Works matching IS 20083866 AND DT 2022 AND VI 25 AND IP 11


Results: 15
    1
    2
    3

    MitoTEMPOL modulates mitophagy and histopathology of Wistar rat liver after streptozotocin injection.

    Published in:
    Iranian Journal of Basic Medical Sciences, 2022, v. 25, n. 11, p. 1382, doi. 10.22038/IJBMS.2022.65285.14375IntroductionDiabetesmellitusisaseriousdiseasethatcancausecomplicationsinvariousorgansofthebody,therebyreducingthequalityoflife(1).Chronichyperglycemiaindiabetescausesglucotoxicitythatmightbecorrelatedwithmitochondrialdynamics(2).Glucotoxicityreferstoexcesscarbohydrateintakeintissuesthatmightbeconvertedtotriglycerides,freefattyacid,andfreecholesterol,inducingsteatosisintheliver(3).Recentstudieshaveevenshownthatglucotoxicitycancauselivercellinjurybyinducingendoplasmicreticulumstressandhepatocytecelldeath(3).Achemicalthatiswidelyusedforinducingdiabetestype1and2inrodentsisSTZ(4-6).AsingleSTZinjectioncausespartialdestructionofthepancreas,providingagoodmodelfortheeffectofglucotoxicityandlipotoxicityonmitochondrialoxidativedysfunction(4,6).Thissingle-doseSTZinjectionislessexpensiveandlesstime-consuming,comparedwithothermodelsthatinducediabetes(4).Withitsglucosemoietythatislinkedtoβcells,STZrecognizesGLUT2receptorsinβ
    By:
    • Virgana, Rova;
    • Gunadi, Julia Windi;
    • Atik, Nur;
    • Limdawati, Kwee;
    • Jasaputra, Diana Krisanti;
    • Wahyudianingsih, Roro;
    • Adrina Suardi, Nadya Naurah;
    • Soetadji, Ray Sebastian;
    • Goenawan, Hanna;
    • Lesmana, Ronny;
    • Kartasasmita, Arief Sjamsulaksan
    Publication type:
    Article
    4
    5
    6
    7
    8
    9
    10
    11
    12
    13
    14
    15