Works in Diabetes & Metabolism Journal, 2017, Vol 41, Issue 5

Results: 13
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    Monotherapy in Patients with Type 2 Diabetes Mellitus.

    Published in:
    Diabetes & Metabolism Journal, 2017, v. 41, n. 5, p. 349, doi. 10.4093/dmj.2017.41.5.349
    By:
    • Sang Youl Rhee;
    • Hyun Jin Kim;
    • Seung-Hyun Ko;
    • Kyu-Yeon Hur;
    • Nan-Hee Kim;
    • Min Kyong Moon;
    • Seok-O Park;
    • Byung-Wan Lee;
    • Kyung Mook Choi;
    • Jin Hwa Kim
    Publication type:
    Article
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    Obesity and diabetes has become a major epidemic across the globe. Controlling obesity has been a challenge since this would require either increased physical activity or reduced caloric intake; both are difficult to enforce. There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCPl)-mediated uncoupling in brown adipose tissue (BAT) and white adipose tissue to increase energy expenditure to control weight gain. However, relying on UCPl-based thermogenesis alone may not be sufficient to control obesity in humans. On the other hand, skeletal muscle is the largest organ and a major contributor to basal metabolic rate and increasing energy expenditure in muscle through nonshivering thermogenic mechanisms, which can substantially affect whole body metabolism and weight gain. In this review we will describe the role of Sarcolipin-mediated uncoupling of Sarcoplasmic Reticulum Calcium ATPase (SERCA) as a potential mechanism for increased energy expenditure both during cold and diet-induced thermogenesis.

    Published in:
    Diabetes & Metabolism Journal, 2017, v. 41, n. 5, p. 327, doi. 10.4093/dmj.2017.41.5.327
    By:
    • Periasamy, Muthu;
    • Herrera, Jose Luis;
    • Reis, Felipe C. G.
    Publication type:
    Article