Works matching IS 2160763X AND DT 2014 AND VI 3

Results: 53

Safety, tolerability, pharmacokinetics, and pharmacodynamics of compound SFDAC by intranasal administration of multiple escalating dose in healthy male subjects.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 6, p. 428, doi. 10.1002/cpdd.136

By:

Thennati, Rajamannar;
Khanna, Aman;
Khanna, Mallika;
Sonaiya, Tushar;
Mehta, Tejas;
Mehta, Kalpana;
Shahi, Pradeep;
Patel, Jigneshkumar

Publication type:

Article

Effects of peginesatide injection on QTc interval in healthy adults.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 6, p. 449, doi. 10.1002/cpdd.141

By:

Czerniak, Richard;
Kukulka, Michael;
Wu, Jing Tao;
Qiu, Ping

Publication type:

Article

Single-dose pharmacokinetics, safety, and tolerability of modified-release formulations of lersivirine in healthy subjects.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 6, p. 472, doi. 10.1002/cpdd.117

By:

Vourvahis, Manoli;
Wang, Ronnie;
Mendes da Costa, Laure;
Wang, Cunshan;
Weatherley, Barry;
Mukwaya, Geoffrey;
Tawadrous, Margaret;
Heera, Jayvant

Publication type:

Article

The effect of mild and moderate hepatic impairment on the pharmacokinetics of tofacitinib, an orally active Janus kinase inhibitor.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 6, p. 421, doi. 10.1002/cpdd.143

By:

Lawendy, Nervin;
Lamba, Manisha;
Chan, Gary;
Wang, Rong;
Alvey, Christine W.;
Krishnaswami, Sriram

Publication type:

Article

PRTX-100 and methotrexate in patients with active rheumatoid arthritis: A Phase Ib randomized, double-blind, placebo-controlled, dose-escalation study.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 6, p. 477, doi. 10.1002/cpdd.116

By:

Bernton, Edward;
Gannon, William;
Kramer, William;
Kranz, Eduard

Publication type:

Article

Effect of food on the oral bioavailability of amlodipine/valsartan and amlodipine/valsartan/hydrochlorothiazide fixed dose combination tablets in healthy subjects.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 6, p. 487, doi. 10.1002/cpdd.131

By:

Sunkara, Gangadhar;
Jiang, Xuemin;
Reynolds, Christine;
Serra, Denise;
Zhang, Yiming;
Ligueros‐Saylan, Monica;
Ayalasomayajula, Surya;
Winter, Serge;
Jarugula, Venkateswar

Publication type:

Article

A randomized, double blind, dose escalation, first time in human study to assess the safety, tolerability, pharmacokinetics, and antiviral activity of single doses of GSK2485852 in chronically infected hepatitis C subjects.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 6, p. 439, doi. 10.1002/cpdd.142

By:

Wilfret, David A.;
Walker, Jill;
Voitenleitner, Christian;
Baptiste‐Brown, Sharon;
Lovern, Mark;
Kim, Joseph;
Adkison, Kimberly;
Shotwell, Brad;
Mathis, Amanda;
Moss, Lee;
Lee, Daniel;
Yu, Lou;
Gan, Jianjun;
Spaltenstein, Andrew

Publication type:

Article

Issue Information.

Published in:: 2014
Publication type:: Other

Piroxicam immediate release formulations: A fasting randomized open-label crossover bioequivalence study in healthy volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 6, p. 466, doi. 10.1002/cpdd.106

By:

Helmy, Sally A.;
El‐Bedaiwy, Heba M.

Publication type:

Article

Rivaroxaban crushed tablet suspension characteristics and relative bioavailability in healthy adults when administered orally or via nasogastric tube.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 4, p. 321, doi. 10.1002/cpdd.123

By:

Moore, Kenneth T.;
Krook, Mark A.;
Vaidyanathan, Seema;
Sarich, Troy C.;
Damaraju, C. V.;
Fields, Larry E.

Publication type:

Article

Evaluation of the potential interaction between tofacitinib and drugs that undergo renal tubular secretion using metformin, an in vivo marker of renal organic cation transporter 2.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 6, p. 499, doi. 10.1002/cpdd.120

By:

Klamerus, Karen J.;
Alvey, Christine;
Li, Lei;
Feng, Bo;
Wang, Rong;
Kaplan, Irina;
Shi, Haihong;
Dowty, Martin E.;
Krishnaswami, Sriram

Publication type:

Article

The pharmacokinetic effect of coadministration of apremilast and methotrexate in individuals with rheumatoid arthritis and psoriatic arthritis.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 6, p. 456, doi. 10.1002/cpdd.109

By:

Liu, Yong;
Zhou, Simon;
Nissel, James;
Wu, Anfan;
Lau, Henry;
Palmisano, Maria

Publication type:

Article

Bioequivalence of enalapril oral solution for treatment of pediatric hypertension and enalapril tablets.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 6, p. 493, doi. 10.1002/cpdd.129

By:

Moffett, Brady S.;
DiSanto, Anthony R.;
Espinosa, Orlando;
Hou, Jingguo;
Colabuono, Peter

Publication type:

Article

Volume of distribution - Again.

Published in:

2014

By:

Greenblatt, David J.

Publication type:

Editorial

2014 American College of Clinical Pharmacology annual meeting September 14th-16th Atlanta, Georgia.

Published in:: Clinical Pharmacology in Drug Development, 2014, v. 3, p. 1, doi. 10.1002/cpdd.148
Publication type:: Article

Pharmacokinetics and comparative bioavailability of allopurinol formulations in healthy subjects.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 5, p. 353, doi. 10.1002/cpdd.95

By:

Helmy, Sally A.;
El‐Bedaiwy, Heba M.

Publication type:

Article

Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 4, p. 297, doi. 10.1002/cpdd.87

By:

Marier, Jean‐Francois;
Mouksassi, Mohamad‐Samer;
Gosselin, Nathalie H.;
Li, Jianke

Publication type:

Article

Pharmacokinetic bioequivalence crossover study of branded generic and innovator formulations of the cholesterol lowering agent ezetimibe.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 3, p. 242, doi. 10.1002/cpdd.80

By:

Palmer, Jonathan L.;
Kunhihitlu, Anil;
Costantini, Andrea;
Esquivel, Florencia;
Roush, John;
Edwards, Karina;
Hill, Thomas W.K.

Publication type:

Article

Pharmacokinetics and pharmacodynamics of guanfacine extended release in adolescents aged 13-17 years with attention-deficit/hyperactivity disorder.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 4, p. 252, doi. 10.1002/cpdd.124

By:

Martin, Patrick;
Satin, Lawrence;
Vince, Bradley D.;
Padilla, Americo F.;
White, Carla;
Corcoran, Mary;
Stevenson, Annette;
Ermer, James

Publication type:

Article

Pharmacokinetics of darunavir after administration of an oral suspension with low-dose ritonavir and with or without food.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 5, p. 346, doi. 10.1002/cpdd.88

By:

Kakuda, Thomas N.;
Sekar, Vanitha;
Lavreys, Ludo;
De Paepe, Els;
Stevens, Tanja;
Vanstockem, Marc;
Vangeneugden, Tony;
Hoetelmans, Richard M.W.

Publication type:

Article

Population pharmacokinetic and pharmacodynamic analysis of plasma Aβ40 and Aβ42 following single oral doses of the BACE1 inhibitor AZD3839 to healthy volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 5, p. 396, doi. 10.1002/cpdd.130

By:

Quartino, Angelica;
Huledal, Gunilla;
Sparve, Erik;
Lüttgen, Maria;
Bueters, Tjerk;
Karlsson, Pär;
Olsson, Tina;
Paraskos, Jonathan;
Maltby, Justine;
Claeson‐Bohnstedt, Kristina;
Lee, Chi‐Ming;
Alexander, Robert;
Fälting, Johanna;
Paulsson, Björn

Publication type:

Article

Issue Information.

Published in:: Clinical Pharmacology in Drug Development, 2014, v. 3, n. 5, p. i, doi. 10.1002/cpdd.68
Publication type:: Article

Effect of carbamazepine on the pharmacokinetics of paliperidone extended-release tablets at steady-state.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 5, p. 371, doi. 10.1002/cpdd.122

By:

Kerbusch‐Herben, Virginie;
Cleton, Adriaan;
Berwaerts, Joris;
Vandebosch, An;
Remmerie, Bart

Publication type:

Article

Effects of omeprazole and ritonavir on absorption and elimination of the hepatitis C virus NS5A inhibitor GSK2336805 in healthy adults.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 5, p. 338, doi. 10.1002/cpdd.104

By:

Adkison, Kimberly K.;
Jones, Lori S.;
Lou, Yu;
Gan, Jianjun;
Wilfret, David A.

Publication type:

Article

Statistical analysis of Amenamevir (ASP2151) between pharmacokinetics and clinical efficacies with non-linear effect model for the treatment of genital herpes.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 5, p. 365, doi. 10.1002/cpdd.108

By:

Takada, Akitsugu;
Katashima, Masataka;
Kaibara, Atsunori;
Sawamoto, Taiji;
Zhang, Wenhui;
Keirns, James

Publication type:

Article

Letter to the editor regarding: 'Pharmacokinetics of teneligliptin in subjects with renal impairment.' Halabi et al., Clinical Pharmacology in Drug Development 2013;2:246-254.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 5, p. 417, doi. 10.1002/cpdd.119

By:

Graefe‐Mody, Ulrike;
Friedrich, Christian;
von Eynatten, Maximilian;
Thiemann, Sandra;
Heise, Tim;
Woerle, Hans‐Juergen

Publication type:

Article

Antiretroviral boosting by cobicistat, a structural analog of ritonavir.

Published in:

2014

By:

Greenblatt, David J.

Publication type:

Editorial

Pharmacokinetics and bioavailability of a new testosterone gel formulation in comparison to Testogel® in healthy men.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 5, p. 358, doi. 10.1002/cpdd.110

By:

Olsson, Håkan;
Sandström, Rikard;
Neijber, Anders;
Carrara, Dario;
Grundemar, Lars

Publication type:

Article

Safety and pharmacokinetics of olokizumab, an anti-IL-6 monoclonal antibody, administered to healthy male volunteers: A randomized phase I study.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 5, p. 388, doi. 10.1002/cpdd.121

By:

Kretsos, Kosmas;
Golor, Georg;
Jullion, Astrid;
Hickling, Matthew;
McCabe, Suzanne;
Shaw, Stevan;
Jose, Joby;
Oliver, Ruth

Publication type:

Article

Pharmacokinetic interactions between topiramate and diltiazem, hydrochlorothiazide, or propranolol.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 5, p. 378, doi. 10.1002/cpdd.107

By:

Manitpisitkul, Prasarn;
Curtin, Christopher R.;
Shalayda, Kevin;
Wang, Shean‐Sheng;
Ford, Lisa;
Heald, Donald

Publication type:

Article

Pharmacokinetics of rabeprazole granules versus tablets, and the effect of food on the pharmacokinetics of rabeprazole granules in healthy adults-cross-study comparison.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 5, p. 406, doi. 10.1002/cpdd.118

By:

Thyssen, An;
Solanki, Bhavna;
Gonzalez, Martha;
Leitz, Gerhard;
Treem, William;
Mannaert, Erik

Publication type:

Article

A food effect study and dose proportionality study to assess the pharmacokinetics and safety of bardoxolone methyl in healthy volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 4, p. 314, doi. 10.1002/cpdd.74

By:

Teuscher, Nathan S.;
Kelley, Richard J.;
Dumas, Emily O.;
Klein, Cheri Enders;
Awni, Walid M.;
Meyer, Colin J.

Publication type:

Article

Issue Information.

Published in:: Clinical Pharmacology in Drug Development, 2014, v. 3, n. 4, p. i, doi. 10.1002/cpdd.67
Publication type:: Article

Pharmacokinetics and safety of teneligliptin in subjects with hepatic impairment.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 4, p. 290, doi. 10.1002/cpdd.89

By:

Halabi, Atef;
Maatouk, Haidar;
Siegler, Karl Ernst;
Faisst, Nadja;
Hinrichsen, Holger

Publication type:

Article

Drug interactions with methadone: Time to revise the product label.

Published in:

2014

By:

Greenblatt, David J.

Publication type:

Editorial

A semi-mechanistic model to characterize the pharmacokinetics and pharmacodynamics of brodalumab in healthy volunteers and subjects with psoriasis in a first-in-human single ascending dose study.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 4, p. 276, doi. 10.1002/cpdd.103

By:

Salinger, David H.;
Endres, Christopher J.;
Martin, David A.;
Gibbs, Megan A.

Publication type:

Article

A double-blind, randomized, ascending, multiple-dose study of bazedoxifene in healthy postmenopausal women.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 4, p. 262, doi. 10.1002/cpdd.102

By:

McKeand, William E.;
Orczyk, Gayle P.;
Ermer, James C.;
Chines, Arkadi A.

Publication type:

Article

A Phase I cardiac safety and pharmacokinetic study of tivozanib hydrochloride in patients with advanced solid tumors.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 4, p. 284, doi. 10.1002/cpdd.113

By:

Moore, Kathleen;
Infante, Jeffrey R.;
Cotreau, Monette M.;
Wilson, Lindsey;
Strahs, Andrew L.;
Vargo, Dennis L.;
Chadha, Manpreet

Publication type:

Article

The effect of maraviroc on the pharmacokinetics of digoxin in healthy volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 3, p. 202, doi. 10.1002/cpdd.91

By:

Vourvahis, Manoli;
Fang, Juanzhi;
Choo, Heng Wee;
Heera, Jayvant

Publication type:

Article

Issue Information.

Published in:: Clinical Pharmacology in Drug Development, 2014, v. 3, n. 3, p. i, doi. 10.1002/cpdd.66
Publication type:: Article

Evaluation of the pharmacokinetics and pharmacodynamics of two leuprolide acetate 45 mg 6-month depot formulations in patients with prostate cancer.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 4, p. 270, doi. 10.1002/cpdd.112

By:

Mostafa, Nael M.;
Chwalisz, Kristof;
Larsen, Lois;
Mattia‐Goldberg, Cynthia;
Spitz, Aaron;
Pradhan, Rajendra S.

Publication type:

Article

Evaluation of the effect of ruxolitinib on cardiac repolarization: A thorough QT study.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 3, p. 207, doi. 10.1002/cpdd.90

By:

Punwani, Naresh;
Yeleswaram, Swamy;
Chen, Xuejun;
Bowman, Jill;
Soloviev, Maxim;
Williams, William

Publication type:

Article

A phase 1, randomized study to assess the pharmacokinetic comparability of siltuximab derived from two different cell lines in healthy subjects.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 4, p. 328, doi. 10.1002/cpdd.86

By:

Xu, Chao;
Han, Chao;
Marini, Joseph;
Ford, Joyce;
Marciniak, Stanley;
Lopez, Manny;
Frederick, Bart;
de Vries, Dick;
Bandekar, Rajesh;
Davis, Hugh M.;
Zhou, Honghui;
Puchalski, Thomas A.

Publication type:

Article

Pharmacokinetics and pharmacodynamics of GSK961081, a novel inhaled muscarinic antagonist β2-agonist, and fluticasone propionate administered alone, concurrently and as a combination blend formulation in healthy volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 4, p. 305, doi. 10.1002/cpdd.105

By:

Norris, Virginia;
Ambery, Claire;
Riley, Trevor

Publication type:

Article

An evaluation of the systemic bioavailability of mometasone furoate (MF) after oral inhalation from a MF/formoterol fumarate metered-dose inhaler versus an MF dry-powder inhaler in healthy subjects.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 3, p. 229, doi. 10.1002/cpdd.97

By:

Kosoglou, Teddy;
Hubbell, James;
Kantesaria, Bhavna;
Hanson, Mary E.;
Cutler, David L.

Publication type:

Article

Evaluation of the effect of mericitabine at projected therapeutic and supratherapeutic doses on cardiac repolarization in healthy subjects: A thorough QT/QTc study.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 3, p. 179, doi. 10.1002/cpdd.79

By:

Chen, Ya‐Chi;
Haznedar, Joshua;
Kulkarni, Rohit;
Vistuer, Christelle;
Washington, Carla;
Liu, Mei;
Smith, Patrick

Publication type:

Article

Sleep-promoting medications: Weighing the hazards of use versus non-use.

Published in:

2014

By:

Greenblatt, David J.

Publication type:

Editorial

Safety, tolerability, pharmacokinetics, and pharmacodynamics of vilanterol, a novel inhaled long-acting β-agonist, in children aged 5-11 years with persistent asthma: A randomized trial.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 3, p. 215, doi. 10.1002/cpdd.92

By:

Oliver, Amanda;
VanBuren, Sandi;
Allen, Ann;
Hamilton, Melanie;
Tombs, Lee;
Kempsford, Rodger;
Qaqundah, Paul

Publication type:

Article

Steady-state pharmacokinetics of sirolimus in stable adult Chinese renal transplant patients.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 3, p. 235, doi. 10.1002/cpdd.96

By:

Wang, Huifen Faye;
Qiu, Feng;
Wu, Xiongfe;
Fang, Juanzhi;
Crownover, Penelope;
Korth‐Bradley, Joan;
Schulman, Seth

Publication type:

Article

No influence of the CYP2C19-selective inhibitor omeprazole on the pharmacokinetics of the dopamine receptor agonist rotigotine.

Published in:

Clinical Pharmacology in Drug Development, 2014, v. 3, n. 3, p. 187, doi. 10.1002/cpdd.78

By:

Elshoff, Jan‐Peer;
Cawello, Willi;
Andreas, Jens‐Otto;
Braun, Marina

Publication type:

Article