Works in mAbs (1942-0862), 2020, Vol 12, Issue 1

Results: 115

On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies.

Published in:

2020

By:

Tan, Zhijun;
Ehamparanathan, Vivekh;
Ren, Tingwei;
Tang, Peifeng;
Hoffman, Laurel;
Kuang, June;
Liu, Peiran;
Huang, Chao;
Du, Cheng;
Tao, Li;
Chemmalil, Letha;
Lewandowski, Angela;
Ghose, Sanchayita;
Li, Zheng Jian;
Liu, Shijie

Publication type:

Report

Targeted IgMs agonize ocular targets with extended vitreal exposure.

Published in:

2020

By:

Chen, Yvonne;
Paluch, Maciej;
Zorn, Julie A.;
Rajan, Sharmila;
Leonard, Brandon;
Estevez, Alberto;
Brady, John;
Chiu, Henry;
Phung, Wilson;
Famili, Amin;
Yan, Minhong;
Ciferri, Claudio;
Matsumoto, Marissa L.;
Lazar, Greg A.;
Crowell, Susan;
Hass, Phil;
Agard, Nicholas J.

Publication type:

Report

Therapeutic blockade of CXCR2 rapidly clears inflammation in arthritis and atopic dermatitis models: demonstration with surrogate and humanized antibodies.

Published in:

2020

By:

Alam, Md Jahangir;
Xie, Liang;
Ang, Caroline;
Fahimi, Farnaz;
Willingham, Stephen B.;
Kueh, Andrew J.;
Herold, Marco J.;
Mackay, Charles R.;
Robert, Remy

Publication type:

Report

Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipeline.

Published in:

mAbs (1942-0862), 2020, v. 12, n. 1, p. 1, doi. 10.1080/19420862.2020.1854149

By:

Tuccori, Marco;
Ferraro, Sara;
Convertino, Irma;
Cappello, Emiliano;
Valdiserra, Giulia;
Blandizzi, Corrado;
Maggi, Fabrizio;
Focosi, Daniele

Publication type:

Article

Monoclonal antibody 2C5 specifically targets neutrophil extracellular traps.

Published in:

2020

By:

Mendes, Livia P.;
Rostamizadeh, Kobra;
Gollomp, Kandace;
Myerson, Jacob W.;
Marcos-Contreras, Oscar A.;
Zamora, Marco;
Luther, Ed;
Brenner, Jacob S.;
Filipczak, Nina;
Li, Xiang;
Torchilin, Vladimir P.

Publication type:

Report

Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice.

Published in:

2020

By:

Low, Benjamin E.;
Christianson, Gregory J.;
Lowell, Emily;
Qin, Wenning;
Wiles, Michael V.

Publication type:

Report

Identification and quantitation of hinge cysteinylation on endogenous IgG2 antibodies from human serum.

Published in:

2020

By:

Ayalew, Luladey;
D'Souza, Alicia D.;
Chen, Yan;
Kim, Michael T.

Publication type:

Report

Vaccine-induced CD8 T cells are redirected with peptide-MHC class I-IgG antibody fusion proteins to eliminate tumor cells in vivo.

Published in:

2020

By:

Fischer, Cornelia;
Munks, Michael W.;
Hill, Ann B.;
Kroczek, Richard A.;
Bissinger, Stefan;
Brand, Verena;
Schmittnaegel, Martina;
Imhof-Jung, Sabine;
Hoffmann, Eike;
Herting, Frank;
Klein, Christian;
Knoetgen, Hendrik

Publication type:

Report

Rabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinity.

Published in:

2020

By:

Ros, Francesca;
Offner, Sonja;
Klostermann, Stefan;
Thorey, Irmgard;
Niersbach, Helmut;
Breuer, Sebastian;
Zarnt, Grit;
Lorenz, Stefan;
Puels, Juergen;
Siewe, Basile;
Schueler, Nicole;
Dragicevic, Tajana;
Ostler, Dominique;
Hansen-Wester, Imke;
Lifke, Valeria;
Kaluza, Brigitte;
Kaluza, Klaus;
van Schooten, Wim;
Buelow, Roland;
Tissot, Alain C

Publication type:

Report

Diverse HIV-1 escape pathways from broadly neutralizing antibody PGDM1400 in humanized mice.

Published in:

mAbs (1942-0862), 2020, v. 12, n. 1, p. 1, doi. 10.1080/19420862.2020.1845908

By:

van der Velden, Yme U.;
Villaudy, Julien;
Siteur - van Rijnstra, Esther;
van der Linden, Cynthia A.;
Vink, Monique A.;
Schermer, Edith E.;
Weijer, Kees;
Berkhout, Ben;
Sanders, Rogier W.;
van Gils, Marit J.

Publication type:

Article

Impact of Fc N-linked glycans on in vivo clearance of an immunoglobulin G1 antibody produced by NS0 cell line.

Published in:

2020

By:

Kim, Jun;
Luo, Haibin;
White, Wendy;
Rees, William;
Venkat, Raghavan;
Albarghouthi, Methal

Publication type:

Report

Selection and verification of antibodies against the cytoplasmic domain of M2 of influenza, a transmembrane protein.

Published in:

2020

By:

Velappan, Nileena;
Micheva-Viteva, Sofiya;
Adikari, Samantha H.;
Waldo, Geoffrey S.;
Lillo, Antonietta M.;
Bradbury, Andrew R.M.

Publication type:

Report

CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins.

Published in:

2020

By:

Jost, Christian;
Darowski, Diana;
Challier, John;
Pulko, Vesna;
Hanisch, Lydia J;
Xu, Wei;
Mössner, Ekkehard;
Bujotzek, Alexander;
Klostermann, Stefan;
Umana, Pablo;
Kontermann, Roland E.;
Klein, Christian

Publication type:

Report

Hiding in plain sight: structure and sequence analysis reveals the importance of the antibody DE loop for antibody-antigen binding.

Published in:

2020

By:

Kelow, Simon P.;
Adolf-Bryfogle, Jared;
Dunbrack, Roland L.

Publication type:

Report

Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism.

Published in:

2020

By:

Spatola, Bradley N.;
Lerner, Alana G.;
Wong, Clifford;
dela Cruz, Tracy;
Welch, Megan;
Fung, Wanchi;
Kovalenko, Maria;
Losenkova, Karolina;
Yegutkin, Gennady G.;
Beers, Courtney;
Corbin, John;
Soros, Vanessa B.

Publication type:

Report

Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies.

Published in:

2020

By:

Chuang, Gwo-Yu;
Asokan, Mangaiarkarasi;
Ivleva, Vera B.;
Pegu, Amarendra;
Yang, Eun Sung;
Zhang, Baoshan;
Chaudhuri, Rajoshi;
Geng, Hui;
Lin, Bob C.;
Louder, Mark K.;
McKee, Krisha;
O'Dell, Sijy;
Wang, Hairong;
Zhou, Tongqing;
Doria-Rose, Nicole A.;
Kueltzo, Lisa A.;
Lei, Q. Paula;
Mascola, John R.;
Kwong, Peter D.

Publication type:

Report

Isolation of monoclonal antibodies from anti-synthetase syndrome patients and affinity maturation by recombination of independent somatic variants.

Published in:

2020

By:

Burman, Luke;
Chong, Yeeting E.;
Duncan, Sherie;
Klaus, Anders;
Rauch, Kaitlyn;
Hamel, Kristina;
Hervé, Karine;
Pfaffen, Stephanie;
Collins, David W.;
Heyries, Kevin;
Nangle, Leslie;
Hansen, Carl;
King, David J.

Publication type:

Report

Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody.

Published in:

2020

By:

Boyles, Jeffrey S.;
Beidler, Catherine B.;
Strifler, Beth A.;
Girard, Daniel S.;
Druzina, Zhanna;
Durbin, Jim D.;
Swearingen, Michelle L.;
Lee, Linda N.;
Kikly, Kristine;
Chintharlapalli, Sudhakar;
Witcher, Derrick R.

Publication type:

Report

A monoclonal antibody with broad specificity for the ligands of insulin B:9-23 reactive T cells prevents spontaneous type 1 diabetes in mice.

Published in:

2020

By:

Cepeda, Joseph Ray;
Sekhar, Nitin S;
Han, Junying;
Xiong, Wei;
Zhang, Ningyan;
Yu, Liping;
Dai, Shaodong;
Davidson, Howard W.;
Kappler, John W.;
An, Zhiqiang;
Zhang, Li

Publication type:

Report

Novel human monoclonal antibodies specific to the alternatively spliced domain D of Tenascin C efficiently target tumors in vivo.

Published in:

2020

By:

Nadal, Lisa;
Corbellari, Riccardo;
Villa, Alessandra;
Weiss, Tobias;
Weller, Michael;
Neri, Dario;
De Luca, Roberto

Publication type:

Report

Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics.

Published in:

mAbs (1942-0862), 2020, v. 12, n. 1, p. 1, doi. 10.1080/19420862.2020.1829338

By:

Chen, Zhiqiang;
Qian, Yueming;
Song, Yuanli;
Xu, Xuankuo;
Tao, Li;
Mussa, Nesredin;
Ghose, Sanchayita;
Li, Zheng Jian

Publication type:

Article

Cross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humans.

Published in:

2020

By:

Sepp, Armin;
Bergström, Mats;
Davies, Marie

Publication type:

Report

Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models.

Published in:

2020

By:

Valente, Delphine;
Mauriac, Christine;
Schmidt, Thorsten;
Focken, Ingo;
Beninga, Jochen;
Mackness, Brian;
Qiu, Huawei;
Vicat, Pascale;
Kandira, Abdullah;
Radošević, Katarina;
Rao, Srini;
Darbyshire, John;
Kabiri, Mostafa

Publication type:

Report

Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses.

Published in:

2020

By:

Tang, Peifeng;
Tan, Zhijun;
Ehamparanathan, Vivekh;
Ren, Tingwei;
Hoffman, Laurel;
Du, Cheng;
Song, Yuanli;
Tao, Li;
Lewandowski, Angela;
Ghose, Sanchayita;
Li, Zheng Jian;
Liu, Shijie

Publication type:

Report

Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform.

Published in:

2020

By:

Pekar, Lukas;
Busch, Michael;
Valldorf, Bernhard;
Hinz, Steffen C.;
Toleikis, Lars;
Krah, Simon;
Zielonka, Stefan

Publication type:

Report

Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries.

Published in:

2020

By:

Dyson, Michael R.;
Masters, Edward;
Pazeraitis, Deividas;
Perera, Rajika L.;
Syrjanen, Johanna L.;
Surade, Sachin;
Thorsteinson, Nels;
Parthiban, Kothai;
Jones, Philip C.;
Sattar, Maheen;
Wozniak-Knopp, Gordana;
Rueker, Florian;
Leah, Rachael;
McCafferty, John

Publication type:

Report

An accelerated surface-mediated stress assay of antibody instability for developability studies.

Published in:

2020

By:

Kopp, Marie R.G.;
Wolf Pérez, Adriana-Michelle;
Zucca, Marta Virginia;
Capasso Palmiero, Umberto;
Friedrichsen, Brigitte;
Lorenzen, Nikolai;
Arosio, Paolo

Publication type:

Report

Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity.

Published in:

2020

By:

Cloutier, Theresa K.;
Sudrik, Chaitanya;
Mody, Neil;
Hasige, Sathish A.;
Trout, Bernhardt L.

Publication type:

Report

Engineered Fc-glycosylation switch to eliminate antibody effector function.

Published in:

2020

By:

Zhou, Qun;
Jaworski, Julie;
Zhou, Yanfeng;
Valente, Delphine;
Cotton, Joanne;
Honey, Denise;
Boudanova, Ekaterina;
Beninga, Jochen;
Rao, Ercole;
Wei, Ronnie;
Mauriac, Christine;
Pan, Clark;
Park, Anna;
Qiu, Huawei

Publication type:

Report

A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model.

Published in:

2020

By:

Zheng, Songmao;
Niu, Jin;
Geist, Brian;
Fink, Damien;
Xu, Zhenhua;
Zhou, Honghui;
Wang, Weirong

Publication type:

Report

Biased anti-idiotype response in rabbits leads to high-affinity monoclonal antibodies to biologics.

Published in:

2020

By:

Großerichter-Wagener, Christina;
Kos, Dorien;
van Leeuwen, Astrid;
Dijk, Lisanne;
Jeremiasse, Jorn;
Loeff, Floris C.;
Rispens, Theo

Publication type:

Report

Measuring aggregates, self-association, and weak interactions in concentrated therapeutic antibody solutions.

Published in:

2020

By:

Chaturvedi, Sumit K.;
Parupudi, Arun;
Juul-Madsen, Kristian;
Nguyen, Ai;
Vorup-Jensen, Thomas;
Dragulin-Otto, Sonia;
Zhao, Huaying;
Esfandiary, Reza;
Schuck, Peter

Publication type:

Report

CD40- and CD95-specific antibody single chain-Baff fusion proteins display BaffR-, TACI- and BCMA-restricted agonism.

Published in:

2020

By:

Nelke, Johannes;
Medler, Juliane;
Weisenberger, Daniela;
Beilhack, Andreas;
Wajant, Harald

Publication type:

Report

Assessment of the role of afucosylated glycoforms on the in vitro antibody-dependent phagocytosis activity of an antibody to Aβ aggregates.

Published in:

2020

By:

Kwiatkowski, Allyson;
Co, Carl;
Kameoka, Sei;
Zhang, An;
Coughlin, John;
Cameron, Tom;
Chiao, Eric;
Bergelson, Svetlana;
Schmid Mason, Cullen

Publication type:

Report

COBRA™: a highly potent conditionally active T cell engager engineered for the treatment of solid tumors.

Published in:

2020

By:

Panchal, Anand;
Seto, Pui;
Wall, Russell;
Hillier, Brian J.;
Zhu, Ying;
Krakow, Jessica;
Datt, Aakash;
Pongo, Elizabeth;
Bagheri, Andisheh;
Chen, Tseng-Hui T.;
Degenhardt, Jeremiah D.;
Culp, Patricia A.;
Dettling, Danielle E.;
Vinogradova, Maia V.;
May, Chad;
DuBridge, Robert B.

Publication type:

Report

Investigation of monoclonal antibody dimers in a final formulated drug by separation techniques coupled to native mass spectrometry.

Published in:

2020

By:

Rouby, G.;
Tran, N. T.;
Leblanc, Y.;
Taverna, M.;
Bihoreau, N.

Publication type:

Report

Novel monoclonal antibodies to the SERINC5 HIV-1 restriction factor detect endogenous and virion-associated SERINC5.

Published in:

2020

By:

Molnar, Sebastian;
Wieczorek, Lindsay;
Zemil, Michelle;
Schulte, Bianca;
Martinez, Elizabeth;
Gift, Syna;
Tang, Lan;
Streeck, Hendrik;
Gramzinski, Robert A.;
Michael, Nelson L.;
Joyce, Gordon;
Polonis, Victoria R.

Publication type:

Report

Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR.

Published in:

2020

By:

Simons, Jan Fredrik;
Lim, Yoong Wearn;
Carter, Kyle P.;
Wagner, Ellen K.;
Wayham, Nicholas;
Adler, Adam S.;
Johnson, David S.

Publication type:

Report

A novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy.

Published in:

mAbs (1942-0862), 2020, v. 12, n. 1, p. 1, doi. 10.1080/19420862.2020.1804241

By:

Miao, Xiaoniu;
Luo, Yi;
Huang, Xi;
Lee, Suki M. Y.;
Yuan, Zhijun;
Tang, Yongzhou;
Chen, Liandi;
Wang, Chao;
Wu, Fan;
Xu, Yifeng;
Jiang, Wenchao;
Gao, Wei;
Song, Xuedong;
Yan, Yao;
Pang, Tuling;
Chen, Cheng;
Zou, Yuefeng;
Fu, Weihui;
Wan, Liping;
Gilbert-Jaramillo, Javier

Publication type:

Article

AlbuCORE: an albumin-based molecular scaffold for multivalent biologics design.

Published in:

2020

By:

Sanches, Mario;
D'Angelo, Igor;
Jaramillo, Maria;
Baardsnes, Jason;
Zwaagstra, John;
Schrag, Joe;
Schoenhofen, Ian;
Acchione, Mauro;
Lawn, Sam;
Wickman, Grant;
Weisser, Nina;
Poon, David K. Y.;
Ng, Gordon;
Dixit, Surjit

Publication type:

Report

Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity.

Published in:

2020

By:

Sun, Yue;
Estevez, Alberto;
Schlothauer, Tilman;
Wecksler, Aaron T.

Publication type:

Report

Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.

Published in:

2020

By:

Austin, Mark;
Burschowsky, Daniel;
Chan, Denice T.Y.;
Jenkinson, Lesley;
Haynes, Stuart;
Diamandakis, Agata;
Seewooruthun, Chitra;
Addyman, Alexandra;
Fiedler, Sebastian;
Ryman, Stephanie;
Whitehouse, Jessica;
Slater, Louise H.;
Hadjinicolaou, Andreas V.;
Gileadi, Uzi;
Gowans, Ellen;
Shibata, Yoko;
Barnard, Michelle;
Kaserer, Teresa;
Sharma, Pooja;
Luheshi, Nadia M.

Publication type:

Report

Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies.

Published in:

2020

By:

Evers, Mitchell;
Ten Broeke, Toine;
Jansen, J.H. Marco;
Nederend, Maaike;
Hamdan, Firas;
Reiding, Karli R.;
Meyer, Saskia;
Moerer, Petra;
Brinkman, Iris;
Rösner, Thies;
Lebbink, Robert Jan;
Valerius, Thomas;
Leusen, Jeanette H.W.

Publication type:

Report

Development and validation of an LC-MS/MS method for simultaneous quantification of co-administered trastuzumab and pertuzumab.

Published in:

2020

By:

Schokker, Sandor;
Fusetti, Fabrizia;
Bonardi, Francesco;
Molenaar, Remco J.;
Mathôt, Ron A.A.;
van Laarhoven, Hanneke W.M.

Publication type:

Report

Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region.

Published in:

2020

By:

Handlogten, Michael W.;
Peng, Li;
Christian, Elizabeth A.;
Xu, Weichen;
Lin, Shihua;
Venkat, Raghavan;
Dall'Acqua, William;
Ahuja, Sanjeev

Publication type:

Report

Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity.

Published in:

2020

By:

Camacho, Raul C.;
You, Seohee;
D'Aquino, Katharine E.;
Li, Wenyu;
Wang, Yuanping;
Gunnet, Joseph;
Littrell, James;
Qi, Jian Shen;
Kang, Lijuan;
Jian, Wenying;
MacDonald, Mary;
Tat, Timothy;
Steiner, Derek;
Zhang, Yue-Mei;
Lanter, James;
Patch, Raymond;
Zhang, Rui;
Li, Jiali;
Edavettal, Suzanne;
Edwards, Wilson

Publication type:

Report

The Antibody Society's antibody validation webinar series.

Published in:

mAbs (1942-0862), 2020, v. 12, n. 1, p. 1, doi. 10.1080/19420862.2020.1794421

By:

Voskuil, Jan L.A.;
Bandrowski, Anita;
Begley, C. Glenn;
Bradbury, Andrew R.M.;
Chalmers, Andrew D.;
Gomes, Aldrin V.;
Hardcastle, Travis;
Lund-Johansen, Fridtjof;
Plückthun, Andreas;
Roncador, Giovanna;
Solache, Alejandra;
Taussig, Michael J.;
Trimmer, James S.;
Williams, Cecilia;
Goodman, Simon L.

Publication type:

Article

Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms.

Published in:

2020

By:

Walsh, Robin E.;
Lannan, Megan;
Wen, Yi;
Wang, Xiaoli;
Moreland, Christopher A.;
Willency, Jill;
Knierman, Michael D.;
Spindler, Laura;
Liu, Ling;
Zeng, Wei;
Rocha, Guilherme V.;
Obungu, Victor;
Lu, Jirong;
Kaliyaperumal, Arunan;
Ferrante, Andrea;
Siegel, Robert;
Malherbe, Laurent P.

Publication type:

Report

Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent.

Published in:

2020

By:

Bondza, Sina;
ten Broeke, Toine;
Nestor, Marika;
Leusen, Jeanette H. W.;
Buijs, Jos

Publication type:

Report

Enabling speed to clinic for monoclonal antibody programs using a pool of clones for IND-enabling toxicity studies.

Published in:

2020

By:

Bolisetty, Parimala;
Tremml, Gabi;
Xu, Sen;
Khetan, Anurag

Publication type:

Report