Shanmuga;
Fischetti, Vincent A.

Publication type:

Article

Isolation of Clostridium perfringens Type B in an Individual at First Clinical Presentation of Multiple Sclerosis Provides Clues for Environmental Triggers of the Disease.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076359

By:

Rumah, Kareem Rashid;
Linden, Jennifer;
Fischetti, Vincent A.;
Vartanian, Timothy

Publication type:

Article

Use of a Bacteriophage Lysin to Identify a Novel Target for Antimicrobial Development.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0060754

By:

Schuch, Raymond;
Pelzek, Adam J.;
Raz, Assaf;
Euler, Chad W.;
Ryan, Patricia A.;
Winer, Benjamin Y.;
Farnsworth, Andrew;
Bhaskaran, Shyam S.;
Stebbins, C. Erec;
Xu, Yong;
Clifford, Adrienne;
Bearss, David J.;
Vankayalapati, Hariprasad;
Goldberg, Allan R.;
Fischetti, Vincent A.

Publication type:

Article

The Secret Life of the Anthrax Agent Bacillus anthracis: Bacteriophage-Mediated Ecological Adaptations.

Published in:

PLoS ONE, 2009, v. 4, n. 8, p. 1, doi. 10.1371/journal.pone.0006532

By:

Schuch, Raymond;
Fischetti, Vincent A.

Publication type:

Article

A bacteriophage endolysin that eliminates intracellular streptococci.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.13152

By:

Yang Shen;
Barros, Marilia;
Vennemann, Tarek;
Gallagher, D. Travis;
Yizhou Yin;
Linden, Sara B.;
Heselpoth, Ryan D.;
Spencer, Dennis J.;
Donovan, David M.;
Moult, John;
Fischetti, Vincent A.;
Heinrich, Frank;
Lösche, Mathias;
Nelson, Daniel C.

Publication type:

Article

Relationships Between Plasminogen-Binding M-Protein and Surface Enolase for Human Plasminogen Acquisition and Activation in Streptococcus pyogenes.

Published in:

Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.905670

By:

Ayinuola, Yetunde A.;
Tjia-Fleck, Sheiny;
Readnour, Bradley M.;
Liang, Zhong;
Ayinuola, Olawole;
Paul, Lake N.;
Lee, Shaun W.;
Fischetti, Vincent A.;
Ploplis, Victoria A.;
Castellino, Francis J.

Publication type:

Article

PaP1, a Broad-Spectrum Lysin-Derived Cationic Peptide to Treat Polymicrobial Skin Infections.

Published in:

Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.817228

By:

Heselpoth, Ryan D.;
Euler, Chad W.;
Fischetti, Vincent A.

Publication type:

Article