Works matching Immune support

Results: 2594
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    Relationship between perceived social support and immune function.

    Published in:
    Stress & Health: Journal of the International Society for the Investigation of Stress, 2003, v. 19, n. 1, p. 3, doi. 10.1002/smi.950
    By:
    • Miyazaki, Takao;
    • Ishikawa, Toshio;
    • Iimori, Hirofumi;
    • Miki, Akiko;
    • Wenner, Marcus;
    • Fukunishi, Isao;
    • Kawamura, Noriyuki
    Publication type:
    Article
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    Transcoelomic spread of cancer cells across the peritoneal cavity occurs in most initially diagnosed ovarian cancer (OC) patients and accounts for most cancer-related death. However, how OC cells interact with peritoneal stromal cells to evade the immune surveillance remains largely unexplored. Here, through an in vivo genome-wide CRISPR/Cas9 screen, we identified IL20RA, which decreased dramatically in OC patients during peritoneal metastasis, as a key factor preventing the transcoelomic metastasis of OC. Reconstitution of IL20RA in highly metastatic OC cells greatly suppresses the transcoelomic metastasis. OC cells, when disseminate into the peritoneal cavity, greatly induce peritoneum mesothelial cells to express IL-20 and IL-24, which in turn activate the IL20RA downstream signaling in OC cells to produce mature IL-18, eventually resulting in the polarization of macrophages into the M1-like subtype to clear the cancer cells. Thus, we show an IL-20/IL20RA-mediated crosstalk between OC and mesothelial cells that supports a metastasis-repressing immune microenvironment.

    Published in:
    eLife, 2021, p. 1, doi. 10.7554/eLife.66222
    By:
    • Jia Li;
    • Xuan Qin;
    • Jie Shi;
    • Xiaoshuang Wang;
    • Tong Li;
    • Mengyao Xu;
    • Xiaosu Chen;
    • Yujia Zhao;
    • Jiahao Han;
    • Yongjun Piao;
    • Wenwen Zhang;
    • Pengpeng Qu;
    • Longlong Wang;
    • Rong Xiang;
    • Yi Shi
    Publication type:
    Article
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