Works matching IS 2160763X AND DT 2015 AND VI 4

Results: 70

Evaluation of opicapone on cardiac repolarization in a thorough QT/QTc study.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 6, p. 454, doi. 10.1002/cpdd.188

By:

Pinto, Roberto;
l'Hostis, Philippe;
Patat, Alain;
Homery, Marie‐Claude;
Falcão, Amílcar;
Nunes, Teresa;
Rocha, José‐Francisco;
Soares‐da‐Silva, Patrício

Publication type:

Article

Effect of lapatinib on oral digoxin absorption in patients.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 6, p. 449, doi. 10.1002/cpdd.189

By:

Koch, Kevin M.;
Smith, Deborah A.;
Botbyl, Jeff;
Arya, Nikita;
Briley, Linda P.;
Cartee, Leanne;
White, Jane Holshouser;
Beyer, Jennifer;
Dar, Mohammed M.;
Chung, Hyun Choel;
Chu, Quincy;
Bang, Yung‐Jue

Publication type:

Article

Pharmacokinetic drug-drug interaction assessment between LCZ696, an angiotensin receptor neprilysin inhibitor, and hydrochlorothiazide, amlodipine, or carvedilol.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 6, p. 407, doi. 10.1002/cpdd.183

By:

Hsiao, Hsiu‐ling;
Langenickel, Thomas Heiko;
Greeley, Michael;
Roberts, John;
Zhou, Wei;
Pal, Parasar;
Rebello, Sam;
Rajman, Iris;
Sunkara, Gangadhar

Publication type:

Article

Oral tramadol pharmacokinetics in pediatric subjects versus adults-Is there a role of delayed gastric emptying in pediatric subjects?

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 6, p. 473, doi. 10.1002/cpdd.230

By:

Srinivas, Nuggehally R.

Publication type:

Article

Safety, tolerability, and pharmacokinetics of multiple ascending doses of naloxegol.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 6, p. 442, doi. 10.1002/cpdd.204

By:

Eldon, Michael A.;
Kugler, Alan R.;
Medve, Robert A.;
Bui, Khanh;
Butler, Kathleen;
Sostek, Mark

Publication type:

Article

Issue Information.

Published in:: Clinical Pharmacology in Drug Development, 2015, v. 4, n. 6, p. i, doi. 10.1002/cpdd.158
Publication type:: Article

Population pharmacokinetic modeling of motesanib and its active metabolite, M4, in cancer patients.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 6, p. 463, doi. 10.1002/cpdd.196

By:

Gosselin, Nathalie H.;
Mouksassi, Mohamad‐Samer;
Lu, Jian‐Feng;
Hsu, Cheng‐Pang

Publication type:

Article

Effect of tamsulosin on the pharmacokinetics of dutasteride in Chinese male healthy volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 6, p. 427, doi. 10.1002/cpdd.197

By:

Li, Huafang;
Yang, Jiansong;
Zhao, Hongxin;
Fossler, Michael J.;
Wang, Chunrong

Publication type:

Article

A single- and multiple-dose study to investigate the pharmacokinetics of epelsiban and its metabolite, GSK2395448, in healthy female volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 6, p. 418, doi. 10.1002/cpdd.210

By:

Mahar, Kelly M.;
Stier, Brendt;
Fries, Michael;
McCallum, Stewart W.

Publication type:

Article

Safety, tolerability, pharmacokinetics, and pharmacodynamic effects of naloxegol at peripheral and central nervous system receptors in healthy male subjects: A single ascending-dose study.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 6, p. 434, doi. 10.1002/cpdd.206

By:

Eldon, Michael A.;
Kugler, Alan R.;
Medve, Robert A.;
Bui, Khanh;
Butler, Kathleen;
Sostek, Mark

Publication type:

Article

Authors' response to the letter from Dr. Srinivas.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 6, p. 475, doi. 10.1002/cpdd.231

By:

Vandenbossche, J.;
Richards, H.;
Solanki, B.;
Van Peer, A.

Publication type:

Article

The expanding utility of microdosing.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 6, p. 401, doi. 10.1002/cpdd.235

By:

Lappin, Graham

Publication type:

Article

Single- and multiple-dose study to evaluate pharmacokinetics, safety and tolerability in healthy volunteers: A comparison of extended-release oxycodone with sequestered naltrexone 40 mg twice daily to oxycontin 40 mg twice daily and extended-release oxycodone with sequestered naltrexone 80 mg once daily

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 5, p. 361, doi. 10.1002/cpdd.179

By:

Gandelman, Kuan;
Lamson, Michael;
Bramson, Candace;
Matschke, Kyle;
Salageanu, Joanne;
Malhotra, Bimal

Publication type:

Article

2015 Annual Meeting of the American College of Clinical Pharmacology, September 27-29, 2015, San Francisco, CA.

Published in:: Clinical Pharmacology in Drug Development, 2015, v. 4, p. 1, doi. 10.1002/cpdd.216
Publication type:: Article

Developing antisense oligonucleotide and short-interfering RNA therapeutics - a few considerations.

Published in:

2015

By:

Cotreau, Monette M.

Publication type:

Editorial

Evaluation of the effect of multiple doses of rifampin on the pharmacokinetics and safety of ponatinib in healthy subjects.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 5, p. 354, doi. 10.1002/cpdd.182

By:

Narasimhan, Narayana I.;
Dorer, David J.;
Davis, Jeffrey;
Turner, Christopher D.;
Sonnichsen, Daryl

Publication type:

Article

Quantitation of the impact of CYP3A5 A6986G polymorphism on quetiapine pharmacokinetics by simulation of target attainment.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 5, p. 387, doi. 10.1002/cpdd.172

By:

Shilbayeh, Sireen A.R.;
Sy, Sherwin K.B.;
Melhem, Murad;
Zmeili, Rawan;
Derendorf, Hartmut

Publication type:

Article

Issue Information.

Published in:: 2015
Publication type:: Other

Evaluation of the effect of food and age on the pharmacokinetics of oral netupitant and palonosetron in healthy subjects: A randomized, open-label, crossover phase 1 study.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 5, p. 377, doi. 10.1002/cpdd.192

By:

Calcagnile, Selma;
Lanzarotti, Corinna;
Gutacker, Michaela;
Jakob‐Rodamer, Verena;
Peter Kammerer, Klaus;
Timmer, Wolfgang

Publication type:

Article

Inhibition of prostacyclin and thromboxane biosynthesis in healthy volunteers by single and multiple doses of acetaminophen and indomethacin.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 5, p. 337, doi. 10.1002/cpdd.194

By:

Schwartz, Jules I.;
Musser, Bret J.;
Tanaka, Wesley K.;
Taggart, William V.;
Mehta, Anish;
Gottesdiener, Keith M.;
Greenberg, Howard E.

Publication type:

Article

Single-dose pharmacokinetics of bupropion hydrobromide and metabolites in healthy adolescent and adult subjects.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 5, p. 346, doi. 10.1002/cpdd.195

By:

Oh, D. Alexander;
Crean, Christopher S.

Publication type:

Article

Effect of food on the pharmacokinetics of oxycodone and naltrexone from ALO-02, an extended release formulation of oxycodone with sequestered naltrexone.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 5, p. 370, doi. 10.1002/cpdd.177

By:

Gandelman, Kuan;
Lamson, Michael;
Salageanu, Joanne;
Bramson, Candace;
Matschke, Kyle;
Malhotra, Bimal

Publication type:

Article

Single- and multiple-dose pharmacokinetics of tofacitinib in healthy Chinese volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 5, p. 395, doi. 10.1002/cpdd.202

By:

Krishnaswami, Sriram;
Wang, Tao;
Yuan, Yi;
Alvey, Christine W.;
Checchio, Tina;
Peterson, Mark;
Shi, Haihong;
Riese, Richard

Publication type:

Article

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Losmapimod in Healthy Japanese Volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 4, p. 262, doi. 10.1002/cpdd.190

By:

Ino, Hiroko;
Takahashi, Naoki;
Terao, Takumi;
Igarashi, Harue;
Sarai, Nobuaki

Publication type:

Article

Identification of new oral dosing regimens for the neuraminidase inhibitor oseltamivir in patients with moderate and severe renal impairment.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 5, p. 326, doi. 10.1002/cpdd.203

By:

Kamal, Mohamed A.;
Brennan, Barbara J.;
Subramoney, Vishak;
Lien, Yi Ting (Kayla);
Morcos, Peter N.;
Frey, Nicolas;
Rayner, Craig R.

Publication type:

Article

Clinical Pharmacology in Drug Development -- An Update.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 4, p. 243, doi. 10.1002/cpdd.211

By:

Greenblatt, David J.

Publication type:

Article

Pharmacokinetics and Adhesion of a Transdermal Patch Containing Ethinyl Estradiol and Gestodene Under Conditions of Heat, Humidity, and Exercise: A Single-Center, Open-Label, Randomized, Crossover Study.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 4, p. 245, doi. 10.1002/cpdd.185

By:

Zurth, Christian;
Schuett, Barbara;
Casjens, Manuela;
Ludwig, Matthias;
Waellnitz, Katrin

Publication type:

Article

Population Pharmacokinetic/ Pharmacodynamic Assessment of Pharmacological Effect of a Selective Estrogen Receptor β Agonist on Total Testosterone in Healthy Men.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 4, p. 305, doi. 10.1002/cpdd.184

By:

Hu, Leijun;
Jin, Yan;
Li, Ying Grace;
Borel, Anthony

Publication type:

Article

Absolute Oral Bioavailability and Pharmacokinetics of Canagliflozin: A Microdose Study in Healthy Participants.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 4, p. 295, doi. 10.1002/cpdd.162

By:

Devineni, Damayanthi;
Murphy, Joseph;
Wang, Shean‐Sheng;
Stieltjes, Hans;
Rothenberg, Paul;
Scheers, Ellen;
Mamidi, Rao N.V.S.

Publication type:

Article

Effect of Food on the Bioavailability and Tolerability of the JAK2-Selective Inhibitor Fedratinib (SAR302503): Results From Two Phase I Studies in Healthy Volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 4, p. 315, doi. 10.1002/cpdd.161

By:

Zhang, Meng;
Xu, Christine;
Ma, Lei;
Shamiyeh, Elias;
Yin, Jianyun;
von Moltke, Lisa L.;
Smith, William B.

Publication type:

Article

Relative Bioavailability of Pediatric Oral Solution and Tablet Formulations of Trametinib in Adult Patients With Solid Tumors.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 4, p. 287, doi. 10.1002/cpdd.152

By:

Cox, Donna S.;
Allred, Alicia;
Zhou, YanYan;
Infante, Jeffrey R.;
Gordon, Michael S.;
Bendell, Johanna;
Jones, Suzanne;
Burris, Howard;
Orford, Keith

Publication type:

Article

Effect of Food on the Pharmacokinetics of Canagliflozin, a Sodium Glucose Co-Transporter 2 Inhibitor, and Assessment of Dose Proportionality in Healthy Participants.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 4, p. 279, doi. 10.1002/cpdd.151

By:

Devineni, Damayanthi;
Manitpisitkul, Prasarn;
Murphy, Joseph;
Stieltjes, Hans;
Ariyawansa, Jay;
Di Prospero, Nicholas A.;
Rothenberg, Paul

Publication type:

Article

An Open-Label Study to Determine the Pharmacokinetics and Safety of Migalastat HCl in Subjects With Impaired Renal Function and Healthy Subjects With Normal Renal Function.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 4, p. 256, doi. 10.1002/cpdd.149

By:

Johnson, Franklin K.;
Mudd, Paul N.;
DiMino, Tara;
Vosk, Jennie;
Sitaraman, Sheela;
Boudes, Pol;
France, Nicholas;
Barlow, Carrolee

Publication type:

Article

Pharmacokinetic Profile After Multiple Deltoid or Gluteal Intramuscular Injections of Paliperidone Palmitate in Patients With Schizophrenia.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 4, p. 270, doi. 10.1002/cpdd.144

By:

Rossenu, Stefaan;
Cleton, Adriaan;
Hough, David;
Crauwels, Herta;
Vandebosch, An;
Berwaerts, Joris;
Eerdekens, Marielle;
Herben, Virginie;
De Meulder, Marc;
Remmerie, Bart;
Francetic, Igor

Publication type:

Article

A thorough QT/QTc study of the effect of fasiglifam, a GPR40 agonist, on cardiac repolarization in healthy adults.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 3, p. 175, doi. 10.1002/cpdd.170

By:

Lee, Ronald D.;
Nudurupati, Sai;
Marcinak, John;
Viswanathan, Prabhakar

Publication type:

Article

Relative bioavailability and the effect of meal type and timing on the pharmacokinetics of migalastat in healthy volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 3, p. 193, doi. 10.1002/cpdd.147

By:

Johnson, Franklin K.;
Mudd, Paul N.;
Janmohamed, Salim G.

Publication type:

Article

Effects of ketoconazole or rifampin on the pharmacokinetics of tivozanib hydrochloride, a vascular endothelial growth factor receptor tyrosine kinase inhibitor.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 2, p. 137, doi. 10.1002/cpdd.145

By:

Cotreau, Monette M.;
Siebers, Nicholas M.;
Miller, James;
Strahs, Andrew L.;
Slichenmyer, William

Publication type:

Article

Issue Information.

Published in:: 2015
Publication type:: Other

Vorapaxar, an oral PAR-1 receptor antagonist, does not affect the pharmacokinetics of rosiglitazone.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 1, p. 56, doi. 10.1002/cpdd.133

By:

Kosoglou, Teddy;
Kumar, Bharath;
Statkevich, Paul;
Schiller, James E.;
Kantesaria, Bhavna;
Hanson, Mary E.;
Sisk, Christine McCrary;
Cutler, David L.

Publication type:

Article

The pharmacodynamics, pharmacokinetics, safety and tolerability of inhaled fluticasone furoate and vilanterol administered alone or simultaneously as fluticasone furoate/vilanterol.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 1, p. 2, doi. 10.1002/cpdd.160

By:

Kempsford, Rodger;
Allen, Ann;
Bareille, Philippe;
Hamilton, Melanie;
Cheesbrough, Anne

Publication type:

Article

Population pharmacokinetic analysis of thrombomodulin alfa to support dosing rationale in patients with renal impairment.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 3, p. 210, doi. 10.1002/cpdd.163

By:

Mouksassi, Mohamad-Samer;
Marier, Jean-Francois;
Bax, Leon;
Osawa, Yutaka;
Tsuruta, Kazuhisa

Publication type:

Article

Pharmacokinetic and bioequivalence evaluation of single-tablet and separate-tablet regimens for once-daily cobicistat-boosted elvitegravir in healthy Japanese male subjects: A randomized, two-way crossover study.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 3, p. 218, doi. 10.1002/cpdd.164

By:

Shiomi, Mari;
Matsuki, Shunji;
Ikeda, Atsushi;
Ishikawa, Tomohiro;
Nishino, Noriaki;
Kimura, Miyuki;
Kumagai, Yuji;
Irie, Shin

Publication type:

Article

Effect of canagliflozin on the pharmacokinetics of glyburide, metformin, and simvastatin in healthy participants.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 3, p. 226, doi. 10.1002/cpdd.166

By:

Devineni, Damayanthi;
Manitpisitkul, Prasarn;
Murphy, Joseph;
Skee, Donna;
Wajs, Ewa;
Mamidi, Rao N. V. S.;
Tian, Hong;
Vandebosch, An;
Wang, Shean-Sheng;
Verhaeghe, Tom;
Stieltjes, Hans;
Usiskin, Keith

Publication type:

Article

Population pharmacokinetics of recombinant factor VIII Fc fusion protein.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 3, p. 163, doi. 10.1002/cpdd.167

By:

Nestorov, Ivan;
Neelakantan, Srividya;
Ludden, Thomas M;
Li, Shuanglian;
Jiang, Haiyan;
Rogge, Mark

Publication type:

Article

Assessment of relative bioavailability of two presentations of moroctocog alfa (AF-CC) in subjects with moderately severe or severe hemophilia A.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 3, p. 237, doi. 10.1002/cpdd.168

By:

Shafer, Frank;
Charnigo, Robert J.;
Plotka, Anna;
Baumann, James;
Liang, Yali;
Korth-Bradley, Joan

Publication type:

Article

Single- and multiple-dose pharmacokinetic studies of tramadol immediate-release tablets in children and adolescents.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 3, p. 184, doi. 10.1002/cpdd.169

By:

Vandenbossche, J.;
Richards, H.;
Solanki, B.;
Van Peer, A.

Publication type:

Article

Bioequivalence study with lapatinib powder for oral suspension and the original tablet formulation in cancer patients.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 3, p. 203, doi. 10.1002/cpdd.139

By:

Koch, Kevin M.;
Ferron-Brady, Geraldine;
Lemmon, Colleen;
Cartee, Leanne;
Hollyfield, Hedy;
D'Amelio, Anthony M.;
Piepszak, Alexandra;
Swaby, Ramona F.;
Curran, David;
Arya, Niki

Publication type:

Article

Regression and Correlation.

Published in:: Clinical Pharmacology in Drug Development, 2015, v. 4, n. 3, p. 161, doi. 10.1002/cpdd.200
Publication type:: Article

Issue Information.

Published in:: 2015
Publication type:: Other

Effects of ketoconazole on the pharmacokinetics of lenvatinib (E7080) in healthy participants.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 2, p. 155, doi. 10.1002/cpdd.140

By:

Shumaker, Robert;
Aluri, Jagadeesh;
Fan, Jean;
Martinez, Gresel;
Thompson, Gary A.;
Ren, Min

Publication type:

Article