Works by Coppens, Isabelle

Results: 62

Targeting lipid biosynthesis and salvage in apicomplexan parasites for improved chemotherapies.

Published in:

Nature Reviews Microbiology, 2013, v. 11, n. 12, p. 823, doi. 10.1038/nrmicro3139

By:

Coppens, Isabelle

Publication type:

Article

The inclusion membrane protein IncS is critical for initiation of the Chlamydia intracellular developmental cycle.

Published in:

PLoS Pathogens, 2022, v. 18, n. 9, p. 1, doi. 10.1371/journal.ppat.1010818

By:

Cortina, María Eugenia;
Bishop, R. Clayton;
DeVasure, Brittany A.;
Coppens, Isabelle;
Derré, Isabelle

Publication type:

Article

Toxoplasma FER1 is a versatile and dynamic mediator of differential microneme trafficking and microneme exocytosis.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-72628-0

By:

Tagoe, Daniel N. A.;
Ribeiro E Silva, Adeline;
Drozda, Allison A.;
Coppens, Isabelle;
Coleman, Bradley I.;
Gubbels, Marc-Jan

Publication type:

Article

The Modular Circuitry of Apicomplexan Cell Division Plasticity.

Published in:

Frontiers in Cellular & Infection Microbiology, 2021, v. 11, p. N.PAG, doi. 10.3389/fcimb.2021.670049

By:

Gubbels, Marc-Jan;
Coppens, Isabelle;
Zarringhalam, Kourosh;
Duraisingh, Manoj T.;
Engelberg, Klemens

Publication type:

Article

Cell cycle-regulated vesicular trafficking of Toxoplasma APT1, a protein localized to multiple apicoplast membranes.

Published in:

Molecular Microbiology, 2007, v. 63, n. 6, p. 1653, doi. 10.1111/j.1365-2958.2007.05619.x

By:

Karnataki, Anuradha;
DeRocher, Amy;
Coppens, Isabelle;
Nash, Coral;
Feagin, Jean E.;
Parsons, Marilyn

Publication type:

Article

Molecular dissection and expression of the LdK39 kinesin in the human pathogen, Leishmania donovani.

Published in:

Molecular Microbiology, 2007, v. 63, n. 4, p. 962, doi. 10.1111/j.1365-2958.2006.05487.x

By:

Gerald, Noel J.;
Coppens, Isabelle;
Dwyer, Dennis M.

Publication type:

Article

A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25987-5

By:

Li, Zhu-Hong;
King, Thayer P.;
Ayong, Lawrence;
Asady, Beejan;
Cai, Xinjiang;
Rahman, Taufiq;
Vella, Stephen A.;
Coppens, Isabelle;
Patel, Sandip;
Moreno, Silvia N. J.

Publication type:

Article

Systematic characterization of all Toxoplasma gondii TBC domain-containing proteins identifies an essential regulator of Rab2 in the secretory pathway.

Published in:

PLoS Biology, 2024, v. 22, n. 5, p. 1, doi. 10.1371/journal.pbio.3002634

By:

Quan, Justin J.;
Nikolov, Lachezar A.;
Sha, Jihui;
Wohlschlegel, James A.;
Coppens, Isabelle;
Bradley, Peter J.

Publication type:

Article

The Plasmodium PHIST and RESA-Like Protein Families of Human and Rodent Malaria Parasites.

Published in:

PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0152510

By:

Moreira, Cristina K.;
Naissant, Bernina;
Coppi, Alida;
Bennett, Brandy L.;
Aime, Elena;
Franke-Fayard, Blandine;
Janse, Chris J.;
Coppens, Isabelle;
Sinnis, Photini;
Templeton, Thomas J.

Publication type:

Article

Correction: Hostile intruder: Toxoplasma holds host organelles captive.

Published in:

2018

By:

Coppens, Isabelle;
Romano, Julia D.

Publication type:

Correction Notice

Hostile intruder: Toxoplasma holds host organelles captive.

Published in:

PLoS Pathogens, 2018, v. 14, n. 3, p. 1, doi. 10.1371/journal.ppat.1006893

By:

Coppens, Isabelle;
Romano, Julia D.

Publication type:

Article

Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondii.

Published in:

PLoS Pathogens, 2017, v. 13, n. 6, p. 1, doi. 10.1371/journal.ppat.1006362

By:

Nolan, Sabrina J.;
Romano, Julia D.;
Coppens, Isabelle

Publication type:

Article

Chemoprophylaxis vaccination with a Plasmodium liver stage autophagy mutant affords enhanced and long-lasting protection.

Published in:

NPJ Vaccines, 2021, v. 6, n. 1, p. 1, doi. 10.1038/s41541-021-00360-1

By:

Sahu, Tejram;
Gehrke, Ella J.;
Flores-Garcia, Yevel;
Mlambo, Godfree;
Romano, Julia D.;
Coppens, Isabelle

Publication type:

Article

Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.59384

By:

Smith, David;
Kannan, Geetha;
Coppens, Isabelle;
Wang, Fengrong;
Nguyen, Hoa Mai;
Cerutti, Aude;
Olafsson, Einar B.;
Rimple, Patrick A.;
Schultz, Tracey L.;
Mercado Soto, Nayanna M.;
Di Cristina, Manlio;
Besteiro, Sébastien;
Carruthers, Vern B.

Publication type:

Article

A Membrane Protease is Targeted to the Relict Plastid of Toxoplasma via an Internal Signal Sequence.

Published in:

Traffic, 2007, v. 8, n. 11, p. 1543, doi. 10.1111/j.1600-0854.2007.00637.x

By:

Karnataki, Anuradha;
DeRocher, Amy E.;
Coppens, Isabelle;
Feagin, Jean E.;
Parsons, Marilyn

Publication type:

Article

Peculiarities of Host Cholesterol Transport to the Unique Intracellular Vacuole Containing Toxoplasma.

Published in:

Traffic, 2005, v. 6, n. 12, p. 1125, doi. 10.1111/j.1600-0854.2005.00348.x

By:

Sehgal, Alfica;
Bettiol, Silvana;
Pypaert, Marc;
Wenk, Markus R.;
Kaasch, Achim;
Blader, Ira J.;
Joiner, Keith A.;
Coppens, Isabelle

Publication type:

Article

A transient forward-targeting element for microneme-regulated secretion in Toxoplasma gondii.

Published in:

Biology of the Cell (Wiley-Blackwell), 2008, v. 100, n. 4, p. 253, doi. 10.1042/BC20070076

By:

Susannah D. Brydges;
Jill M. Harper;
Fabiola Parussini;
Isabelle Coppens;
Vern B. Carruthers

Publication type:

Article

Fussing About Fission: Defining Variety Among Mainstream and Exotic Apicomplexan Cell Division Modes.

Published in:

Frontiers in Cellular & Infection Microbiology, 2020, v. 10, p. 1, doi. 10.3389/fcimb.2020.00269

By:

Gubbels, Marc-Jan;
Keroack, Caroline D.;
Dangoudoubiyam, Sriveny;
Worliczek, Hanna L.;
Paul, Aditya S.;
Bauwens, Ciara;
Elsworth, Brendan;
Engelberg, Klemens;
Howe, Daniel K.;
Coppens, Isabelle;
Duraisingh, Manoj T.

Publication type:

Article

Identification and Localization of the First Known Proteins of the Trypanosoma cruzi Cytostome Cytopharynx Endocytic Complex.

Published in:

Frontiers in Cellular & Infection Microbiology, 2020, v. 10, p. 1, doi. 10.3389/fcimb.2019.00445

By:

Chasen, Nathan Michael;
Coppens, Isabelle;
Etheridge, Ronald Drew

Publication type:

Article

The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels.

Published in:

Cellular Microbiology, 2006, v. 8, n. 2, p. 339, doi. 10.1111/j.1462-5822.2005.00628.x

By:

Spear, Wade;
Chan, Denise;
Coppens, Isabelle;
Johnson, Randall S.;
Giaccia, Amato;
Blader, Ira J.

Publication type:

Article

Contribution of host lipids to Toxoplasma pathogenesis.

Published in:

Cellular Microbiology, 2006, v. 8, n. 1, p. 1, doi. 10.1111/j.1462-5822.2005.00647.x

By:

Coppens, Isabelle

Publication type:

Article

Host cell lipids control cholesteryl ester synthesis and storage in intracellular Toxoplasma.

Published in:

Cellular Microbiology, 2005, v. 7, n. 6, p. 849, doi. 10.1111/j.1462-5822.2005.00518.x

By:

Nishikawa, Yoshifumi;
Quittnat, Friederike;
Stedman, Timothy T.;
Voelker, Dennis R.;
Choi, Jae-Yeon;
Zahn, Matt;
Yang, Mei;
Pypaert, Marc;
Joiner, Keith A.;
Coppens, Isabelle

Publication type:

Article

Toxoplasma gondii Rab5 enhances cholesterol acquisition from host cells.

Published in:

Cellular Microbiology, 2002, v. 4, n. 3, p. 139, doi. 10.1046/j.1462-5822.2002.00178.x

By:

Robibaro, Bruno;
Stedman, Timothy T;
Coppens, Isabelle;
Ngô, Huân M;
Pypaert, Marc;
Bivona, Trevor;
Nam, Hoo Woo;
Joiner, Keith A

Publication type:

Article

Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface.

Published in:

PLoS Pathogens, 2015, v. 11, n. 10, p. 1, doi. 10.1371/journal.ppat.1005211

By:

Hammoudi, Pierre-Mehdi;
Jacot, Damien;
Mueller, Christina;
Di Cristina, Manlio;
Dogga, Sunil Kumar;
Marq, Jean-Baptiste;
Romano, Julia;
Tosetti, Nicolò;
Dubrot, Juan;
Emre, Yalin;
Lunghi, Matteo;
Coppens, Isabelle;
Yamamoto, Masahiro;
Sojka, Daniel;
Pino, Paco;
Soldati-Favre, Dominique

Publication type:

Article

A Toxoplasma Palmitoyl Acyl Transferase and the Palmitoylated Armadillo Repeat Protein TgARO Govern Apical Rhoptry Tethering and Reveal a Critical Role for the Rhoptries in Host Cell Invasion but Not Egress.

Published in:

PLoS Pathogens, 2013, v. 9, n. 2, p. 1, doi. 10.1371/journal.ppat.1003162

By:

Beck, Josh R.;
Fung, Connie;
Straub, Kurtis W.;
Coppens, Isabelle;
Vashisht, Ajay A.;
Wohlschlegel, James A.;
Bradley, Peter J.

Publication type:

Article

Deficiency of a Niemann-Pick, Type C1-related Protein in Toxoplasma Is Associated with Multiple Lipidoses and Increased Pathogenicity.

Published in:

PLoS Pathogens, 2011, v. 7, n. 12, p. 1, doi. 10.1371/journal.ppat.1002410

By:

Lige, Bao;
Romano, Julia D.;
Bandaru, Veera Venkata Ratnam;
Ehrenman, Karen;
Levitskaya, Jelena;
Sampels, Vera;
Haughey, Norman J.;
Coppens, Isabelle

Publication type:

Article

The Glutathione Biosynthetic Pathway of Plasmodium Is Essential for Mosquito Transmission.

Published in:

PLoS Pathogens, 2009, v. 5, n. 2, p. 1, doi. 10.1371/journal.ppat.1000302

By:

Vega-Rodríguez, Joel;
Franke-Fayard, Blandine;
Dinglasan, Rhoel R.;
Janse, Chris J.;
Pastrana-Mena, Rebecca;
Waters, Andrew P.;
Coppens, Isabelle;
Rodríguez-Orengo, José F.;
Jacobs-Lorena, Marcelo;
Serrano, Adelfa E.

Publication type:

Article

Distinct Roles of Plasmodium Rhomboid 1 in Parasite Development and Malaria Pathogenesis.

Published in:

PLoS Pathogens, 2009, v. 5, n. 1, p. 1, doi. 10.1371/journal.ppat.1000262

By:

Srinivasan, Prakash;
Coppens, Isabelle;
Jacobs-Lorena, Marcelo

Publication type:

Article

The parasite Toxoplasma sequesters diverse Rab host vesicles within an intravacuolar network.

Published in:

Journal of Cell Biology, 2017, v. 216, n. 12, p. 4235, doi. 10.1083/jcb.201701108

By:

Romano, Julia D.;
Nolan, Sabrina J.;
Porter, Corey;
Ehrenman, Karen;
Hartman, Eric J.;
Ru-ching Hsia;
Coppens, Isabelle

Publication type:

Article

A Plasmodium homolog of ER tubule‐forming proteins is required for parasite virulence.

Published in:

Molecular Microbiology, 2020, v. 114, n. 3, p. 454, doi. 10.1111/mmi.14526

By:

Shi, Xiaoyu;
Hai, Lei;
Govindasamy, Kavitha;
Gao, Jian;
Coppens, Isabelle;
Hu, Junjie;
Wang, Qian;
Bhanot, Purnima

Publication type:

Article

Characterization of a second sterol-esterifying enzyme in Toxoplasma highlights the importance of cholesterol storage pathways for the parasite.

Published in:

Molecular Microbiology, 2013, v. 87, n. 5, p. 951, doi. 10.1111/mmi.12142

By:

Lige, Bao;
Sampels, Vera;
Coppens, Isabelle

Publication type:

Article

Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole.

Published in:

Molecular Microbiology, 2010, v. 76, n. 6, p. 1358, doi. 10.1111/j.1365-2958.2010.07165.x

By:

Miranda, Kildare;
Pace, Douglas A.;
Cintron, Roxana;
Rodrigues, Juliany C. F.;
Fang, Jianmin;
Smith, Alyssa;
Rohloff, Peter;
Coelho, Elvis;
De Haas, Felix;
De Souza, Wanderley;
Coppens, Isabelle;
Sibley, L. David;
Moreno, Silvia N. J.

Publication type:

Article

Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii.

Published in:

Molecular Microbiology, 2010, v. 76, n. 6, p. 1340, doi. 10.1111/j.1365-2958.2010.07181.x

By:

Parussini, Fabiola;
Coppens, Isabelle;
Shah, Parag P.;
Diamond, Scott L.;
Carruthers, Vern B.

Publication type:

Article

Novel roles for ATP-binding cassette G transporters in lipid redistribution in Toxoplasma.

Published in:

Molecular Microbiology, 2010, v. 76, n. 5, p. 1232, doi. 10.1111/j.1365-2958.2010.07169.x

By:

Ehrenman, Karen;
Sehgal, Alfica;
Lige, Bao;
Stedman, Timothy T.;
Joiner, Keith A.;
Coppens, Isabelle

Publication type:

Article

A high-affinity putrescine-cadaverine transporter from Trypanosoma cruzi.

Published in:

Molecular Microbiology, 2010, v. 76, n. 1, p. 78, doi. 10.1111/j.1365-2958.2010.07081.x

By:

Hasne, Marie-Pierre;
Coppens, Isabelle;
Soysa, Radika;
Ullman, Buddy

Publication type:

Article

Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection.

Published in:

Molecular Microbiology, 2008, v. 69, n. 1, p. 152, doi. 10.1111/j.1365-2958.2008.06271.x

By:

Aly, Ahmed S. I.;
Mikolajczak, Sebastian A.;
Rivera, Hilda Silva;
Camargo, Nelly;
Jacobs-Lorena, Vanessa;
Labaied, Mehdi;
Coppens, Isabelle;
Kappe, Stefan H. I.

Publication type:

Article

Modelling Toxoplasma gondii infection in a 3D cell culture system In Vitro: Comparison with infection in 2D cell monolayers.

Published in:

PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0208558

By:

Danielson, Jeffrey J.;
Perez, Nicolas;
Romano, Julia D.;
Coppens, Isabelle

Publication type:

Article

Characterization of the ATG8-conjugation system in 2 Plasmodium species with special focus on the liver stage.

Published in:

Autophagy, 2014, v. 10, n. 2, p. 269, doi. 10.4161/auto.27166

By:

Jayabalasingham, Bamini;
Voss, Christiane;
Ehrenman, Karen;
Romano, Julia D.;
Smith, Maria E.;
Fidock, David A.;
Bosch, Juergen;
Coppens, Isabelle

Publication type:

Article

Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation.

Published in:

Autophagy, 2013, v. 9, n. 10, p. 1540, doi. 10.4161/auto.25832

By:

Tomlins, Andrew M.;
Ben-Rached, Fathia;
Williams, Roderick A. M.;
Proto, William R.;
Coppens, Isabelle;
Ruch, Ulrike;
Gilberger, Tim W.;
Coombs, Graham H.;
Mottram, Jeremy C.;
Müller, Sylke;
Langsley, Gordon

Publication type:

Article

Autophagy in protists.

Published in:

Autophagy, 2011, v. 7, n. 2, p. 127, doi. 10.4161/auto.7.2.13310

By:

Duszenko, Michael;
Ginger, Michael L.;
Brennand, Ana;
Gualdrón-López, Melisa;
Colombo, Maria-Isabel;
Coombs, Graham H.;
Coppens, Isabelle;
Jayabalasingham, Bamini;
Langsley, Gordon;
de Castro, Solange Lisboa;
Menna-Barreto, Rubem;
Mottram, Jeremy C.;
Navarro, Miguel;
Rigden, Daniel J.;
Romano, Patricia S.;
Stoka, Veronika;
Turk, Boris;
Michels, Paul A. M.

Publication type:

Article

Sitting in the driver's seat: Manipulation of mammalian cell Rab GTPase functions by apicomplexan parasites.

Published in:

Biology of the Cell (Wiley-Blackwell), 2020, v. 112, n. 7, p. 187, doi. 10.1111/boc.201900107

By:

Coppens, Isabelle;
Romano, Julia D.

Publication type:

Article

A novel dense granule protein, GRA41, regulates timing of egress and calcium sensitivity in Toxoplasma gondii.

Published in:

Cellular Microbiology, 2017, v. 19, n. 9, p. n/a, doi. 10.1111/cmi.12749

By:

LaFavers, Kaice A.;
Márquez‐Nogueras, Karla M.;
Coppens, Isabelle;
Moreno, Silvia N. J.;
Arrizabalaga, Gustavo

Publication type:

Article

Cryptosporidium parvum scavenges LDL-derived cholesterol and micellar cholesterol internalized into enterocytes.

Published in:

Cellular Microbiology, 2013, v. 15, n. 7, p. 1182, doi. 10.1111/cmi.12107

By:

Ehrenman, Karen;
Wanyiri, Jane W.;
Bhat, Najma;
Ward, Honorine D.;
Coppens, Isabelle

Publication type:

Article

A novel co-infection model with Toxoplasma and Chlamydia trachomatis highlights the importance of host cell manipulation for nutrient scavenging.

Published in:

Cellular Microbiology, 2013, v. 15, n. 4, p. 619, doi. 10.1111/cmi.12060

By:

Romano, Julia D.;
Beaumont, Catherine;
Carrasco, Jose A.;
Ehrenman, Karen;
Bavoil, Patrik M.;
Coppens, Isabelle

Publication type:

Article

Plasmodium salvages cholesterol internalized by LDL and synthesized de novo in the liver.

Published in:

Cellular Microbiology, 2011, v. 13, n. 4, p. 569, doi. 10.1111/j.1462-5822.2010.01555.x

By:

Labaied, Mehdi;
Jayabalasingham, Bamini;
Bano, Nazneen;
Cha, Sung-Jae;
Sandoval, Juan;
Guan, Guimin;
Coppens, Isabelle

Publication type:

Article

New host nuclear functions are not required for the modifications of the parasitophorous vacuole of Toxoplasma.

Published in:

Cellular Microbiology, 2008, v. 10, n. 2, p. 465, doi. 10.1111/j.1462-5822.2007.01061.x

By:

Romano, Julia D.;
Bano, Nazneen;
Coppens, Isabelle

Publication type:

Article

KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect.

Published in:

2018

By:

Metz, Kyle A.;
Teng, Xinchen;
Coppens, Isabelle;
Lamb, Heather M.;
Wagner, Bart E.;
Rosenfeld, Jill A.;
Chen, Xianghui;
Zhang, Yu;
Kim, Hee Jong;
Meadow, Michael E.;
Wang, Tim Sen;
Haberlandt, Edda D.;
Anderson, Glenn W.;
Leshinsky‐Silver, Esther;
Bi, Weimin;
Markello, Thomas C.;
Pratt, Marsha;
Makhseed, Nawal;
Garnica, Adolfo;
Danylchuk, Noelle R.

Publication type:

journal article

Function and regulation of a steroidogenic CYP450 enzyme in the mitochondrion of Toxoplasma gondii.

Published in:

PLoS Pathogens, 2023, v. 19, n. 8, p. 1, doi. 10.1371/journal.ppat.1011566

By:

Asady, Beejan;
Samples, Vera;
Romano, Julia D.;
Levitskaya, Jelena;
Lige, Bao;
Khare, Pratik;
Le, Anne;
Coppens, Isabelle

Publication type:

Article

Golgi biogenesis in Toxoplasma gondii.

Published in:

Nature, 2002, v. 418, n. 6897, p. 548, doi. 10.1038/nature00946

By:

Pelletier, Laurence;
Stern, Charlene A.;
Pypaert, Marc;
Sheff, David;
Ngo, Huan M.;
Roper, Nitin;
He, Cynthia Y.;
Hu, Ke;
Toomre, Derek;
Coppens, Isabelle;
Roos, David S.;
Joiner, Keith A.;
Warren, Graham

Publication type:

Article

Phosphoregulation accommodates Type III secretion and assembly of a tether of ER-Chlamydia inclusion membrane contact sites.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.74535

By:

Ende, Rachel J.;
Murray, Rebecca L.;
D'Spain, Samantha K.;
Coppens, Isabelle;
Derré, Isabelle

Publication type:

Article