Works matching Matrix metalloproteinases

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    Assessment of serum concentrations of matrix metalloproteinase 1, matrix metalloproteinase 2 and tissue inhibitors of metalloproteinases 1 in atopic dermatitis in correlation with disease severity and epidermal barrier parameters.

    Published in:
    Advances in Dermatology & Allergology / Postępy Dermatologii i Alergologii, 2021, v. 38, n. 5, p. 773, doi. 10.5114/ada.2021.110043
    By:
    • Basałygo, Magdalena;
    • Śliwińska, Joanna;
    • Żbikowska-Gotz, Magdalena;
    • Lis, Kinga;
    • Socha, Ewa;
    • Bartuzi, Zbigniew;
    • Zegarska, Barbara
    Publication type:
    Article
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    Enhanced Age-Dependent Motor Impairment in Males of Drosophila melanogaster Modeling Spinocerebellar Ataxia Type 1 Is Linked to Dysregulation of a Matrix Metalloproteinase Over the past two decades, Drosophila melanogaster has proven to be successful in modeling the polyglutamine (polyQ) (caused by CAG repeats) family of neurodegenerative disorders, including the faithful recapitulation of pathological features such as polyQ length-dependent formation of protein aggregates and progressive neuronal degeneration. In this study, pan-neuronal expression of human Ataxin-1 with long polyQ repeat of 82 amino acids was driven using an elav-GAL4 driver line. This would essentially model the polyQ disease spinocerebellar ataxia type 1 (SCA1). Longevity and behavioral analysis of male flies expressing human Ataxin-1 revealed compromised lifespan and accelerated locomotor activity deficits both in diurnal activity and negative geotaxis response compared to control flies. Interestingly, this decline in motor response was coupled to an enhancement of matrix metalloproteinase 1 (dMMP1) expression together with declining expression of extracellular matrix (ECM) fibroblast growth factor (FGF) signaling by hedgehog (Hh) and branchless (bnl) and a significant decrease in expression of survival motor neuron gene (dsmn) in old (30 d) flies. Taken together, our results indicate a role for dysregulation of matrix metalloproteinase in polyQ disease with consequent impact on ECM signaling factors, as well as SMN at the neuromuscular junction causing overt physiological and behavioral deficits.

    Published in:
    Biology (2079-7737), 2024, v. 13, n. 11, p. 854, doi. 10.3390/biology13110854
    By:
    • Palmer, Emma M.;
    • Snoddy, Caleb A.;
    • York, Peyton M.;
    • Davis, Sydney M.;
    • Hunter, Madelyn F.;
    • Krishnan, Natraj
    Publication type:
    Article
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    Expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of matrix metalloproteinases 2 and 1 in the glomeruli of human glomerular diseases: the results of studies using immunofluorescence, in situ hybridization, and immunoelectron microscopy

    Published in:
    Clinical & Experimental Nephrology, 2012, v. 16, n. 6, p. 863, doi. 10.1007/s10157-012-0633-3
    By:
    • Sekiuchi, Makiho;
    • Kudo, Akihiko;
    • Nakabayashi, Kimimasa;
    • Kanai-Azuma, Masami;
    • Akimoto, Yoshihiro;
    • Kawakami, Hayato;
    • Yamada, Akira
    Publication type:
    Article
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    Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy.

    Published in:
    Alzheimer's Research & Therapy, 2023, v. 15, n. 1, p. 1, doi. 10.1186/s13195-023-01171-3
    By:
    • Vervuurt, Marc;
    • de Kort, Anna M.;
    • Jäkel, Lieke;
    • Kersten, Iris;
    • Abdo, Wilson F.;
    • Schreuder, Floris H. B. M.;
    • Rasing, Ingeborg;
    • Terwindt, Gisela M.;
    • Wermer, Marieke J. H.;
    • Greenberg, Steven M.;
    • Klijn, Catharina J. M.;
    • Kuiperij, H. Bea;
    • Verbeek, Marcel M.
    Publication type:
    Article
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    Deciphering the Molecular Mechanism Responsible for Efficiently Inhibiting Metastasis of Human Non-Small Cell Lung and Colorectal Cancer Cells Targeting the Matrix Metalloproteinases by Selaginella repanda.

    Published in:
    Plants (2223-7747), 2021, v. 10, n. 5, p. 979, doi. 10.3390/plants10050979
    By:
    • Adnan, Mohd;
    • Siddiqui, Arif Jamal;
    • Hamadou, Walid Sabri;
    • Snoussi, Mejdi;
    • Badraoui, Riadh;
    • Ashraf, Syed Amir;
    • Jamal, Arshad;
    • Awadelkareem, Amir Mahgoub;
    • Sachidanandan, Manojkumar;
    • Hadi, Sibte;
    • Khan, Mushtaq Ahmad;
    • Patel, Mitesh;
    • Maggi, Filippo
    Publication type:
    Article
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    Matrix metalloproteinases and their tissue inhibitors as upcoming biomarker signatures of connective tissue diseases-related interstitial lung disease: towards an earlier and accurate diagnosis.

    Published in:
    Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01128-2
    By:
    • Pulito-Cueto, Verónica;
    • Atienza-Mateo, Belén;
    • Batista-Liz, Joao C.;
    • Sebastián Mora-Gil, María;
    • Mora-Cuesta, Víctor M.;
    • Iturbe-Fernández, David;
    • Izquierdo Cuervo, Sheila;
    • Aguirre Portilla, Carolina;
    • Blanco, Ricardo;
    • López-Mejías, Raquel
    Publication type:
    Article
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