Works by Chinopoulos, Christos

Results: 54

Exclusive neuronal expression of SUCLA2 in the human brain.

Published in:

Brain Structure & Function, 2015, v. 220, n. 1, p. 135, doi. 10.1007/s00429-013-0643-2

By:

Dobolyi, Arpád;
Ostergaard, Elsebet;
Bagó, Attila;
Dóczi, Tamás;
Palkovits, Miklós;
Gál, Aniko;
Molnár, Mária;
Adam-Vizi, Vera;
Chinopoulos, Christos

Publication type:

Article

Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 36, p. 7779, doi. 10.1523/JNEUROSCI.1899-04.2004

By:

Starkov, Anatoly A.;
Fiskum, Gary;
Chinopoulos, Christos;
Lorenzo, Beverly J.;
Browne, Susan E.;
Patel, Mulchand S.;
Beal, M. Flint

Publication type:

Article

Modulation of F.

Published in:

FEBS Journal, 2011, v. 278, n. 7, p. 1112, doi. 10.1111/j.1742-4658.2011.08026.x

By:

Chinopoulos, Christos;
Konràd, Csaba;
Kiss, Gergely;
Metelkin, Eugeniy;
Töröcsik, Beata;
Zhang, Steven F.;
Starkov, Anatoly A.

Publication type:

Article

A distinct sequence in the adenine nucleotide translocase from Artemia franciscana embryos is associated with insensitivity to bongkrekate and atypical effects of adenine nucleotides on Ca.

Published in:

FEBS Journal, 2011, v. 278, n. 5, p. 822, doi. 10.1111/j.1742-4658.2010.08001.x

By:

Konràd, Csaba;
Kiss, Gergely;
Töröcsik, Beata;
Lábár, János L.;
Gerencser, Akos A.;
Mándi, Miklós;
Adam-Vizi, Vera;
Chinopoulos, Christos

Publication type:

Article

The ‘ins and outs’ of Ca2+ in mitochondria.

Published in:

FEBS Journal, 2010, v. 277, n. 18, p. 3621, doi. 10.1111/j.1742-4658.2010.07753.x

By:

Chinopoulos, Christos;
Adam-Vizi, Vera

Publication type:

Article

Mitochondrial Ca2+ sequestration and precipitation revisited.

Published in:

FEBS Journal, 2010, v. 277, n. 18, p. 3637, doi. 10.1111/j.1742-4658.2010.07755.x

By:

Chinopoulos, Christos;
Adam-Vizi, Vera

Publication type:

Article

Modeling of ATP–ADP steady-state exchange rate mediated by the adenine nucleotide translocase in isolated mitochondria.

Published in:

FEBS Journal, 2009, v. 276, n. 23, p. 6942, doi. 10.1111/j.1742-4658.2009.07394.x

By:

Metelkin, Eugeniy;
Demin, Oleg;
Kovács, Zsuzsanna;
Chinopoulos, Christos

Publication type:

Article

A re-evaluation of the role of matrix acidification in uncoupler-induced Ca2+ release from mitochondria.

Published in:

FEBS Journal, 2009, v. 276, n. 10, p. 2713, doi. 10.1111/j.1742-4658.2009.06995.x

By:

Vajda, Szilvia;
Mándi, Miklós;
Konràd, Csaba;
Kiss, Gergely;
Ambrus, Attila;
Adam-Vizi, Vera;
Chinopoulos, Christos

Publication type:

Article

Calcium, mitochondria and oxidative stress in neuronal pathology.

Published in:

FEBS Journal, 2006, v. 273, n. 3, p. 433, doi. 10.1111/j.1742-4658.2005.05103.x

By:

Chinopoulos, Christos;
Adam-Vizi, Vera

Publication type:

Article

Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma.

Published in:

Communications Biology, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42003-019-0455-x

By:

Mukherjee, Purna;
Augur, Zachary M.;
Li, Mingyi;
Hill, Collin;
Greenwood, Bennett;
Domin, Marek A.;
Kondakci, Gramoz;
Narain, Niven R.;
Kiebish, Michael A.;
Bronson, Roderick T.;
Arismendi-Morillo, Gabriel;
Chinopoulos, Christos;
Seyfried, Thomas N.

Publication type:

Article

Can the Mitochondrial Metabolic Theory Explain Better the Origin and Management of Cancer than Can the Somatic Mutation Theory?

Published in:

Metabolites (2218-1989), 2021, v. 11, n. 9, p. 572, doi. 10.3390/metabo11090572

By:

Seyfried, Thomas N.;
Chinopoulos, Christos

Publication type:

Article

The Warburg hypothesis and the emergence of the mitochondrial metabolic theory of cancer.

Published in:

Journal of Bioenergetics & Biomembranes, 2025, v. 57, n. 2, p. 57, doi. 10.1007/s10863-025-10059-w

By:

Seyfried, Thomas N.;
Lee, Derek C.;
Duraj, Tomas;
Ta, Nathan L.;
Mukherjee, Purna;
Kiebish, Michael;
Arismendi-Morillo, Gabriel;
Chinopoulos, Christos

Publication type:

Article

Proline Oxidation Supports Mitochondrial ATP Production When Complex I Is Inhibited.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 9, p. 5111, doi. 10.3390/ijms23095111

By:

Pallag, Gergely;
Nazarian, Sara;
Ravasz, Dora;
Bui, David;
Komlódi, Timea;
Doerrier, Carolina;
Gnaiger, Erich;
Seyfried, Thomas N.;
Chinopoulos, Christos

Publication type:

Article

The Mystery of Extramitochondrial Proteins Lysine Succinylation.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 11, p. 6085, doi. 10.3390/ijms22116085

By:

Chinopoulos, Christos

Publication type:

Article

Which way does the citric acid cycle turn during hypoxia? The critical role of α-ketoglutarate dehydrogenase complex.

Published in:

Journal of Neuroscience Research, 2013, v. 91, n. 8, p. 1030, doi. 10.1002/jnr.23196

By:

Chinopoulos, Christos

Publication type:

Article

The 'B Space' of mitochondrial phosphorylation.

Published in:

Journal of Neuroscience Research, 2011, v. 89, n. 12, p. 1897, doi. 10.1002/jnr.22659

By:

Chinopoulos, Christos

Publication type:

Article

Guest Editorial.

Published in:

2019

By:

Chinopoulos, Christos;
Starkov, Anatoly

Publication type:

Editorial

The Effect of 2-Ketobutyrate on Mitochondrial Substrate-Level Phosphorylation.

Published in:

Neurochemical Research, 2019, v. 44, n. 10, p. 2301, doi. 10.1007/s11064-019-02759-8

By:

Bui, David;
Ravasz, Dora;
Chinopoulos, Christos

Publication type:

Article

Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost.

Published in:

Functional Ecology, 2018, v. 32, n. 9, p. 2149, doi. 10.1111/1365-2435.13125

By:

Salin, Karine;
Villasevil, Eugenia M.;
Anderson, Graeme J.;
Auer, Sonya K.;
Selman, Colin;
Hartley, Richard C.;
Mullen, William;
Chinopoulos, Christos;
Metcalfe, Neil B.

Publication type:

Article

Glutaminases as a Novel Target for SDHB-Associated Pheochromocytomas/Paragangliomas.

Published in:

Cancers, 2020, v. 12, n. 3, p. 599, doi. 10.3390/cancers12030599

By:

Sarkadi, Balazs;
Meszaros, Katalin;
Krencz, Ildiko;
Canu, Letizia;
Krokker, Lilla;
Zakarias, Sara;
Barna, Gabor;
Sebestyen, Anna;
Papay, Judit;
Hujber, Zoltan;
Butz, Henriett;
Darvasi, Otto;
Igaz, Peter;
Doczi, Judit;
Luconi, Michaela;
Chinopoulos, Christos;
Patocs, Attila

Publication type:

Article

Mitochondrial consumption of cytosolic ATP: Not so fast

Published in:

FEBS Letters, 2011, v. 585, n. 9, p. 1255, doi. 10.1016/j.febslet.2011.04.004

By:

Chinopoulos, Christos

Publication type:

Article

The RCR and ATP/O Indices Can Give Contradictory Messages about Mitochondrial Efficiency.

Published in:

Integrative & Comparative Biology, 2018, v. 58, n. 3, p. 486, doi. 10.1093/icb/icy085

By:

Salin, Karine;
Villasevil, Eugenia M;
Anderson, Graeme J;
Selman, Colin;
Chinopoulos, Christos;
Metcalfe, Neil B

Publication type:

Article

Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria.

Published in:

Journal of Physiology, 2012, v. 590, n. 12, p. 2845, doi. 10.1113/jphysiol.2012.228387

By:

Gerencser, Akos A.;
Chinopoulos, Christos;
Birket, Matthew J.;
Jastroch, Martin;
Vitelli, Cathy;
Nicholls, David G.;
Brand, Martin D.

Publication type:

Article

Metabolic management of microenvironment acidity in glioblastoma.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.968351

By:

Seyfried, Thomas N.;
Arismendi-Morillo, Gabriel;
Zuccoli, Giulio;
Lee, Derek C.;
Duraj, Tomas;
Elsakka, Ahmed M.;
Maroon, Joseph C.;
Mukherjee, Purna;
Linh Ta;
Shelton, Laura;
D'Agostino, Dominic;
Kiebish, Michael;
Chinopoulos, Christos

Publication type:

Article

Divalent cation chelators citrate and EDTA unmask an intrinsic uncoupling pathway in isolated mitochondria.

Published in:

Journal of Bioenergetics & Biomembranes, 2017, v. 49, n. 1, p. 3, doi. 10.1007/s10863-016-9656-x

By:

Starkov, Anatoly;
Chinopoulos, Christos;
Starkova, Natalia;
Konrad, Csaba;
Kiss, Gergely;
Stepanova, Anna;
Popov, Vasily

Publication type:

Article

Localization of SUCLA2 and SUCLG2 subunits of succinyl CoA ligase within the cerebral cortex suggests the absence of matrix substrate-level phosphorylation in glial cells of the human brain.

Published in:

Journal of Bioenergetics & Biomembranes, 2015, v. 47, n. 1/2, p. 33, doi. 10.1007/s10863-014-9586-4

By:

Dobolyi, Arpád;
Bagó, Attila;
Gál, Aniko;
Molnár, Mária;
Palkovits, Miklós;
Adam-Vizi, Vera;
Chinopoulos, Christos

Publication type:

Article

Exclusive neuronal detection of KGDHC-specific subunits in the adult human brain cortex despite pancellular protein lysine succinylation.

Published in:

Brain Structure & Function, 2020, v. 225, n. 2, p. 639, doi. 10.1007/s00429-020-02026-5

By:

Dobolyi, Arpad;
Bago, Attila;
Palkovits, Miklos;
Nemeria, Natalia S.;
Jordan, Frank;
Doczi, Judit;
Ambrus, Attila;
Adam-Vizi, Vera;
Chinopoulos, Christos

Publication type:

Article

Cyclophilin D disruption attenuates lipopolysaccharide-induced inflammatory response in primary mouse macrophages.

Published in:

Biochemistry & Cell Biology, 2015, v. 93, n. 3, p. 241, doi. 10.1139/bcb-2014-0120

By:

Priber, Janos;
Fonai, Fruzsina;
Jakus, Peter Balazs;
Racz, Boglarka;
Chinopoulos, Christos;
Tretter, Laszlo;
Gallyas, Ferenc;
Sumegi, Balazs;
Veres, Balazs

Publication type:

Article

DEPOLARIZATION BY HYDROGEN PEROXIDE OF MITOCHONDRIA IN ISOLATED NERVE TERMINALS.

Published in:

1999

By:

Chinopoulos, Christos;
Adam-Vizi, Vera

Publication type:

Abstract

Depolarization of In Situ Mitochondria Due to Hydrogen Peroxide-Induced Oxidative Stress in Nerve Terminals.

Published in:

Journal of Neurochemistry, 1999, v. 73, n. 1, p. 220, doi. 10.1046/j.1471-4159.1999.0730220.x

By:

Chinopoulos, Christos;
Tretter, Laszlo;
Adam-Vizi, Vera

Publication type:

Article

Enhanced Depolarization-Evoked Calcium Signal and Reduced [ATP]/[ADP] Ratio Are Unrelated Events Induced by Oxidative Stress in Synaptosomes.

Published in:

Journal of Neurochemistry, 1997, v. 69, n. 6, p. 2529, doi. 10.1046/j.1471-4159.1997.69062529.x

By:

Tretter, Laszlo;
Chinopoulos, Christos;
Adam-Vizi, Vera

Publication type:

Article

Mitochondrial Mechanisms of Neural Cell Death and Neuroprotective Interventions in Parkinson's Disease.

Published in:

Annals of the New York Academy of Sciences, 2003, v. 991, n. 1, p. 111, doi. 10.1111/j.1749-6632.2003.tb07469.x

By:

FISKUM, GARY;
STARKOV, ANATOLY;
POLSTER, BRIAN M.;
CHINOPOULOS, CHRISTOS

Publication type:

Article

Cell-specific expression of key mitochondrial enzymes limits OXPHOS in astrocytes of the adult human neocortex and hippocampal formation.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06751-z

By:

Dobolyi, Arpád;
Cservenák, Melinda;
Bagó, Attila G.;
Chen, Chun;
Stepanova, Anna;
Paal, Krisztina;
Lee, Jeonghyoun;
Palkovits, Miklós;
Hudson, Gavin;
Chinopoulos, Christos

Publication type:

Article

Reverse and Forward Electron Flow-Induced H 2 O 2 Formation Is Decreased in α-Ketoglutarate Dehydrogenase (α-KGDH) Subunit (E2 or E3) Heterozygote Knock Out Animals.

Published in:

Antioxidants, 2022, v. 11, n. 8, p. N.PAG, doi. 10.3390/antiox11081487

By:

Horváth, Gergő;
Sváb, Gergely;
Komlódi, Tímea;
Ravasz, Dora;
Kacsó, Gergely;
Doczi, Judit;
Chinopoulos, Christos;
Ambrus, Attila;
Tretter, László

Publication type:

Article

Viability of HepG2 and MCF-7 cells is not correlated with mitochondrial bioenergetics.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-37677-x

By:

Doczi, Judit;
Karnok, Noemi;
Bui, David;
Azarov, Victoria;
Pallag, Gergely;
Nazarian, Sara;
Czumbel, Bence;
Seyfried, Thomas N.;
Chinopoulos, Christos

Publication type:

Article

What makes you can also break you, part II: mitochondrial permeability transition pore formation by dimers of the F1FO ATP-synthase?

Published in:

2013

By:

Szabadkai, Gyorgy;
Chinopoulos, Christos

Publication type:

Opinion

What makes you can also break you: mitochondrial permeability transition pore formation by the c subunit of the F1F0 ATP-synthase?

Published in:

Frontiers in Oncology, 2013, v. 3, p. 1, doi. 10.3389/fonc.2013.00025

By:

Chinopoulos, Christos;
Szabadkai, Gyorgy;
Galluzzi, Lorenzo

Publication type:

Article

Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage.

Published in:

FASEB Journal, 2016, v. 30, n. 1, p. 286, doi. 10.1096/fj.15-279398

By:

Németh, Beáta;
Doczi, Judit;
Csete, Dániel;
Kacso, Gergely;
Ravasz, Dora;
Adams, Daniel;
Kiss, Gergely;
Nagy, Adam M.;
Horvath, Gergo;
Tretter, Laszlo;
Mócsai, Attila;
Csépányi-Kömi, Roland;
Iordanov, Iordan;
Adam-Vizi, Vera;
Chinopoulos, Christos

Publication type:

Article

Mitochondrial diaphorases as NAD+ donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition.

Published in:

FASEB Journal, 2014, v. 28, n. 4, p. 1682, doi. 10.1096/fj.13-243030

By:

Kiss, Gergely;
Konrad, Csaba;
Pour-Ghaz, Issa;
Mansour, Josef J.;
Németh, Beata;
Starkov, Anatoly A.;
Adam-Vizi, Vera;
Chinopoulos, Christos

Publication type:

Article

The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.

Published in:

FASEB Journal, 2013, v. 27, n. 6, p. 2392, doi. 10.1096/fj.12-220202

By:

Kiss, Gergely;
Konrad, Csaba;
Doczi, Judit;
Starkov, Anatoly A.;
Kawamata, Hibiki;
Manfredi, Giovanni;
Zhang, Steven F.;
Gibson, Gary E.;
Beal, M. Flint;
Adam-Vizi, Vera;
Chinopoulos, Christos

Publication type:

Article

Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation.

Published in:

FASEB Journal, 2010, v. 24, n. 7, p. 2405, doi. 10.1096/fj.09-149898

By:

Chinopoulos, Christos;
Gerencser, Akos A.;
Mandi, Miklos;
Mathe, Katalin;
Töröcsik, Beata;
Doczi, Judit;
Turiak, Lilla;
Kiss, Gergely;
Konràd, Csaba;
Vajda, Szilvia;
Vereczki, Viktoria;
Oh, Richard J.;
Adam-Vizi, Vera

Publication type:

Article

Inhibition of glutamate-induced delayed calcium deregulation by 2-APB and La3+ in cultured cortical neurones.

Published in:

Journal of Neurochemistry, 2004, v. 91, n. 2, p. 471, doi. 10.1111/j.1471-4159.2004.02732.x

By:

Chinopoulos, Christos;
Gerencser, Akos A.;
Doczi, Judit;
Fiskum, Gary;
Adam-Vizi, Vera

Publication type:

Article

What makes you can also break you, part III: mitochondrial permeability transition pore formation by an uncoupling channel within the c-subunit ring of the F1FO ATP synthase?

Published in:

Frontiers in Oncology, 2014, v. 4, p. 1, doi. 10.3389/fonc.2014.00235

By:

Chinopoulos, Christos;
Szabadkai, Gyorgy

Publication type:

Article

The Suppressor of AAC2 Lethality SAL1 Modulates Sensitivity of Heterologously Expressed Artemia ADP/ATP Carrier to Bongkrekate in Yeast.

Published in:

PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0074187

By:

Wysocka-Kapcinska, Monika;
Torocsik, Beata;
Turiak, Lilla;
Tsaprailis, George;
David, Cynthia L.;
Hunt, Andrea M.;
Vekey, Karoly;
Adam-Vizi, Vera;
Kucharczyk, Roza;
Chinopoulos, Christos

Publication type:

Article

Absence of Ca2+-Induced Mitochondrial Permeability Transition but Presence of Bongkrekate-Sensitive Nucleotide Exchange in C. crangon and P. serratus.

Published in:

PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0039839

By:

Konrad, Csaba;
Kiss, Gergely;
Torocsik, Beata;
Adam-Vizi, Vera;
Chinopoulos, Christos

Publication type:

Article

Depolarization of in Situ Mitochondria by Hydrogen Peroxide in Nerve Terminals.

Published in:

Annals of the New York Academy of Sciences, 1999, v. 893, n. 1, p. 269, doi. 10.1111/j.1749-6632.1999.tb07834.x

By:

CHINOPOULOS, CHRISTOS;
ADAM-VIZI, VERA

Publication type:

Article

Simultaneous measurement of mitochondrial respiration and ATP production in tissue homogenates and calculation of effective P/O ratios.

Published in:

Physiological Reports, 2016, v. 4, n. 20, p. 1, doi. 10.14814/phy2.13007

By:

Salin, Karine;
Villasevil, Eugenia M.;
Auer, Sonya K.;
Anderson, Graeme J.;
Selman, Colin;
Metcalfe, Neil B.;
Chinopoulos, Christos

Publication type:

Article

From Glucose to Lactate and Transiting Intermediates Through Mitochondria, Bypassing Pyruvate Kinase: Considerations for Cells Exhibiting Dimeric PKM2 or Otherwise Inhibited Kinase Activity.

Published in:

Frontiers in Physiology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphys.2020.543564

By:

Chinopoulos, Christos

Publication type:

Article

ATP synthase complex and the mitochondrial permeability transition pore: poles of attraction.

Published in:

EMBO Reports, 2017, v. 18, n. 7, p. 1041, doi. 10.15252/embr.201744412

By:

Chinopoulos, Christos

Publication type:

Article

Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis.

Published in:

ASN Neuro, 2018, v. 10, n. 1, p. 1, doi. 10.1177/1759091418818261

By:

Chinopoulos, Christos;
Seyfried, Thomas N.

Publication type:

Article