Works in Signal Transduction & Targeted Therapy, 2023, Vol 8, Issue 1

Results: 404

Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01705-z

By:

Bahar, Md Entaz;
Kim, Hyun Joon;
Kim, Deok Ryong

Publication type:

Article

An unexpected cellular fountain of youth: platelets provide factors rejuvenating brain functions.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01716-w

By:

Langer, Harald F.

Publication type:

Article

UniBind: a novel artificial intelligence-based prediction model for SARS-CoV-2 infectivity and variant evolution.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01691-2

By:

Yan, Qihong;
Zhao, Jincun

Publication type:

Article

Targeting complement hyperactivation: a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection.

Published in:

2023

By:

Jia, Leili;
Luo, Haihua;
Li, Lizhong;
Wang, Mingyao;
Liu, Jiangfeng;
Liang, Yuan;
Li, Shan;
Jiang, Yong;
Yang, Juntao;
Song, Hongbin

Publication type:

Letter

Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01708-w

By:

Zhai, You;
Du, Yicong;
Li, Guanzhang;
Yu, Mingchen;
Hu, Huimin;
Pan, Changqing;
Wang, Di;
Shi, Zhongfang;
Yan, Xu;
Li, Xuesong;
Jiang, Tao;
Zhang, Wei

Publication type:

Article

Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01724-w

By:

Ao, Danyi;
He, Xuemei;
Liu, Jian;
Xu, Li

Publication type:

Article

Simultaneously targeting extracellular vesicle trafficking and TGF-β receptor kinase activity blocks signaling hyperactivation and metastasis.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01711-1

By:

Teixeira, Adilson Fonseca;
Wang, Yanhong;
Iaria, Josephine;
ten Dijke, Peter;
Zhu, Hong-Jian

Publication type:

Article

Mpox (formerly monkeypox): pathogenesis, prevention, and treatment.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01675-2

By:

Lu, Junjie;
Xing, Hui;
Wang, Chunhua;
Tang, Mengjun;
Wu, Changcheng;
Ye, Fan;
Yin, Lijuan;
Yang, Yang;
Tan, Wenjie;
Shen, Liang

Publication type:

Article

Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine.

Published in:

2023

By:

Guo, Mengyu;
Cao, Mingjing;
Sun, Jiufeng;
Chen, Ziwei;
Wang, Xin;
Dai, Lianpan;
Gao, George F.;
Zhao, Yuliang;
Wang, Yaling;
Chen, Chunying

Publication type:

Letter

New insights into the correlations between circulating tumor cells and target organ metastasis.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01725-9

By:

Zhan, Qinru;
Liu, Bixia;
Situ, Xiaohua;
Luo, Yuting;
Fu, Tongze;
Wang, Yanxia;
Xie, Zhongpeng;
Ren, Lijuan;
Zhu, Ying;
He, Weiling;
Ke, Zunfu

Publication type:

Article

Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy.

Published in:

2023

By:

Yu, Lei;
Zhao, Pengcheng;
Sun, Yaoliang;
Zheng, Zening;
Du, Wenhao;
Zhang, Lishan;
Li, Yaxu;
Xie, Longyan;
Xu, Shilin;
Wang, Ping

Publication type:

Letter

Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01710-2

By:

Chen, Liping;
Zhu, Shihao;
Liu, Tianyuan;
Zhao, Xuan;
Xiang, Tao;
Hu, Xiao;
Wu, Chen;
Lin, Dongxin

Publication type:

Article

Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages.

Published in:

2023

By:

Chen, Huili;
Fu, Shengyang;
Li, Xiangyu;
Shi, Meng;
Qian, Jiazhen;
Zhao, Shu;
Yuan, Ping;
Ding, Lu;
Xia, Xiaohuan;
Zheng, Jialin C.

Publication type:

Letter

Host cyclophilin A facilitates SARS-CoV-2 infection by binding and stabilizing spike on virions.

Published in:

2023

By:

Sheng, Xiangpeng;
Zhu, Fang;
Peng, Hong;
Yang, Fan;
Yang, Yi;
Yang, Cong;
Wang, Zhen;
Chen, Wei;
Guo, Deyin;
Hu, Ronggui

Publication type:

Letter

Long-COVID-19: the persisting imprint of SARS-CoV-2 infections on the innate immune system.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01717-9

By:

Boes, Marianne;
Falter-Braun, Pascal

Publication type:

Article

Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01713-z

By:

Wei, Jun;
Li, Min;
Ye, Zhi;
Hu, Xinqian;
He, Xiaoyan;
Wang, Jia;
Chen, Gaofeng;
Zou, Chengyu;
Xu, Daichao;
Zhang, Hongbing;
Yuan, Junying;
Zha, Yunhong

Publication type:

Article

Therapeutic cancer vaccines: advancements, challenges, and prospects.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01674-3

By:

Fan, Ting;
Zhang, Mingna;
Yang, Jingxian;
Zhu, Zhounan;
Cao, Wanlu;
Dong, Chunyan

Publication type:

Article

Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01696-x

By:

Brichkina, Anna;
Suezov, Roman;
Huber, Magdalena

Publication type:

Article

IgE-Mast cell mediated allergy: a sensor of food quality.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01695-y

By:

Udoye, Christopher C.;
Manz, Rudolf A.

Publication type:

Article

Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01686-z

By:

Sun, Yan;
Yang, Xiu-Na;
Yang, Shuang-Shuang;
Lyu, Yi-Zhu;
Zhang, Bing;
Liu, Kai-Wen;
Li, Na;
Cui, Jia-Chen;
Huang, Guang-Xiang;
Liu, Cheng-Lin;
Xu, Jie;
Mi, Jian-Qing;
Chen, Zhu;
Fan, Xiao-Hu;
Chen, Sai-Juan;
Chen, Shuo

Publication type:

Article

Tau in the pancreas: understanding the link between type 2 diabetes mellitus and Alzheimer's disease.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01701-3

By:

Li, Wenlu;
Tiedt, Steffen;
Lo, Eng H.

Publication type:

Article

Going only half the way: cell cycle exit after the G1 restriction point.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01692-1

By:

Müller, Lisa;
Gutschner, Tony;
Hatzfeld, Mechthild

Publication type:

Article

SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01712-0

By:

Wang, Xinling;
Lu, Lu;
Jiang, Shibo

Publication type:

Article

BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01478-5

By:

Huang, Chongbiao;
Li, Hui;
Xu, Yang;
Xu, Chao;
Sun, Huizhi;
Li, Zengxun;
Ge, Yi;
Wang, Hongwei;
Zhao, Tiansuo;
Gao, Song;
Wang, Xiuchao;
Yang, Shengyu;
Sun, Peiqing;
Liu, Zhe;
Liu, Jing;
Chang, Antao;
Hao, Jihui

Publication type:

Article

Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01683-2

By:

Xie, Daoyuan;
Tian, Yaomei;
Hu, Die;
Wang, Yuanda;
Yang, Yuling;
Zhou, Bailing;
Zhang, Rui;
Ren, Zhixiang;
Liu, Mohan;
Xu, Jie;
Dong, Chunyan;
Zhao, Binyan;
Yang, Li

Publication type:

Article

Predictive biomarkers of response and survival following immunotherapy with a PD-L1 inhibitor benmelstobart (TQB2450) and antiangiogenic therapy with a VEGFR inhibitor anlotinib for pretreated advanced triple negative breast cancer.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01672-5

By:

Han, Yiqun;
Wang, Jiayu;
Sun, Tao;
Ouyang, Quchang;
Li, Jianwen;
Yuan, Jie;
Xu, Binghe

Publication type:

Article

Signaling pathways and targeted therapies for psoriasis.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01655-6

By:

Guo, Jia;
Zhang, Hanyi;
Lin, Wenri;
Lu, Lixia;
Su, Juan;
Chen, Xiang

Publication type:

Article

Multifunctional mesoporous silica nanoparticles for biomedical applications.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01654-7

By:

Xu, Bolong;
Li, Shanshan;
Shi, Rui;
Liu, Huiyu

Publication type:

Article

γδ T cells: origin and fate, subsets, diseases and immunotherapy.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01653-8

By:

Hu, Yi;
Hu, Qinglin;
Li, Yongsheng;
Lu, Ligong;
Xiang, Zheng;
Yin, Zhinan;
Kabelitz, Dieter;
Wu, Yangzhe

Publication type:

Article

The Vγ4/butyrophilin conspiracy: novel role of intraepithelial γδ T cells in chronic inflammatory bowel disease.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01697-w

By:

Kabelitz, Dieter

Publication type:

Article

Correction: Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L.

Published in:

2023

By:

Xu, Xia;
Yu, Tao;
Dong, Lingling;
Glauben, Rainer;
Wu, Siyuan;
Huang, Ronghua;
Qumu, Shiwei;
Chang, Chenli;
Guo, Jing;
Pan, Lin;
Yang, Ting;
Lin, Xin;
Huang, Ke;
Chen, Zhihua;
Wang, Chen

Publication type:

Correction Notice

Decoding γδ T cell anticancer therapies: integrating CRISPR screens with tumor organoids.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01678-z

By:

Zhou, Jian;
Wu, Min;
Yang, Gen

Publication type:

Article

Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01651-w

By:

Talukdar, Priyanka Dey;
Chatterji, Urmi

Publication type:

Article

Single-cell genomics: the human biomolecular and cell atlases.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01676-1

By:

Mei, Yuqing;
Wang, Jingjing;
Guo, Guoji

Publication type:

Article

Nuclear transport proteins: structure, function, and disease relevance.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01649-4

By:

Yang, Yang;
Guo, Lu;
Chen, Lin;
Gong, Bo;
Jia, Da;
Sun, Qingxiang

Publication type:

Article

Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01667-2

By:

Yang, Hange;
Zhang, Xiaowei;
Wang, Cong;
Zhang, Hailong;
Yi, Juan;
Wang, Kun;
Hou, Yanzhe;
Ji, Peihong;
Jin, Xiaojie;
Li, Chenghao;
Zhang, Min;
Huang, Shan;
Jia, Haoyuan;
Hu, Kuan;
Mou, Lingyun;
Wang, Rui

Publication type:

Article

Human embryo models: unveiling sophisticated self-organization of stem cells during post-implantation stages.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01677-0

By:

Lin, Manqiang;
Sigal, Michael

Publication type:

Article

The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01640-z

By:

Li, Jingwei;
Zhou, Yun;
Ma, Jiechao;
Zhang, Qin;
Shao, Jun;
Liang, Shufan;
Yu, Yizhou;
Li, Weimin;
Wang, Chengdi

Publication type:

Article

Sell<sup>hi</sup> neutrophils: a key to triumph in cancer therapy.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01671-6

By:

Pylaeva, Ekaterina;
Jablonska, Jadwiga

Publication type:

Article

Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01559-5

By:

Jing, Junjun;
Wu, Zhuoxuan;
Wang, Jiahe;
Luo, Guowen;
Lin, Hengyi;
Fan, Yi;
Zhou, Chenchen

Publication type:

Article

Discovery of novel non-peptidic and non-covalent small-molecule 3CL<sup>pro</sup> inhibitors as potential candidate for COVID-19 treatment.

Published in:

2023

By:

Jiang, Zhidong;
Feng, Bo;
Zhang, Yumin;
Nie, Tianqing;
Liu, Hong;
Li, Jia;
Su, Haixia;
Zhang, Leike;
Zang, Yi;
Zhou, Yu

Publication type:

Letter

The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01666-3

By:

Qu, Jiaorong;
Qiu, Bojun;
Zhang, Yuxin;
Hu, Yan;
Wang, Zhixing;
Guan, Zhiang;
Qin, Yiming;
Sui, Tongtong;
Wu, Fan;
Li, Boyang;
Han, Wei;
Peng, Xiaozhong

Publication type:

Article

Starving out brain tumors: a reprogrammed lysine catabolism serves as a novel target for glioblastoma treatment.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01616-z

By:

Gül, Désirée;
Krämer, Oliver H.;
Reinhardt, Christoph

Publication type:

Article

Bromodomain and extraterminal (BET) proteins: biological functions, diseases, and targeted therapy.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01647-6

By:

Wang, Zhi-Qiang;
Zhang, Zhao-Cong;
Wu, Yu-Yang;
Pi, Ya-Nan;
Lou, Sheng-Han;
Liu, Tian-Bo;
Lou, Ge;
Yang, Chang

Publication type:

Article

SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01685-0

By:

Diao, Xiayao;
Guo, Chao;
Zheng, Hanhao;
Zhao, Ke;
Luo, Yuming;
An, Mingjie;
Lin, Yan;
Chen, Jiancheng;
Li, Yuanlong;
Li, Yuting;
Gao, Xuehan;
Zhang, Jiaqi;
Zhou, Mengxin;
Bai, Wenliang;
Liu, Lei;
Wang, Guige;
Zhang, Lanjun;
He, Xiaotian;
Zhang, Rusi;
Li, Zhihua

Publication type:

Article

Smart nanoparticles for cancer therapy.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01642-x

By:

Sun, Leming;
Liu, Hongmei;
Ye, Yanqi;
Lei, Yang;
Islam, Rehmat;
Tan, Sumin;
Tong, Rongsheng;
Miao, Yang-Bao;
Cai, Lulu

Publication type:

Article

Smart nanoparticles for cancer therapy.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01642-x

By:

Sun, Leming;
Liu, Hongmei;
Ye, Yanqi;
Lei, Yang;
Islam, Rehmat;
Tan, Sumin;
Tong, Rongsheng;
Miao, Yang-Bao;
Cai, Lulu

Publication type:

Article

Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01670-7

By:

Huang, Liangjiang;
Zhang, Song;
Wu, Jun;
Guo, Baojie;
Gao, Tingting;
Shah, Sayed Zulfiqar Ali;
Huang, Bo;
Li, Yajie;
Zhu, Bo;
Fan, Jiaqi;
Wang, Liu;
Xiao, Yani;
Liu, Wenjing;
Tian, Yao;
Fang, Zhengyu;
Lv, Yingying;
Xie, Lingfeng;
Yao, Sheng;
Ke, Gaotan;
Huang, Xiaolin

Publication type:

Article

Commanding the Commander: structure of a key protein machinery in endosomal trafficking.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01568-4

By:

Yong, Xin;
Zhou, Chunzhuang;
Billadeau, Daniel D.;
Jia, Da

Publication type:

Article

Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01635-w

By:

Liu, Yan;
Shao, Yi-hui;
Zhang, Jun-meng;
Wang, Ying;
Zhou, Mei;
Li, Hui-qin;
Zhang, Cong-cong;
Yu, Pei-jie;
Gao, Shi-juan;
Wang, Xue-rui;
Jia, Li-xin;
Piao, Chun-mei;
Du, Jie;
Li, Yu-lin

Publication type:

Article