Works matching IS 18607179 AND DT 2009 AND VI 4 AND IP 7

Results: 26

Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on an N, N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1069, doi. 10.1002/cmdc.200900069

By:

Whitman, David B.;
Cox, Christopher D.;
Breslin, Michael J.;
Brashear, Karen M.;
Schreier, John D.;
Bogusky, Michael J.;
Bednar, Rodney A.;
Lemaire, Wei;
Bruno, Joseph G.;
Hartman, George D.;
Reiss, Duane R.;
Harrell, C. Meacham;
Kraus, Richard L.;
Li, Yuxing;
Garson, Susan L.;
Doran, Scott M.;
Prueksaritanont, Thomayant;
Li, Chunze;
Winrow, Christopher J.;
Koblan, Kenneth S.

Publication type:

Article

Graphical Abstract: ChemMedChem 7/2009.

Published in:: ChemMedChem, 2009, v. 4, n. 7, p. 1031, doi. 10.1002/cmdc.200990032
Publication type:: Article

Biological Profiling of Anti-HIV Agents and Insight into CCR5 Antagonist Binding Using in silico Techniques.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1153, doi. 10.1002/cmdc.200900101

By:

Carrieri, Antonio;
Pérez-Nueno, Violeta I.;
Fano, Alessandra;
Pistone, Carlo;
Ritchie, David W.;
Teixidó, Jordi

Publication type:

Article

Truncation and Optimisation of Peptide Inhibitors of Cyclin-Dependent Kinase 2-Cyclin A Through Structure-Guided Design.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1120, doi. 10.1002/cmdc.200900093

By:

Kontopidis, George;
Andrews, Martin J.;
McInnes, Campbell;
Plater, Andy;
Innes, Lorraine;
Renachowski, Scott;
Cowan, Angela;
Fischer, Peter M.

Publication type:

Article

Fragment Formal Concept Analysis Accurately Classifies Compounds with Closely Related Biological Activities.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1174, doi. 10.1002/cmdc.200900035

By:

Krüger, Felix;
Lounkine, Eugen;
Bajorath, Jürgen

Publication type:

Article

Unlocking the Chemotherapeutic Potential of β-Aminovinyl Ketones and Related Compounds.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1043, doi. 10.1002/cmdc.200900006

By:

Gaber, Hatem M.;
Bagley, Mark C.

Publication type:

Article

Mutagenesis and Molecular Modeling of the Orthosteric Binding Site of the mGlu2 Receptor Determining Interactions of the Group II Receptor Antagonist 3H-HYDIA.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1086, doi. 10.1002/cmdc.200900028

By:

Lundström, Linda;
Kuhn, Bernd;
Beck, Jennifer;
Borroni, Edilio;
Wettstein, Joseph G.;
Woltering, Thomas J.;
Gatti, Silvia

Publication type:

Article

Inside Cover: Silicon Analogues of the RXR-Selective Retinoid Agonist SR11237 (BMS649): Chemistry and Biology (ChemMedChem 7/2009).

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1030, doi. 10.1002/cmdc.200990031

By:

Lippert, W. Peter;
Burschka, Christian;
Götz, Kathrin;
Kaupp, Martin;
Ivanova, Diana;
Gaudon, Claudine;
Sato, Yoshiteru;
Antony, Pierre;
Rochel, Natacha;
Moras, Dino;
Gronemeyer, Hinrich;
Tacke, Reinhold

Publication type:

Article

Design and Discovery of Plasmepsin II Inhibitors Using an Automated Workflow on Large-Scale Grids.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1164, doi. 10.1002/cmdc.200900111

By:

Degliesposti, Gianluca;
Kasam, Vinod;
Da Costa, Ana;
Kang, Hee-Kyoung;
Kim, Nahyun;
Kim, Do-Won;
Breton, Vincent;
Kim, Doman;
Rastelli, Giulio

Publication type:

Article

Meropenem-Clavulanate: A New Strategy for the Treatment of Tuberculosis?

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1051, doi. 10.1002/cmdc.200900155

By:

Holzgrabe, Ulrike

Publication type:

Article

Derivation of a Retinoid X Receptor Scaffold from Peroxisome Proliferator-Activated Receptor γ Ligand 1-Di(1 H-indol-3-yl)methyl-4-trifluoromethylbenzene.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1106, doi. 10.1002/cmdc.200800447

By:

Dawson, Marcia I.;
Ye, Mao;
Cao, Xihua;
Farhana, Lulu;
Hu, Qiong-Ying;
Zhao, Yong;
Xu, Li Ping;
Kiselyuk, Alice;
Correa, Ricardo G.;
Yang, Li;
Hou, Tingjun;
Reed, John C.;
Itkin-Ansari, Pamela;
Levine, Fred;
Sanner, Michel F.;
Fontana, Joseph A.;
Zhang, Xiao-Kun

Publication type:

Article

Anticancer Therapeutics. Edited by Sotiris Missailidis.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1203, doi. 10.1002/cmdc.200900119

By:

Foley, David

Publication type:

Article

Synthesis and Biological Characterization of (3 R,4 R)-4-(2-(Benzhydryloxy)ethyl)-1-(( R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and Its Stereoisomers for Activity toward Monoamine Transporters.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1075, doi. 10.1002/cmdc.200900085

By:

Kharkar, Prashant S.;
Batman, Angela M.;
Zhen, Juan;
Beardsley, Patrick M.;
Reith, Maarten E. A.;
Dutta, Aloke K.

Publication type:

Article

Characterization of New PPARγ Agonists: Benzimidazole Derivatives - the Importance of Position 2.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1136, doi. 10.1002/cmdc.200900067

By:

Goebel, Matthias;
Staels, Bart;
Unger, Thomas;
Kintscher, Ulrich;
Gust, Ronald

Publication type:

Article

Further Evidence of the Anti-inflammatory Effects of Silver Nanoparticles.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1129, doi. 10.1002/cmdc.200900049

By:

Wong, Kenneth K. Y.;
Cheung, Stephanie O. F.;
Huang, Liuming;
Niu, Jun;
Tao, Chang;
Ho, Chi-Ming;
Che, Chi-Ming;
Tam, Paul K. H.

Publication type:

Article

Cover Picture: Photonucleophilic Addition of the ε-Amino Group of Lysine to a Triflusal Metabolite as a Mechanistic Key to Photoallergy Mediated by the Parent Drug (ChemMedChem 7/2009).

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1029, doi. 10.1002/cmdc.200990030

By:

Montanaro, Sara;
Lhiaubet-Vallet, Virginie;
Jiménez, M. Consuelo;
Blanca, Miguel;
Miranda, Miguel Angel

Publication type:

Article

Searching for Disease Modifiers-PKC Activation and HDAC Inhibition-A Dual Drug Approach to Alzheimer's Disease that Decreases Aβ Production while Blocking Oxidative Stress.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1095, doi. 10.1002/cmdc.200900045

By:

Kozikowski, Alan P.;
Chen, Yihua;
Subhasish, Tapadar;
Lewin, Nancy E.;
Blumberg, Peter M.;
Zhong, Zhenyu;
D'Annibale, Melissa A.;
Wang, Weng-Long;
Shen, Yong;
Langley, Brett

Publication type:

Article

Preview: ChemMedChem 8/2009.

Published in:: ChemMedChem, 2009, v. 4, n. 7, p. 1207, doi. 10.1002/cmdc.200990034
Publication type:: Article

Discovery of a New Class of Non-imidazole Oxazoline-Based Histamine H3 Receptor (H3R) Inverse Agonists.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1063, doi. 10.1002/cmdc.200900055

By:

Célanire, Sylvain;
Wijtmans, Maikel;
Christophe, Bernard;
Collart, Philippe;
de Esch, Iwan;
Dassesse, Donald;
Delaunoy, Christel;
Denonne, Frédéric;
Durieu, Véronique;
Gelens, Edith;
Gillard, Michel;
Lallemand, Bénédicte;
Lamberty, Yves;
Lebon, Florence;
Nicolas, Jean-Marie;
Quéré, Luc;
Snip, Erwin;
Vanbellinghen, Alain;
Van houtvin, Nathalie;
Verbois, Valérie

Publication type:

Article

Photonucleophilic Addition of the ε-Amino Group of Lysine to a Triflusal Metabolite as a Mechanistic Key to Photoallergy Mediated by the Parent Drug.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1196, doi. 10.1002/cmdc.200900066

By:

Montanaro, Sara;
Lhiaubet-Vallet, Virginie;
Jiménez, M. Consuelo;
Blanca, Miguel;
Miranda, Miguel Angel

Publication type:

Article

Design and Synthesis of Trypanosoma brucei Active 1-Alkyloxy and 1-Benzyloxyadamantano 2-Guanylhydrazones.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1059, doi. 10.1002/cmdc.200900019

By:

Papanastasiou, Ioannis;
Tsotinis, Andrew;
Zoidis, Grigoris;
Kolocouris, Nicolas;
Prathalingam, S. Radhika;
Kelly, John M.

Publication type:

Article

Spotlights on our sister journals: ChemMedChem 7/2009.

Published in:: ChemMedChem, 2009, v. 4, n. 7, p. 1040, doi. 10.1002/cmdc.200990033
Publication type:: Article

Silicon Analogues of the RXR-Selective Retinoid Agonist SR11237 (BMS649): Chemistry and Biology.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1143, doi. 10.1002/cmdc.200900090

By:

Lippert, W. Peter;
Burschka, Christian;
Götz, Kathrin;
Kaupp, Martin;
Ivanova, Diana;
Gaudon, Claudine;
Sato, Yoshiteru;
Antony, Pierre;
Rochel, Natacha;
Moras, Dino;
Gronemeyer, Hinrich;
Tacke, Reinhold

Publication type:

Article

Medicinal Chemistry Teaching and Training: A Continuous Adaptation.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1055, doi. 10.1002/cmdc.200900128

By:

Timmerman, Henk;
de Souza, Noel J.

Publication type:

Article

Azido and Diazarinyl Analogues of Bis-Tyrphostin as Asymmetrical Inhibitors of Dynamin GTPase.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1182, doi. 10.1002/cmdc.200900054

By:

Odell, Luke R.;
Chau, Ngoc;
Mariana, Anna;
Graham, Mark E.;
Robinson, Phillip J.;
McCluskey, Adam

Publication type:

Article

Discovery of Selective Luteinizing Hormone Receptor Agonists Using the Bivalent Ligand Method.

Published in:

ChemMedChem, 2009, v. 4, n. 7, p. 1189, doi. 10.1002/cmdc.200900058

By:

Bonger, Kimberly M.;
van den Berg, Richard J. B. H. N.;
Knijnenburg, Annemiek D.;
Heitman, Laura H.;
van Koppen, Chris J.;
Timmers, Cornelis M.;
Overkleeft, Herman S.;
van der Marel, Gijsbert A.

Publication type:

Article

Works matching IS 18607179 AND DT 2009 AND VI 4 AND IP 7

Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on an N, N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats.

Graphical Abstract: ChemMedChem 7/2009.

Biological Profiling of Anti-HIV Agents and Insight into CCR5 Antagonist Binding Using in silico Techniques.

Truncation and Optimisation of Peptide Inhibitors of Cyclin-Dependent Kinase 2-Cyclin A Through Structure-Guided Design.

Fragment Formal Concept Analysis Accurately Classifies Compounds with Closely Related Biological Activities.

Unlocking the Chemotherapeutic Potential of β-Aminovinyl Ketones and Related Compounds.

Mutagenesis and Molecular Modeling of the Orthosteric Binding Site of the mGlu2 Receptor Determining Interactions of the Group II Receptor Antagonist <sup>3</sup>H-HYDIA.

Inside Cover: Silicon Analogues of the RXR-Selective Retinoid Agonist SR11237 (BMS649): Chemistry and Biology (ChemMedChem 7/2009).

Design and Discovery of Plasmepsin II Inhibitors Using an Automated Workflow on Large-Scale Grids.

Meropenem-Clavulanate: A New Strategy for the Treatment of Tuberculosis?

Derivation of a Retinoid X Receptor Scaffold from Peroxisome Proliferator-Activated Receptor γ Ligand 1-Di(1 H-indol-3-yl)methyl-4-trifluoromethylbenzene.

Anticancer Therapeutics. Edited by Sotiris Missailidis.

Synthesis and Biological Characterization of (3 R,4 R)-4-(2-(Benzhydryloxy)ethyl)-1-(( R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and Its Stereoisomers for Activity toward Monoamine Transporters.

Characterization of New PPARγ Agonists: Benzimidazole Derivatives - the Importance of Position 2.

Further Evidence of the Anti-inflammatory Effects of Silver Nanoparticles.

Cover Picture: Photonucleophilic Addition of the ε-Amino Group of Lysine to a Triflusal Metabolite as a Mechanistic Key to Photoallergy Mediated by the Parent Drug (ChemMedChem 7/2009).

Searching for Disease Modifiers-PKC Activation and HDAC Inhibition-A Dual Drug Approach to Alzheimer's Disease that Decreases Aβ Production while Blocking Oxidative Stress.

Preview: ChemMedChem 8/2009.

Discovery of a New Class of Non-imidazole Oxazoline-Based Histamine H<sub>3</sub> Receptor (H<sub>3</sub>R) Inverse Agonists.

Photonucleophilic Addition of the ε-Amino Group of Lysine to a Triflusal Metabolite as a Mechanistic Key to Photoallergy Mediated by the Parent Drug.

Design and Synthesis of Trypanosoma brucei Active 1-Alkyloxy and 1-Benzyloxyadamantano 2-Guanylhydrazones.

Spotlights on our sister journals: ChemMedChem 7/2009.

Silicon Analogues of the RXR-Selective Retinoid Agonist SR11237 (BMS649): Chemistry and Biology.

Medicinal Chemistry Teaching and Training: A Continuous Adaptation.

Azido and Diazarinyl Analogues of Bis-Tyrphostin as Asymmetrical Inhibitors of Dynamin GTPase.

Discovery of Selective Luteinizing Hormone Receptor Agonists Using the Bivalent Ligand Method.