Works matching IS 18607179 AND DT 2016 AND VI 11 AND IP 12

Results: 25

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1264, doi. 10.1002/cmdc.201500383

By:

Benek, Ondrej;
Soukup, Ondrej;
Pasdiorova, Marketa;
Hroch, Lukas;
Sepsova, Vendula;
Jost, Petr;
Hrabinova, Martina;
Jun, Daniel;
Kuca, Kamil;
Zala, Dominykas;
Ramsay, Rona R.;
Marco‐Contelles, José;
Musilek, Kamil

Publication type:

Article

Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1328, doi. 10.1002/cmdc.201500385

By:

Aguilera, Elena;
Varela, Javier;
Birriel, Estefanía;
Serna, Elva;
Torres, Susana;
Yaluff, Gloria;
de Bilbao, Ninfa Vera;
Aguirre‐López, Beatriz;
Cabrera, Nallely;
Díaz Mazariegos, Selma;
de Gómez‐Puyou, Marieta Tuena;
Gómez‐Puyou, Armando;
Pérez‐Montfort, Ruy;
Minini, Lucia;
Merlino, Alicia;
Cerecetto, Hugo;
González, Mercedes;
Alvarez, Guzmán

Publication type:

Article

Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1259, doi. 10.1002/cmdc.201500521

By:

Bottegoni, Giovanni;
Veronesi, Marina;
Bisignano, Paola;
Kacker, Puneet;
Favia, Angelo D.;
Cavalli, Andrea

Publication type:

Article

Metabolism-Activated Multitargeting (MAMUT): An Innovative Multitargeting Approach to Drug Design and Development.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1197, doi. 10.1002/cmdc.201500406

By:

Mátyus, Péter;
Chai, Christina L. L.

Publication type:

Article

Cover Picture: Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB2R Ligands To Combat Neurodegenerative Disorders (ChemMedChem 12/2016).

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1188, doi. 10.1002/cmdc.201600285

By:

Dolles, Dominik;
Nimczick, Martin;
Scheiner, Matthias;
Ramler, Jacqueline;
Stadtmüller, Patricia;
Sawatzky, Edgar;
Drakopoulos, Antonios;
Sotriffer, Christoph;
Wittmann, Hans‐Joachim;
Strasser, Andrea;
Decker, Michael

Publication type:

Article

Inside Cover: Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments (ChemMedChem 12/2016).

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1189, doi. 10.1002/cmdc.201600286

By:

Bottegoni, Giovanni;
Veronesi, Marina;
Bisignano, Paola;
Kacker, Puneet;
Favia, Angelo D.;
Cavalli, Andrea

Publication type:

Article

Polypharmacology in Drug Development: A Minireview of Current Technologies.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1211, doi. 10.1002/cmdc.201600067

By:

Tan, Zhi;
Chaudhai, Rajan;
Zhang, Shuxing

Publication type:

Article

Multitarget Drug Discovery and Polypharmacology.

Published in:

2016

By:

Bolognesi, Maria Laura;
Cavalli, Andrea

Publication type:

Editorial

Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P-Glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP).

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1380, doi. 10.1002/cmdc.201500592

By:

Schwarz, Theresa;
Montanari, Floriane;
Cseke, Anna;
Wlcek, Katrin;
Visvader, Lene;
Palme, Sarah;
Chiba, Peter;
Kuchler, Karl;
Urban, Ernst;
Ecker, Gerhard F.

Publication type:

Article

Fighting Cancer with Transition Metal Complexes: From Naked DNA to Protein and Chromatin Targeting Strategies.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1199, doi. 10.1002/cmdc.201500478

By:

Palermo, Giulia;
Magistrato, Alessandra;
Riedel, Tina;
von Erlach, Thibaud;
Davey, Curt A.;
Dyson, Paul J.;
Rothlisberger, Ursula

Publication type:

Article

Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer's Disease.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1309, doi. 10.1002/cmdc.201500422

By:

Simoni, Elena;
Serafini, Melania M.;
Bartolini, Manuela;
Caporaso, Roberta;
Pinto, Antonella;
Necchi, Daniela;
Fiori, Jessica;
Andrisano, Vincenza;
Minarini, Anna;
Lanni, Cristina;
Rosini, Michela

Publication type:

Article

Back Cover: Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity (ChemMedChem 12/2016).

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1395, doi. 10.1002/cmdc.201600287

By:

Aguilera, Elena;
Varela, Javier;
Birriel, Estefanía;
Serna, Elva;
Torres, Susana;
Yaluff, Gloria;
de Bilbao, Ninfa Vera;
Aguirre‐López, Beatriz;
Cabrera, Nallely;
Díaz Mazariegos, Selma;
de Gómez‐Puyou, Marieta Tuena;
Gómez‐Puyou, Armando;
Pérez‐Montfort, Ruy;
Minini, Lucia;
Merlino, Alicia;
Cerecetto, Hugo;
González, Mercedes;
Alvarez, Guzmán

Publication type:

Article

Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer′s Disease.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1284, doi. 10.1002/cmdc.201600014

By:

Prati, Federica;
Bergamini, Christian;
Fato, Romana;
Soukup, Ondrej;
Korabecny, Jan;
Andrisano, Vincenza;
Bartolini, Manuela;
Bolognesi, Maria Laura

Publication type:

Article

Spotlights on our sister journals: ChemMedChem 12/2016.

Published in:: ChemMedChem, 2016, v. 11, n. 12, p. 1193, doi. 10.1002/cmdc.201681213
Publication type:: Article

Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1219, doi. 10.1002/cmdc.201500391

By:

Passeri, Daniela;
Camaioni, Emidio;
Liscio, Paride;
Sabbatini, Paola;
Ferri, Martina;
Carotti, Andrea;
Giacchè, Nicola;
Pellicciari, Roberto;
Gioiello, Antimo;
Macchiarulo, Antonio

Publication type:

Article

Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1296, doi. 10.1002/cmdc.201500392

By:

Montanari, Serena;
Bartolini, Manuela;
Neviani, Paolo;
Belluti, Federica;
Gobbi, Silvia;
Pruccoli, Letizia;
Tarozzi, Andrea;
Falchi, Federico;
Andrisano, Vincenza;
Miszta, Przemysław;
Cavalli, Andrea;
Filipek, Sławomir;
Bisi, Alessandra;
Rampa, Angela

Publication type:

Article

Multitarget Drugs: an Epigenetic Epiphany.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1227, doi. 10.1002/cmdc.201500394

By:

Ganesan, A.

Publication type:

Article

A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1242, doi. 10.1002/cmdc.201500395

By:

Scarpelli, Rita;
Sasso, Oscar;
Piomelli, Daniele

Publication type:

Article

Light-Tunable Generation of Singlet Oxygen and Nitric Oxide with a Bichromophoric Molecular Hybrid: a Bimodal Approach to Killing Cancer Cells.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1371, doi. 10.1002/cmdc.201500396

By:

Fraix, Aurore;
Blangetti, Marco;
Guglielmo, Stefano;
Lazzarato, Loretta;
Marino, Nino;
Cardile, Venera;
Graziano, Adriana C. E.;
Manet, Ilse;
Fruttero, Roberta;
Gasco, Alberto;
Sortino, Salvatore

Publication type:

Article

Systematic Assessment of Molecular Selectivity at the Level of Targets, Bioactive Compounds, and Structural Analogues.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1362, doi. 10.1002/cmdc.201500340

By:

Hu, Ye;
Bajorath, Jürgen

Publication type:

Article

Predicting Molecular Targets for Small-Molecule Drugs with a Ligand-Based Interaction Fingerprint Approach.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1352, doi. 10.1002/cmdc.201500228

By:

Cao, Ran;
Wang, Yanli

Publication type:

Article

Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB2R Ligands To Combat Neurodegenerative Disorders.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1270, doi. 10.1002/cmdc.201500418

By:

Dolles, Dominik;
Nimczick, Martin;
Scheiner, Matthias;
Ramler, Jacqueline;
Stadtmüller, Patricia;
Sawatzky, Edgar;
Drakopoulos, Antonios;
Sotriffer, Christoph;
Wittmann, Hans‐Joachim;
Strasser, Andrea;
Decker, Michael

Publication type:

Article

Redox Polypharmacology as an Emerging Strategy to Combat Malarial Parasites.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1339, doi. 10.1002/cmdc.201600009

By:

Sidorov, Pavel;
Desta, Israel;
Chessé, Matthieu;
Horvath, Dragos;
Marcou, Gilles;
Varnek, Alexandre;
Davioud‐Charvet, Elisabeth;
Elhabiri, Mourad

Publication type:

Article

The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1252, doi. 10.1002/cmdc.201500507

By:

Palermo, Giulia;
Favia, Angelo D.;
Convertino, Marino;
De Vivo, Marco

Publication type:

Article

Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1−42 Aggregation Inhibitors for Alzheimer's Disease Therapy.

Published in:

ChemMedChem, 2016, v. 11, n. 12, p. 1318, doi. 10.1002/cmdc.201500539

By:

Dgachi, Youssef;
Ismaili, Lhassane;
Knez, Damijan;
Benchekroun, Mohamed;
Martin, Hélène;
Szałaj, Natalia;
Wehle, Sarah;
Bautista‐Aguilera, Oscar M.;
Luzet, Vincent;
Bonnet, Alexandre;
Malawska, Barbara;
Gobec, Stanislav;
Chioua, Mourad;
Decker, Michael;
Chabchoub, Fakher;
Marco‐Contelles, José

Publication type:

Article

Works matching IS 18607179 AND DT 2016 AND VI 11 AND IP 12

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease.

Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity.

Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments.

Metabolism-Activated Multitargeting (MAMUT): An Innovative Multitargeting Approach to Drug Design and Development.

Cover Picture: Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB<sub>2</sub>R Ligands To Combat Neurodegenerative Disorders (ChemMedChem 12/2016).

Inside Cover: Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments (ChemMedChem 12/2016).

Polypharmacology in Drug Development: A Minireview of Current Technologies.

Multitarget Drug Discovery and Polypharmacology.

Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P-Glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP).

Fighting Cancer with Transition Metal Complexes: From Naked DNA to Protein and Chromatin Targeting Strategies.

Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer's Disease.

Back Cover: Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity (ChemMedChem 12/2016).

Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer′s Disease.

Spotlights on our sister journals: ChemMedChem 12/2016.

Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors.

Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives.

Multitarget Drugs: an Epigenetic Epiphany.

A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation.

Light-Tunable Generation of Singlet Oxygen and Nitric Oxide with a Bichromophoric Molecular Hybrid: a Bimodal Approach to Killing Cancer Cells.

Systematic Assessment of Molecular Selectivity at the Level of Targets, Bioactive Compounds, and Structural Analogues.

Predicting Molecular Targets for Small-Molecule Drugs with a Ligand-Based Interaction Fingerprint Approach.

Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB<sub>2</sub>R Ligands To Combat Neurodegenerative Disorders.

Redox Polypharmacology as an Emerging Strategy to Combat Malarial Parasites.

The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition.

Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ<sub>1−42</sub> Aggregation Inhibitors for Alzheimer's Disease Therapy.