Works matching IS 19466234 AND DT 2025 AND VI 17 AND IP 801

Results: 7

A phase 1 clinical trial shows safe, sustained, AAV-mediated expression of IL-1Ra in the human osteoarthritic knee joint.

Published in:

Science Translational Medicine, 2025, v. 17, n. 801, p. 1, doi. 10.1126/scitranslmed.adu9804

By:

De la Vega, Rodolfo E.;
Sellon, Jacob L.;
Smith, Jay;
Wisniewski, Stephen J.;
Jurisson, Mary L.;
Frick, Matthew A.;
Scrabeck, Tyson L.;
Block, Julie B.;
Mills, Candee J.;
Pohlkamp, Zachary W.;
Coenen, Michael J.;
Hawse, Gresin P.;
Abdul, Temilola Y.;
Conaghan, Philip;
Keravala, Annahita;
Chalberg, Thomas W.;
Robbins, Paul D.;
Ghivizzani, Steven C.;
Evans, Christopher H.

Publication type:

Article

Longitudinally stable T cell function and innate immune activation distinguish healthy adult immunotypes.

Published in:

Science Translational Medicine, 2025, v. 17, n. 801, p. 1, doi. 10.1126/scitranslmed.adt4605

By:

Smithmyer, Megan E.;
Hu, Alex;
Dufort, Matthew J.;
Hocking, Anne M.;
Wiedeman, Alice E.;
Fasano, Kayla J.;
Torgerson, Troy R.;
Skene, Peter J.;
Reading, Julian;
Li, Xiaojun;
Gong, Qiuyu;
Long, S. Alice;
Lacy-Hulbert, Adam;
Gustafson, Claire E.;
Buckner, Jane H.;
Speake, Cate

Publication type:

Article

Molecular hallmarks of hydrocephalus.

Published in:

Science Translational Medicine, 2025, v. 17, n. 801, p. 1, doi. 10.1126/scitranslmed.adq1810

By:

Hale, Andrew T.;
Zhou, Blake;
Rajan, Arjun;
Duy, Phan Q.;
Goolam, Mubeen;
Alper, Seth L.;
Lehtinen, Maria K.;
Lancaster, Madeline A.;
Fame, Ryann M.;
Kahle, Kristopher T.

Publication type:

Article

IFN-γ–resistant CD28 CAR T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models.

Published in:

Science Translational Medicine, 2025, v. 17, n. 801, p. 1, doi. 10.1126/scitranslmed.adp8166

By:

Bailey, Stefanie R.;
Takei, Hana N.;
Escobar, Giulia;
Kann, Michael C.;
Bouffard, Amanda A.;
Kienka, Tamina;
Supper, Valentina M.;
Armstrong, Alexander;
Salas-Benito, Diego;
Phillips, Merle K.;
Birocchi, Filippo;
Vatsa, Sonika;
Silva, Harrison;
Scarfò, Irene;
Wehrli, Marc;
Grauwet, Korneel;
Darnell, Eli P.;
Graham, Charlotte E.;
Leick, Mark B.;
Korell, Felix

Publication type:

Article

Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors.

Published in:

Science Translational Medicine, 2025, v. 17, n. 801, p. 1, doi. 10.1126/scitranslmed.adn6921

By:

Yang, Ruirui;
Wang, Bei;
Su, Zhaoming;
Song, Ying;
Zhang, Yingying;
Liu, Yadan;
Zhang, Yinghui;
He, Changyu;
Yang, Xi;
Zhong, Feisheng;
Fu, Zunyun;
Ding, Yiluan;
Zhang, Naixia;
Li, Rui;
Chu, Shuqing;
Xu, Chuanhai;
Sun, Jian;
Shen, Haiwei;
Geng, Wei;
Zhang, Sulin

Publication type:

Article

A host defense peptide–mimicking prodrug activated by drug-resistant Gram-negative bacterial infections.

Published in:

Science Translational Medicine, 2025, v. 17, n. 801, p. 1, doi. 10.1126/scitranslmed.adl4870

By:

Xie, Jiayang;
Zhou, Min;
Cong, Zihao;
Xiao, Ximian;
Liu, Longqiang;
Chen, Sheng;
Jiang, Weinan;
Wu, Yueming;
Liu, Runhui

Publication type:

Article

Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancers.

Published in:

Science Translational Medicine, 2025, v. 17, n. 801, p. 1, doi. 10.1126/scitranslmed.adk7786

By:

Cai, Yanyan;
Zhao, Peihua;
Wu, Fan;
Zhao, Huiyong;
Shao, Hong;
Marra, Antonio;
Patel, Payal;
O'Connell, Elizabeth;
Fink, Emma;
Miele, Matthew M.;
Li, Zhuoning;
De Stanchina, Elisa;
Cocco, Emiliano;
Razavi, Pedram;
Toska, Eneda;
Fanning, Sean W.;
Xu, Guotai;
Sablina, Anna A.;
Scaltriti, Maurizio;
Chandarlapaty, Sarat

Publication type:

Article