Works matching Knockout mice

Results: 5000

Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer's, and liver cancer.

Published in:

European Journal of Medical Research, 2024, v. 29, n. 1, p. 1, doi. 10.1186/s40001-024-02225-4

By:

Yan, Lu;
Song, Yin-Sen;
Zhou, Jian;
Zhu, Lin;
Shi, Tian-Wei;
Yu, Hui-Qian;
Dong, Zi-Qing;
Wang, Wei;
Long, Ting;
Liu, Hao-Ying;
Shi, Zhe-Ye;
Li, Jian-Guo

Publication type:

Article

Cardiovascular and respiratory evaluation in adenosine A<sub>2A</sub> receptor knockout mice submitted to short‐term sustained hypoxia.

Published in:

Experimental Physiology, 2023, v. 108, n. 11, p. 1434, doi. 10.1113/EP091221

By:

Souza, Juliana R.;
Machado, Benedito H.

Publication type:

Article

Analyses of Conditional Knockout Mice for Pogz , a Gene Responsible for Neurodevelopmental Disorders in Excitatory and Inhibitory Neurons in the Brain.

Published in:

Cells (2073-4409), 2024, v. 13, n. 6, p. 540, doi. 10.3390/cells13060540

By:

Hamada, Nanako;
Nishijo, Takuma;
Iwamoto, Ikuko;
Shifman, Sagiv;
Nagata, Koh-ichi

Publication type:

Article

Transient CSF1R inhibition ameliorates behavioral deficits in Cntnap2 knockout and valproic acid-exposed mouse models of autism.

Published in:

Journal of Neuroinflammation, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12974-024-03259-5

By:

Meng, Jiao;
Pan, Pengming;
Guo, Gengshuo;
Chen, Anqi;
Meng, Xiangbao;
Liu, Heli

Publication type:

Article

A Comprehensive Plasma Metabolomics Dataset for a Cohort of Mouse Knockouts within the International Mouse Phenotyping Consortium.

Published in:

Metabolites (2218-1989), 2019, v. 9, n. 5, p. 101, doi. 10.3390/metabo9050101

By:

Barupal, Dinesh K.;
Zhang, Ying;
Shen, Tong;
Fan, Sili;
Roberts, Bryan S.;
Fitzgerald, Patrick;
Wancewicz, Benjamin;
Valdiviez, Luis;
Wohlgemuth, Gert;
Byram, Gregory;
Choy, Ying Yng;
Haffner, Bennett;
Showalter, Megan R.;
Vaniya, Arpana;
Bloszies, Clayton S.;
Folz, Jacob S.;
Kind, Tobias;
Flenniken, Ann M.;
McKerlie, Colin;
Nutter, Lauryl M. J.

Publication type:

Article

Short-Chain Inulin Modulates the Cecal Microbiota Structure of Leptin Knockout Mice in High-Fat Diet.

Published in:

Frontiers in Microbiology, 2021, v. 12, p. 1, doi. 10.3389/fmicb.2021.703929

By:

Feng, Yan;
Feng, Jianghao;
Wang, Lei;
Meng, Ai;
Wei, Siang;
Cui, Jie;
Hu, Xiongbing;
Yan, Lihuan

Publication type:

Article

Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior.

Published in:

Molecular Brain, 2020, v. 13, n. 1, p. 1, doi. 10.1186/s13041-020-00591-8

By:

Huang, Dehua;
Liu, Huiqing;
Zhu, Aoxue;
Zhou, Yi;
Li, Yong

Publication type:

Article

A Lipid Nanoparticle-Based Method for the Generation of Liver-Specific Knockout Mice.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 18, p. 14299, doi. 10.3390/ijms241814299

By:

Morita, Sumiyo;
Horii, Takuro;
Kimura, Mika;
Kobayashi, Ryosuke;
Tanaka, Hiroki;
Akita, Hidetaka;
Hatada, Izuho

Publication type:

Article

Natural Killer T Cells Are Involved in Atherosclerotic Plaque Instability in Apolipoprotein-E Knockout Mice.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 22, p. 12451, doi. 10.3390/ijms222212451

By:

Ohmura, Yoshinori;
Ishimori, Naoki;
Saito, Akimichi;
Yokota, Takashi;
Horii, Shunpei;
Tokuhara, Satoshi;
Iwabuchi, Kazuya;
Tsutsui, Hiroyuki

Publication type:

Article

Evaluation of the Usefulness of Breast Cancer Resistance Protein (BCRP) Knockout Mice and BCRP Inhibitor-Treated Monkeys to Estimate the Clinical Impact of BCRP Modulation on the Pharmacokinetics of BCRP Substrates.

Published in:

Pharmaceutical Research, 2015, v. 32, n. 5, p. 1634, doi. 10.1007/s11095-014-1563-4

By:

Karibe, Tsuyoshi;
Hagihara-Nakagomi, Rie;
Abe, Koji;
Imaoka, Tomoki;
Mikkaichi, Tsuyoshi;
Yasuda, Satoru;
Hirouchi, Masakazu;
Watanabe, Nobuaki;
Okudaira, Noriko;
Izumi, Takashi

Publication type:

Article

Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin.

Published in:

Frontiers in Endocrinology, 2021, v. 12, p. 1, doi. 10.3389/fendo.2021.698115

By:

Wargent, Edward T.;
Ahmad, Suhaib J. S.;
Lu, Qing Richard;
Kostenis, Evi;
Arch, Jonathan R. S.;
Stocker, Claire J.

Publication type:

Article

Islets of Langerhans from prohormone convertase-2 knockout mice show α-cell hyperplasia and tumorigenesis with elevated α-cell neogenesis.

Published in:

International Journal of Experimental Pathology, 2014, v. 95, n. 1, p. 29, doi. 10.1111/iep.12066

By:

Jones, Huw B.;
Reens, Jaimini;
Brocklehurst, Simon R.;
Betts, Catherine J.;
Bickerton, Sue;
Bigley, Alison L.;
Jenkins, Richard P.;
Whalley, Nicky M.;
Morgan, Derrick;
Smith, David M.

Publication type:

Article

Gpr75 knockout mice display age‐dependent cone photoreceptor cell loss.

Published in:

Journal of Neurochemistry, 2023, v. 167, n. 4, p. 538, doi. 10.1111/jnc.15979

By:

Vasudevan, Sreelakshmi;
Samuels, Ivy S.;
Park, Paul S.‐H.

Publication type:

Article

Metyrapone Treatment Protects Low-Density Lipoprotein Receptor Knockout Mice against Hypercorticosteronemia Development without Changing Atherosclerosis Susceptibility.

Published in:

Biomolecules (2218-273X), 2023, v. 13, n. 9, p. 1287, doi. 10.3390/biom13091287

By:

van der Sluis, Ronald J.;
van den Aardweg, Tim;
Sijsenaar, Timothy J. P.;
Van Eck, Miranda;
Hoekstra, Menno

Publication type:

Article

Knockout Mouse Models for Peroxiredoxins.

Published in:

Antioxidants, 2020, v. 9, n. 2, p. 182, doi. 10.3390/antiox9020182

By:

Lee, Young Jae

Publication type:

Article

A comprehensive analysis of TDO2 expression in immune cells and characterization of immune cell phenotype in TDO2 knockout mice.

Published in:

Transgenic Research, 2021, v. 30, n. 6, p. 781, doi. 10.1007/s11248-021-00281-8

By:

Li, Susu;
Li, Siyu;
Zhao, Yingjie;
Zhang, Bingjie;
Wang, Xinwei;
Yang, Xuezhi;
Wang, Yueye;
Jia, Chengyan;
Chang, Yan;
Wei, Wei

Publication type:

Article

Mendel: a simple excel workbook to compare the observed and expected distributions of genotypes/phenotypes in transgenic and knockout mouse crosses involving up to three unlinked loci by means of a χ test.

Published in:

Transgenic Research, 2012, v. 21, n. 3, p. 677, doi. 10.1007/s11248-011-9544-4

By:

Montoliu, Lluís

Publication type:

Article

Toll-like receptor-4 knockout mice are more resistant to optic nerve crush damage than wild-type mice.

Published in:

Clinical & Experimental Ophthalmology, 2015, v. 43, n. 7, p. 655, doi. 10.1111/ceo.12521

By:

Morzaev, Dana;
Nicholson, James D;
Caspi, Tomm;
Weiss, Shirel;
Hochhauser, Edith;
Goldenberg‐Cohen, Nitza

Publication type:

Article

Conditional Knockout of Pdha1 in Mouse Hippocampus Impairs Cognitive Function: The Possible Involvement of Lactate.

Published in:

Frontiers in Neuroscience, 2021, v. 15, p. 1, doi. 10.3389/fnins.2021.767560

By:

Chen, Wanxin;
Sun, Xiaoxia;
Zhan, Libin;
Zhou, Wen;
Bi, Tingting

Publication type:

Article

Impaired cognitive function and decreased monoamine neurotransmitters in the DNAJC12 gene knockout mouse model.

Published in:

Orphanet Journal of Rare Diseases, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13023-025-03580-z

By:

Wang, Shunan;
Shen, Ming;
Pang, Bo;
Zhou, Bo;
Yuan, Yuan;
Lu, Mei;
Deng, Xiangling;
Yang, Min;
Liu, Shufang;
Wang, Qiong;
Xue, Mei;
Xia, Qisheng;
Zhang, Zhixin

Publication type:

Article

Renin‐angiotensin blockade ameliorates the progression of glomerular injury in podocyte‐specific Ctcf knockout mice.

Published in:

Nephrology, 2024, v. 29, n. 12, p. 815, doi. 10.1111/nep.14400

By:

Fujioka, Keisuke;
Nagai, Takashi;
Hattori, Tomoki;
Kagami, Shoji;
Yasutomo, Koji;
Galjart, Niels;
Hirayama, Teruyoshi;
Kawachi, Hiroshi;
Urushihara, Maki

Publication type:

Article

Analysis of A4gnt Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda.

Published in:

Journal of Histochemistry & Cytochemistry, 2019, v. 67, n. 10, p. 759, doi. 10.1369/0022155419860134

By:

Kawakubo, Masatomo;
Komura, Hitomi;
Goso, Yukinobu;
Okumura, Motohiro;
Sato, Yoshiko;
Fujii, Chifumi;
Miyashita, Masaki;
Arisaka, Nobuhiko;
Harumiya, Satoru;
Yamanoi, Kazuhiro;
Yamada, Shigenori;
Kakuta, Shigeru;
Kawashima, Hiroto;
Fukuda, Michiko N.;
Fukuda, Minoru;
Nakayama, Jun

Publication type:

Article

Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice.

Published in:

Cellular & Molecular Life Sciences, 2019, v. 76, n. 23, p. 4663, doi. 10.1007/s00018-019-03238-7

By:

Kage, Hidenori;
Flodby, Per;
Zhou, Beiyun;
Borok, Zea

Publication type:

Article

Protein kinase C beta relieves autism‐like behavior in EN2 knockout mice via upregulation of the FTO/PGC‐1α/UCP1 axis.

Published in:

Journal of Biochemical & Molecular Toxicology, 2023, v. 37, n. 1, p. 1, doi. 10.1002/jbt.23236

By:

Song, Xingyu;
Hu, Qibo;
Xu, Xiaoheng;
Pan, Wei

Publication type:

Article

Metabolic Alterations Due to Caloric Restriction and Every Other Day Feeding in Normal and Growth Hormone Receptor Knockout Mice.

Published in:

Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2014, v. 69, n. 1, p. 25, doi. 10.1093/gerona/glt080

By:

Westbrook, Reyhan;
Bonkowski, Michael S.;
Arum, Oge;
Strader, April D.;
Bartke, Andrzej

Publication type:

Article

The Effect of Celastrol on Body Weight of ApoE Knockout Mice Fed with High-fat Diet.

Published in:

2024

By:

Damahuri, Arifah Ahmad;
Azme, Nasibah;
Rahman, Thuhairah Hasrah Abd.;
R. M. T. Balasubramaniam, B. Vimala

Publication type:

Abstract

Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity.

Published in:

Viruses (1999-4915), 2022, v. 14, n. 9, p. 1862, doi. 10.3390/v14091862

By:

Li, Chen;
He, Wen-Feng;
Li, Long-Xi;
Chen, Jing;
Yang, Guo-Qing;
Chang, Hong-Tao;
Liu, Hui-Min

Publication type:

Article

Histone Deacetylase 6 Knockout Mice Exhibit Higher Susceptibility to Influenza A Virus Infection.

Published in:

Viruses (1999-4915), 2020, v. 12, n. 7, p. 728, doi. 10.3390/v12070728

By:

Zanin, Mark;
DeBeauchamp, Jennifer;
Vangala, Gowthami;
Webby, Richard J.;
Husain, Matloob

Publication type:

Article

Reduced Post-ischemic Brain Injury in Transient Receptor Potential Vanilloid 4 Knockout Mice.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00453

By:

Tanaka, Koji;
Matsumoto, Shoji;
Yamada, Takeshi;
Yamasaki, Ryo;
Suzuki, Makoto;
Kido, Mizuho A.;
Kira, Jun-Ichi

Publication type:

Article

Effects of insulin-like growth factor 1 on glutathione S-transferases and thioredoxin in growth hormone receptor knockout mice.

Published in:

Age (0161-9152), 2014, v. 36, n. 4, p. 1, doi. 10.1007/s11357-014-9687-3

By:

Rojanathammanee, Lalida;
Rakoczy, Sharlene;
Kopchick, John;
Brown-Borg, Holly

Publication type:

Article

Pathological and molecular analyses of atherosclerotic lesions in ApoE-knockout mice.

Published in:

Medical Molecular Morphology, 2017, v. 50, n. 3, p. 130, doi. 10.1007/s00795-017-0154-y

By:

Shibata, Masa-Aki;
Shibata, Eiko;
Maemura, Kentaro;
Kondo, Yoichi;
Harada-Shiba, Mariko

Publication type:

Article

Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea.

Published in:

Cell & Tissue Research, 2014, v. 358, n. 3, p. 717, doi. 10.1007/s00441-014-1977-7

By:

Radojevic, Vesna;
Bodmer, Daniel

Publication type:

Article

The essential role of CYP2E1 in metabolism and hepatotoxicity of N,N-dimethylformamide using a novel Cyp2e1 knockout mouse model and a population study.

Published in:

Archives of Toxicology, 2019, v. 93, n. 11, p. 3169, doi. 10.1007/s00204-019-02567-7

By:

Wu, Zhijun;
Liu, Qiang;
Wang, Lei;
Zheng, Min;
Guan, Mingyue;
Zhang, Man;
Zhao, Wenjin;
Wang, Chunmin;
Lu, Songwen;
Cheng, Juan;
Leng, Shuguang

Publication type:

Article

Rapid Generation of Long Noncoding RNA Knockout Mice Using CRISPR/Cas9 Technology.

Published in:

Non-Coding RNA, 2019, v. 5, n. 1, p. 1, doi. 10.3390/ncrna5010012

By:

Hansmeier, Nils R.;
Widdershooven, Pia J. M.;
Khani, Sajjad;
Kornfeld, Jan-Wilhelm

Publication type:

Article

Mesenchymal Stem Cells Decrease Oxidative Stress in the Bowels of Interleukin-10 Knockout Mice.

Published in:

Gut & Liver, 2020, v. 14, n. 1, p. 100, doi. 10.5009/gnl18438

By:

Kyong Jin Jung;
Gun Woo Lee;
Chul Hyun Park;
Tae Jin Lee;
Joo Young Kim;
Eon Gi Sung;
Seong Yong Kim;
Byung Ik Jang;
In Hwan Song

Publication type:

Article

Nicotinamide Mononucleotide and Nicotinamide Riboside Improve Dyslipidemia and Fatty Liver but Promote Atherosclerosis in Apolipoprotein E Knockout Mice.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 3, p. 281, doi. 10.3390/ph18030281

By:

Wang, Pin;
Li, Jia-Xin;
Kong, Yuan-Yuan;
Zheng, Si-Li;
Miao, Chao-Yu

Publication type:

Article

Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice.

Published in:

Frontiers in Behavioral Neuroscience, 2015, v. 9, p. 1, doi. 10.3389/fnbeh.2015.00141

By:

Akito Nakao;
Takafumi Miki;
Hirotaka Shoji;
Miyuki Nishi;
Hiroshi Takeshima;
Tsuyoshi Miyakawa;
Yasuo Mori;
Stiedl, Oliver;
Franklin, Tamara B.

Publication type:

Article

Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice.

Published in:

Frontiers in Behavioral Neuroscience, 2012, v. 6, p. 1, doi. 10.3389/fnbeh.2012.00058

By:

Hattori, Satoko;
Takao, Keizo;
Tanda, Koichi;
Toyama, Keiko;
Shintani, Norihito;
Baba, Akemichi;
Hashimoto, Hitoshi;
Miyakawa, Tsuyoshi

Publication type:

Article

Brain Region-Specific Expression Levels of Synuclein Genes in an Acid Sphingomyelinase Knockout Mouse Model: Correlation with Depression-/Anxiety-Like Behavior and Locomotor Activity in the Absence of Genotypic Variation.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 16, p. 8685, doi. 10.3390/ijms25168685

By:

Brazdis, Razvan-Marius;
Zoicas, Iulia;
Kornhuber, Johannes;
Mühle, Christiane

Publication type:

Article

A Cross-Tissue Investigation of Molecular Targets and Physiological Functions of Nsun6 Using Knockout Mice.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 12, p. 6584, doi. 10.3390/ijms23126584

By:

Wang, Wen;
Huang, Hengjun;
Jiang, Hao;
Tian, Chi;
Tang, Yisen;
Gan, Diwen;
Wen, Xiaozhen;
Song, Zhenyu;
He, Yuhao;
Ou, Xijun;
Fang, Liang

Publication type:

Article

Nischarin Deletion Reduces Oxidative Metabolism and Overall ATP: A Study Using a Novel NISCH Δ5-6 Knockout Mouse Model.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 3, p. 1374, doi. 10.3390/ijms23031374

By:

Nguyen, Tina H.;
Yousefi, Hassan;
Okpechi, Samuel C.;
Lauterboeck, Lothar;
Dong, Shengli;
Yang, Qinglin;
Alahari, Suresh K.

Publication type:

Article

Molecular Characterization of Constipation Disease as Novel Phenotypes in CRISPR-Cas9-Generated Leptin Knockout Mice with Obesity.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 24, p. 9464, doi. 10.3390/ijms21249464

By:

Kim, Ji Eun;
Choi, Yun Ju;
Lee, Su Jin;
Gong, Jeong Eun;
Lim, Yong;
Hong, Jin Tae;
Hwang, Dae Youn

Publication type:

Article

Reduced Cholinergic Activity in the Hippocampus of Hippocampal Cholinergic Neurostimulating Peptide Precursor Protein Knockout Mice.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 21, p. 5367, doi. 10.3390/ijms20215367

By:

Madokoro, Yuta;
Yoshino, Yuta;
Kato, Daisuke;
Sato, Toyohiro;
Mizuno, Masayuki;
Kanamori, Tetsuko;
Shimazawa, Masamitsu;
Hida, Hideki;
Hara, Hideaki;
Yoshida, Mari;
Borlongan, Cesario V.;
Ojika, Kosei;
Matsukawa, Noriyuki

Publication type:

Article

Aldh2 Knockout Mice Were More Sensitive to DNA Damage in Leukocytes due to Ethyl Tertiary Butyl Ether Exposure.

Published in:

Industrial Health, 2011, v. 49, n. 3, p. 396, doi. 10.2486/indhealth.MS1188

By:

Weng, Zuquan;
Suda, Megumi;
Ohtani, Katsumi;
Mei, Nan;
Kawamoto, Toshihiro;
Nakajima, Tamie;
Wang, Rui-Sheng

Publication type:

Article

Impaired actin dynamics and suppression of Shank2-mediated spine enlargement in cortactin knockout mice.

Published in:

Microscopy, 2020, v. 69, n. 1, p. 44, doi. 10.1093/jmicro/dfaa001

By:

Tanaka, Shinji;
Masuda, Yasutaka;
Harada, Akihiro;
Okabe, Shigeo

Publication type:

Article

Late development of OCD-like phenotypes in Dlgap1 knockout mice.

Published in:

Psychopharmacology, 2025, v. 242, n. 1, p. 215, doi. 10.1007/s00213-024-06668-9

By:

Minagawa, Kimino;
Hayakawa, Takashi;
Akimoto, Hayato;
Nagashima, Takuya;
Takahashi, Yasuo;
Asai, Satoshi

Publication type:

Article

An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice.

Published in:

Psychopharmacology, 2013, v. 227, n. 4, p. 685, doi. 10.1007/s00213-013-2988-x

By:

Fox, Meredith;
Panessiti, Micaella;
Hall, F.;
Uhl, George;
Murphy, Dennis

Publication type:

Article

Impaired cliff avoidance reaction in dopamine transporter knockout mice.

Published in:

Psychopharmacology, 2013, v. 227, n. 4, p. 741, doi. 10.1007/s00213-013-3009-9

By:

Yamashita, Motoyasu;
Sakakibara, Yasufumi;
Hall, F.;
Numachi, Yohtaro;
Yoshida, Sumiko;
Kobayashi, Hideaki;
Uchiumi, Osamu;
Uhl, George;
Kasahara, Yoshiyuki;
Sora, Ichiro

Publication type:

Article

Interleukin-10 Knockout Mice Do Not Reliably Exhibit Macroscopic Inflammation: A Natural History Endoscopic Surveillance Study.

Published in:

Digestive Diseases & Sciences, 2023, v. 68, n. 5, p. 1858, doi. 10.1007/s10620-023-07871-y

By:

Kim, Seung Young;
Park, Jae Ho;
Leite, Gabriela;
Pimentel, Mark;
Rezaie, Ali

Publication type:

Article

Mouse Knockout Models for Pelvic Organ Prolapse: a Systematic Review.

Published in:

International Urogynecology Journal, 2022, v. 33, n. 7, p. 1765, doi. 10.1007/s00192-021-05066-5

By:

Allen-Brady, Kristina;
Bortolini, Maria A. T.;
Damaser, Margot S.

Publication type:

Article