Works matching AU Lim, Junxian

Results: 16

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats.

Published in:

2010

By:

Iyer, Abishek;
Fenning, Andrew;
Lim, Junxian;
Le, Giang T;
Reid, Robert C;
Halili, Maria A;
Fairlie, David P;
Brown, Lindsay

Publication type:

journal article

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00414-w

By:

Lohman, Rink-Jan;
Hamidon, Johan K.;
Reid, Robert C.;
Rowley, Jessica A.;
Yau, Mei-Kwan;
Halili, Maria A.;
Nielsen, Daniel S.;
Junxian Lim;
Wu, Kai-Chen;
Zhixuan Loh;
Do, Anh;
Suen, Jacky Y.;
Iyer, Abishek;
Fairlie, David P.

Publication type:

Article

Downsizing a human inflammatory protein to a small molecule with equal potency and functionality.

Published in:

Nature Communications, 2013, v. 4, n. 11, p. 2802, doi. 10.1038/ncomms3802

By:

Reid, Robert C.;
Yau, Mei-Kwan;
Singh, Ranee;
Hamidon, Johan K.;
Reed, Anthony N.;
Chu, Peifei;
Suen, Jacky Y.;
Stoermer, Martin J.;
Blakeney, Jade S.;
Lim, Junxian;
Faber, Jonathan M.;
Fairlie, David P.

Publication type:

Article

Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition.

Published in:

Communications Biology, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42003-020-01504-0

By:

Kennedy, Amanda J.;
Sundström, Linda;
Geschwindner, Stefan;
Poon, Eunice K. Y.;
Jiang, Yuhong;
Chen, Rongfeng;
Cooke, Rob;
Johnstone, Shawn;
Madin, Andrew;
Lim, Junxian;
Liu, Qingqi;
Lohman, Rink-Jan;
Nordqvist, Anneli;
Fridén-Saxin, Maria;
Yang, Wenzhen;
Brown, Dean G.;
Fairlie, David P.;
Dekker, Niek

Publication type:

Article

Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages.

Published in:

Journal of Innate Immunity, 2023, v. 15, n. 1, p. 468, doi. 10.1159/000530012

By:

Wu, Kai-Chen;
Condon, Nicholas D;
Hill, Timothy A.;
Reid, Robert C.;
Fairlie, David P.;
Lim, Junxian

Publication type:

Article

A novel inhibitor of class IIa histone deacetylases attenuates collagen‐induced arthritis.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 23, p. 4804, doi. 10.1111/bph.17306

By:

Poon, Eunice K.;
Liu, Ligong;
Wu, Kai‐Chen;
Lim, Junxian;
Sweet, Matthew J.;
Lohman, Rink‐Jan;
Iyer, Abishek;
Fairlie, David P.

Publication type:

Article

PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR.

Published in:

British Journal of Pharmacology, 2021, v. 178, n. 4, p. 913, doi. 10.1111/bph.15332

By:

Jiang, Yuhong;
Lim, Junxian;
Wu, Kai‐Chen;
Xu, Weijun;
Suen, Jacky Y.;
Fairlie, David P.

Publication type:

Article

The histone deacetylase Hdac7 supports LPS‐inducible glycolysis and Il‐1β production in murine macrophages via distinct mechanisms.

Published in:

Journal of Leukocyte Biology, 2022, v. 111, n. 2, p. 327, doi. 10.1002/JLB.2MR1021-260R

By:

Ramnath, Divya;
Das Gupta, Kaustav;
Wang, Yizhuo;
Abrol, Rishika;
Curson, James E. B.;
Lim, Junxian;
Reid, Robert C.;
Mansell, Ashley;
Blumenthal, Antje;
Karunakaran, Denuja;
Fairlie, David P.;
Sweet, Matthew J.

Publication type:

Article

Tuning Electrostatic and Hydrophobic Surfaces of Aromatic Rings to Enhance Membrane Association and Cell Uptake of Peptides.

Published in:

Angewandte Chemie International Edition, 2022, v. 61, n. 29, p. 1, doi. 10.1002/anie.202203995

By:

de Araujo, Aline D.;
Hoang, Huy N.;
Lim, Junxian;
Mak, Jeffrey Y. W.;
Fairlie, David P.

Publication type:

Article

Tuning Electrostatic and Hydrophobic Surfaces of Aromatic Rings to Enhance Membrane Association and Cell Uptake of Peptides.

Published in:

Angewandte Chemie, 2022, v. 134, n. 29, p. 1, doi. 10.1002/ange.202203995

By:

de Araujo, Aline D.;
Hoang, Huy N.;
Lim, Junxian;
Mak, Jeffrey Y. W.;
Fairlie, David P.

Publication type:

Article

Protease activated receptor 2 (PAR2) modulators: a patent review (2010–2015).

Published in:

Expert Opinion on Therapeutic Patents, 2016, v. 26, n. 4, p. 471, doi. 10.1517/13543776.2016.1154540

By:

Yau, Mei-Kwan;
Lim, Junxian;
Liu, Ligong;
Fairlie, David P.

Publication type:

Article

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

Published in:

Scientific Reports, 2016, p. 24575, doi. 10.1038/srep24575

By:

Seow, Vernon;
Lim, Junxian;
Cotterell, Adam J.;
Yau, Mei-Kwan;
Xu, Weijun;
Lohman, Rink-Jan;
Kok, W. Mei;
Stoermer, Martin J.;
Sweet, Matthew J.;
Reid, Robert C.;
Suen, Jacky Y.;
Fairlie, David P.

Publication type:

Article

Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism.

Published in:

FASEB Journal, 2013, v. 27, n. 12, p. 4757, doi. 10.1096/fj.13-232702

By:

Junxian Lim;
Abishek Iyer;
Ligong Liu;
Suen, Jacky Y.;
Rink-Jan Lohman;
Vernon Seow;
Mei-Kwan Yau;
Brown, Lindsay;
Fairlie, David P.

Publication type:

Article

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling.

Published in:

FASEB Journal, 2013, v. 27, n. 2, p. 822, doi. 10.1096/fj.12-220582

By:

Junxian Lim;
Iyer, Abishek;
Suen, Jacky Y.;
Seow, Vernon;
Reid, Robert C.;
Brown, Lindsay;
Fairlie, David P.

Publication type:

Article

An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats.

Published in:

2012

By:

Iyer A;
Lim J;
Poudyal H;
Reid RC;
Suen JY;
Webster J;
Prins JB;
Whitehead JP;
Fairlie DP;
Brown L;
Iyer, Abishek;
Lim, Junxian;
Poudyal, Hemant;
Reid, Robert C;
Suen, Jacky Y;
Webster, Julie;
Prins, Johannes B;
Whitehead, Jonathan P;
Fairlie, David P;
Brown, Lindsay

Publication type:

journal article

An Inhibitor of Phospholipase A<sub>2</sub> Group IIA Modulates Adipocyte Signaling and Protects Against Diet-Induced Metabolic Syndrome in Rats.

Published in:

Diabetes, 2012, v. 61, n. 9, p. 2320, doi. 10.2337/db11-1179

By:

Iyer, Abishek;
Junxian Lim;
Poudyal, Hemant;
Reid, Robert C.;
Suen, Jacky Y.;
Webster, Julie;
Prins, Johannes B.;
Whitehead, Jonathan P.;
Fairlie, David P.;
Brown, Lindsay

Publication type:

Article