Works matching Mutagenesis and cancer

Results: 555

DNA replication initiation drives focal mutagenesis and rearrangements in human cancers.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-55148-3

By:

Murat, Pierre;
Guilbaud, Guillaume;
Sale, Julian E.

Publication type:

Article

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers.

Published in:

Nature Genetics, 2013, v. 45, n. 9, p. 970, doi. 10.1038/ng.2702

By:

Roberts, Steven A;
Lawrence, Michael S;
Klimczak, Leszek J;
Grimm, Sara A;
Fargo, David;
Stojanov, Petar;
Kiezun, Adam;
Kryukov, Gregory V;
Carter, Scott L;
Saksena, Gordon;
Harris, Shawn;
Shah, Ruchir R;
Resnick, Michael A;
Getz, Gad;
Gordenin, Dmitry A

Publication type:

Article

APOBEC Mutagenesis in Cancer Development and Susceptibility.

Published in:

Cancers, 2024, v. 16, n. 2, p. 374, doi. 10.3390/cancers16020374

By:

Dananberg, Alexandra;
Striepen, Josefine;
Rozowsky, Jacob S.;
Petljak, Mia

Publication type:

Article

Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse.

Published in:

Nature, 2005, v. 436, n. 7048, p. 272, doi. 10.1038/nature03681

By:

Collier, Lara S.;
Carlson, Corey M.;
Ravimohan, Shruthi;
Dupuy, Adam J.;
Largaespada, David A.

Publication type:

Article

Mechanisms of Base Substitution Mutagenesis in Cancer Genomes.

Published in:

Genes, 2014, v. 5, n. 1, p. 108, doi. 10.3390/genes5010108

By:

Bacolla, Albino;
Cooper, David N.;
Vasquez, Karen M.

Publication type:

Article

APOBEC3B mutagenesis in cancer.

Published in:

Nature Genetics, 2013, v. 45, n. 9, p. 964, doi. 10.1038/ng.2736

By:

Kuong, Kawai J;
Loeb, Lawrence A

Publication type:

Article

Transposon Insertion Mutagenesis in Mice for Modeling Human Cancers: Critical Insights Gained and New Opportunities.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 3, p. 1172, doi. 10.3390/ijms21031172

By:

Beckmann, Pauline J.;
Largaespada, David A.

Publication type:

Article

Identification of a signature of evolutionarily conserved stress-induced mutagenesis in cancer.

Published in:

Frontiers in Genetics, 2022, v. 13, p. 1, doi. 10.3389/fgene.2022.932763

By:

Cisneros, Luis H.;
Vaske, Charles;
Bussey, Kimberly J.

Publication type:

Article

The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42653-0

By:

Bayona-Feliu, Aleix;
Herrera-Moyano, Emilia;
Badra-Fajardo, Nibal;
Galván-Femenía, Iván;
Soler-Oliva, María Eugenia;
Aguilera, Andrés

Publication type:

Article

Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness.

Published in:

BioEssays, 2014, v. 36, n. 4, p. 382, doi. 10.1002/bies.201300140

By:

Roberts, Steven A.;
Gordenin, Dmitry A.

Publication type:

Article

Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer.

Published in:

Nature Methods, 2013, v. 10, n. 2, p. 155, doi. 10.1038/nmeth.2331

By:

Ranzani, Marco;
Cesana, Daniela;
Bartholomae, Cynthia C;
Sanvito, Francesca;
Pala, Mauro;
Benedicenti, Fabrizio;
Gallina, Pierangela;
Sergi, Lucia Sergi;
Merella, Stefania;
Bulfone, Alessandro;
Doglioni, Claudio;
von Kalle, Christof;
Kim, Yoon Jun;
Schmidt, Manfred;
Tonon, Giovanni;
Naldini, Luigi;
Montini, Eugenio

Publication type:

Article

Clonal Expansion Analysis of Transposon Insertions by High-Throughput Sequencing Identifies Candidate Cancer Genes in a PiggyBac Mutagenesis Screen.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0072338

By:

Friedel, Roland H.;
Friedel, Caroline C.;
Bonfert, Thomas;
Shi, Ruijin;
Rad, Roland;
Soriano, Philippe

Publication type:

Article

FAM72A promotes UNG2 degradation and mutagenesis in human cancer cells.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-07723-x

By:

Feng, Yuqing;
Barbulescu, Philip;
Chana, Chetan K.;
Shirdarreh, Melika;
Yang, Hong;
Wu, Lizhen;
Mamand, Sami;
Kashem, Mohammad;
Zia, Amin;
Han, Ming;
Tsao, Julissa;
Pugh, Trevor;
Cescon, David;
Schatz, David G.;
Sicheri, Frank;
Martin, Alberto;
Pezo, Rossanna C.

Publication type:

Article

Parental mutagenesis and familial cancer.

Published in:

Nature, 1982, v. 296, n. 5857, p. 488, doi. 10.1038/296488a0

By:

Evans, H.J.

Publication type:

Article

Elucidating PIK3CA‐cooperating mutations in breast cancer using an inducible and mammary‐specific genetic mutagenesis system.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R2907

By:

Palisoc, Maryknoll;
Gestl, Shelley;
Gunther, Edward

Publication type:

Article

Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis.

Published in:

Cancer Science, 2021, v. 112, n. 6, p. 2089, doi. 10.1111/cas.14901

By:

Takeda, Haruna;
Jenkins, Nancy A.;
Copeland, Neal G.

Publication type:

Article

Gene trap mutagenesis in mice: New perspectives and tools in cancer research.

Published in:

Cancer Science, 2008, v. 99, n. 1, p. 1, doi. 10.1111/j.1349-7006.2007.00611.x

By:

Yamamura, Ken-ichi;
Araki, Kimi

Publication type:

Article

Computational identification of insertional mutagenesis targets for cancer gene discovery.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 15, p. e105, doi. 10.1093/nar/gkr447

By:

de Jong, Johann;
de Ridder, Jeroen;
van der Weyden, Louise;
Sun, Ning;
van Uitert, Miranda;
Berns, Anton;
van Lohuizen, Maarten;
Jonkers, Jos;
Adams, David J.;
Wessels, Lodewyk F. A.

Publication type:

Article

MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer.

Published in:

Nature Genetics, 2007, v. 39, n. 6, p. 759, doi. 10.1038/ng2034

By:

Theodorou, Vassiliki;
Kimm, Melanie A.;
Boer, Mandy;
Wessels, Lodewyk;
Theelen, Wendy;
Jonkers, Jos;
Hilkens, John

Publication type:

Article

Decreased Mitochondrial DNA Mutagenesis in Human Colorectal Cancer.

Published in:

PLoS Genetics, 2012, v. 8, n. 6, p. 1, doi. 10.1371/journal.pgen.1002689

By:

Ericson, Nolan G.;
Kulawiec, Mariola;
Vermulst, Marc;
Sheahan, Kieran;
O'Sullivan, Jacintha;
Salk, Jesse J.;
Bielas, Jason H.

Publication type:

Article

δ-Catenin, a Wnt/β-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming.

Published in:

Oncogene, 2015, v. 34, n. 12, p. 1542, doi. 10.1038/onc.2014.89

By:

Nopparat, J;
Zhang, J;
Lu, J-P;
Chen, Y-H;
Zheng, D;
Neufer, P D;
Fan, J M;
Hong, H;
Boykin, C;
Lu, Q

Publication type:

Article

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers.

Published in:

Nature Genetics, 2015, v. 47, n. 9, p. 1067, doi. 10.1038/ng.3378

By:

Sterling, Joan F;
Malc, Ewa P;
Fargo, David C;
Mieczkowski, Piotr A;
Kwiatkowski, David J;
Saini, Natalie;
Kim, Jaegil;
Roberts, Steven A;
Getz, Gad;
Chan, Kin;
Gordenin, Dmitry A;
Klimczak, Leszek J

Publication type:

Article

Evidence for APOBEC3B mutagenesis in multiple human cancers.

Published in:

Nature Genetics, 2013, v. 45, n. 9, p. 977, doi. 10.1038/ng.2701

By:

Burns, Michael B;
Temiz, Nuri A;
Harris, Reuben S

Publication type:

Article

Chemically-Induced DNA Damage, Mutagenesis, and Cancer.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 6, p. 1767, doi. 10.3390/ijms19061767

By:

Basu, Ashis K.;
Nohmi, Takehiko

Publication type:

Article

DNA Damage, Mutagenesis and Cancer.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 4, p. 970, doi. 10.3390/ijms19040970

By:

Basu, Ashis K.

Publication type:

Article

Curcumin inhibits B[a]PDE-induced procarcinogenic signals in lung cancer cells, and curbs B[a]P-induced mutagenesis and lung carcinogenesis.

Published in:

Biofactors, 2015, v. 41, n. 6, p. 431, doi. 10.1002/biof.1244

By:

Puliyappadamba, Vineshkumar T.;
Thulasidasan, Arun Kumar T;
Vijayakurup, Vinod;
Antony, Jayesh;
Bava, Smitha V.;
Anwar, Shabna;
Sundaram, Sankar;
Anto, Ruby John

Publication type:

Article

Carcinogen susceptibility is regulated by genome architecture and predicts cancer mutagenesis.

Published in:

EMBO Journal, 2017, v. 36, n. 19, p. 2829, doi. 10.15252/embj.201796717

By:

García‐Nieto, Pablo E;
Schwartz, Erin K;
King, Devin A;
Paulsen, Jonas;
Collas, Philippe;
Herrera, Rafael E;
Morrison, Ashby J

Publication type:

Article

Next‐Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk.

Published in:

Environmental & Molecular Mutagenesis, 2020, v. 61, n. 1, p. 135, doi. 10.1002/em.22342

By:

Salk, Jesse J.;
Kennedy, Scott R.

Publication type:

Article

Mutator phenotype in cancer: Timing and perspectivesInvited article: 25th anniversary of Environmental and Molecular Mutagenesis.

Published in:

Environmental & Molecular Mutagenesis, 2005, v. 45, n. 2/3, p. 206

By:

Jason H. Bielas;
Lawrence A. Loeb

Publication type:

Article

Promoterless Transposon Mutagenesis Drives Solid Cancers via Tumor Suppressor Inactivation.

Published in:

Cancers, 2021, v. 13, n. 2, p. 225, doi. 10.3390/cancers13020225

By:

Aiderus, Aziz;
Contreras-Sandoval, Ana M.;
Meshey, Amanda L.;
Newberg, Justin Y.;
Ward, Jerrold M.;
Swing, Deborah A.;
Copeland, Neal G.;
Jenkins, Nancy A.;
Mann, Karen M.;
Mann, Michael B.

Publication type:

Article

CpG/CpNpG motifs in the coding region are preferred sites for mutagenesis in the breast cancer susceptibility genes

Published in:

FEBS Letters, 2007, v. 581, n. 24, p. 4668, doi. 10.1016/j.febslet.2007.08.061

By:

Cheung, Lydia W.T.;
Lee, Yiu Fai;
Ng, Tuen Wai;
Ching, Wai Ki;
Khoo, Ui Soon;
Ng, Michael K.P.;
Wong, Alice S.T.

Publication type:

Article

AAV Vectors, Insertional Mutagenesis, and Cancer.

Published in:

Molecular Therapy, 2007, v. 15, n. 10, p. 1740, doi. 10.1038/sj.mt.6300299

By:

Russell, David W.

Publication type:

Article

Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-33527-3

By:

Clark, Christopher R.;
Maile, Makayla;
Blaney, Patrick;
Hellweg, Stefano R.;
Strauss, Anna;
Durose, Wilaiwan;
Priya, Sambhawa;
Habicht, Juri;
Burns, Michael B.;
Blekhman, Ran;
Abrahante, Juan E.;
Starr, Timothy K.

Publication type:

Article

Molecular epidemiology and cancer prevention. Inhibition of benzo[a]pyrene-induced mutagenesis by (-)-epigallocatechin gallate in the lung of rpsL transgenic mice.

Published in:

Carcinogenesis, 1999, v. 20, n. 3, p. 421, doi. 10.1093/carcin/20.3.421

By:

Muto, S;
Yokoi, T;
Gondo, Y;
Katsuki, M;
Shioyama, Y;
Fujita, K-i;
Kamataki, T

Publication type:

Article

APOBEC-mediated mutagenesis is a favorable predictor of prognosis and immunotherapy for bladder cancer patients: evidence from pan-cancer analysis and multiple databases.

Published in:

Theranostics, 2022, v. 12, n. 9, p. 4181, doi. 10.7150/thno.73235

By:

Run Shi;
Xin Wang;
Yang Wu;
Bin Xu;
Tianyu Zhao;
Trapp, Christian;
Xuanbin Wang;
Unger, Kristian;
Cheng Zhou;
Shun Lu;
Buchner, Alexander;
Schulz, Gerald Bastian;
Fengjun Cao;
Belka, Claus;
Chuan Su;
Minglun Li;
Yongqian Shu

Publication type:

Article

The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.

Published in:

Nature Communications, 2016, v. 7, n. 9, p. 12918, doi. 10.1038/ncomms12918

By:

Starrett, Gabriel J.;
Luengas, Elizabeth M.;
McCann, Jennifer L.;
Ebrahimi, Diako;
Temiz, Nuri A.;
Love, Robin P.;
Feng, Yuqing;
Adolph, Madison B.;
Chelico, Linda;
Law, Emily K.;
Carpenter, Michael A.;
Harris, Reuben S

Publication type:

Article

Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.

Published in:

PLoS ONE, 2018, v. 13, n. 5, p. 1, doi. 10.1371/journal.pone.0197372

By:

Thomenius, Michael J.;
Totman, Jennifer;
Harvey, Darren;
Mitchell, Lorna H.;
Riera, Thomas V.;
Cosmopoulos, Kat;
Grassian, Alexandra R.;
Klaus, Christine;
Foley, Megan;
Admirand, Elizabeth A.;
Jahic, Haris;
Majer, Christina;
Wigle, Tim;
Jacques, Suzanne L.;
Gureasko, Jodi;
Brach, Dorothy;
Lingaraj, Trupti;
West, Kip;
Smith, Sherri;
Rioux, Nathalie

Publication type:

Article

Common Fragile Sites and Cancer: Targeted Cloning by Insertional Mutagenesis.

Published in:

Annals of the New York Academy of Sciences, 2004, v. 1028, n. 1, p. 14, doi. 10.1196/annals.1322.002

By:

BÜTTEL, ISABEL;
FECHTER, ANNE;
SCHWAB, MANFRED

Publication type:

Article

Lentiviral vector-mediated insertional mutagenesis screen identifies genes that influence androgen independent prostate cancer progression and predict clinical outcome.

Published in:

Molecular Carcinogenesis, 2016, v. 55, n. 11, p. 1761, doi. 10.1002/mc.22425

By:

Nalla, Arun K.;
Williams, Theodore F.;
Collins, Casey P.;
Rae, Dustin T.;
Trobridge, Grant D.

Publication type:

Article

In silico mutagenesis-based designing of oncogenic SHP2 peptide to inhibit cancer progression.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-37020-4

By:

Shahab, Muhammad;
Khan, Shahin Shah;
Zulfat, Maryam;
Bin Jardan, Yousef A.;
Mekonnen, Amare Bitew;
Bourhia, Mohammed;
Zheng, Guojun

Publication type:

Article

Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene.

Published in:

Oncogene, 2003, v. 22, n. 25, p. 3911, doi. 10.1038/sj.onc.1206492

By:

Paterlini-Brechot, Patrizia;
Saigo, Kenichi;
Murakami, Yoshiki;
Chami, Mounia;
Gozuacik, Devrim;
Mugnier, Claude;
Lagorce, David;
Brechot, Christian

Publication type:

Article

Transmicron: accurate prediction of insertion probabilities improves detection of cancer driver genes from transposon mutagenesis screens.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 4, p. e21, doi. 10.1093/nar/gkac1215

By:

Bredthauer, Carl;
Fischer, Anja;
Ahari, Ata Jadid;
Cao, Xueqi;
Weber, Julia;
Rad, Lena;
Rad, Roland;
Wachutka, Leonhard;
Gagneur, Julien

Publication type:

Article

DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 14, p. 7163, doi. 10.1093/nar/gkz531

By:

Pilzecker, Bas;
Buoninfante, Olimpia Alessandra;
Jacobs, Heinz

Publication type:

Article

Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05748-7

By:

Braun, Simon;
Enculescu, Mihaela;
Setty, Samarth T.;
Cortés-López, Mariela;
de Almeida, Bernardo P.;
Sutandy, F. X. Reymond;
Schulz, Laura;
Busch, Anke;
Seiler, Markus;
Ebersberger, Stefanie;
Barbosa-Morais, Nuno L.;
Legewie, Stefan;
König, Julian;
Zarnack, Kathi

Publication type:

Article

Adaptive Mutagenesis-Cause of Alimentary Cancer??

Published in:

Scandinavian Journal of Gastroenterology, 1992, v. 27, n. S193, p. 68, doi. 10.3109/00365529209096009

By:

Wormsley, K. G.

Publication type:

Article

The Use of Mutational Signatures to Decipher the Inter-Relationship of Reactive Oxygen Species with Homologous Recombination and Non-Homologous End-Joining Deficiencies as Well as Their Effects on APOBEC Mutagenesis in Breast Cancer.

Published in:

Cancers, 2025, v. 17, n. 10, p. 1627, doi. 10.3390/cancers17101627

By:

Farmanbar, Amir;
Kneller, Robert;
Firouzi, Sanaz

Publication type:

Article

DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer.

Published in:

Genome Biology, 2016, v. 17, p. 1, doi. 10.1186/s13059-016-1042-9

By:

Kanu, Nnennaya;
Cerone, Maria Antonietta;
Goh, Gerald;
Zalmas, Lykourgos-Panagiotis;
Bartkova, Jirina;
Dietzen, Michelle;
McGranahan, Nicholas;
Rogers, Rebecca;
Law, Emily K.;
Gromova, Irina;
Kschischo, Maik;
Walton, Michael I.;
Rossanese, Olivia W.;
Bartek, Jiri;
Harris, Reuben S.;
Venkatesan, Subramanian;
Swanton, Charles

Publication type:

Article

The utility of transposon mutagenesis for cancer studies in the era of genome editing.

Published in:

Genome Biology, 2015, v. 16, p. 1, doi. 10.1186/s13059-015-0794-y

By:

De Nicola, Gina M.;
Karreth, Florian A.;
Adams, David J.;
Wong, Chi C.

Publication type:

Article

Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer.

Published in:

Breast Cancer Research, 2015, v. 17, n. 1, p. 1, doi. 10.1186/s13058-014-0498-3

By:

Harris, Reuben S.

Publication type:

Article

Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer.

Published in:

Breast Cancer Research, 2015, v. 17, n. 1, p. 1, doi. 10.1186/s13058-014-0498-3

By:

Harris, Reuben S.

Publication type:

Article