Works matching IS 18607179 AND DT 2014 AND VI 9 AND IP 4

Results: 29

The Di PPro Approach: Synthesis, Hydrolysis, and Antiviral Activity of Lipophilic d4T Diphosphate Prodrugs.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 762, doi. 10.1002/cmdc.201300500

By:

Schulz, Tilmann;
Balzarini, Jan;
Meier, Chris

Publication type:

Article

Structure-Based Design of Novel Human Toll-like Receptor 8 Agonists.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 719, doi. 10.1002/cmdc.201300573

By:

Kokatla, Hari Prasad;
Sil, Diptesh;
Tanji, Hiromi;
Ohto, Umeharu;
Malladi, Subbalakshmi S.;
Fox, Lauren M.;
Shimizu, Toshiyoki;
David, Sunil A.

Publication type:

Article

Introduction to Biological and Small Molecule Drug Research and Development: Theory and Case Studies. Edited by C. Robin Ganellin, Roy Jefferis and Stanley M. Roberts.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 856, doi. 10.1002/cmdc.201300492

By:

Kalesse, Markus

Publication type:

Article

Cover Picture: Time-Dependent Diaryl Ether Inhibitors of InhA: Structure-Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy (ChemMedChem 4/2014).

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 673, doi. 10.1002/cmdc.201490010

By:

Pan, Pan;
Knudson, Susan E.;
Bommineni, Gopal R.;
Li, Huei‐Jiun;
Lai, Cheng‐Tsung;
Liu, Nina;
Garcia‐Diaz, Miguel;
Simmerling, Carlos;
Patil, Sachindra S.;
Slayden, Richard A.;
Tonge, Peter J.

Publication type:

Article

Binding Kinetics of ZM241385 Derivatives at the Human Adenosine A<sub>2A</sub> Receptor.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 752, doi. 10.1002/cmdc.201300474

By:

Guo, Dong;
Xia, Lizi;
van Veldhoven, Jacobus P. D.;
Hazeu, Marc;
Mocking, Tamara;
Brussee, Johannes;
IJzerman, Adriaan P.;
Heitman, Laura H.

Publication type:

Article

Prospective Virtual Screening in a Sparse Data Scenario: Design of Small-Molecule TLR2 Antagonists.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 813, doi. 10.1002/cmdc.201300445

By:

Murgueitio, Manuela S.;
Henneke, Philipp;
Glossmann, Hartmut;
Santos‐Sierra, Sandra;
Wolber, Gerhard

Publication type:

Article

Back Cover: The Di PPro Approach: Synthesis, Hydrolysis, and Antiviral Activity of Lipophilic d4T Diphosphate Prodrugs (ChemMedChem 4/2014).

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 860, doi. 10.1002/cmdc.201490014

By:

Schulz, Tilmann;
Balzarini, Jan;
Meier, Chris

Publication type:

Article

Mitochondrial Fragmentation Is an Important Cellular Event Induced by Ruthenium(II) Polypyridyl Complexes in Osteosarcoma Cells.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 714, doi. 10.1002/cmdc.201300379

By:

Du, Yanxin;
Fu, Xiaoyan;
Li, Hong;
Chen, Bolai;
Guo, Yuhai;
Su, Guoyi;
Zhang, Hu;
Ning, Feipeng;
Lin, Yongpeng;
Mei, Wenjie;
Chen, Tianfeng

Publication type:

Article

Methyl, Ethyl, Propyl, Butyl: Futile But Not for Water, as the Correlation of Structure and Thermodynamic Signature Shows in a Congeneric Series of Thermolysin Inhibitors.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 833, doi. 10.1002/cmdc.201400013

By:

Krimmer, Stefan G.;
Betz, Michael;
Heine, Andreas;
Klebe, Gerhard

Publication type:

Article

Synthesis, Anti-tubulin and Antiproliferative SAR of Steroidomimetic Dihydroisoquinolinones.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 798, doi. 10.1002/cmdc.201400017

By:

Leese, Mathew P.;
Jourdan, Fabrice L.;
Major, Meriel R.;
Dohle, Wolfgang;
Thomas, Mark P.;
Hamel, Ernest;
Ferrandis, Eric;
Mahon, Mary F.;
Newman, Simon P.;
Purohit, Atul;
Potter, Barry V. L.

Publication type:

Article

Bis-(1,2,3,4-tetrahydroisoquinolinium): A Chiral Scaffold for Developing High-Affinity Ligands for SK Channels.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 737, doi. 10.1002/cmdc.201400028

By:

Liégeois, Jean‐François;
Wouters, Johan;
Seutin, Vincent;
Dilly, Sébastien

Publication type:

Article

Pain Therapeutics: Current and Future Treatment Paradigms. Edited by Charlotte Allerton.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 855, doi. 10.1002/cmdc.201400039

By:

Tidgewell, Kevin

Publication type:

Article

Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 823, doi. 10.1002/cmdc.201300480

By:

Saalau‐Bethell, Susanne M.;
Berdini, Valerio;
Cleasby, Anne;
Congreve, Miles;
Coyle, Joseph E.;
Lock, Victoria;
Murray, Christopher W.;
O'Brien, M. Alistair;
Rich, Sharna J.;
Sambrook, Tracey;
Vinkovic, Mladen;
Yon, Jeff R.;
Jhoti, Harren

Publication type:

Article

Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 699, doi. 10.1002/cmdc.201300525

By:

Jnoff, Eric;
Albrecht, Claudia;
Barker, John J.;
Barker, Oliver;
Beaumont, Edward;
Bromidge, Steven;
Brookfield, Frederick;
Brooks, Mark;
Bubert, Christian;
Ceska, Tom;
Corden, Vincent;
Dawson, Graham;
Duclos, Stephanie;
Fryatt, Tara;
Genicot, Christophe;
Jigorel, Emilie;
Kwong, Jason;
Maghames, Rosemary;
Mushi, Innocent;
Pike, Richard

Publication type:

Article

GluN2B-Selective N-Methyl- d-aspartate (NMDA) Receptor Antagonists Derived from 3-Benzazepines: Synthesis and Pharmacological Evaluation of Benzo[7]annulen-7-amines.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 741, doi. 10.1002/cmdc.201300547

By:

Benner, Andre;
Bonifazi, Alessandro;
Shirataki, Chikako;
Temme, Louisa;
Schepmann, Dirk;
Quaglia, Wilma;
Shoji, Osami;
Watanabe, Yoshihito;
Daniliuc, Constantin;
Wünsch, Bernhard

Publication type:

Article

Structural Basis for the Inhibition of AKR1B10 by Caffeic Acid Phenethyl Ester (CAPE).

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 706, doi. 10.1002/cmdc.201300455

By:

Zhang, Liping;
Zhang, Hong;
Zheng, Xuehua;
Zhao, Yining;
Chen, Shangke;
Chen, Yunyun;
Zhang, Renwei;
Li, Qing;
Hu, Xiaopeng

Publication type:

Article

Spotlights on our sister journals: ChemMedChem 4/2014.

Published in:: ChemMedChem, 2014, v. 9, n. 4, p. 688, doi. 10.1002/cmdc.201490013
Publication type:: Article

In Silico Models for Drug Discovery. Edited by Sandhya Kortagere.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 856, doi. 10.1002/cmdc.201400063

By:

Selzer, Paul M.

Publication type:

Article

100 Issues of ChemMedChem.

Published in:

2014

By:

Williams, Scott D.;
Ortúzar, Natalia

Publication type:

Editorial

Effects of the Tumor-Vasculature-Disrupting Agent Verubulin and Two Heteroaryl Analogues on Cancer Cells, Endothelial Cells, and Blood Vessels.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 847, doi. 10.1002/cmdc.201300531

By:

Mahal, Katharina;
Resch, Marcus;
Ficner, Ralf;
Schobert, Rainer;
Biersack, Bernhard;
Mueller, Thomas

Publication type:

Article

Targeted Fluorination of a Nonsteroidal Anti-inflammatory Drug to Prolong Metabolic Half-Life.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 733, doi. 10.1002/cmdc.201300490

By:

Shaughnessy, Maxwell J.;
Harsanyi, Antal;
Li, Jingji;
Bright, Tara;
Murphy, Cormac D.;
Sandford, Graham

Publication type:

Article

Developing an Irreversible Inhibitor of Human DDAH-1, an Enzyme Upregulated in Melanoma.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 792, doi. 10.1002/cmdc.201300557

By:

Wang, Yun;
Hu, Shougang;
Gabisi, Abdul M.;
Er, Joyce A. V.;
Pope, Arthur;
Burstein, Gayle;
Schardon, Christopher L.;
Cardounel, Arturo J.;
Ekmekcioglu, Suhendan;
Fast, Walter

Publication type:

Article

In Silico Solid State Perturbation for Solubility Improvement.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 724, doi. 10.1002/cmdc.201300454

By:

Briggner, Lars‐Erik;
Kloo, Lars;
Rosdahl, Jan;
Svensson, Per H.

Publication type:

Article

Graphical Abstract: ChemMedChem 4/2014.

Published in:: ChemMedChem, 2014, v. 9, n. 4, p. 679, doi. 10.1002/cmdc.201490012
Publication type:: Article

Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 693, doi. 10.1002/cmdc.201300482

By:

Mercier, Joël;
Archen, Laurence;
Bollu, Véronique;
Carré, Stéphane;
Evrard, Yves;
Jnoff, Eric;
Kenda, Benoît;
Lallemand, Bénédicte;
Michel, Philippe;
Montel, Florian;
Moureau, Florence;
Price, Nathalie;
Quesnel, Yannick;
Sauvage, Xavier;
Valade, Anne;
Provins, Laurent

Publication type:

Article

Inside Cover: Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex (ChemMedChem 4/2014).

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 674, doi. 10.1002/cmdc.201490011

By:

Jnoff, Eric;
Albrecht, Claudia;
Barker, John J.;
Barker, Oliver;
Beaumont, Edward;
Bromidge, Steven;
Brookfield, Frederick;
Brooks, Mark;
Bubert, Christian;
Ceska, Tom;
Corden, Vincent;
Dawson, Graham;
Duclos, Stephanie;
Fryatt, Tara;
Genicot, Christophe;
Jigorel, Emilie;
Kwong, Jason;
Maghames, Rosemary;
Mushi, Innocent;
Pike, Richard

Publication type:

Article

A β-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 710, doi. 10.1002/cmdc.201300325

By:

Weinandy, Franziska;
Lorenz‐Baath, Katrin;
Korotkov, Vadim S.;
Böttcher, Thomas;
Sethi, Shneh;
Chakraborty, Trinad;
Sieber, Stephan A.

Publication type:

Article

Bis-arylidene Oxindoles as Anti-Breast-Cancer Agents Acting via the Estrogen Receptor.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 727, doi. 10.1002/cmdc.201400003

By:

Pal, Abhishek;
Ganguly, Anirban;
Ghosh, Avijit;
Yousuf, Md;
Rathore, Bhowmira;
Banerjee, Rajkumar;
Adhikari, Susanta

Publication type:

Article

Time-Dependent Diaryl Ether Inhibitors of InhA: Structure-Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy.

Published in:

ChemMedChem, 2014, v. 9, n. 4, p. 776, doi. 10.1002/cmdc.201300429

By:

Pan, Pan;
Knudson, Susan E.;
Bommineni, Gopal R.;
Li, Huei‐Jiun;
Lai, Cheng‐Tsung;
Liu, Nina;
Garcia‐Diaz, Miguel;
Simmerling, Carlos;
Patil, Sachindra S.;
Slayden, Richard A.;
Tonge, Peter J.

Publication type:

Article