Works matching Mutation and mutagenesis

Results: 1757

Mutation Induced Extinction in Finite Populations: Lethal Mutagenesis and Lethal Isolation.

Published in:

PLoS Computational Biology, 2012, v. 8, n. 8, p. 1, doi. 10.1371/journal.pcbi.1002609

By:

Wylie, C. Scott;
Shakhnovich, Eugene I.

Publication type:

Article

Quantitative evaluation of DNA damage and mutation rate by atmospheric and room-temperature plasma (ARTP) and conventional mutagenesis.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 13, p. 5639, doi. 10.1007/s00253-015-6678-y

By:

Zhang, Xue;
Zhang, Chong;
Zhou, Qian-Qian;
Zhang, Xiao-Fei;
Wang, Li-Yan;
Chang, Hai-Bo;
Li, He-Ping;
Oda, Yoshimitsu;
Xing, Xin-Hui

Publication type:

Article

A machine learning enhanced EMS mutagenesis probability map for efficient identification of causal mutations in Caenorhabditis elegans.

Published in:

PLoS Genetics, 2024, v. 20, n. 8, p. 1, doi. 10.1371/journal.pgen.1011377

By:

Guo, Zhengyang;
Wang, Shimin;
Wang, Yang;
Wang, Zi;
Ou, Guangshuo

Publication type:

Article

High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31818-y

By:

Cortés-López, Mariela;
Schulz, Laura;
Enculescu, Mihaela;
Paret, Claudia;
Spiekermann, Bea;
Quesnel-Vallières, Mathieu;
Torres-Diz, Manuel;
Unic, Sebastian;
Busch, Anke;
Orekhova, Anna;
Kuban, Monika;
Mesitov, Mikhail;
Mulorz, Miriam M.;
Shraim, Rawan;
Kielisch, Fridolin;
Faber, Jörg;
Barash, Yoseph;
Thomas-Tikhonenko, Andrei;
Zarnack, Kathi;
Legewie, Stefan

Publication type:

Article

Editorial: Mutational breeding: from induced mutations to site-directed mutagenesis.

Published in:

Frontiers in Plant Science, 2024, p. 1, doi. 10.3389/fpls.2024.1511363

By:

Rasmussen, Søren K.;
Jain, Shri Mohan

Publication type:

Article

Computational saturation mutagenesis to explore the effect of pathogenic mutations on extra-cellular domains of TREM2 associated with Alzheimer's and Nasu-Hakola disease.

Published in:

Journal of Molecular Modeling, 2023, v. 29, n. 11, p. 1, doi. 10.1007/s00894-023-05770-7

By:

Swain, Preety Sthutika;
Panda, Sunita;
Pati, Sanghamitra;
Dehury, Budheswar

Publication type:

Article

Efficient collection of a large number of mutations by mutagenesis of DNA damage response defective animals.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-87226-7

By:

Suehiro, Yuji;
Yoshina, Sawako;
Motohashi, Tomoko;
Iwata, Satoru;
Dejima, Katsufumi;
Mitani, Shohei

Publication type:

Article

Generation of eight adjacent mutations in a single step using a site-directed mutagenesis kit.

Published in:

Clinical Chemistry & Laboratory Medicine, 2004, v. 42, n. 4, p. 384, doi. 10.1515/CCLM.2004.068

By:

Cabré, Anna;
Girona, Josefa;
Zalba, Guillermo;
Moreno, María-Ujué;
Díez, Javier;
Masana, Lluís

Publication type:

Article

Amino acid substitutions in random mutagenesis libraries: lessons from analyzing 3000 mutations.

Published in:

Applied Microbiology & Biotechnology, 2017, v. 101, n. 8, p. 3177, doi. 10.1007/s00253-016-8035-1

By:

Zhao, Jing;
Frauenkron-Machedjou, Victorine;
Kardashliev, Tsvetan;
Ruff, Anna;
Zhu, Leilei;
Bocola, Marco;
Schwaneberg, Ulrich

Publication type:

Article

Population persistence under high mutation rate: From evolutionary rescue to lethal mutagenesis.

Published in:

Evolution, 2019, v. 73, n. 8, p. 1517, doi. 10.1111/evo.13771

By:

Anciaux, Yoann;
Lambert, Amaury;
Ronce, Ophélie;
Roques, Lionel;
Martin, Guillaume

Publication type:

Article

Adaptive Resistance Mutations at Suprainhibitory Concentrations Independent of SOS Mutagenesis.

Published in:

Molecular Biology & Evolution, 2021, v. 38, n. 10, p. 4095, doi. 10.1093/molbev/msab196

By:

Gutiérrez, Ricardo;
Ram, Yoav;
Berman, Judith;
Sousa, Keyla Carstens Marques de;
Nachum-Biala, Yaarit;
Britzi, Malka;
Elad, Daniel;
Glaser, Gad;
Covo, Shay;
Harrus, Shimon

Publication type:

Article

Identification of a Novel Point Mutation of Mouse Proto-Oncogene c-kit Through N-Ethyl-N-nitrosourea Mutagenesis.

Published in:

Genetics, 2005, v. 169, n. 2, p. 819, doi. 10.1534/genetics.104.027177

By:

Hai-Bin Ruan;
Nian Zhang;
Xiang Gao

Publication type:

Article

Dependence of Epistasis on Environment and Mutation Severity as Revealed by in Silico Mutagenesis of Phage T7.

Published in:

Genetics, 2002, v. 160, n. 4, p. 1273, doi. 10.1093/genetics/160.4.1273

By:

Lingchong You;
Yin, John

Publication type:

Article

Zinc finger nucleases for targeted mutagenesis and repair of the sickle-cell disease mutation: An in-silico study.

Published in:: BMC Blood Disorders, 2012, v. 12, n. 1, p. 5, doi. 10.1186/1471-2326-12-5
Publication type:: Article

Prenatal diagnosis of X-linked hyper-IGM syndrome by direct detection of mutation Q220X in the CD40L gene using PCR-mediated site directed mutagenesis.

Published in:

Prenatal Diagnosis, 2000, v. 20, n. 10, p. 822, doi. 10.1002/1097-0223(200010)20:10<822::AID-PD935>3.0.CO;2-K

By:

Jayoussi-Assalia, R.;
Etzioni, A.;
Notarangelo, L.D.;
Brill-Zamir, R.;
Kasinetz, L.;
Kadouri, E;
Gershoni-Baruch, R.

Publication type:

Article

Hypomorphic mutation in the large subunit of replication protein A affects mutagenesis by human APOBEC cytidine deaminases in yeast.

Published in:

G3: Genes | Genomes | Genetics, 2024, v. 14, n. 10, p. 1, doi. 10.1093/g3journal/jkae196

By:

Dennen, Matthew S;
Kockler, Zachary W;
Roberts, Steven A;
Burkholder, Adam B;
Klimczak, Leszek J;
Gordenin, Dmitry A

Publication type:

Article

Random Mutagenesis of β-Tubulin Defines a Set of Dispersed Mutations That Confer Paclitaxel Resistance.

Published in:

Pharmaceutical Research, 2012, v. 29, n. 11, p. 2994, doi. 10.1007/s11095-012-0794-5

By:

Yin, Shanghua;
Zeng, Changqing;
Hari, Malathi;
Cabral, Fernando

Publication type:

Article

An updated system for the targeted mutagenesis of the psbDI:psbC operon in Synechocystis sp. PCC 6803: mutations targeting Asp460 in CP43 of Photosystem II reduce oxygen-evolving activity and perturb electron transfer in the quinone-Fe-acceptor complex.

Published in:

New Zealand Journal of Botany, 2020, v. 58, n. 4, p. 389, doi. 10.1080/0028825X.2020.1771383

By:

Khaing, Ei Phyo;
Zhong, Victor;
Eaton-Rye, Julian J.

Publication type:

Article

An improved system for the targeted mutagenesis of the psbA2 gene in Synechocystis sp. PCC 6803: mutation of D1-Glu244 to His impairs electron transfer between QA and QB of Photosystem II.

Published in:

New Zealand Journal of Botany, 2019, v. 57, n. 2, p. 125, doi. 10.1080/0028825X.2019.1617321

By:

Forsman, Jack A.;
Winter, Regan T.;
Eaton-Rye, Julian J.

Publication type:

Article

Rapid Mutation of Spirulina platensis by a New Mutagenesis System of Atmospheric and Room Temperature Plasmas (ARTP) and Generation of a Mutant Library with Diverse Phenotypes.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0077046

By:

Fang, Mingyue;
Jin, Lihua;
Zhang, Chong;
Tan, Yinyee;
Jiang, Peixia;
Ge, Nan;
Heping Li;
Xing, Xinhui

Publication type:

Article

A shifting mutational landscape in 6 nutritional states: Stress-induced mutagenesis as a series of distinct stress input–mutation output relationships.

Published in:

PLoS Biology, 2017, v. 15, n. 6, p. 1, doi. 10.1371/journal.pbio.2001477

By:

Maharjan, Ram P.;
Ferenci, Thomas

Publication type:

Article

TP53 mutations in squamous-cell carcinomas of the conjunctiva: evidence for UV-induced mutagenesis.

Published in:

Mutagenesis, 2004, v. 19, n. 5, p. 399, doi. 10.1093/mutage/geh048

By:

Ateenyi-Agaba, Charles;
Min Dai;
Le Calvez, Florence;
Katongole-Mbidde, Edward;
Smet, Anouk;
Tommasino, Massimo;
Franceschi, Silvia;
Hainaut, Pierre;
Weiderpass, Elisabete

Publication type:

Article

Computational Saturation Mutagenesis to Investigate the Effects of Neurexin-1 Mutations on AlphaFold Structure.

Published in:

Genes, 2022, v. 13, n. 5, p. 789, doi. 10.3390/genes13050789

By:

Rhoades, Raina;
Henry, Brianna;
Prichett, Dominique;
Fang, Yayin;
Teng, Shaolei

Publication type:

Article

Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL.

Published in:

Mammalian Genome, 2017, v. 28, n. 11/12, p. 465, doi. 10.1007/s00335-017-9716-5

By:

Speca, David;
Trimmer, James;
Peterson, Andrew;
Díaz, Elva

Publication type:

Article

A phenotype-driven ENU mutagenesis screen for the identification of dominant mutations involved in alcohol consumption.

Published in:

Mammalian Genome, 2008, v. 19, n. 2, p. 77, doi. 10.1007/s00335-007-9087-4

By:

Pawlak, Cornelius R.;
Sanchis-Segura, Carles;
Soewarto, Dian;
Wagner, Sibylle;
de Angelis, Martin Hrabé;
Spanagel, Rainer

Publication type:

Article

Identification of mutations from phenotype-driven ENU mutagenesis in mouse Chromosome 7.

Published in:

Mammalian Genome, 2005, v. 16, n. 8, p. 555, doi. 10.1007/s00335-005-0032-0

By:

Culiat, Cymbeline T.;
Klebig, Mitchell L.;
Zhaowei Liu;
Monroe, Heidi;
Stanford, Beverly;
Desai, Jayashree;
Tandan, Samvit;
Hughes, Lori;
Kerley, Marilyn K.;
Carpenter, Donald A.;
Johnson, Dabney K.;
Rinchik, Eugene M.;
Qingbo Li

Publication type:

Article

Genomewide two-generation screens for recessive mutations by ES cell mutagenesis.

Published in:

Mammalian Genome, 2004, v. 15, n. 12, p. 960, doi. 10.1007/s00335-004-2406-0

By:

Munroe, Robert;
Ackerman, Susan;
Schimenti, John

Publication type:

Article

Identification of dominant mutations that confer increased aluminium tolerance through mutagenesis of the Al-sensitive Arabidopsis mutant, als3-1.

Published in:

Journal of Experimental Botany, 2006, v. 57, n. 4, p. 943, doi. 10.1093/jxb/erj080

By:

Gabrielson, Kelly M.;
Cancel, Jesse D.;
Morua, Luis F.;
Larsen, Paul B.

Publication type:

Article

Prediction of the Effects of Missense Mutations on Human Myeloperoxidase Protein Stability Using In Silico Saturation Mutagenesis.

Published in:

Genes, 2022, v. 13, n. 8, p. 1412, doi. 10.3390/genes13081412

By:

Sobitan, Adebiyi;
Edwards, William;
Jalal, Md Shah;
Kolawole, Ayanfeoluwa;
Ullah, Hemayet;
Duttaroy, Atanu;
Li, Jiang;
Teng, Shaolei

Publication type:

Article

Site‐directed mutagenesis, expression, purification and translesion synthesis analysis of human DNA polymerase η mutations found in xeroderma pigmentosum variant and melanoma patients.

Published in:

FASEB Journal, 2013, v. 27, p. 976.2, doi. 10.1096/fasebj.27.1_supplement.976.2

By:

Kumar, Mukesh;
Jiang, Xiaohua

Publication type:

Article

A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.

Published in:

2004

By:

Toye, Ayo A.;
Moir, Lee;
Hugill, Alison;
Bentley, Liz;
Quarterman, Julie;
Mijat, Vesna;
Hough, Tertius;
Goldsworthy, Michelle;
Haynes, Alison;
Hunter, A. Jacqueline;
Browne, Mick;
Spurr, Nigel;
Cox, Roger D.

Publication type:

journal article

Mechanisms of mutagenesis induced by DNA lesions: multiple factors affect mutations in translesion DNA synthesis.

Published in:

2020

By:

Zhang, Huidong

Publication type:

Literature Review

A method for introducing site-specific mutations using oligonucleotide primers and its application to site-saturation mutagenesis.

Published in:

Molecular Biotechnology, 1996, v. 6, n. 2, p. 179, doi. 10.1007/BF02740772

By:

O'Donohue, Michael;
Geoff Kneale, G.

Publication type:

Article

Site-directed saturation mutagenesis at residue F420 and recombination with another beneficial mutation of Ralstonia eutropha polyhydroxyalkanoate synthase.

Published in:

Biotechnology Letters, 2005, v. 27, n. 10, p. 705, doi. 10.1007/s10529-005-5186-z

By:

Normi, Yahaya M.;
Hiraishi, Tomohiro;
Taguchi, Seiichi;
Sudesh, Kumar;
Najimudin, Nazalan;
Doi, Yoshiharu

Publication type:

Article

Site-directed mutagenesis by biolistic transformation efficiently generates inheritable mutations in a targeted locus in soybean somatic embryos and transgene-free descendants in the T1 generation.

Published in:

Transgenic Research, 2021, v. 30, n. 1, p. 77, doi. 10.1007/s11248-020-00229-4

By:

Adachi, Kohei;
Hirose, Aya;
Kanazashi, Yuhei;
Hibara, Miki;
Hirata, Toshiyuki;
Mikami, Masafumi;
Endo, Masaki;
Hirose, Sakiko;
Maruyama, Nobuyuki;
Ishimoto, Masao;
Abe, Jun;
Yamada, Tetsuya

Publication type:

Article

Analysis of gene expression and mutation data points on contribution of transcription to the mutagenesis by APOBEC enzymes.

Published in:

NAR Cancer, 2021, v. 3, n. 3, p. 1, doi. 10.1093/narcan/zcab025

By:

Chervova, Almira;
Fatykhov, Bulat;
Koblov, Alexander;
Shvarov, Evgeny;
Preobrazhenskaya, Julia;
Vinogradov, Dmitry;
Ponomarev, Gennady V.;
Gelfand, Mikhail S.;
Kazanov, Marat D.

Publication type:

Article

Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.87730

By:

Jain, Nina K.;
Ogden, Pierce J.;
Church, George M.

Publication type:

Article

iMUT-seq: high-resolution DSB-induced mutation profiling reveals prevalent homologous-recombination dependent mutagenesis.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-44167-1

By:

Bader, Aldo S.;
Bushell, Martin

Publication type:

Article

iMUT-seq: high-resolution DSB-induced mutation profiling reveals prevalent homologous-recombination dependent mutagenesis.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-44167-1

By:

Bader, Aldo S.;
Bushell, Martin

Publication type:

Article

Genomic-Destabilization-Associated Mutagenesis and Clonal Evolution of Cells with Mutations in Tumor-Suppressor Genes.

Published in:

Cancers, 2019, v. 11, n. 11, p. 1643, doi. 10.3390/cancers11111643

By:

Yoshioka, Ken-ichi;
Matsuno, Yusuke;
Hyodo, Mai;
Fujimori, Haruka

Publication type:

Article

Are transversion mutations better? A Mutagenesis Assistant Program analysis on P450 BM-3 heme domain.

Published in:

Biotechnology Journal, 2007, v. 2, n. 1, p. 133, doi. 10.1002/biot.200600201

By:

Wong, Tuck Seng;
Roccatano, Danilo;
Schwaneberg, Ulrich

Publication type:

Article

Enhancement of the Enzymatic Activity of Escherichia coli Acetyl Esterase by a Double Mutation Obtained by Random Mutagenesis.

Published in:

Bioscience, Biotechnology & Biochemistry, 2012, v. 76, n. 11, p. 2082, doi. 10.1271/bbb.120430

By:

KOBAYASHI, Ryuichi;
HIRANO, Nobutaka;
KANAYA, Shigenori;
HARUKI, Mitsuru

Publication type:

Article

A Model of Genetic Search for Beneficial Mutations: Estimating the Constructive Capacities of Mutagenesis.

Published in:

Journal of Molecular Evolution, 2011, v. 73, n. 5/6, p. 337, doi. 10.1007/s00239-011-9482-z

By:

Ananko, Grigory

Publication type:

Article

EMS mutagenesis and qPCR-HRM prescreening for point mutations in an embryogenic cell suspension of grapevine.

Published in:

Plant Cell Reports, 2014, v. 33, n. 3, p. 471, doi. 10.1007/s00299-013-1547-6

By:

Acanda, Yosvanis;
Martínez, Óscar;
Prado, María;
González, María;
Rey, Manuel

Publication type:

Article

Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein DinB.

Published in:

Genes to Cells, 1999, v. 4, n. 11, p. 607, doi. 10.1046/j.1365-2443.1999.00289.x

By:

Ogi, Tomoo;
Kato, Tomohisa;
Kato, Takesi;
Ohmori, Haruo

Publication type:

Article

HRM-facilitated rapid identification and genotyping of mutations induced by CRISPR/Cas9 mutagenesis in rice.

Published in:

Crop Breeding & Applied Biotechnology, 2018, v. 18, n. 2, p. 184, doi. 10.1590/1984-70332018v18n2a26

By:

Shan Li;
Songmei Liu;
Yanhua Liu;
Haiping Lu;
Yuanyuan Tan;
Jianzhong Huang;
Pengcheng Wei;
Qing Yao Shu

Publication type:

Article

Site-directed mutagenesis of the T4 endonuclease V Gene: Mutations which enhance enzyme specific activity at low salt concentrations.

Published in:

Proteins, 1989, v. 6, n. 2, p. 128, doi. 10.1002/prot.340060204

By:

Lloyd, R. Stephen;
Augustine, Mary Lou

Publication type:

Article

Error-prone PCR mutagenesis and reverse bacterial two-hybrid screening identify a mutation in asparagine 53 of the Staphylococcus aureus ESAT6-like component EsxB that perturbs interaction with EsxD.

Published in:

Folia Microbiologica, 2018, v. 63, n. 4, p. 483, doi. 10.1007/s12223-018-0591-6

By:

Ibrahim, Amany M.;
Ragab, Yasser M.;
Aly, Khaled A.;
Ramadan, Mohamed A.

Publication type:

Article

The HIV Mutation Browser: A Resource for Human Immunodeficiency Virus Mutagenesis and Polymorphism Data.

Published in:

PLoS Computational Biology, 2014, v. 10, n. 12, p. 1, doi. 10.1371/journal.pcbi.1003951

By:

Davey, Norman E.;
Satagopam, Venkata P.;
Santiago-Mozos, Salvador;
Villacorta-Martin, Carlos;
Bharat, Tanmay A. M.;
Schneider, Reinhard;
Briggs, John A. G.

Publication type:

Article

Molecular Evolution of a Defined DNA Sequence with Accumulation of Mutations in a Single Round by a Dual Approach to Random Chemical Mutagenesis (DuARCheM).

Published in:

ChemBioChem, 2008, v. 9, n. 14, p. 2238, doi. 10.1002/cbic.200800259

By:

Mohan, Utpal;
Banerjee, Uttam Chand

Publication type:

Article