Works matching Pharmacokinetics

Results: 5000

SpatialCNS‐PBPK: An R/Shiny Web‐Based Application for Physiologically Based Pharmacokinetic Modeling of Spatial Pharmacokinetics in the Human Central Nervous System and Brain Tumors.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 5, p. 864, doi. 10.1002/psp4.70026

By:

Wickramasinghe, Charuka D.;
Kim, Seongho;
Li, Jing

Publication type:

Article

Pharmacokinetics of Novel Furoxan/Coumarin Hybrids in Rats Using LC-MS/MS Method and Physiologically Based Pharmacokinetic Model.

Published in:

Molecules, 2023, v. 28, n. 2, p. 837, doi. 10.3390/molecules28020837

By:

Yuan, Yawen;
Li, Zhihong;
Wang, Ke;
Zhang, Shunguo;
He, Qingfeng;
Liu, Lucy;
Tang, Zhijia;
Zhu, Xiao;
Chen, Ying;
Cai, Weimin;
Peng, Chao;
Xiang, Xiaoqiang

Publication type:

Article

Comparison of the Use of a Physiologically Based Pharmacokinetic Model and a Classical Pharmacokinetic Model for Dioxin Exposure Assessments.

Published in:

Environmental Health Perspectives, 2005, v. 113, n. 12, p. 1666, doi. 10.1289/ehp.8016

By:

Emond, Claude;
Michalek, Joel E.;
Birnbaum, Linda S.;
DeVito, Michael J.

Publication type:

Article

Pharmacokinetics of the Recombinant Thrombolytic Agents: What is the Clinical Significance of Their Different Pharmacokinetic Parameters?

Published in:

BioDrugs, 1999, v. 11, n. 2, p. 115, doi. 10.2165/00063030-199911020-00005

By:

Cohen, A.

Publication type:

Article

Meta-analysis of hepatic cytochrome P450 ontogeny to underwrite the prediction of pediatric pharmacokinetics using physiologically based pharmacokinetic modeling.

Published in:

Journal of Clinical Pharmacology, 2016, v. 56, n. 3, p. 266, doi. 10.1002/jcph.585

By:

Upreti, Vijay V.;
Wahlstrom, Jan L.

Publication type:

Article

Interspecies Pharmacokinetics. 1. Allometric Scaling of Pharmacokinetic Parameters (a Review).

Published in:

Pharmaceutical Chemistry Journal, 2014, v. 48, n. 7, p. 421, doi. 10.1007/s11094-014-1124-5

By:

Polekhina, O.;
Obraztsov, N.;
Petrunin, V.;
Vysotskaya, T.

Publication type:

Article

Prospective population pharmacokinetic study of tacrolimus in adult recipients early after liver transplantation: A comparison of Michaelis-Menten and theory-based pharmacokinetic models.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.1031969

By:

Xiao-Jun Cai;
Rui-Dong Li;
Jian-Hua Li;
Yi-Feng Tao;
Quan-Bao Zhang;
Cong-Huan Shen;
Xiao-Fei Zhang;
Zheng-Xin Wang;
Zheng Jiao

Publication type:

Article

First-in-human study to investigate the safety and pharmacokinetics of salvianolic acid A and pharmacokinetic simulation using a physiologically based pharmacokinetic model.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.907208

By:

Jinliang Chen;
Zourong Ruan;
Honggang Lou;
Dandan Yang;
Rong Shao;
Yichao Xu;
Xinhua Hu;
Bo Jiang

Publication type:

Article

Prior information for population pharmacokinetic and pharmacokinetic/pharmacodynamic analysis: overview and guidance with a focus on the NONMEM PRIOR subroutine.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2020, v. 47, n. 5, p. 431, doi. 10.1007/s10928-020-09695-z

By:

Chan Kwong, Anna H.-X. P.;
Calvier, Elisa A. M.;
Fabre, David;
Gattacceca, Florence;
Khier, Sonia

Publication type:

Article

Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2016, v. 43, n. 4, p. 427, doi. 10.1007/s10928-016-9482-0

By:

Glassman, Patrick;
Balthasar, Joseph

Publication type:

Article

Physiologically based pharmacokinetic modelling of Busulfan: a new approach to describe and predict the pharmacokinetics in adults.

Published in:

Cancer Chemotherapy & Pharmacology, 2013, v. 72, n. 5, p. 991, doi. 10.1007/s00280-013-2275-x

By:

Diestelhorst, Christian;
Boos, Joachim;
McCune, Jeannine;
Russell, James;
Kangarloo, S.;
Hempel, Georg

Publication type:

Article

Pharmacokinetics of YK‐1169 in healthy subjects and pharmacokinetic/pharmacodynamic analysis by Monte Carlo simulation.

Published in:

British Journal of Clinical Pharmacology, 2023, v. 89, n. 10, p. 3067, doi. 10.1111/bcp.15804

By:

Li, You;
Yan, Bingqian;
Guo, Siwei;
Tian, Miaomei;
Li, Yuan;
Tong, Huan;
Yu, Yunsong;
Shao, Jing;
Xin, Yuxia;
Chen, Hui;
Xu, Bing;
Li, Xin

Publication type:

Article

Optimizing pharmacokinetic bridging studies in paediatric oncology using physiologically-based pharmacokinetic modelling: application to docetaxel.

Published in:

British Journal of Clinical Pharmacology, 2015, v. 80, n. 3, p. 534, doi. 10.1111/bcp.12702

By:

Thai, Hoai‐Thu;
Mazuir, Florent;
Cartot‐Cotton, Sylvaine;
Veyrat‐Follet, Christine

Publication type:

Article

Physiologically Based Pharmacokinetic Modeling for Prediction of 5-FU Pharmacokinetics in Cancer Patients with Hepatic Impairment After 5-FU and Capecitabine Administration.

Published in:

Pharmaceutical Research, 2023, v. 40, n. 9, p. 2177, doi. 10.1007/s11095-023-03585-y

By:

Wang, Yu;
Hu, Haihong;
Yu, Lushan;
Zeng, Su

Publication type:

Article

A Population Pharmacokinetic Modelling Approach to Unravel the Complex Pharmacokinetics of Vincristine in Children.

Published in:

Pharmaceutical Research, 2022, v. 39, n. 10, p. 2487, doi. 10.1007/s11095-022-03364-1

By:

Nijstad, A. Laura;
Chu, Wan-Yu;
de Vos-Kerkhof, Evelien;
Enters-Weijnen, Catherine F.;
van de Velde, Mirjam E.;
Kaspers, Gertjan J. L.;
Barnett, Shelby;
Veal, Gareth J.;
Lalmohamed, Arief;
Zwaan, C. Michel;
Huitema, Alwin D. R.

Publication type:

Article

Re-writing Oral Pharmacokinetics Using Physiologically Based Finite Time Pharmacokinetic (PBFTPK) Models.

Published in:

Pharmaceutical Research, 2022, v. 39, n. 4, p. 691, doi. 10.1007/s11095-022-03230-0

By:

Chryssafidis, Pavlos;
Tsekouras, Athanasios A.;
Macheras, Panos

Publication type:

Article

Characterization of Preclinical Pharmacokinetic Properties and Prediction of Human PK Using a Physiologically Based Pharmacokinetic Model for a Novel Anti-Arrhythmic Agent Sulcardine Sulfate.

Published in:

Pharmaceutical Research, 2021, v. 38, n. 11, p. 1847, doi. 10.1007/s11095-021-03128-3

By:

Ren, Chang;
Wang, Yao;
Zhang, Mei;
Kong, Dexuan;
Ning, Chen;
Cheng, Yujie;
Bian, Yueying;
Sun, Mengqi;
Su, Shengdi;
Wang, Yucong;
Zhang, Yongjie;
Lu, Yang;
Li, Ning;
Zhao, Di;
Chen, Xijing

Publication type:

Article

Interspecies prediction of pharmacokinetics and tissue distribution of doxorubicin by physiologically‐based pharmacokinetic modeling.

Published in:

Biopharmaceutics & Drug Disposition, 2020, v. 41, n. 4/5, p. 192, doi. 10.1002/bdd.2229

By:

Lee, Jong Bong;
Zhou, Simon;
Chiang, Manting;
Zang, Xiaowei;
Kim, Tae Hwan;
Kagan, Leonid

Publication type:

Article

Virtual population pharmacokinetic using physiologically based pharmacokinetic model for evaluating bioequivalence of oral lacidipine formulations in dogs.

Published in:

Asian Journal of Pharmaceutical Sciences, 2017, v. 12, n. 1, p. 98, doi. 10.1016/j.ajps.2016.03.003

By:

Bin Yang;
Chunnuan Wu;
Bin Ji;
Mingrui Wu;
Zhonggui He;
Lei Shang;
Jin Sun

Publication type:

Article

Whole-Body Pharmacokinetics and Physiologically Based Pharmacokinetic Model for Monomethyl Auristatin E (MMAE).

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 6, p. 1332, doi. 10.3390/jcm10061332

By:

Chang, Hsuan Ping;
Cheung, Yuen Kiu;
Shah, Dhaval K.;
Junutula, Jagath Reddy

Publication type:

Article

Phase I clinical trial of NH130 and the prediction of its pharmacokinetics using physiologically based pharmacokinetic modeling.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1474868

By:

Kun Zhang;
Shanshan Zhao;
Jialin Du;
Lan Zhang

Publication type:

Article

Physiologically based pharmacokinetic modeling to predict the pharmacokinetics of codeine in different CYP2D6 phenotypes.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1342515

By:

Yujie Yang;
Xiqian Zhang;
Yirong Wang;
Heng Xi;
Min Xu;
Liang Zheng

Publication type:

Article

Clinical pharmacokinetics and pharmacodynamics of insulin lispro mixtures.

Published in:

2002

By:

Roach, P.;
Woodworth, J.R.;
Roach, Paris;
Woodworth, James R

Publication type:

journal article

Population pharmacokinetics of haloperidol using routine clinical pharmacokinetic data in Japanese patients.

Published in:

2002

By:

Yukawa, E.;
Hokazono, T.;
Yukawa, M.;
Ichimaru, R.;
Maki, T.;
Matsunaga, K.;
Ohdo, S.;
Anai, M.;
Higuchi, S.;
Goto, Y.;
Yukawa, Eiji;
Hokazono, Tsuyoshi;
Yukawa, Miho;
Ichimaru, Ritsuko;
Maki, Takako;
Matsunaga, Kanemitsu;
Ohdo, Shigehiro;
Anai, Motoaki;
Higuchi, Shun;
Goto, Yoshinobu

Publication type:

journal article

Population pharmacokinetics of digoxin in Japanese patients: a 2-compartment pharmacokinetic model.

Published in:

2001

By:

Yukawa, E.;
Suematu, F.;
Yukawa, M.;
Minemoto, M.;
Ohdo, S.;
Higuchi, S.;
Goto, Y.;
Aoyama, T.

Publication type:

journal article

Population pharmacokinetics of clinafloxacin in healthy volunteers and patients with infections: experience with heterogeneous pharmacokinetic data.

Published in:

2001

By:

Frame, B.;
Koup, J.;
Miller, R.;
Lalonde, R.

Publication type:

journal article

Simultaneously Predicting the Pharmacokinetics of CES1-Metabolized Drugs and Their Metabolites Using Physiologically Based Pharmacokinetic Model in Cirrhosis Subjects.

Published in:

Pharmaceutics, 2024, v. 16, n. 2, p. 234, doi. 10.3390/pharmaceutics16020234

By:

Luo, Xin;
Zhang, Zexin;
Mu, Ruijing;
Hu, Guangyu;
Liu, Li;
Liu, Xiaodong

Publication type:

Article

Physiologically Based Pharmacokinetic Modelling to Predict Pharmacokinetics of Enavogliflozin, a Sodium-Dependent Glucose Transporter 2 Inhibitor, in Humans.

Published in:

Pharmaceutics, 2023, v. 15, n. 3, p. 942, doi. 10.3390/pharmaceutics15030942

By:

Kim, Min-Soo;
Song, Yoo-Kyung;
Choi, Ji-Soo;
Ji, Hye Young;
Yang, Eunsuk;
Park, Joon Seok;
Kim, Hyung Sik;
Kim, Min-Joo;
Cho, In-Kyung;
Chung, Suk-Jae;
Chae, Yoon-Jee;
Lee, Kyeong-Ryoon

Publication type:

Article

Application of Physiologically Based Pharmacokinetic Modeling to Predict Maternal Pharmacokinetics and Fetal Exposure to Oxcarbazepine.

Published in:

Pharmaceutics, 2022, v. 14, n. 11, p. 2367, doi. 10.3390/pharmaceutics14112367

By:

He, Lixia;
Ke, Meng;
Wu, Wanhong;
Chen, Jiarui;
Guo, Guimu;
Lin, Rongfang;
Huang, Pinfang;
Lin, Cuihong

Publication type:

Article

The Impact of Low Cardiac Output on Propofol Pharmacokinetics across Age Groups—An Investigation Using Physiologically Based Pharmacokinetic Modelling.

Published in:

Pharmaceutics, 2022, v. 14, n. 9, p. N.PAG, doi. 10.3390/pharmaceutics14091957

By:

Allegaert, Karel;
Abbasi, Mohammad Yaseen;
Michelet, Robin;
Olafuyi, Olusola

Publication type:

Article

A Physiologically Based Pharmacokinetic Model for Predicting Diazepam Pharmacokinetics after Intravenous, Oral, Intranasal, and Rectal Applications.

Published in:

Pharmaceutics, 2021, v. 13, n. 9, p. 1480, doi. 10.3390/pharmaceutics13091480

By:

Khalid, Sundus;
Rasool, Muhammad Fawad;
Imran, Imran;
Majeed, Abdul;
Saeed, Hamid;
Rehman, Anees ur;
Ashraf, Waseem;
Ahmad, Tanveer;
Bin Jardan, Yousef A.;
Alqahtani, Faleh

Publication type:

Article

Pharmacokinetic Characterization of Supinoxin and Its Physiologically Based Pharmacokinetic Modeling in Rats.

Published in:

Pharmaceutics, 2021, v. 13, n. 3, p. 373, doi. 10.3390/pharmaceutics13030373

By:

Song, Yoo-Kyung;
Seol, Yun-Hwan;
Kim, Min Ju;
Jeong, Jong-Woo;
Choi, Hae-In;
Lee, Seung-Won;
Chae, Yoon-Jee;
Ahn, Sunjoo;
Gong, Young-Dae;
Lee, Kyeong-Ryoon;
Koo, Tae-Sung;
Kim, Yu Chul

Publication type:

Article

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen.

Published in:

Pharmaceutics, 2020, v. 12, n. 11, p. 1049, doi. 10.3390/pharmaceutics12111049

By:

Loisios-Konstantinidis, Ioannis;
Cristofoletti, Rodrigo;
Jamei, Masoud;
Turner, David;
Dressman, Jennifer

Publication type:

Article

Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients.

Published in:

Pharmaceutics, 2020, v. 12, n. 10, p. 908, doi. 10.3390/pharmaceutics12100908

By:

Kovar, Lukas;
Weber, Andreas;
Zemlin, Michael;
Kohl, Yvonne;
Bals, Robert;
Meibohm, Bernd;
Selzer, Dominik;
Lehr, Thorsten

Publication type:

Article

Predicting Pharmacokinetics of Active Constituents in Spatholobi caulis by Using Physiologically Based Pharmacokinetic Models.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 12, p. 1621, doi. 10.3390/ph17121621

By:

Liu, Xiaoyan;
Du, Ruihu;
Zhang, Tao;
Li, Yingzi;
Li, Ludi;
Yang, Zheng;
Zhang, Youbo;
Wang, Qi

Publication type:

Article

Simulation of differential drug pharmacokinetics under heat and exercise stress using a physiologically based pharmacokinetic modeling approach.

Published in:

Canadian Journal of Physiology & Pharmacology, 2011, v. 89, n. 5, p. 365, doi. 10.1139/y11-030

By:

Sidhu, Pardeep;
Peng, Henry T.;
Cheung, Bob;
Edginton, Andrea

Publication type:

Article

Evaluation of Oral and Intravenous Route Pharmacokinetics, Plasma Protein Binding, and Uterine Tissue Dose Metrics of Bisphenol A: A Physiologically Based Pharmacokinetic Approach.

Published in:

Toxicological Sciences, 2005, v. 85, n. 2, p. 823, doi. 10.1093/toxsci/kfi135

By:

Teeguarden, Justin G.;
Waechter Jr., John M.;
Clewell III, Harvey J.;
Covington, Tammie R.;
Barton, Hugh A.

Publication type:

Article

Determination of Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Parameters of Doxycycline against Edwardsiella ictaluri in Yellow Catfish (Pelteobagrus fulvidraco).

Published in:

Antibiotics (2079-6382), 2021, v. 10, n. 3, p. 329, doi. 10.3390/antibiotics10030329

By:

Xu, Ning;
Li, Miao;
Ai, Xiaohui;
Lin, Zhoumeng;
Puvača, Nikola

Publication type:

Article

Pharmacokinetics of Levornidazole Tablet in Healthy Chinese Subjects and Proposed Dosing Regimen Based on Pharmacokinetic/Pharmacodynamic Analysis.

Published in:

Infectious Diseases & Therapy, 2021, v. 10, n. 2, p. 911, doi. 10.1007/s40121-021-00428-4

By:

Wu, Hailan;
Wang, Zhiqiang;
Wang, Yu;
Yu, Jicheng;
Fan, Yaxin;
Li, Yi;
Wang, Jingjing;
Cao, Guoying;
Guo, Beining;
Chen, Yuancheng;
Liu, Xiaofen;
Bian, Xingchen;
Wu, Jufang;
Li, Hongtao;
Wu, Xiaojie;
Zhang, Jing

Publication type:

Article

Pharmacokinetics of plasma-derived and recombinant factor IX: using population pharmacokinetics with sparse sampling data needs further study.

Published in:

Haemophilia, 2013, v. 19, n. 6, p. 805, doi. 10.1111/hae.12277

By:

Berntorp, E.

Publication type:

Article

Unraveling bisphenol A pharmacokinetics using physiologically based pharmacokinetic modeling.

Published in:

Frontiers in Pharmacology, 2015, v. 5, p. 1, doi. 10.3389/fphar.2014.00292

By:

Xiaoxia Yang;
Fisher, Jeffrey W.;
Barton, Hugh A.

Publication type:

Article

UNDERSTANDING AND APPLICATION OF CLINICAL PHARMACOKINETIC PRINCIPLES: SINGLE-COMPARTMENT PHARMACOKINETIC SIMULATION MODEL.

Published in:

National Journal of Physiology, Pharmacy & Pharmacology, 2015, v. 5, n. 1, p. 76, doi. 10.5455/njppp.2015.5.010820143

By:

Zala, Ashishkumar;
Kantharia, N. D.;
Shah, Aashal B.

Publication type:

Article

Pre-clinical pharmacokinetics of UK-453,061, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI), and use of in silico physiologically based prediction tools to predict the oral pharmacokinetics of UK-453,061 in man.

Published in:

Xenobiotica, 2008, v. 38, n. 6, p. 620, doi. 10.1080/00498250802069088

By:

Allan, G.;
Davis, J.;
Dickins, M.;
Gardner, I.;
Jenkins, T.;
Jones, H.;
Webster, R.;
Westgate, H.

Publication type:

Article

Pharmacokinetic–pharmacodynamic relationship of rocuronium under stable nitrous oxide–fentanyl or nitrous oxide–sevoflurane anesthesia in children.

Published in:

Pediatric Anesthesia, 2006, v. 16, n. 7, p. 761, doi. 10.1111/j.1460-9592.2005.01840.x

By:

Woloszczuk-Gebicka, Bogumila;
Wyska, Elzbieta;
Grabowski, Tomasz;
Świerczewska, Anna;
Sawicka, Renata

Publication type:

Article

Factors influencing lithium pharmacokinetics in patients with acute mania: A population pharmacokinetic analysis.

Published in:

Human Psychopharmacology: Clinical & Experimental, 2019, v. 34, n. 3, p. 1, doi. 10.1002/hup.2697

By:

Methaneethorn, Janthima;
Sringam, Sawitree

Publication type:

Article

Plasma and CNS pharmacokinetics of O-benzylfolic acid (OBF) and metabolite in a non-human primate model.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 67, n. 6, p. 1291, doi. 10.1007/s00280-010-1407-9

By:

Chuk, Meredith;
Cole, Diane;
McCully, Cynthia;
Loktionova, Natalia;
Pegg, Anthony;
Parker, Robert;
Pauly, Gary;
Widemann, Brigitte;
Balis, Frank;
Fox, Elizabeth

Publication type:

Article

Plasma and cerebrospinal fluid pharmacokinetics of gemcitabine after intravenous administration in nonhuman primates.

Published in:

2001

By:

Kerr, Jody Z.;
Berg, Stacey L.;
Dauser, Robert;
Nuchtern, Jed;
Egorin, Merrill J.;
McGuffey, Leticia;
Aleksic, Alexander;
Blaney, Susan;
Kerr, J Z;
Berg, S L;
Dauser, R;
Nuchtern, J;
Egorin, M J;
McGuffey, L;
Aleksic, A;
Blaney, S

Publication type:

journal article

Population pharmacokinetics of micafungin over repeated doses in critically ill patients: a need for a loading dose?

Published in:

Journal of Pharmacy & Pharmacology, 2020, v. 72, n. 12, p. 1750, doi. 10.1111/jphp.13353

By:

Kapralos, Iasonas;
Mainas, Efstratios;
Neroutsos, Efthymios;
Apostolidi, Stella;
Siopi, Maria;
Apostolopoulou, Olympia;
Dimopoulos, George;
Sambatakou, Helen;
Valsami, Georgia;
Meletiadis, Joseph;
Dokoumetzidis, Aristides

Publication type:

Article

Herb-drug pharmacokinetic interaction of artificial calculus bovis with diclofenac sodium and chlorpheniramine maleate in rats.

Published in:

Journal of Pharmacy & Pharmacology, 2013, v. 65, n. 7, p. 1064, doi. 10.1111/jphp.12069

By:

Peng, Can;
Lv, Mengying;
Tian, Jixin;
Huang, Yin;
Tian, Yuan;
Zhang, Zunjian

Publication type:

Article

Integration of dissolution into physiologically-based pharmacokinetic models III: PK-Sim<sup>®</sup>.

Published in:

Journal of Pharmacy & Pharmacology, 2012, v. 64, n. 7, p. 997, doi. 10.1111/j.2042-7158.2012.01534.x

By:

Willmann, Stefan;
Thelen, Kirstin;
Lippert, Jörg

Publication type:

Article