Works in mAbs, 2023, Vol 15, Issue 1

Results: 102

Accelerating the speed of innovative anti-tumor drugs to first-in-human trials incorporating key de-risk strategies.

Published in:

2023

By:

Wang, Yuqi;
Quan, Quan;
Gleason, Camille;
Yu, Helin;
Peng, Lujia;
Kang, Yanshen;
Jiang, Ling;
Wu, Kailun;
Pan, Jie;
Bao, Moxiyele;
Zhu, Qing;
Yi, Meiqi;
Fang, Ming;
Zheng, Yue;
Qiu, Ling;
Xu, Bin;
Li, Xiang;
Song, Jinfeng;
Sun, Jiamu;
Zhang, Zheng

Publication type:

Report

Determining the affinities of high-affinity antibodies using KinExA and surface plasmon resonance.

Published in:

2023

By:

Erasmus, M. Frank;
Dovner, Molly;
Ferrara, Fortunato;
D'Angelo, Sara;
Teixeira, André A.;
Leal-Lopes, Camila;
Spector, Laura;
Hopkins, Elizabeth;
Bradbury, Andrew R. M.

Publication type:

Report

Discovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer.

Published in:

2023

By:

Davies, Gareth C. G.;
Dedi, Neesha;
Jones, Paul S.;
Kevorkian, Lara;
McMillan, David;
Ottone, Cristina;
Schulze, Monika-Sarah E. D.;
Scott-Tucker, Anthony;
Tewari, Roohi;
West, Shauna;
Wright, Michael;
Rowley, Tania F.

Publication type:

Report

Development and pharmacokinetic assessment of a fully canine anti-PD-1 monoclonal antibody for comparative translational research in dogs with spontaneous tumors.

Published in:

2023

By:

Yoshimoto, Sho;
Chester, Nicholas;
Xiong, Ailian;
Radaelli, Enrico;
Wang, Hong;
Brillantes, Marc;
Gulendran, Gayathri;
Glassman, Patrick;
Siegel, Don L.;
Mason, Nicola J.

Publication type:

Report

BERT2DAb: a pre-trained model for antibody representation based on amino acid sequences and 2D-structure.

Published in:

2023

By:

Luo, Xiaowei;
Tong, Fan;
Zhao, Wenbin;
Zheng, Xiangwen;
Li, Jiangyu;
Li, Jing;
Zhao, Dongsheng

Publication type:

Report

Correction.

Published in:: 2023
Publication type:: Correction Notice

Epitope mapping of monoclonal antibodies: a comprehensive comparison of different technologies.

Published in:

2023

By:

Dang, Xibei;
Guelen, Lars;
Lutje Hulsik, David;
Ermakov, Grigori;
Hsieh, Edward J.;
Kreijtz, Joost;
Stammen-Vogelzangs, Judith;
Lodewijks, Imke;
Bertens, Astrid;
Bramer, Arne;
Guadagnoli, Marco;
Nazabal, Alexis;
van Elsas, Andrea;
Fischmann, Thierry;
Juan, Veronica;
Beebe, Amy;
Beaumont, Maribel;
van Eenennaam, Hans

Publication type:

Report

Monoclonal antibody and protein therapeutic formulations for subcutaneous delivery: high-concentration, low-volume vs. low-concentration, high-volume.

Published in:

mAbs (1942-0862), 2023, v. 15, n. 1, p. 1, doi. 10.1080/19420862.2023.2285277

By:

Desai, M.;
Kundu, A.;
Hageman, M.;
Lou, H.;
Boisvert, D.

Publication type:

Article

A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization.

Published in:

2023

By:

Arras, Paul;
Yoo, Han Byul;
Pekar, Lukas;
Schröter, Christian;
Clarke, Thomas;
Krah, Simon;
Klewinghaus, Daniel;
Siegmund, Vanessa;
Evers, Andreas;
Zielonka, Stefan

Publication type:

Report

Anti-citrullinated histone monoclonal antibody CIT-013, a dual action therapeutic for neutrophil extracellular trap-associated autoimmune diseases.

Published in:

2023

By:

van der Linden, Maarten;
Kumari, Sangeeta;
Montizaan, Daphne;
van Dalen, Stephanie;
Kip, Annemarie;
Foster, Martyn;
Reinieren-Beeren, Inge;
Neubert, Elsa;
Erpenbeck, Luise;
Waaijenberg, Kelsy;
Bruurmijn, Tirza;
te Poele, Rezie;
van Zandvoort, Peter;
Vink, Paul;
Meldrum, Eric;
van Es, Helmuth;
Chirivi, Renato G.S.

Publication type:

Report

Breaking barriers in antibody discovery: harnessing divergent species for accessing difficult and conserved drug targets.

Published in:

mAbs (1942-0862), 2023, v. 15, n. 1, p. 1, doi. 10.1080/19420862.2023.2273018

By:

Banik, Soma S.R.;
Kushnir, Natasha;
Doranz, Benjamin J.;
Chambers, Ross

Publication type:

Article

A window into the human immune system: comprehensive characterization of the complexity of antibody complementary-determining regions in functional antibodies.

Published in:

2023

By:

Mejias-Gomez, Oscar;
Madsen, Andreas V.;
Skovgaard, Kerstin;
Pedersen, Lasse E.;
Morth, J. Preben;
Jenkins, Timothy P.;
Kristensen, Peter;
Goletz, Steffen

Publication type:

Report

Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice.

Published in:

2023

By:

Liu, Shufang;
Humphreys, Sara C.;
Cook, Kevin D.;
Conner, Kip P.;
Correia, Ana R.;
Jacobitz, Alex W.;
Yang, Melissa;
Primack, Ronya;
Soto, Marcus;
Padaki, Rupa;
Lubomirski, Mariusz;
Smith, Richard;
Mock, Marissa;
Thomas, Veena A.

Publication type:

Report

Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans.

Published in:

2023

By:

Grimm, Hans Peter;
Schumacher, Vanessa;
Schäfer, Martin;
Imhof-Jung, Sabine;
Freskgård, Per-Ola;
Brady, Kevin;
Hofmann, Carsten;
Rüger, Petra;
Schlothauer, Tilman;
Göpfert, Ulrich;
Hartl, Maximilian;
Rottach, Sylvia;
Zwick, Adrian;
Seger, Shanon;
Neff, Rachel;
Niewoehner, Jens;
Janssen, Niels

Publication type:

Report

Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-Cλ interface.

Published in:

2023

By:

Bagert, John D.;
Oganesyan, Vaheh;
Chiang, Chi-I;
Iannotti, Mike;
Lin, Jia;
Yang, Chunning;
Payne, Sterling;
McMahon, Will;
Edwards, Samuel;
Dippel, Andrew;
Hutchinson, Mark;
Huang, Fengying;
Aleti, Vineela;
Niu, Chendi;
Qian, Chen;
Denham, Jessica;
Ferreira, Sofia;
Pradhan, Pallab;
Penney, Mark;
Wang, Chunlei

Publication type:

Report

Identification of tyrosine sulfation in the variable region of a bispecific antibody and its effect on stability and biological activity.

Published in:

2023

By:

Lietz, Christopher B.;
Deyanova, Ekaterina;
Cho, Younhee;
Cordia, Jon;
Franc, Sarah;
Kabro, Sally;
Wang, Steven;
Mikolon, David;
Banks, Douglas D.

Publication type:

Report

Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies.

Published in:

2023

By:

Mock, Marissa;
Jacobitz, Alex W.;
Langmead, Christopher James;
Sudom, Athena;
Yoo, Daniel;
Humphreys, Sara C.;
Alday, Mai;
Alekseychyk, Larysa;
Angell, Nicolas;
Bi, Vivian;
Catterall, Hannah;
Chen, Chen-Chun;
Chou, Hui-Ting;
Conner, Kip P.;
Cook, Kevin D.;
Correia, Ana R.;
Dykstra, Andrew;
Ghimire-Rijal, Sudipa;
Graham, Kevin;
Grandsard, Peter

Publication type:

Report

Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates.

Published in:

2023

By:

Petersen, Inga;
Ali, Muhammad Ilyas;
Petrovic, Alex;
Ytterberg, Anders Jimmy;
Staxäng, Karin;
Hodik, Monika;
Rofo, Fadi;
Bondza, Sina;
Hultqvist, Greta

Publication type:

Report

Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders.

Published in:

2023

By:

Maciuba, Stephanie;
Bowden, Gregory D.;
Stratton, Harrison J.;
Wisniewski, Kazimierz;
Schteingart, Claudio D.;
Almagro, Juan C.;
Valadon, Philippe;
Lowitz, Joshua;
Glaser, Scott M.;
Lee, Grace;
Dolatyari, Mahdi;
Navratilova, Edita;
Porreca, Frank;
Rivière, Pierre J.M.

Publication type:

Report

Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT.

Published in:

2023

By:

Diong, SJ J.;
Jashnani, Aarti;
Drake, Andrew W.;
Bee, Christine;
Findeisen, Felix;
Dollinger, Gavin;
Wang, Feng;
Rajpal, Arvind;
Strop, Pavel;
Lee, Peter S.

Publication type:

Report

Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4+ T cell interleukin-2 secretion.

Published in:

2023

By:

Arata, Yoshiyuki;
Motoyama, Shigeki;
Yano, Mariko;
Ikuno, Tatsuya;
Ito, Shunsuke;
Matsushita, Tomochika;
Takeiri, Akira;
Nishito, Yukari;
Yabuki, Nami;
Mizuno, Hideaki;
Sampei, Zenjiro;
Mishima, Masayuki;
Honda, Masaki;
Kiyokawa, Jumpei;
Suzuki, Hiromi;
Chiba, Shuichi;
Tabo, Mitsuyasu;
Kubo, Chiyomi

Publication type:

Report

Mammalian display to secretion switchable libraries for antibody preselection and high throughput functional screening.

Published in:

2023

By:

Gaa, Ramona;
Mayer, Hannah Melina;
Noack, Daniela;
Kumari, Kavita;
Guenther, Ralf;
Tsai, Shang-Pu;
Ji, Qingyong;
Doerner, Achim

Publication type:

Report

Use of poxvirus display to select antibodies specific for complex membrane antigens.

Published in:

2023

By:

Smith, Ernest S.;
Balch, Leslie A.;
Scrivens, Maria;
Shi, Shuying;
Wang, Wei;
Harvey, Caroline D.;
Cornelison, Angelica A.;
Gil-Moore, Malgorzata;
Kirk, Renee A.;
Mueller, Loretta L.;
Hall, Richard L.;
Howell, Alan P.;
Reilly, Christine A.;
Mayer, Jessica M.;
Murante, Francis G.;
Viggiani, Kari A;
Gersz, Elaine M.;
Bussler, Holm;
Keefe, Madeleine R.;
Evans, Elizabeth E.

Publication type:

Report

Unique epitope–antibody interactions in the intrinsically disordered proteoglycan-like domain of human carbonic anhydrase IX defined by high-resolution NMR combined with yeast surface display.

Published in:

2023

By:

Ni, Feng;
Wu, Cunle;
Xu, Ping;
Wang, Ping;
Fortin, Yves;
Arbour, Melanie;
Masson, Luke;
L'Abbé, Denis;
Acel, Andrea;
Gosselin, Mylene;
Lenferink, Anne E.G.

Publication type:

Report

A machine learning strategy for the identification of key in silico descriptors and prediction models for IgG monoclonal antibody developability properties.

Published in:

2023

By:

Waight, Andrew B.;
Prihoda, David;
Shrestha, Rojan;
Metcalf, Kevin;
Bailly, Marc;
Ancona, Marco;
Widatalla, Talal;
Rollins, Zachary;
Cheng, Alan C;
Bitton, Danny A.;
Fayadat-Dilman, Laurence

Publication type:

Report

Selection of bispecific antibodies with optimal developability using FcRn‑pH‑HPLC as an optimized FcRn affinity chromatography method.

Published in:

2023

By:

Müller, Thomas;
Tasser, Carolin;
Tesar, Michael;
Fucek, Ivica;
Schniegler-Mattox, Ute;
Koch, Joachim;
Ellwanger, Kristina

Publication type:

Report

Targeted chain-exchange-mediated reconstitution of a split type-I cytokine for conditional immunotherapy.

Published in:

2023

By:

Vasic, Vedran;
Buldun, Can;
Ritz, Manfred;
Dickopf, Steffen;
Georges, Guy J.;
Spick, Christian;
Peuker, Alessa;
Meier, Thomas;
Mayer, Klaus;
Brinkmann, Ulrich

Publication type:

Report

Monte Carlo Thompson sampling-guided design for antibody engineering.

Published in:

2023

By:

Kakuzaki, Taro;
Koga, Hikaru;
Takizawa, Shuuki;
Metsugi, Shoichi;
Shiraiwa, Hirotake;
Sampei, Zenjiro;
Yoshida, Kenji;
Tsunoda, Hiroyuki;
Teramoto, Reiji

Publication type:

Report

Interplay of heavy chain introns influences efficient transcript splicing and affects product quality of recombinant biotherapeutic antibodies from CHO cells.

Published in:

2023

By:

Kelsall, Emma;
Harris, Claire;
Sen, Titash;
Hatton, Diane;
Dunn, Sarah;
Gibson, Suzanne

Publication type:

Report

Bivalent non-human gal-α1-3-gal glycan epitopes in the Fc region of a monoclonal antibody model can be recognized by anti-Gal-α1-3-Gal IgE antibodies.

Published in:

2023

By:

Hatfield, Grayson;
Tepliakova, Lioudmila;
Tran, Jessica;
Lu, Huixin;
Gilbert, Michel;
Tam, Roger Y.

Publication type:

Report

Advances in the structural characterization of complexes of therapeutic antibodies with PD-1 or PD-L1.

Published in:

mAbs (1942-0862), 2023, v. 15, n. 1, p. 1, doi. 10.1080/19420862.2023.2236740

By:

Jiang, Mengzhen;
Liu, Man;
Liu, Guodi;
Ma, Jiawen;
Zhang, Lixin;
Wang, Shenlin

Publication type:

Article

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition.

Published in:

2023

By:

Lipinski, Britta;
Unmuth, Laura;
Arras, Paul;
Becker, Stefan;
Bauer, Christina;
Toleikis, Lars;
Krah, Simon;
Doerner, Achim;
Yanakieva, Desislava;
Boje, Ammelie Svea;
Klausz, Katja;
Peipp, Matthias;
Siegmund, Vanessa;
Evers, Andreas;
Kolmar, Harald;
Pekar, Lukas;
Zielonka, Stefan

Publication type:

Report

Prediction of long-term polysorbate degradation according to short-term degradation kinetics.

Published in:

2023

By:

Zhang, Sisi;
Riccardi, Caterina;
Carlson, Dane;
Kamen, Douglas;
Graham, Kenneth S.;
Shameem, Mohammed;
Bak, Hanne;
Xiao, Hui;
Li, Ning

Publication type:

Report

Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework.

Published in:

2023

By:

Ollier, Romain;
Fuchs, Aline;
Gauye, Florence;
Piorkowska, Katarzyna;
Menant, Sébastien;
Ratnam, Monisha;
Montanari, Paolo;
Guilhot, Florence;
Phillipe, Didier;
Audrain, Mickael;
Egesipe, Anne-Laure;
Névoltris, Damien;
Seredenina, Tamara;
Pfeifer, Andrea;
Kosco-Vilbois, Marie;
Afroz, Tariq

Publication type:

Report

Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies.

Published in:

2023

By:

Loh, Han Ping;
Mahfut, Farouq Bin;
Chen, Serene W;
Huang, Yuhan;
Huo, Jianxin;
Zhang, Wei;
Lam, Kong Peng;
Xu, Shengli;
Yang, Yuansheng

Publication type:

Report

Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG.

Published in:

2023

By:

Crowley, Andrew R.;
Mehlenbacher, Matthew R.;
Sajadi, Mohammad M.;
DeVico, Anthony L.;
Lewis, George K.;
Ackerman, Margaret E.

Publication type:

Report

Therapeutic index improvement of antibody-drug conjugates.

Published in:

mAbs (1942-0862), 2023, v. 15, n. 1, p. 1, doi. 10.1080/19420862.2023.2230618

By:

Gerber, Hans-Peter;
Gangwar, Sanjeev;
Betts, Alison

Publication type:

Article

Interrogating heterogeneity of cysteine-engineered antibody-drug conjugates and antibody-oligonucleotide conjugates by capillary zone electrophoresis-mass spectrometry.

Published in:

2023

By:

Xu, Tian;
Zhang, Fan;
Chen, Daoyang;
Sun, Liangliang;
Tomazela, Daniela;
Fayadat-Dilman, Laurence

Publication type:

Report

Exploration of the antibody–drug conjugate clinical landscape.

Published in:

mAbs (1942-0862), 2023, v. 15, n. 1, p. 1, doi. 10.1080/19420862.2023.2229101

By:

Maecker, Heather;
Jonnalagadda, Vidya;
Bhakta, Sunil;
Jammalamadaka, Vasu;
Junutula, Jagath R.

Publication type:

Article

Modifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier.

Published in:

2023

By:

Tien, Jason;
Leonoudakis, Dmitri;
Petrova, Ralitsa;
Trinh, Vivian;
Taura, Tetsuya;
Sengupta, Debapriya;
Jo, Lisa;
Sho, Angela;
Yun, Yong;
Doan, Eric;
Jamin, Anita;
Hallak, Hussein;
Wilson, David S.;
Stratton, Jennifer R.

Publication type:

Report

Understanding the structure–property relationship of bispecific monoclonal antibodies with Fc site-specific substitutions.

Published in:

2023

By:

Zhao, Bo;
Zhao, Yunlong;
Adaniya, Stephanie;
Fu, Yue;
Moon, Youmi;
Heftel, Justin;
Chen, Shuzhen;
Xiao, Hui;
Li, Ning

Publication type:

Report

A PDGFRB- and CD40-targeting bispecific AffiMab induces stroma-targeted immune cell activation.

Published in:

2023

By:

Mega, Alessandro;
Mebrahtu, Aman;
Aniander, Gustav;
Ryer, Eva;
Sköld, Annette;
Sandegren, Anna;
Backström Rydin, Eva;
Rockberg, Johan;
Östman, Arne;
Frejd, Fredrik Y.

Publication type:

Report

Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain.

Published in:

2023

By:

Kwon, Young D.;
Pegu, Amarendra;
Yang, Eun Sung;
Zhang, Baoshan;
Bender, Michael F.;
Asokan, Mangaiarkarasi;
Liu, Qingbo;
McKee, Krisha;
Lin, Bob C.;
Liu, Tracy;
Louder, Mark K.;
Rawi, Reda;
Reveiz, Mateo;
Schaub, Andrew J.;
Shen, Chen-Hsiang;
Doria-Rose, Nicole A.;
Lusso, Paolo;
Mascola, John R.;
Kwong, Peter D.

Publication type:

Report

Characterization of anti-SARS-CoV-2 monoclonal antibodies focusing on antigen binding, neutralization, and FcγR activation via formation of immune complex.

Published in:

2023

By:

Tada, Minoru;
Aoyama, Michihiko;
Ishii-Watabe, Akiko

Publication type:

Report

Efficient production of bispecific antibody by FAST-IgTM and its application to NXT007 for the treatment of hemophilia A.

Published in:

2023

By:

Koga, Hikaru;
Yamano, Takashi;
Betancur, Juan;
Nagatomo, Satoko;
Ikeda, Yousuke;
Yamaguchi, Kazuki;
Nabuchi, Yoshiaki;
Sato, Kazuki;
Teranishi-Ikawa, Yuri;
Sato, Motohiko;
Hirayama, Hiroyuki;
Hayasaka, Akira;
Torizawa, Takuya;
Haraya, Kenta;
Sampei, Zenjiro;
Shiraiwa, Hirotake;
Kitazawa, Takehisa;
Igawa, Tomoyuki;
Kuramochi, Taichi

Publication type:

Report

Generation of a novel fully human non-superagonistic anti-CD28 antibody with efficient and safe T-cell co-stimulation properties.

Published in:

2023

By:

Elsayed, Abdullah;
Pellegrino, Christian;
Plüss, Louis;
Peissert, Frederik;
Benz, Ramon;
Ulrich, Franziska;
Thorhallsdottir, Gudrun;
Plaza, Sheila Dakhel;
Villa, Alessandra;
Mock, Jacqueline;
Puca, Emanuele;
De Luca, Roberto;
Manz, Markus G.;
Halin, Cornelia;
Neri, Dario

Publication type:

Report

A HER2-targeted antibody-novel DNA topoisomerase I inhibitor conjugate induces durable adaptive antitumor immunity by activating dendritic cells.

Published in:

2023

By:

Tan, Xiaoding;
Fang, Peng;
Li, Kaiying;
You, Meng;
Cao, Yuxia;
Xu, Hui;
Zhu, Xiaohong;
Wang, Lu;
Wei, Xin;
Wen, Haiying;
Li, Wendi;
Shi, Lei;
Sun, Xiaowei;
Yu, Dongan;
Zhu, Huikai;
Wang, Zhenzhen;
Liu, Datao;
Shen, Hui;
Zhou, Wei;
An, Maomao

Publication type:

Report

Effects of the COVID-19 pandemic: new approaches for accelerated delivery of gene to first-in-human CMC data for recombinant proteins.

Published in:

mAbs (1942-0862), 2023, v. 15, n. 1, p. 1, doi. 10.1080/19420862.2023.2220150

By:

Broly, Hervé;
Souquet, Jonathan;
Beck, Alain

Publication type:

Article

In-line product quality monitoring during biopharmaceutical manufacturing using computational Raman spectroscopy.

Published in:

2023

By:

Wang, Jiarui;
Chen, Jingyi;
Studts, Joey;
Wang, Gang

Publication type:

Report

Affinity-controlled capture and release of engineered monoclonal antibodies by macroporous dextran hydrogels using coiled-coil interactions.

Published in:

2023

By:

Baniahmad, Seyed Farzad;
Oliverio, Romane;
Obregon-Gomez, Ines;
Robert, Alma;
Lenferink, Anne E.G.;
Pazos, Elena;
Virgilio, Nick;
Banquy, Xavier;
De Crescenzo, Gregory;
Durocher, Yves

Publication type:

Report